Transcutaneous Electrical Nerve Stimulation (TENS) Alleviates Brain Ischemic Injury by Regulating Neuronal Oxidative Stress, Pyroptosis, and Mitophagy by Zixuan Tan, Fang Dong, Linyu Wu, Yashuo Feng, Min Zhang, Feng Zhang

“…In conclusion, our results indicated that TENS alleviated brain damage following ischemic stroke via inhibiting neuronal oxidative stress and pyroptosis and activating mitophagy, possibly via the regulation of TXNIP, BRCC3/NLRP3, and HIF-1α/BNIP3 pathways.…”
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Validation of heavy metals in geothermal to support water management practices and mitigation strategies by G.M. Idroes, D.P. Rezeki, K. Khairi, K. Khairan, R. Idroes, E. Suhartono, R. Prasetio, S.A. Rahman, S. Suhendrayatna

“…This implies a substantial danger to the health of those who drink or are exposed to this water, as both lead and cadmium are associated with severe health complications, including damage to the nervous system and kidneys. The findings underscore the urgent need for targeted water treatment and continuous monitoring, providing critical data to support sustainable water management and mitigation strategies in geothermal regions.CONCLUSION: The findings of this study underscore the urgent need for water treatment initiatives and continuous monitoring of geothermal water sources in the Mount Kembar Region. …”
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Ex vivo biotransformation of lady’s mantle extracts via the human gut microbiota: the formation of phenolic metabolites and their impact on human normal and colon cancer cell lines... by Katarzyna Jakimiuk, Aleksandra Kruk, Marta Kinga Lemieszek, Jakub W. Strawa, Sebastian Granica, Adrian Wiater, Michał Tomczyk

“…Samples from AVD1, AVD2, and AVD3 increase the lactate dehydrogenase (LDH) released from damaged colon cancer cells in a dose-dependent manner. …”
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Mitigation of environmental impacts in ornamental rock and limestone aggregate quarries in arid and semi-arid areas by M.A. Peñaranda Barba, V. Alarcón Martínez, I. Gómez Lucas, J. Navarro Pedreño

“…FINDINGS: According to the environmental impact assessment studies analysed, the importance of the most significant environmental impacts has been calculated, indicating whether the impacts are critical, severe, moderate or compatible, and based on it, preventive and corrective measures are proposed together in an impact mitigation management system based in flow charts that will serve to more easily apply and control these measures, in order to prevent them from causing significant or irreversible damage to the environment. Analysing these measures, it has been observed that 90% of the measures applied to control the different negative environmental factors in this type of quarry are the same.CONCLUSION: Open-pit mining extraction systems have a series of similar characteristics that allow a systematic approach to be established when analysing the impacts. …”
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A Pine Wilt Disease Detection Model Integrated with Mamba Model and Attention Mechanisms Using UAV Imagery by Minhui Bai, Xinyu Di, Lechuan Yu, Jian Ding, Haifeng Lin

“…Pine wilt disease (PWD) is a highly destructive worldwide forest quarantine disease that has the potential to destroy entire pine forests in a relatively brief period, resulting in significant economic losses and environmental damage. Manual monitoring, biochemical detection and satellite remote sensing are frequently inadequate for the timely detection and control of pine wilt disease. …”
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Evaluating H2BC9 as a potential diagnostic and prognostic biomarker in head and neck squamous cell carcinoma by Lanhua Wu, Liang Li, Mingjing Zhu, Ziyan Zhou, Xuejin Su, Yueming Jiang, Min Kang, Li Jiang

“…Silencing H2BC9 suppressed cell proliferation, induced G2/M cell cycle arrest, and enhanced apoptosis and DNA damage in HNSCC cells. Conclusion We demonstrated that H2BC9 expression may be associated with HNSCC development and prognosis. …”
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The Impact of Drug Abuse on The Learner's Academic Performance in Kisoro Municipality Kisoro District. by Arinitwe, Edward

