hUC-MSC preserves erectile function by restoring mitochondrial mass of penile smooth muscle cells in a rat model of cavernous nerve injury via SIRT1/PGC-1a/TFAM signaling by Mengbo Yang, Xinda Chen, Ming Zhang, Xiaolin Zhang, Dongdong Xiao, Huiming Xu, Mujun Lu

“…It remains unclear whether hUC-MSC can ameliorate mitochondrial damage in CCSMCs. In this study, we aimed to investigate the impacts of hUC-MSC on the mitochondrial mass and function of CCSMCs, as well as elucidate its underlying molecular mechanism. …”
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Sarcolemma resilience and skeletal muscle health require O-mannosylation of dystroglycan by Jeffrey M. Hord, Sarah Burns, Tobias Willer, Matthew M. Goddeeris, David Venzke, Kevin P. Campbell

“…Furthermore, our data indicate that genetic rescue of Pomt1 in Pomt1skm mice limits contraction-induced sarcolemma damage and skeletal muscle pathology. Conclusions Collectively, our data indicate that DG modification by Pomt1/2 results in core M3 capped with matriglycan, and that this is required to reinforce the sarcolemma and enable skeletal muscle health and neuromuscular strength.…”
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The management and clinical outcome of paracetamol poisoning in South African adults: A single-centre retrospective review by C Kotze, J Swanepoel, E C Kruger, E Decloedt

“…To describe the characteristics of patients presenting with paracetamol poisoning, and to identify factors associated with severity of liver injury and poor outcomes in adults with biochemical evidence of paracetamol-induced liver damage treated at a South African (SA) tertiary hospital. …”
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A Pilot Study on Cognitive Processing Characteristics and Cerebral Mechanisms of Native Chinese-Speaking Savant Calendar Calculators with Autism Spectrum Disorder by CHEN Jian, XU Shutian, WU Yuwei, CHEN Songmei, SHAN Chunlei

“…The patient with SCC was examined with crainial MRI and compared with healthy subjects to explore the organic brain damage.Results(1) Calendar calculation ability test: the correct rate of random normal calendar calculation in the SCC patient was 80%, and the average time of answering each question was 11.8 s, while the average correct rate of random normal calendar calculation in the healthy subjects was only 16%. (2) Calendar memorizing ability test: the correct rate of the adjusted new calendar calculation in the SCC patient was only 20%. (3) Numerical calculation ability: the correct rate of addition and division in the SCC patient was 100%, and the average time was 10.67 s and 58.19 s respectively. …”
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Suberosin attenuates rheumatoid arthritis by repolarizing macrophages and inhibiting synovitis via the JAK/STAT signaling pathway by Huan Liu, Qianwei Li, Yuehong Chen, Min Dong, Hongjiang Liu, Jiaqian Zhang, Leiyi Yang, Geng Yin, Qibing Xie

“…Conclusion SBR significantly reduced clinical symptoms, joint pathological damage, and expression inflammatory cytokine expression in CIA mice. …”
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Real-World Health Care Outcomes and Costs Among Patients With Juvenile Idiopathic Arthritis in Spain by Jordi Antón, Estefania Moreno Ruzafa, Mireia Lopez Corbeto, Rosa Bou, Judith Sánchez Manubens, Sonia Carriquí Arenas, Joan Calzada Hernández, Violetta Bittermann, Carolina Estepa Guillén, Juan Mosquera Angarita, Lucía Rodríguez Díez, Estíbaliz Iglesias, Miguel Marti Masanet, Berta Lopez Montesinos, Maria I. González Fernández, Alfonso de Lossada, Carmen Peral, Mónica Valderrama, Noelia Llevat, María Montoro Álvarez, Immaculada Calvo Penadés

“…If inflammation is not adequately treated, joint damage, long-term disability, and active disease during adulthood can occur. …”
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Progressive subchondral bone cyst formation following autologous chondrocyte implantation with all-suture anchors: a Case Report with histological evaluation by Takuma Kaibara, Eiji Kondo, Masatake Matsuoka, Koji Iwasaki, Tomohiro Onodera, Daisuke Momma, Zen-Ichi Tanei, Shinya Tanaka, Norimasa Iwasaki

“…These observations may inform future strategies for the early detection of SBC formation and its progression, as well as timely intervention to prevent further joint damage in similar cases, though further research is needed to establish broader clinical implications.…”
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Current status and factors influencing kinesiophobia in patients with meniscus injury: a cross-sectional study by Faqiang Tang, Pan Xu, Cai Jiang, Xiaohua Ke, Dunbing Huang, Yaling Dai, Zhonghua Lin, Shizhong Wang

“…The knee range of motion test was used to determine limitations in knee joint mobility, whereas magnetic resonance imaging (MRI) was used to assess the severity of meniscus damage. Several validated scales were administered: the Tampa Scale of Kinesiophobia (TSK-17) to measure kinesiophobia, the visual analog scale (VAS) to assess pain intensity, the general self-efficacy scale (GSES) to evaluate self-efficacy, and the Lysholm knee score (LKS) to assess knee functional status. …”
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Pirfenidone regulates seizures through the HMGB1/TLR4 axis to improve cognitive functions and modulate oxidative stress and neurotransmitters in PTZ-induced kindling in mice by Mansi Dahalia, Sparsh Gupta, Haya Majid, Divya Vohora, Nidhi

