Irisin reshapes bone metabolic homeostasis to delay age-related osteoporosis by regulating the multipotent differentiation of BMSCs via Wnt pathway by Shangman Xing, Yifan Ma, Bing Song, Bing Song, Min Bai, Kexin Wang, Wenjing Song, Tingting Cao, Chao Guo, Yanying Zhang, Zhandong Wang, Yongfeng Wang, Yongfeng Wang

“…More significantly, irisin has the capacity to enhance bone mass recovery and sustain overall bone health. …”
Get full text

Conversion of placental hemogenic endothelial cells to hematopoietic stem and progenitor cells by Guixian Liang, Shicheng Liu, Chunyu Zhou, Mengyao Liu, Yifan Zhang, Dongyuan Ma, Lu Wang, Jing-Dong J. Han, Feng Liu

“…Next, through VN-EC co-culture, we showed that placental HE (pHE) cells, a type of extra-embryonic HE cells, were successfully converted into iHSPCs (pHE-iHSPCs), which have multilineage differentiation capacity, but exhibit limited self-renewal ability. …”
Get full text

Comparative experimental anesthesia efficacy study of epidural injection at the sacrococcygeal space using ultrasound guidance versus blindness technique in Egyptian donkeys (Equus... by Mohamed A. Hamed, Hazem Hamouda, Mohammed Elmetwally, Foad Farrag, Mohamed Abdo Rizk, Mohamed M. A. Abumandour, Yamen Mohammed Hegazy, Alaa Samy

“…In conclusion, the ultrasound-guided technique of the epidural injection provided a number of benefits over the blind one, including the capacity to directly view the needle and distribute local anesthetic and avoid unintentional vascular damage, in comparison with traditional blind techniques. …”
Get full text

