Intercellular TIMP-1-CD63 signaling directs the evolution of immune escape and metastasis in KRAS-mutated pancreatic cancer cells by Chu-An Wang, Ya-Chin Hou, Yi-Kai Hong, Yu-Jing Tai, Chieh Shen, Pei-Chi Hou, Jhao-Lin Fu, Cheng-Lin Wu, Siao Muk Cheng, Daw-Yang Hwang, Yung-Yeh Su, Yan-Shen Shan, Shaw-Jenq Tsai

“…This study investigates how KRAS-mutated epithelial cells acquire the capacity to escape senescence or even immune clearance, thereby progressing to advanced PDAC. …”
Get full text

Driving effect of P16 methylation on telomerase reverse transcriptase-mediated immortalization and transformation of normal human fibroblasts by Xuehong Zhang, Paiyun Li, Ying Gan, Shengyan Xiang, Liankun Gu, Jing Zhou, Xiaorui Zhou, Peihuang Wu, Baozhen Zhang, Dajun Deng, Jing Ni

“…Furthermore, the subclone formation capacity of P16-Dnmt&TERT cells was two-fold that of TERT cells. …”
Get full text

Rapid antigen testing by community health workers for detection of SARS-CoV-2 in Dhaka, Bangladesh: a cross-sectional study by Mahbubur Rahman, Ayesha Sania, Seonjoo Lee, Tahmina Shirin, A S M Alamgir, Yael K Rayport, Ahmed Nawsher Alam, Joanna Andrecka, Eric Brum, Fergus Chadwick, Tasnuva Chowdhury, Zakiul Hasan, Davina L Hill, Farzana Khan, Mikolaj Kundegorski, Motahara Tasneem, Katie Hampson

“…Household testing by community health workers in low-resource settings is an inexpensive approach that can increase testing capacity, accessibility and the effectiveness of control measures through immediately actionable results.…”
Get full text

Effect of Eight-Week Transcranial Direct-Current Stimulation Combined with Lat Pull-Down Resistance Training on Improving Pull-Up Performance for Male College Students by Qian Li, Jiaqi Yan, Hanya Dai, Minjie Qiao, Mingxin Gong, Wenxin Niu, Ye Yang, Lejun Wang

“…These findings suggest that eight weeks of tDCS combined with lat pull-down training and lat pull-down training alone can both significantly improve pull-up performance, which may be attributed to enhanced muscle contraction capacity. Although no significant training gains were found between the two training groups, the RT + tDCS group showed a significant decrease in TB coactivation and the enhancement of elbow flexion muscle contraction efficiency after training.…”
Get full text

Effectiveness of ICS/LABA and LAMA/LABA in COPD due to biomass by Alejandra Ramírez-Venegas, Francisco Montiel-Lopez, Robinson E. Robles-Hernández, Bartolome R. Celli, Raúl H. Sansores, Maricruz Cassou-Martínez, José L. Pérez Lara-Albisua, Claudia González-González, María E. Mayar-Maya, Aloisa P. Hernández-Morales, Rafael J. Hernández-Zenteno, Ramcés Falfán-Valencia, Ireri Thirión-Romero, Oliver Pérez-Bautista, Rogelio Pérez-Padilla

“…The purpose of the study was to compare the efficacy of fluticasone furoate/vilanterol (FF/V) 100/25 μg and umeclidinium/vilanterol (UMEC/VI) 62.5/25 μg on the rate of exacerbations, the time to first exacerbation, on dyspnoea, health-related quality of life (HRQL), forced expiratory volume in 1 s (FEV1) and inspiratory capacity (IC) during a period of 6 months in patients with COPD-B and COPD-C, at a third level referral centre in Mexico City. …”
Get full text

Physical impairments in individuals with Long COVID by Imane Salmam, Imane Salmam, Kadija Perreault, Kadija Perreault, Krista L. Best, Krista L. Best, Imane Zahouani, Gilles Drouin, Jean Tittley, François Desmeules, François Desmeules, Alexandre Campeau-Lecours, Alexandre Campeau-Lecours, Simon Beaulieu-Bonneau, Simon Beaulieu-Bonneau, Jean-Sébastien Paquette, Jean-Sébastien Paquette, Jean-Sébastien Paquette, Simon Deslauriers, Sarah-Maude Brouillard, Katherine Lepage, Jean-Sébastien Roy, Jean-Sébastien Roy

“…ObjectiveThe primary objective was to compare the physical capacities of individuals with Long COVID [Long COVID group (LCG)] to those who had COVID-19 but did not develop persistent symptoms [short COVID group (SCG)], and to individuals without a history of COVID-19 [control group (CG)]. …”
Get full text

Herbal HuoXueTongFu Formula with anti-inflammatory and fibrinolytic activity regulation for the prevention of postoperative peritoneal adhesions by Lili Yang, Lili Yang, Yali Wang, Yali Wang, Zhengjun Li, Zhengjun Li, Wen Li, Yanqi Chen, Ziyang Kong, Huixiang Zhang, Jiafei Wu, Mingqi Shang, Ming Li, Yaoyao Bian, Yaoyao Bian, Yaoyao Bian, Li Zeng, Li Zeng