“…The study results on the causes of drug abuse among secondary learners were; stress, idleness makes people go to drugs drinking, a factor of the working places, lack of effective laws, the factor of peer pressure, and lack of education on its negative side and leisure factors, study results on the effects of drug abuse on the learner's academic performance were; this leads to strikes among students which affects the student's performance, leads to diseases which affects the student's performance, distortion of memory and brain which affects student's performance, damages to the liver of the students which affects the student's performance and interpersonal difficulties which also affects student's performance and the study results on the possible measures to drug abuse on the learners academic performance were; government intervention by restricting students on drugs use, reduce on the rate of drinking, doctor- prescribed medications and abstinence must be part of one's treatment goal. …”
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Effect of Sand Mining on River System: A Case Study of River Rwabakazi Kabale Municipality.. by Kamagara, Denis

“…These included promoting and incentivizing the use of less environmentally damaging sand mining technologies, implementing stricter regulations on sand mining activities within the river, developing and implementing river restoration plans for the affected areas, and encouraging sand miners to shift to alternative sources of clay outside the river. …”
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Antistripping potential of cement kiln dust on recycled asphalt pavement. Innovative Infrastructure Solutions by Usman, Kabiru Rogo, Ali, Atheer Muhammed, Wakawa, Yakubu Mamman, Usman, Abbas

“…Ultimately, the boiling test results indicated that CKD blended RAP mix surpassed the minimum 80% TSR for moisture damage resistance.…”
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Hepatic Fat Content and Liver Enzymes Are Associated with Circulating Free and Protein-Bound Advanced Glycation End Products, Which Are Associated with Low-Grade Inflammation: The... by Mitchell Bijnen, Marleen M. J. van Greevenbroek, Carla J. H. van der Kallen, Jean L. Scheijen, Marjo P. H. van de Waarenburg, Coen D. A. Stehouwer, Kristiaan Wouters, Casper G. Schalkwijk

“…In a cohort study, we investigated the association of liver fat and hepatocellular damage with circulating AGEs and soluble RAGE (sRAGE) and subsequently the association of circulating AGEs and sRAGE with LGI. …”
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Analysis on the Difference of Energy Evolution in the Process of Energy Storage Failure of Strong Coal Rush Rock Samples under Different Adaptive Modification Regulation Measures by Fangfang Zhang

“…Finally, the gradient pressure relief scheme should be considered in order to avoid large stress drop caused by large-scale pressure relief in the region and aggravate the instability of rock mass. …”
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Astaxanthin-loaded brain-permeable liposomes for Parkinson’s disease treatment via antioxidant and anti-inflammatory responses by Thai-Duong Nguyen, Shristi Khanal, Eunhee Lee, Jinsol Choi, Ganesh Bohara, Nikesh Rimal, Dong-Young Choi, Soyeun Park

“…In a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson’s disease mouse model, treatment with Lf-ASX-LPs resulted in 5.0-, 3.1-, and 5.6-fold increases in dopamine levels, TH+ fiber density, and TH+ neurons, respectively, restoring dopaminergic neuron damage. The developed formulation also alleviated behavioral impairment and neuroinflammation, reducing astrocyte and microglial activation in the striatum and substantia nigra of the MPTP-treated animals. …”
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Identification of mitophagy-related key genes and their correlation with immune cell infiltration in acute myocardial infarction via bioinformatics analysis by Zulong Sheng, Rui Zhang, Zhenjun Ji, Zhuyuan Liu, Yaqing Zhou

“…Mitochondrial dysfunction is critically involved in AMI progression, and mitophagy plays a vital role in eliminating damaged mitochondria. This study aimed to explore mitophagy-related biomarkers and their potential molecular basis in AMI.MethodsAMI datasets (GSE24519 and GSE34198) from the Gene Expression Omnibus database were combined and the batch effects were removed. …”
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Wnt signaling as a translational target in rheumatoid and psoriatic arthritis by Gloria Riitano, Francesca Spinelli, Valeria Manganelli, Daniela Caissutti, Antonella Capozzi, Cristina Garufi, Tina Garofalo, Roberta Misasi, Maurizio Sorice, Fabrizio Conti, Agostina Longo, Cristiano Alessandri