Predicting the environmental suitability for onchocerciasis in Africa as an aid to elimination planning. by Elizabeth A Cromwell, Joshua C P Osborne, Thomas R Unnasch, Maria-Gloria Basáñez, Katherine M Gass, Kira A Barbre, Elex Hill, Kimberly B Johnson, Katie M Donkers, Shreya Shirude, Chris A Schmidt, Victor Adekanmbi, Olatunji O Adetokunboh, Mohsen Afarideh, Ehsan Ahmadpour, Muktar Beshir Ahmed, Temesgen Yihunie Akalu, Ziyad Al-Aly, Fahad Mashhour Alanezi, Turki M Alanzi, Vahid Alipour, Catalina Liliana Andrei, Fereshteh Ansari, Mustafa Geleto Ansha, Davood Anvari, Seth Christopher Yaw Appiah, Jalal Arabloo, Benjamin F Arnold, Marcel Ausloos, Martin Amogre Ayanore, Atif Amin Baig, Maciej Banach, Aleksandra Barac, Till Winfried Bärnighausen, Mohsen Bayati, Krittika Bhattacharyya, Zulfiqar A Bhutta, Sadia Bibi, Ali Bijani, Somayeh Bohlouli, Mahdi Bohluli, Oliver J Brady, Nicola Luigi Bragazzi, Zahid A Butt, Felix Carvalho, Souranshu Chatterjee, Vijay Kumar Chattu, Soosanna Kumary Chattu, Natalie Maria Cormier, Saad M A Dahlawi, Giovanni Damiani, Farah Daoud, Aso Mohammad Darwesh, Ahmad Daryani, Kebede Deribe, Samath Dhamminda Dharmaratne, Daniel Diaz, Hoa Thi Do, Maysaa El Sayed Zaki, Maha El Tantawi, Demelash Abewa Elemineh, Anwar Faraj, Majid Fasihi Harandi, Yousef Fatahi, Valery L Feigin, Eduarda Fernandes, Nataliya A Foigt, Masoud Foroutan, Richard Charles Franklin, Mohammed Ibrahim Mohialdeen Gubari, Davide Guido, Yuming Guo, Arvin Haj-Mirzaian, Kanaan Hamagharib Abdullah, Samer Hamidi, Claudiu Herteliu, Hagos Degefa de Hidru, Tarig B Higazi, Naznin Hossain, Mehdi Hosseinzadeh, Mowafa Househ, Olayinka Stephen Ilesanmi, Milena D Ilic, Irena M Ilic, Usman Iqbal, Seyed Sina Naghibi Irvani, Ravi Prakash Jha, Farahnaz Joukar, Jacek Jerzy Jozwiak, Zubair Kabir, Leila R Kalankesh, Rohollah Kalhor, Behzad Karami Matin, Salah Eddin Karimi, Amir Kasaeian, Taras Kavetskyy, Gbenga A Kayode, Ali Kazemi Karyani, Abraham Getachew Kelbore, Maryam Keramati, Rovshan Khalilov, Ejaz Ahmad Khan, Md Nuruzzaman Nuruzzaman Khan, Khaled Khatab, Mona M Khater, Neda Kianipour, Kelemu Tilahun Kibret, Yun Jin Kim, Soewarta Kosen, Kris J Krohn, Dian Kusuma, Carlo La Vecchia, Van Charles Lansingh, Paul H Lee, Kate E LeGrand, Shanshan Li, Joshua Longbottom, Hassan Magdy Abd El Razek, Muhammed Magdy Abd El Razek, Afshin Maleki, Abdullah A Mamun, Ali Manafi, Navid Manafi, Mohammad Ali Mansournia, Francisco Rogerlândio Martins-Melo, Mohsen Mazidi, Colm McAlinden, Birhanu Geta Meharie, Walter Mendoza, Endalkachew Worku Mengesha, Desalegn Tadese Mengistu, Seid Tiku Mereta, Tomislav Mestrovic, Ted R Miller, Mohammad Miri, Masoud Moghadaszadeh, Abdollah Mohammadian-Hafshejani, Reza Mohammadpourhodki, Shafiu Mohammed, Salahuddin Mohammed, Masoud Moradi, Rahmatollah Moradzadeh, Paula Moraga, Jonathan F Mosser, Mehdi Naderi, Ahamarshan Jayaraman Nagarajan, Gurudatta Naik, Ionut Negoi, Cuong Tat Nguyen, Huong Lan Thi Nguyen, Trang Huyen Nguyen, Rajan Nikbakhsh, Bogdan Oancea, Tinuke O Olagunju, Andrew T Olagunju, Ahmed Omar Bali, Obinna E Onwujekwe, Adrian Pana, Hadi Pourjafar, Fakher Rahim, Mohammad Hifz Ur Rahman, Priya Rathi, Salman Rawaf, David Laith Rawaf, Reza Rawassizadeh, Serge Resnikoff, Melese Abate Reta, Aziz Rezapour, Enrico Rubagotti, Salvatore Rubino, Ehsan Sadeghi, Abedin Saghafipour, S Mohammad Sajadi, Abdallah M Samy, Rodrigo Sarmiento-Suárez, Monika Sawhney, Megan F Schipp, Amira A Shaheen, Masood Ali Shaikh, Morteza Shamsizadeh, Kiomars Sharafi, Aziz Sheikh, B Suresh Kumar Shetty, B Suresh Kumar Shetty, Jae Il Shin, K M Shivakumar, Biagio Simonetti, Jasvinder A Singh, Eirini Skiadaresi, Amin Soheili, Shahin Soltani, Emma Elizabeth Spurlock, Mu'awiyyah Babale Sufiyan, Takahiro Tabuchi, Leili Tapak, Robert L Thompson, Alan J Thomson, Eugenio Traini, Bach Xuan Tran, Irfan Ullah, Saif Ullah, Chigozie Jesse Uneke, Bhaskaran Unnikrishnan, Olalekan A Uthman, Natalie V S Vinkeles Melchers, Francesco S Violante, Haileab Fekadu Wolde, Tewodros Eshete Wonde, Tomohide Yamada, Sanni Yaya, Vahid Yazdi-Feyzabadi, Paul Yip, Naohiro Yonemoto, Hebat-Allah Salah A Yousof, Chuanhua Yu, Yong Yu, Hasan Yusefzadeh, Leila Zaki, Sojib Bin Zaman, Maryam Zamanian, Zhi-Jiang Zhang, Yunquan Zhang, Arash Ziapour, Simon I Hay, David M Pigott

“…National onchocerciasis elimination programmes may wish to consider prioritising these IUs for mapping surveys as human resources, laboratory capacity, and programmatic schedules may constrain survey implementation, and possibly delaying MDA initiation in areas that would ultimately qualify.…”
Get full text

Comparative Economic Analysis Between Bioenergy and Forage Types of Switchgrass for Sustainable Biofuel Feedstock Production: A Data Envelopment Analysis and Cost–Benefit Analysis... by Muhammad Umer Arshad, David Archer, Daniel Wasonga, Nictor Namoi, Arvid Boe, Rob Mitchell, Emily Heaton, Madhu Khanna, DoKyoung Lee

“…ABSTRACT The capacity to produce switchgrass efficiently and cost‐effectively across diverse environments can be pivotal in achieving the short‐ and medium‐term Sustainable Aviation Fuel targets set by the U.S. …”
Get full text

Epigallocatechin gallate (EGCG) modulates senescent endothelial cell-monocyte communication in age-related vascular inflammation by Sarvatit Patel, Kai Ellis, Kai Ellis, Corey A. Scipione, Jason E. Fish, Jason E. Fish, Jason E. Fish, Jason E. Fish, Kathryn L. Howe, Kathryn L. Howe, Kathryn L. Howe, Kathryn L. Howe, Kathryn L. Howe