“…Validation experiments revealed that HXTF could induce macrophage polarization-mediated anti-inflammatory reactions by increasing the phagocytic capacity of PMs and promoting the release of anti-inflammatory cytokines (IL-4 and IL-10). …”
Get full text

Hepatobiliary scintigraphy and liver function changes in patients with hepatocellular carcinoma treated with 166Ho-radioembolization by Margot T.M. Reinders, Maarten J.L. Smits, Karel van Erpecum, Joep de Bruijne, Rutger C.G. Bruijnen, Dave Sprengers, Rob de Man, Erik Vegt, Jan N.M. IJzermans, Marnix G.E.H. Lam, Arthur J.A.T. Braat

“…Cirrhotic patients do not seem to have the capacity to increase hepatic function in the treated part of the liver. …”
Get full text

Retinal Protection of New Nutraceutical Formulation by Luca Rosario La Rosa, Veronica Pepe, Francesca Lazzara, Giovanni Luca Romano, Federica Conti, Erika Giuffrida, Claudio Bucolo, Santa Viola, Giuseppe De Pasquale, Maria Cristina Curatolo, Cristina Zappulla

“…The antioxidant potential and the scavenging activity of Epicolin compared to the untreated control, and FG and FN, was evaluated in SH-SY5Y cells and through oxygen radical absorbance capacity acellular assay, respectively. Moreover, the protective effect against hypoxic damage was evaluated in Muller cells (MIO-M1) subjected to hypoxia. …”
Get full text

Associations between left atrial indices and cardiorespiratory and muscular fitness among physically active military personnel by Yen-Chen Lin, Yen-Chen Lin, Pang-Yen Liu, Kun-Zhe Tsai, Kun-Zhe Tsai, Kun-Zhe Tsai, Wei-Chun Huang, Wei-Chun Huang, Wen-Chung Yu, Wen-Chung Yu, Xuemei Sui, Carl J. Lavie, Gen-Min Lin, Gen-Min Lin

“…The top 16% of runners were compared sex-specifically, with the remaining 84% as controls to identify LA discriminators for running capacity. LA composite indices were defined as the LA volume index (LAVI) divided by the stiffness index (LASI) or pressure index (mitral E/e′). …”
Get full text

Frailty-adjusted therapy in Transplant Non-Eligible patients with newly diagnosed Multiple Myeloma (FiTNEss (UK-MRA Myeloma XIV Trial)): a study protocol for a randomised phase III... by Roger Owen, John Jones, David Meads, David A Cairns, Christopher Parrish, Gordon Cook, Neil Rabin, Matthew Jenner, Martin Kaiser, Kevin Boyd, Graham Jackson, Catherine Olivier, Amy Beth Coulson, Kara-Louise Royle, Charlotte Pawlyn, Anna Hockaday, Jennifer Bird, Stella Bowcock, Ruth de Tute, Hayley Gardner, Bryony Dawkins, Rowena Henderson, Phillip Best, Bhuvan Kishore, Mark Drayson

“…Following 12 cycles of induction treatment, participants alive and progression free will undergo a second (double-blind) randomisation on a 1:1 basis to maintenance treatment with lenalidomide+placebo versus lenalidomide+ixazomib until disease progression or intolerance.Ethics and dissemination Ethical approval has been obtained from the North East—Tyne & Wear South Research Ethics Committee (19/NE/0125) and capacity and capability confirmed by local research and development departments for each participating centre prior to opening to recruitment. …”
Get full text

The effects of Lepidium meyenii on MSG-induced subfertility in male Wistar rats: Targeting oxidative stress, pro-inflammatory cytokines, steroidogenic enzymes, and reproductive hor... by Temidayo S. Omolaoye, Surendra Singh Rawat, Naglaa Gamil Shehab, Eslam El Nebrisi, Stefan S. Du Plessis

“…Results: MSG administration significantly reduced total and progressive sperm motility (p < 0.05), decreased total antioxidant capacity (TAC) (p < 0.001), increased mRNA expression of TNF-α, IL-6, IL-1β in the testis and prostate (p < 0.05), protein expression of GP130 in the testis, reduced serum testosterone, and altered expression of steroidogenic markers. …”
Get full text

Enhancing CO₂ selectivity in MOFs through a dual-ligand strategy: Experimental and theoretical insights by Amir Kazemi, Akram Karbalaee Hosseini, Mahyar Ashourzadeh Pordsari, Mohsen Tamtaji, Saber Keshavarz, Faranak Manteghi, Azadeh Tadjarodi, Ahad Ghaemi, Sohrab Rohani, William A. Goddard

“…Among the synthesized MOFs, IUST-4 exhibited the highest CO₂ adsorption capacity, capturing 168 cm³ /g at 25°C. This superior performance is attributed to the synergistic interaction of Cd and Zn, which strengthens the coordination between CO₂ molecules and open metal sites. …”
Get full text

