Yiqi Fumai Lyophilized injection protects cardiac contractility in a rat model of heart failure with reduced ejection fraction by modulating SERCA2 by Yongwei Nie, Lu Chen, Yanxin Zhang, Yuqing Yao, Zizhuo Xue, Na Guo, Meixiu Wan, Zhi Li, Chunhua Liu, Dekun Li, Aichun Ju

“…Hematoxylin and Eosin (H&E) staining, Masson's trichrome staining, western blotting, and immunohistochemical analysis were performed to evaluate myocardial damage and investigate the underlying molecular mechanisms. …”
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ROS-regulated SUR1-TRPM4 drives persistent activation of NLRP3 inflammasome in microglia after whole-brain radiation by Yuan Chang, Yihua He, Di Wang, Kunxue Zhang, Yuzhen Zhang, Zhentong Li, Shuxin Zeng, Sheng Xiao, Suyue Pan, Kaibin Huang

“…Utilizing the mouse model of RIBI and irradiated BV2 cells, we further demonstrated that irradiation caused mitochondrial damage to microglia, leading to violent release of reactive oxygen species (ROS), which enhanced the transcription of SUR1, TRPM4, and NLRP3 inflammasome-related molecules. …”
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Posttraumatic stress disorder and associated factors in the aftermath of the 2015 earthquake in Nepal: A systematic review and meta-analysis. by Prayash Paudel, Asutosh Sah, Anil Khanal

“…The subgroup analyses revealed that the incidence of posttraumatic stress disorder after an earthquake varied significantly across studies in terms of the time of assessment, sex, age, marital status, ethnicity, educational level, disease history, bereavement, injury to the body, witnessing death, social support, loss of property and damage to one's house. However, stratified analyses could not fully explain the heterogeneity in the results. …”
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Preparation and Characterization of Auricularia cornea Ehrenb Polysaccharide-Zn Complex and Its Hypoglycemic Activity through Regulating Insulin Resistance in HepG2 Cells by Tingting Liu, Shanshan Zhang, Nan Wang, Xinle Xu, Hongcheng Liu, Dawei Wang, Yanrong Zhang

“…Therefore, it was speculated that the hypoglycemic effect of Auricularia cornea Ehrenb polysaccharide combined with zinc was related to the alleviation of liver cell damage caused by oxidative stress and the improvement of glucose metabolism of IR-HepG2 cells. …”
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Diabetic Ketoacidosis Precipitated by COVID-19: A Case Report by Prathayini Paramanathan, Muhammad Abbas

“…Discussion: Factors precipitating DKA in patients with diabetes in the setting of COVID-19are: the increased secretions of stress hormones that counter the effects of insulin and increase blood glucose levels, and the ways in which severe acute respiratory syndrome coronavirus 2 interacts with human cells, leading to pancreatic islet cell damage. Conclusion: Diabetes and COVID-19 intensify each other’s complications in patients diagnosed with both.…”
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The relationship of growth differentiation factor 15 with some biochemical parameters in cardiovascular disease patients in Babylon City by Hiba Resheed Behayaa, Zinah Abbass Ali, Seenaa Badr Mohammed, Suhayr A. Alqaysi

“…Though in cardiovascular damage, the level of GDF15 may rise, the natural effects of GDF15 may vary according to the stage of the disease. …”
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Functional Tests and Surveys Used to Assess Nervous System Dysfunction in Patients with Fabry Disease – A Review by Stanislaw Jesionek, Jakub Parys, Agnieszka Mikosińska, Martyna Kaźmierczak, Partycja Kałuziak, Marta Jajczak, Maciej Mossakowski, Aleksandra Witek, Mateusz Litwin, Justyna Jankowska

“… Introduction and Purpose: Fabry disease (FD) is a rare, X-linked lysosomal storage disorder caused by a deficiency of the enzyme alpha-galactosidase A, leading to progressive multi-organ damage. Among the various complications, autonomic nervous system dysfunction has been suggested as a significant aspect of the disease’s pathophysiology. …”
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Experimental Study on Electric Resistivity Characteristics of Compacted Loess under Different Loads and Drying-Wetting Cycles by Yu Zhou, Guoyu Li, Wei Ma, Dun Chen, Fei Wang, Yuncheng Mao, Qingsong Du, Jun Zhang, Liyun Tang

“…The electrical resistivity of loess reflects plastic damage under uniaxial unloading-reloading tests, but it is deficient in representing the dissipated energy of loess. …”
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Exosomes derived from liver failure patients’ plasma stimulated mesenchymal stem cells alleviate acute liver failure by Zhuoran Wang, Jun Ling, Shaoli You, Bing Zhu