“…Histopathological analysis revealed that pirfenidone ameliorated cellular disintegration and neuronal damage in the hippocampus and cortex.ConclusionPirfenidone shows potential as an anticonvulsant, anti-inflammatory, hepatoprotective, and neuroprotective agent, with additional benefits in improving cognition and oxidative stress profiles in epilepsy treatment. …”
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Quantifying the spatial patterns of retinal ganglion cell loss and progression in optic neuropathy by applying a deep learning variational autoencoder approach to optical coherence... by Jui-Kai Wang, Jui-Kai Wang, Brett A. Johnson, Zhi Chen, Zhi Chen, Honghai Zhang, Honghai Zhang, David Szanto, Brian Woods, Brian Woods, Michael Wall, Young H. Kwon, Young H. Kwon, Edward F. Linton, Edward F. Linton, Andrew Pouw, Mark J. Kupersmith, Mark J. Kupersmith, Mark J. Kupersmith, Mona K. Garvin, Mona K. Garvin, Mona K. Garvin, Mona K. Garvin, Randy H. Kardon, Randy H. Kardon

“…IntroductionGlaucoma, optic neuritis (ON), and non-arteritic anterior ischemic optic neuropathy (NAION) produce distinct patterns of retinal ganglion cell (RGC) damage. We propose a booster Variational Autoencoder (bVAE) to capture spatial variations in RGC loss and generate latent space (LS) montage maps that visualize different degrees and spatial patterns of optic nerve bundle injury. …”
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New Insights on Childhood Lupus Nephritis by Marchi-Silva R, De Aquino BM, Londe AC, Mazzola TN, Julio PR, Wampler Muskardin T, Appenzeller S

“…Major progress made in recent years includes adjustment of the proportion of fibrous crescents when scoring nephritis in cSLE to better discriminate kidney disease outcomes, and development of non-invasive biomarkers to identify renal disease activity and damage. It is anticipated that accurate non-invasive biomarkers will foster multicenter studies and help identify new treatment approaches to improve outcomes in cSLE nephritis.Keywords: lupus nephritis, childhood-onset SLE, treatment…”
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The injury effect of osteopontin in sepsis-associated lung injury by Qian Wang, Zhicai Yu, Zhixin Song, Xue Lu, Zhu Li, Dandan Pi, Jing Li, Feng Xu

“…Intravenous administration of OPN inhibitor into the tail vein decreased the mortality rate (HR = 0.2695, p = 0.0015), suppressed systemic inflammatory responses and mitigated lung tissue damage. The concentration of tumour necrosis factor (TNF)-α, IL-6 and IL-1β in serum of CLP mice treated with OPN inhibitor decreased compared with CLP mice. …”
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Study on the Effect of Isotropic Initial Stress on the Anchoring Performance of Self-Expanding Bolts by Jie Liu, Hongya Li, Yunzhou Li, Yunan Yang, Tao Sun, Rui Song, Rongqi Sun

“…It is pointed out that this effect can greatly improve the ductility of the anchoring system and the ultimate energy consumption value of damage. A prediction model for the ultimate pull-out force of self-expanding bolts is established. …”
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Exosomes secreted by ATF3/Nrf2-mediated ferroptotic renal tubular epithelial cells promote M1/M2 ratio imbalance inducing renal interstitial fibrosis following ischemia and reperfu... by Qiao Tang, Jiatao Xie, Yifei Wang, Chong Dong, Chong Dong, Qian Sun

“…The IR group had more significant mitochondrial damage and higher PTGS2 and TFRC mRNA levels than those in the sham group. …”
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Eficacia de inhibidores de nitrito de calcio (CNI) en concreto agrietado by Pedro Montes-Garcia, H. Z. López-Calv, T. W Bremner

“…The specimens were also visually inspected on regular basis and the surface damage was recorded. It was found that for most of the cases the use of CNI inhibitor was beneficial in both uncracked and cracked concrete.…”
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Altered expression profile of plasma exosomal microRNAs in exclusive electronic cigarette adult users by Dongmei Li, Zidian Xie, Sadiya Bi Shaikh, Irfan Rahman

“…Overexpression of hsa-miR-125b-5p promoted DNA damage in bronchial epithelial cells. These findings suggest an elevation of carcinogenic cellular signaling pathways in exclusive e-cigarette users.…”
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Life cycle assessment of agricultural waste recycling for sustainable environmental impact by S. Sumiyati, B.P. Samadikun, A. Widiyanti, M.A. Budihardjo, S. Al Qadar, A.S. Puspita

“…The direct environmental effects of waste management are frequently the focus of life cycle assessment studies, but they may overlook secondary effects such as indirect land use change, habitat damage, and biodiversity effects. It is crucial to consider these secondary effects in a more comprehensive analysis.…”
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Association of Prehypertension with Renin Angiotensin System: A Cross-Sectional Study on Tribal Population of Northern India by Vani Kandpal, Mohinder Pal Sachdeva, Kallur Nava Saraswathy

“…Prehypertension, the intermediate stage between HTN and normal blood pressure (BP), is associated with subclinical atherosclerosis and target-organ damage. Evaluating the prevalence of prehypertension is imperative to prevent disease progression. …”
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A More Efficient and Safer Improved Percutaneous Pedicle Screw Insertion Technique—Trajectory Dynamic Adjustment Technique, Technical Note, and Clinical Efficacy by Hao Li, Zhiguo Ding, Bin Wei, Zhihao Ma, Jing Xie, Yonghao Tian, Lianlei Wang, Xinyu Liu, Suomao Yuan

“…ABSTRACT Objective Percutaneous pedicle screw fixation (PPSF) technique requires a very precise entry point of the Jamshidi needle, which leads to repeated adjustments, damaging the pedicle and increasing radiation exposure. …”
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Competence induction of homologous recombination genes protects pneumococcal cells from genotoxic stress by David De Lemos, Anne-Lise Soulet, Violette Morales, Mathieu Berge, Patrice Polard, Calum Johnston

“…However, this was not the case for another DNA-damaging agent, norfloxacin. These results show that competence induction of HR effectors is important for the increased tolerance to genotoxic stress provided to competent pneumococci. …”
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