“…Our findings reveal that EGCG confers anti-senescent effects via modulation of the senescent EC secretome (including EVs) with the capacity to modify monocyte activation. These findings suggest that EGCG could act as a senotherapeutic agent to reduce vascular inflammation related to aging.…”
Get full text

Can Electric Vehicle Charging Stations Be Carbon Neutral With Solar Renewables? by Alpaslan Demirci, Zafer Ozturk, Musa Terkes, Said Mirza Tercan, Recep Yumurtaci, Umit Cali

“…Implementing a more stringent carbon tax has facilitated a notable enhancement in energy storage system capacity, increasing the self-consumption rate by 72% and declining carbon emissions by 25.55%. …”
Get full text

Assessment of upper GI motor activity and GI symptoms in patients with amyotrophic lateral sclerosis: an observational study by Emanuela Ribichini, Nadia Pallotta, Danilo Badiali, Maria Carlucci, Marco Ceccanti, Chiara Cambieri, Laura Libonati, Enrico Stefano Corazziari, Giovanni Ruoppolo, Maurizio Inghilleri, Maurizio Inghilleri

“…We aimed to assess ALS patients upper gastrointestinal (GI) motor activity and GI symptoms according to bulbar and spinal onset and severity of ALS.MethodsALS bulbar (B) and spinal (S) patients with ALS Functional Rating Scale (ALSFRS-r) ≥35, bulbar sub-score ≥10, and Forced Vital Capacity (FVC) >50%, underwent to: Fiberoptic Endoscopic Evaluation of Swallowing (FEES); esophageal manometry; gastric emptying; Rome symptom questionnaire. …”
Get full text

Design and Analysis of Floater Structures using Composite Material in 19 Seaters Aircraft by Andi Muhdiar Kadir, Arief Setyawan, Fithri Nur Purnamasari, Nurhadi Pramana, Muhammad, Ilham Akbar Adi Satriya, Riza Wirawan, Budi Sampurno

“…The N219, referred to for Nusantara, its twin engines, and 19-passenger capacity, represents Indonesia's ambition to link its extensive archipelago through innovation and pride. …”
Get full text

Modulation of adiposity and adipocyte inflammation by methanol extracts of Alpinia calcarata leaf in high-fat-diet induced-obese mice: Involvement of COX-2 and PPAR-γ by Imtiaz Ahmad, Maruful Hasan, Dipty Rani Bhowmik, Rahima Begum, Sourav Roy, Md Monirul Islam, Md Abdur Rahman Ripon, Mohammad Salim Hossain

“…In agreement with the in-silico data, the extract was capable to reduce the mRNA expression of IL-6, COX-2, MCP-1, PPARγ, TNFα, and GLUT-4 which were consistent with the biochemical evidence; demonstrating the extract's capacity to attenuate adiposity and adipocyte inflammation. …”
Get full text

Mitigation of PFOA/PFOS toxicity in zebrafish (Danio rerio) by oxidative stress modulation and gut microbial metabolism through the use of aquatic probiotic Lactobacillus rhamnosus by Chun Wang, Guanyi Li, Sibao Chen, Ruixuan Li, Mengyan Wang, Xia Wang, Ning Ding, Yingxue Sun

“…Research has demonstrated that Lactobacillus rhamnosus can ameliorate the toxic impacts induced by perfluorobutyric acid (PFBS) on zebrafish through regulation of host intestinal microbiota imbalance and enhancement of host antioxidant capacity. However, the potential ameliorative effects of probiotics on the toxic effects caused by PFOA and PFOS in zebrafish have not been studied. …”
Get full text

Application of 2D polymerase chain reaction for single-tube detection of high-risk human papillomaviruses by Weifeng Wang, Min Jiang, Ying Liu, Xuan Wu, Yan Chen, Xiaoyun Zhang, Weiwei Liu

“…The overall concordance between the two detection methods was 96.17% (Kappa = 0.910).ConclusionThe 2D PCR method, which integrates asymmetric PCR amplification with melting curve analysis, has the capacity to detect 11 types of HR-HPVs across three channels. …”
Get full text

Isolation, Characterization, and Safety Evaluation of Human Skin-Derived Precursors from an Adherent Monolayer Culture System by Ru Dai, Wei Hua, Wei Chen, Lidan Xiong, Li Li, Yiming Li

“…Methods. tSKPs generated from our adherent monolayer culture system were investigated for protein expression and differentiation capacity. The aggregated cells and the proliferative cells within tSKP spheres were detected by mix-culturing FBs expressing two different fluorescent proteins and BrdU- or EdU-positive cells, respectively. …”
Get full text

