Comprehensive analysis of the prognostic, immunological, and diagnostic roles of SIRT1 in pan-cancer and its validation in KIRC by Qi Liu, Songxian Sun, Chunxiang Zhou, Houxi Xu, Houxi Xu

“…BackgroundDisturbances in DNA damage repair may lead to cancer. SIRT1, an NAD+-dependent deacetylase, plays a crucial role in maintaining cellular homeostasis through the regulation of processes such as histone posttranslational modifications, DNA repair, and cellular metabolism. …”
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Pulsed Light Accelerated Crosslinking versus Continuous Light Accelerated Crosslinking: One-Year Results by Cosimo Mazzotta, Claudio Traversi, Anna Lucia Paradiso, Maria Eugenia Latronico, Miguel Rechichi

“…Functional outcomes were found to be better in epithelium-off pulsed light accelerated treatment together with showing a deeper stromal penetration. No endothelial damage was recorded during the follow-up in both groups. …”
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Antioxidant protective effect of Nelumbo nucifera extract against spermatogenic cells in male mice due to 2-methoxyethanol exposure by Badriatul Musyarofah, Putri Ayu Ika Setiyowati, Angella Ananda Syaputra, Amelia Kartika Reza, Yunita Ainul Khasanah, Rofiatun Solekha

“…The optimal dose of N. nucifera extract that is most able to repair testicular tissue damage is a high dose.…”
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The motives for non-suicidal self-injury among adolescents with psychiatric disorders by Armon Massoodi, Zeinab Aghajantabar, Sussan Moudi, Hoda Shirafkan

“…Abstract Background Non-suicidal self-injury (NSSI) is an intentional act that results in physical damage to one’s body, without the intent to commit suicide. …”
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Blood absolute lymphocyte count and trajectory are important in understanding severe COVID-19 by Catharine I. Paules, Jacqueline A. Nordwall, Kathryn Shaw-Saliba, Judith A. Aberg, Edward M. Gardner, Anna L. Goodman, N. Kumarasamy, Shikha Vasudeva, David M. Vock, Crystal M. North, Jens Lundgren, Neil R. Aggarwal, for the STRIVE Network and TICO Trial Study Group

“…Persistent and new lymphopenia were associated with older age, male sex; prior immunosuppression, heart failure, aspirin use, and normal body mass index; biomarkers of organ damage (renal and lung), and ineffective immune response (elevated IL-6 and viral nucleocapsid antigen levels). …”
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miR-16-5p aggravates sepsis-associated acute kidney injury by inducing apoptosis by Han Li, Junyan Duan, Tongtong Zhang, Yingjie Fu, Yue Xu, Hongjun Miao, Xuhua Ge

“…In addition, LPS-exposed renal tissue and HK-2 cells lead to upregulation of inflammatory cytokines IL-6, IL-1β, TNF-a, and kidney damage molecules kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL). …”
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Mechanical Properties and Micromorphology of Calcium Oxide Expansion Agent on River Sand/Machine-Made Sand Concrete by Feng Wei, Fei Zhang, Li Gao, Rui Wang, Xiang Ren, Dan Zhang

“…Freeze-thaw damage is one of the main factors affecting the service life and durability of concrete. …”
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The CD4/CD8 ratio is associated with T lymphocyte functions in long-term virally suppressed patients with HIV by Qing Xiao, Fengting Yu, Liting Yan, Xiaojie Lao, Xuelei Liang, Hongxin Zhao, Liuyue Zhai, Zailin Yang, Xiaomei Zhang, Yao Liu, Fujie Zhang

“…As the CD4/CD8 ratio increased, mitochondrial lipid peroxidation damage decreased and MMP was restored. Additionally, the ELR group had more inflammatory markers in CD4+ T cells. …”
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Distribution and species composition of potato viruses in the Novosibirsk region by V. S. Maslennikova, M. B. Pykhtina, K. A. Tabanyukhov, E. V. Shelikhova, K. I. Mosalev, A. V. Katokhin, A. A. Bondar, A. B. Beklemishev, M. I. Voevoda

“…Among the many diseases that affect potato plants, viral infections are the most common and cause significant damage to farms, affecting both the yield and quality of potatoes. …”
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Effect of PCSK9 inhibitor on early neurological deterioration in acute ischemic stroke patients with a history of coronary heart disease: a study protocol for a randomized controll... by Xing Gong, Xinting Yu, Lanlan Pu, Yang Jiao, Lin Liu, Hua Cao, Xiaofei Ji