“…Apoptosis was assessed using the CCK-8 assay and flow cytometry. Liver tissue damage was examined by hematoxylin and eosin staining and immunohistochemistry. …”
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Concentrations, Deposition, and Effects of Nitrogenous Pollutants in Selected California Ecosystems by Andrzej Bytnerowicz, Pamela E. Padgett, Sally D. Parry, Mark E. Fenn, Michael J. Arbaugh

“…HNO3 vapor alone has a potential for toxic effects causing damage of foliar surfaces of pines and oaks. In addition, dry deposition of predominantly HNO3 has lead to changes in vegetation composition and contamination of ground- and stream water where terrestrial N loading is high. …”
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CRISPR-Based Programmable Nucleic Acid-Binding Protein Technology Can Specifically Detect Fatal Tropical Disease-Causing Pathogens by Md. Rashidur Rahman, Toma Rani Majumder, Md. Aminul Islam Apu, Alok K. Paul, Afrina Afrose, Biplab Kumar Dash

“…Furthermore, the discovery of programmable trans-cleavage Cas proteins like Cas12a and Cas13 that can collaterally damage reporter-containing single-stranded DNA or RNA upon formation of target Cas-gRNA complex has strengthened this technology with enhanced sensitivity. …”
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Microbubble dynamics in brain microvessels. by James H Bezer, Paul Prentice, William Lim Kee Chang, Sophie V Morse, Kirsten Christensen-Jeffries, Christopher J Rowlands, Andriy S Kozlov, James J Choi

“…These results present the first direct observations of ultrasound-driven microbubbles within brain tissue, and illustrate a range of microbubble behaviors that have the potential to lead to safe drug delivery or tissue damage.…”
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Unique laparoscopic emergency management of traumatic obstructed abdominal wall hernia: A case report and review of literature by Arwa M. Aljuhani, Ghaith A. Al Saied, Arjmand Reyaz, Mohammed A. Alkahlan, Ibrahim M. Aljohani, Muhammed M. Abukhater

“…This type of hernia is primarily caused by low- or high-energy blunt force trauma, resulting in damage to abdominal wall musculature while the skin is intact. …”
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Analysis of Settlement Induced by Shield Construction of the Metro Passing under Existing Buildings Based on the Finite Difference Method by Rui Wang, Bin Zhang, You Wang

“…Shield excavation placed the soil at the top of the excavation face in a state of tensile stress, causing tensile and shear damage to the soil and forming a local plastic zone.…”
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Safety of transtympanic application of probiotics in a chinchilla animal model by Carol Nhan, Aren Bezdjian, Shyamali Saha, Satya Prakash, Lily H. P. Nguyen, Sam J. Daniel

“…There was no histologic evidence of auditory hair cell damaged evidenced by scanning electron microscopy. …”
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What Matters in Psoriatic Arthritis: A Comparison of Patient and Clinician Perspectives by Philip J. Mease, M. Elaine Husni, Evan Siegel, Daniel E. Furst, Melissa Mcilraith, Vibeke Strand, M. Cameron Hay

“…Other prioritized domains showed disparity: access to care, daily activities, stiffness, future health uncertainty, and sleep quality for patients versus specific disease skin and joint manifestations, comorbidities, structural damage, and disease management goals for clinicians. …”
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Involvement of circRNAs in Proinflammatory Cytokines-Mediated β-Cell Dysfunction by Zhen Wang, Chao Deng, Ying Zheng

“…As little is known about their role in insulin-secreting cells, this study is aimed at evaluating their contribution in the process of inflammation-induced β-cell damage. Methods. circRNA expression profile of MIN6 cells stimulated with a mix of cytokines, including IL-1β, IFN-γ, and TNF-α, was detected by circRNA microarrays. …”
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Impacts of climate-driven insect population change on sawtimber provisioning, carbon sequestration, and water retention: a case study of bark beetle outbreaks in the USA by Haojie Chen, Matthew R. Sloggy, Samuel W. Flake, Samuel Evans, Charles J. Maxwell

“…Enhanced management is more capable than business-as-usual practices to prevent beetle damages to trees and ESs.…”
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Development of spring durum wheat cultivars resistant to stem rust in Western Siberia by V. S. Yusov, M. G. Evdokimov, L. V. Meshkova, D. A. Glushakov

“…., is a dangerous disease that afflicts serious economic damage to the cultivation of durum wheat.Materials and methods. …”
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Defect state enhanced nonlinear absorption and optical limiting behaviour of erbium doped silver molybdate nanostructures by B. Binish, K. Mani Rahulan, T. C. Sabari Girisun, Nisha S. Panicker

“…Abstract Transition metal based optical limiting materials have garnered significant attention due their crucial role in protecting sensitive optical system from high intense laser damage. Transition metal molybdates exhibits nonlinear optical (NLO) response, which attenuate highly intense light by transmitting light of desired intensity. …”
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