Task-shifted approaches to postdiagnostic dementia support: a qualitative study exploring professional views and experiences by Louise Robinson, Greta Rait, Claire Bamford, Jill Manthorpe, Rachael Frost, Jane Wilcock, Karen Harrison Dening, Martin Knapp, Sube Banerjee, Joy Adamson, Alistair Burns, Raphael Wittenberg, Kate Walters, Alison Wheatley, Greta Brunskill, Louise Allan, Lynne Corner, Donna Buxton, Katherine Jacques, Doug Lewins, Sue Tucker

“…Key challenges included the capacity, ability and inclination of primary care to deliver postdiagnostic support for people with dementia and their families. …”
Get full text

Machine learning-based analyses of contributing factors for the development of hypertension: a comparative study by Marenao Tanaka, Yukinori Akiyama, Kazuma Mori, Itaru Hosaka, Keisuke Endo, Toshifumi Ogawa, Tatsuya Sato, Toru Suzuki, Toshiyuki Yano, Hirofumi Ohnishi, Nagisa Hanawa, Masato Furuhashi

“…The AUCs of ML models were 0.765–0.825, and discriminatory capacity was significantly improved in the artificial neural network model compared to that in the logistic regression model.Conclusions The development of hypertension can be simply and accurately predicted by each ML model using systolic blood pressure, age and FLI as selected features. …”
Get full text

Development of a duplex real-time recombinase aided amplification assay for the simultaneous and rapid detection of PCV3 and PCV4 by Renjie Sun, Hanze Liu, Siqi Sun, Yating Wang, Ying Shan, Xiaoliang Li, Weihuan Fang, Yongle Yang, Ronghui Xie, Lingyan Zhao

“…Conclusions This study provides a robust basis for multiplex detection of veterinary pathogens using RAA technique, enhancing the field’s capacity to control PCV3 and PCV4, and supporting reliable aid for epidemiological understanding of emerging circoviruses.…”
Get full text

Genome analysis of Bifidobacterium adolescentis and investigation of its effects on inflammation and intestinal barrier function by Bo Li, Bo Li, Haoyu Wang, Haoyu Wang, Haoyu Wang, Mengmeng Wang, Mengmeng Wang, Hewei Liang, Hewei Liang, Hewei Liang, Tongyuan Hu, Tongyuan Hu, Tongyuan Hu, Jinlong Yang, Jinlong Yang, Jinlong Yang, Shangyong Li, Xinbi You, Xinbi You, Xinbi You, Binbin Xia, Binbin Xia, Binbin Xia, Yue Yuan, Yue Yuan, Yuanqiang Zou, Yuanqiang Zou, Yinglei Miao, Yinglei Miao, Yang Sun, Yang Sun, Yang Sun

“…The restoration of tight junction proteins ZO-1, occludin, and claudin-2 by B. adolescentis AF91-08b2A demonstrated its capacity to safeguard the intestinal epithelial barrier. …”
Get full text

Nurse management of minor problems in primary care emergencies: a non-randomized controlled trial by Jordi Estarlich-Corominas, Neus Soler-Abril, Anna Casanellas-Chuecos, Sara Becerra-Corzo, Andrea Sofia Bianco, Pere Torán-Monserrat, Rosa García-Sierra

“…The results of the study suggest that the Nurse Demand Management programme was a factor in improving the efficiency and in the emergency centre. Nurse resolution capacity, after applying algorithms, offered quality care, with fewer prescriptions and good patient satisfaction without increasing the total number of consultations due to the same problem. …”
Get full text

The Role of Coal Mechanical Characteristics on Reservoir Permeability Evolution and Its Effects on CO2 Sequestration and Enhanced Coalbed Methane Recovery by Hao Han, Shun Liang, Yaowu Liang, Xuehai Fu, Junqiang Kang, Liqiang Yu, Chuanjin Tang

“…Neglecting the weakening effect of CO2 adsorption on coal seam stiffness could underestimate the injection capacity of CO2. Injection of hot CO2 could improve the permeability around injection well and then enhance CO2 cumulative storage and CBM recovery. …”
Get full text

Staphylococcus aureus nt5 gene mutation through CRISPR RNA-guided base editing weakens bacterial virulence and immune evasion by Xinpeng Liu, Lan Huang, Yang Ye, Haiyi Wang, Min Tang, Fuqiang He, Zijing Xia, Shi Deng, Peng Zhang, Ruiwu Dai, Shufang Liang

“…In summary, nt5 gene mutation confers tolerance to DAP and a lower bacterial capacity to form kidney abscesses through phagocytosis of host immune cells, which indicates the targeted inhibition of NT5 protein would offer a potential new therapeutic strategy against S. aureus infection.…”
Get full text