Evolutionary constrained genes associated with autism spectrum disorder across 2,054 nonhuman primate genomes by Yukiko Kikuchi, Mohammed Uddin, Joris A. Veltman, Sara Wells, Christopher Morris, Marc Woodbury-Smith

“…Among macaques, many key ASD-implicated genes were observed to harbour predicted damaging mutations. A small number of key ASD-implicated genes that are highly intolerant to mutation in humans, however, showed no evidence of similar intolerance in macaques (CACNA1D, MBD5, AUTS2 and NRXN1). …”
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Identification of deleterious variants associated with male infertility genes in a cohort of idiopathic hypospermatogenesis patients by Nisha Sharma, Ashutosh Halder, Seema Kaushal, Manoj Kumar, Manish Jain

“…In silico analysis of variants shows deleterious and probably damaging effects on canonical transcripts of the genes.DiscussionThis exploratory genomic analysis conducted on idiopathic hypospermatogenesis patients shows prevalence of rare deleterious candidate variants in genes associated with human male infertility. …”
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Assessing and evaluating human-wildlife interactions for coexistence in shared landscapes by Katia Maria Paschoaletto Micchi de Barros Ferraz, Isabella de Freitas Bento, Anna Beatriz Queiroz Di Souza, Caio da Silveira Nunes, Maria Augusta de Mendonça Guimarães, Monicque Silva Pereira, Monicque Silva Pereira, Livia Lima da Silva, Letícia Keiko Nunes de Campos, Anita Seneme Gobbi, José Caio Quadrado Alves, Loisa Fabrícia Prates Alvarez, Silvio Marchini, Ana Carla Medeiros Morato de Aquino, Vinicius Kenji de Moraes Sato, Roberta Montanheiro Paolino, Roberta Montanheiro Paolino

“…We identified 16 types of HWI that can occur in shared landscapes, 10 were categorized as Human-Wildlife Conflict, six as Unsustainable Use, four as Wildlife Damage and three as Convivencia, with some classified in more than one category. …”
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Nanotechnology-based herbal medicine: Preparation, synthesis, and applications in food and medicine by Farhang H. Awlqadr, Kithar Rasheed Majeed, Ammar B. Altemimi, Arkan Mohammed Hassan, Syamand Ahmed Qadir, Mohammed N. Saeed, Aryan Mahmood Faraj, Tablo H. Salih, Alaa Jabbar Abd Al‐Manhel, Mazin A.A. Najm, Efstathia Tsakali, Jan F.M. Van Impe, Ahmed A. Abd El-Maksoud, Tarek Gamal Abedelmaksoud

“…The ability of nanoherbal formulations to deliver drugs to tumor cells in an improved permeability and retention manner, such as, cancer therapy while minimizing tissue damage, has been largely practiced in many laboratories. …”
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Discharge against Medical Advice (DAMA) from an Emergency Department of a Tertiary Care Hospital in Saudi Arabia by Ashraf El-Metwally, Nesreen Suliman Alwallan, Ali Amin Alnajjar, Nida Zahid, Khalid Alahmary, Paivi Toivola

“…The outcomes of DAMA can have significantly damaging effects, causing possible relapses of disease, readmission, and increases in medical costs for the patient. …”
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Identifying specific subgroups of older patients at risk of repeated hospital readmissions and death after discharge in a prospective multicentre cohort in France by Jean-Baptiste Beuscart, Fabien Visade, Genia Babykina, Jesus Carretero-Bravo, Guillaume Deschasse, Vincent Vandewalle

“…Objective To identify specific subgroups of older patients at risk of repeated hospital readmissions and death.Design Prospective, multicentre, DAMAGE (Patient Outcomes After Hospitalization in Acute Geriatric Unit) cohort of adults aged 75 and over, discharged from an acute geriatric unit (AGU) and followed up for 12 months.Setting Six recruiting hospital centres in the Hauts-de-France and Normandie regions of France.Main outcome measures We performed a latent class analysis to identify subgroups at risk of repeated hospital readmissions and death, followed by a logistic regression analysis to determine the characteristics associated with the identified subgroups.Results 3081 patients were included (mean (SD) age: 86.4 (5.5)) and two subgroups were identified. …”
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Analysis of risk factors for acute cerebral infarction in patients with intracranial tuberculosis by Xiao-Shan Huang, Xiao-Wei Qiu, An-Long Wang, Fei He, Yi-Jing Wang

“…ObjectiveAcute cerebral infarction is a common complication of intracranial tuberculosis (TB), causing irreversible damage to brain tissue and significantly affecting patient prognosis. …”
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Parkinson’s disease and other movement disorders in the context of the SARS-COV-2 pandemic by R. Kaladytė Lokominienė

“…The penetration of SARS-CoV-2 into the brain damaged by Parkinson’s disease can enhance the clinical burden of movement disorder and increase the deficit for substitutional dopaminergic therapy. …”
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An assessment of burden associated with problem joints in children and adults with moderate or severe haemophilia A: analysis of the CHESS-Paediatrics and CHESS II cross-sectional... by Paul McLaughlin, Hortensia De la Corte-Rodriguez, Tom Burke, Francis Nissen, Martynas Aizenas, Katya Moreno, Jamie O’Hara