Rosiglitazone, a Ligand to PPARγ, Improves Blood Pressure and Vascular Function through Renin-Angiotensin System Regulation by María Sánchez-Aguilar, Luz Ibarra-Lara, Leonardo Del Valle-Mondragón, María Esther Rubio-Ruiz, Alicia G. Aguilar-Navarro, Absalom Zamorano-Carrillo, Margarita del Carmen Ramírez-Ortega, Gustavo Pastelín-Hernández, Alicia Sánchez-Mendoza

“…It also decreased 8-hydroxy-2′-deoxyguanosine (8-OH-2dG), malondialdehyde (MDA), and improved the antioxidant capacity. Regarding protein expression of RAS, RGZ decreases ACE and angiotensin II type 1 receptor (AT1R) and improved ACE2, AT2R, and Mas receptor in AoCo rats. …”
Get full text

ONC213: a novel strategy to resensitize resistant AML cells to venetoclax through induction of mitochondrial stress by Jenna L. Carter, Yongwei Su, Eman T. Al-Antary, Jianlei Zhao, Xinan Qiao, Guan Wang, Holly Edwards, Lisa Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Steven A. Buck, Maik Hüttemann, Joshua E. Allen, Varun V. Prabhu, Jay Yang, Jeffrey W. Taub, Yubin Ge

“…The combination significantly reduced colony formation capacity of primary AML progenitors compared to the control and either treatment alone. …”
Get full text

Physiological changes induced by green fodder expansion into grasslands and croplands enhance water-use efficiency in the Northeastern Tibetan Plateau by Xu Wang, Jilin Yang, Jie Wang, Tong Yang, Chuchen Chang, Yanbo Zhao, Xiaocui Wu, Geli Zhang, Xiangming Xiao

“…The changes in plant physiology and canopy structure induced by green fodder cultivation enhanced the CO2 assimilation capacity, reduced soil evaporation, and allocated more water toward transpiration, emerging as the dominant factors driving the observed changes in gross primary productivity and evapotranspiration. …”
Get full text

Preparation, Structural Characterization and Antioxidant Activity of Extracellular Nanovesicles from Hericium erinaceus by Xueli YANG, Ben NIU, Hangjun CHEN, Weijie WU, Guannan WANG, Xiangjun FANG, Honglei MU, Haiyan GAO

“…The in vitro antioxidant activity of HEDENVs was evaluated by determining the DPPH, ABTS+, and O2− radical scavenging capacity. A Caco-2 cell oxidative stress damage model was created using H2O2, and changes in ROS content in cells were measured using laser confocal microscopy. …”
Get full text

Global burden of ischemic heart disease in older adult populations linked to non-optimal temperatures: past (1990–2021) and future (2022–2050) analysis by Lihui Liu, Lihui Liu, Yisong He, Yisong He, Gang Huang, Yangxi Zeng, Yangxi Zeng, Jiaan Lu, Ru He, Haiqing Chen, Yuheng Gu, Qingwen Hu, Bin Liao, Bin Liao, Juyi Wan, Juyi Wan

“…Forecasts are that in the future, the burden of IHD due to high temperatures will continue to rise, especially in areas with limited adaptive capacity.ConclusionAlthough low temperature remains the most important contributor to IHD burden among the older adult, the burden attributable to high temperature is on the rise, which increases the need to address the extreme temperature fluctuation. …”
Get full text

Response surface methodology for the design of malachite green dye removal by γ-Fe2O3 dispersed on reduced graphene oxide sheets by Liu Zhu, Anam Sana, Muhammad Tariq Qamar, Ali Bahadur, Guocong Liu, Mohammad Aslam, Ammar Zidan, İsmail Seçkin Çardaklı, Shahid Iqbal, Sajid Mahmood, Muhammad Saad, Khalid M. Alotaibi

“…The optimal adsorption parameters obtained from the within-range numerical optimization based on 0.923 Derringer’s desirability function were 200 mg/100 mL dose, 80 ppm dye solution, 7.99 pH and 112.68 min. contact time for ~ 90% MG dye removal and 40.64 mg/g adsorption capacity (qm) by rGO/γ-Fe2O3. However, ~ 98% MG dye removal with 64.26 mg/g (qm) was achieved upon extended-range estimation of adsorption parameters. …”
Get full text

Comprehensive safety and toxicity analysis of 2,2’-Bipyridine derivatives in combating MRSA biofilm formation and persistence by Priyanka, Priyanka, Mohini Sharma, Bhavna Vaid, Bhavna Vaid, Ram Bharti, Ram Bharti, Sachin Raut, Sachin Raut, R. S. Jolly, Neeraj Khatri, Neeraj Khatri

“…IntroductionMethicillin-resistant Staphylococcus aureus (MRSA) infections have become arduous to treat due to their capacity to form biofilms, develop persistence, and exhibit significant antimicrobial resistance. …”
Get full text