“…RA primarily targets the synovial joints and is characterized by cartilage and bone erosion, whereas PsA is associated with skin and nail psoriasis and is characterized by erosive bone damage with an exuberant bone formation and soft tissue involvement. …”
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Tumor Necrosis Factor Receptor 1 Is Required for Human Umbilical Cord–Derived Mesenchymal Stem Cell–Mediated Rheumatoid Arthritis Therapy by Guangyang Liu, Herui Wang, Chenliang Zhang, Xin Li, Yi Mi, Yaoyao Chen, Liqiang Xu, Li Miao, Haomiao Long, Yongjun Liu

“…One of the key cytokines involved in the pathogenesis of RA is tumor necrosis factor α (TNF-α), which plays a crucial role in the differentiation of T cells and B cells and serves as a primary trigger of inflammation and joint damage in RA. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) have shown potential in alleviating the symptoms of RA. …”
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Wu-Mei-Wan enhances brown adipose tissue function and white adipose browning in obese mice via upregulation of HSF1 by Shen Chen, Kexin Nie, Hongzhan Wang, Yang Gao, Xinyue Jiang, Hao Su, Zhi Wang, Yueheng Tang, Fuer Lu, Hui Dong, Jingbin Li

“…WMW also reversed structural damage in BAT, enhancing mitochondrial integrity and thermogenic function, particularly at the low dose. …”
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Personal determinants of vandal behaviour among urban school and student youth from a gender perspective by O. V. Kruzhkova, I. V. Deviatovskaia, M. S. Krivoshchekova

“…This problem is especially acute for modern megalopolises, the environment of which is often a subject for damages and unauthorised changes. However, the megalopolis, possessing specific environmental characteristics, in a sense creates favourable conditions for vandalism through anonymisation, a decrease in social control, the adoption of borderline deviant-like forms of behaviour, etc. …”
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Extracellular Vesicles in Periodontitis: Pathogenic Mechanisms and Therapeutic Potential by Zhang L, Li X, Zhang B, Li R

“…Recent research has indicated that EVs derived from periodontal pathogens can trigger periodontitis, exacerbate the periodontal damage, and potentially disseminate to other parts of the body, leading to systemic conditions. …”
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Malícia honey (Mimosa quadrivalvis L.) produced by the jandaíra bee (Melipona subnitida D.) shows antioxidant activity via phenolic compound action in obese rats by Maria Luiza Rolim Bezerra, Maria Luiza Rolim Bezerra, Mirela Gouveia-Nhanca, Mirela Gouveia-Nhanca, Maria Letícia da Veiga Dutra, Maria Letícia da Veiga Dutra, Kamila Sabino Batista, Alana Natalícia Vasconcelos de Araújo, Alana Natalícia Vasconcelos de Araújo, Marcos dos Santos Lima, Marcos dos Santos Lima, Mateus Duarte Ribeiro, Mateus Duarte Ribeiro, Alexandre Sergio Silva, Alexandre Sergio Silva, Alexandre Sergio Silva, Adriano Francisco Alves, Tatiana Colombo Pimentel, Marciane Magnani, Marciane Magnani, Jailane de Souza Aquino, Jailane de Souza Aquino, Jailane de Souza Aquino

“…Specifically, the brain in the OGH showed greater procyanidin B2 and gallic acid deposition; the liver showed increased procyanidin B1 and B2, epicatechin, and myricetin concentrations; the gut showed higher procyanidin B2 and kaempferol 3-glucoside concentrations; and the kidneys had increased catechin, procyanidin B1 and B2, and gallic acid deposition compared to the OG.ConclusionHistologically, the OGH displayed reduced neuronal damage and prevention of hepatic steatosis induced by the cafeteria diet. …”
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Effects of Reduced Substrate Volumetric Water Contents on the Morphology and Physiology of Three Landscape Shrubs Grown in a Greenhouse by Ji-Jhong Chen, Youping Sun

“…As the substrate volumetric water content declined, plants exhibited an increase in the proportion of visibly wilted and damaged leaves as well as chlorosis. Rose, rosemary, and vitex experienced up to a 30% decrease in the plant growth index [(height + width 1 + width 2)/3], whereas leaf dry weights (DWs) decreased by 84%, 66%, and 58%, respectively. …”
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