“…Abstract Background Clinical research has offered many definitions and fragmented perspectives of joint morbidity in haemophilia. As joint damage, pain and mobility impairment can be present without clinical record of persistent bleeding, a person-centric joint morbidity characterisation remained a priority for the haemophilia community, giving rise to the ‘problem joint’ concept. …”
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Altered medial temporal lobe subregion volumes in systemic lupus erythematosus patients with neuropsychiatric symptoms by Z. Makdad Najeeb, P. C. Sundgren, A. Jönsen, K. Zervides, J. Lätt, T. Salomonsson, J. Nystedt, P. Nilsson, A. Bengtsson, G. Kuchcinski, L. E. M. Wisse

“…These findings are suggestive of neuronal damage in MTL subregions in NPSLE patients on a group level.…”
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Oxidative Stress and Risk of Dementia in Older Patients with Depression: A Longitudinal Cohort Study Using Plasma Biomarkers by Yoo-Jin Jang, Min-Ji Kim, Su-Jin Lee, Shinn-Won Lim, Doh-Kwan Kim

“…<i>Conclusions:</i> Nitrotyrosine, a biomarker that reflects nitrosative damage, emerged as a significant predictor of dementia risk in older patients with depression, highlighting its potential as an early biomarker of dementia. …”
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Transmission Failure Prediction Using AI and Structural Modeling Informed by Distribution Outages by Sita Nyame, William O. Taylor, William Hughes, Mingguo Hong, Marika Koukoula, Feifei Yang, Aaron Spaulding, Xiaochuan Luo, Slava Maslennikov, Diego Cerrai

“…Long term, this model can assist with resilience investments as it highlights areas of the system more susceptible to damage.…”
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Inhibition of the mTOR Pathway Exerts Cardioprotective Effects Partly through Autophagy in CLP Rats by Wen Han, Hao Wang, Longxiang Su, Yun Long, Na Cui, Dawei Liu

“…Rapamycin alleviated the pathological damage of myocardial tissue, attenuated cardiac dysfunction (left ventricular ejection fraction (LVEF), p<0.05; fractional shortening (FS), p<0.05), and reduced HIF-1a expression (p<0.05). …”
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Comprehensive computational analysis of differentially expressed miRNAs and their influence on transcriptomic signatures in prostate cancer by Fahad M. Aldakheel, Hadeel Alnajran, Ayesha Mateen, Shatha A. Alduraywish, Mohammed S. Alqahtani, Rabbani Syed

“…This analysis uncovered their substantial impact on critical biological processes and molecular functions, such as cyclin-dependent protein kinase activity, mitotic DNA damage checkpoint signalling, stress-activated MAPK cascade, regulation of extrinsic apoptotic signalling pathway, and positive regulation of cell adhesion. …”
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Study on a cable jumper method for offshore floating photovoltaic systems with multiple floating bodies by Xiangyu KONG, Yangping SHAO, Qiang FU, Lujie YU, Hongbin LIU

“…The research shows that through reasonable planning of the jumper cable path, the bending state of the cable can be alleviated to a certain extent, thereby reducing fatigue damage and ensuring reliable operation during the operational period. (1) Optimizing the jumper parameters through reasonable planning of the jumper path can improve the reliability of flexible cables in harsh environments. …”
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Successful treatment of cardiac dysfunction due to left main trunk obstruction and severe acute aortic regurgitation secondary to acute type A aortic dissection using Impella: a ca... by Ai Sakai, Kenji Iino, Hideyasu Ueda, Yoshitaka Yamamoto, Hirofumi Takemura

“…Subsequently, Impella 5.5 was introduced via a branch of the vascular graft to address the extensive myocardial damage due to preoperative LMT obstruction, acute AR-induced left ventricular volume overload, and increased afterload from VA-ECMO. …”
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Investigating Fire Collapse Early Warning Systems for Portal Frames by Ming Xie, Fangbo Xu, Zhangdong Wang, Li’e Yin, Xiangdong Wu, Mengqi Xu, Xiang Li

“…Combined with an ultrasonic experiment, the theoretical relationships between the transverse and longitudinal wave velocities and the elastic modulus of steel at high temperatures are verified, and the relationship between the transverse and longitudinal wave velocities and the overall damage of the portal frame is further constructed; then, a new early warning method for portal frame stability during a fire is proposed. …”
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Determination of HLA Tissue Type According to the Etiology of Patients with Chronic Renal Failure by Burcu KARAKUS TURAN, Fahri UCAR, Vural Taner YILMAZ, Yahya KILINC, Sule DARBAŞ ARAS, Huseyin KOCAK, Nurten SAYIN EKINCI, Bulent AYDINLI, Habibe Sema ARSLAN

“…Objective: Chronic kidney disease (CKD) is a prominent public health concern, is defined as functional and structural damage to the kidneys. This study aims to investigate the association between human leukocyte antigen (HLA) alleles individuals with CKD and the different etiological subgroups of diesease. …”
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Strength, Hydraulic, and Microstructural Characteristics of Expansive Soils Incorporating Marble Dust and Rice Husk Ash by Fazal E. Jalal, Sultani Mulk, Shazim Ali Memon, Babak Jamhiri, Ahsan Naseem

“…In an attempt to counter the treacherous damage of such soils in modern geotechnical engineering, efforts are underway to utilize environmentally friendly and sustainable waste materials as stabilizers. …”
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Assessment of the Effect of Flooding on Agricultural Lands in Kaharo Sub-County of Kabale District South Western Uganda. by Nyakiti, Dorcas Awino

“…Loss of life (52) was the major effect of flooding on agricultural lands in Kaharo sub county Kabale district (Table 4.2), 49% of the respondents recorded that damage to crops and food supplies were the effects of flooding in an area whereas 46% of the respondents mentioned that Famine was also an effect of flooding due to destruction of crops and other agricultural lands. …”
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