“…Shared risk factors between CHD and AIS, especially elevated low-density lipoprotein cholesterol (LDL-C), contribute to atherosclerosis and inflammation, which worsen brain tissue damage. Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors offer a promising treatment option. …”
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Influence of Methylprednisolone Pulse Therapy on Liver Function in Patients with Graves’ Orbitopathy by Piotr Miśkiewicz, Anna Jankowska, Kinga Brodzińska, Justyna Milczarek-Banach, Urszula Ambroziak

“…Therapy of GO with higher doses (1.0 g) of IVMP in consecutive days is associated with higher risk of liver damage than treatment with moderate doses (≤0.5 g) in every week schedule. …”
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Environmental trade-offs of meeting nutritional requirements with a lower share of animal protein for adult subpopulations by J. Aubin, F. Vieux, S. Le Féon, M. Tharrey, J.L. Peyraud, N. Darmon

“…Conversely, it increased three environmental impacts: freshwater eutrophication and water use (both by ca. 40%) and biodiversity damage potential (potential loss of species associated with land use) (by 66%). …”
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An Innovation to Address the Anterior Pelvic Ring Disruptions by Ramesh Perumal, Harish Mahesan, Dheenadhayalan Jayaramaraju, Rajasekaran Shanmuganathan

“…Hemodynamically unstable are stabilized with external fixator as a damage control procedure and planned for plating as a secondary procedure. …”
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L’avenir des ressources génétiques marines au-delà des juridictions nationales : enjeux à l’aube d’un nouveau traité international by Nathan Brison, Christine Frison

“…In addition to the already visible impact of activities such as deep-sea fishing and maritime traffic, the future development of several other activities, particularly the exploitation of gas, oil, mineral resources and genetic resources, raises fears of potential serious damage to the environment of ABNJ. For this reason, on December 24, 2017, the United Nations General Assembly (UNGA) opened negotiations on a new treaty for the conservation and sustainable use of marine biodiversity of the ABNJ. …”
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Therapeutic Potential of Combined 5% Lifitegrast and Tocopherol Eye Drops in Managing Inflammation and Oxidative Stress in Murine Dry Eye by Jayoung Moon, Enying Jiang, Jingting Liu, Hui Jin, Hee Su Yoon, Hoon-In Choi, Ji Suk Choi, Hong Qi, Hyeon-Jeong Yoon, Kyung Chul Yoon

“…<b>Background/Objectives</b>: This study aimed to evaluate the therapeutic effects of combined 5% lifitegrast (LF) and tocopherol (TCP) eye drops in a murine experimental dry eye (EDE) model. …”
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Рerioperative period of high-risk patients with coronary artery disease by O.K. Gogayeva

“…Careful preoperative diagnosis, preparation, risk stratification, determination of the term of surgery, choice of CABG method taking into account the anthropometric data, the state of the lower extremities veins, anatomical location of coronary arteries, their diameter and degree of damage, personalized drug therapy, allows to achieve good results with minimal complications.…”
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Neuroprotective Efficacy of <i>Astragalus mongholicus</i> in Ischemic Stroke: Antioxidant and Anti-Inflammatory Mechanisms by Yongjae Hong, Geon Ko, Yeong-Jae Jeon, Hyeon-Man Baek, Juni Lee, Donghun Lee, Jieun Park, Jaehong Kim, Keun-A Chang

“…AM treatment significantly reduced ischemic damage and improved neurological outcomes in both acute and chronic stages of PTB and tMCAO models. …”
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Retinal Protection of New Nutraceutical Formulation by Luca Rosario La Rosa, Veronica Pepe, Francesca Lazzara, Giovanni Luca Romano, Federica Conti, Erika Giuffrida, Claudio Bucolo, Santa Viola, Giuseppe De Pasquale, Maria Cristina Curatolo, Cristina Zappulla

“…Moreover, the protective effect against hypoxic damage was evaluated in Muller cells (MIO-M1) subjected to hypoxia. …”
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Evaluating lead leaching from uPVC pipes into drinking water: Characterization with SEM-EDX and ICP-OES by Yassin T.H. Mehdar

“…Furthermore, there are many studies about lead exposure and its damage to the kidneys and reproductive system, as well as contributing to elevated blood pressure and hypertension.This study investigates the presence of lead and its leaching rate from some uPVC pipes into drinking water under different conditions of temperature and time. …”
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Predictive Values of Preoperative Tests for Difficult Laryngoscopy and Intubation in Adult Patients at Tikur Anbessa Specialized Hospital by Tadese Tamire, Habtamu Demelash, Wosenyeleh Admasu

“…Difficulties in intubation have been associated with serious complications, such as brain damage or death, particularly when failed intubation has occurred. …”
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