Bioequivalence study of fluticasone propionate nebuliser suspensions in healthy Chinese subjects by Feng Cheng, Tao Shen, Fucheng Zhang, Chenghao Lei, Ye Zhu, GuoJun Luo, Dawei Xiao

“…The blood sample was collected at predetermined time points up to 48 h and the plasma concentration of fluticasone propionate was determined by HPLC-MS/MS in healthy subjects after inhalation of test or reference formulation. The non-compartment model method (NCA module) of the WinNonlin® software (version 8.3) was used to calculate the pharmacokinetic parameters (Cmax, AUC0-t, AUC0-∞) between the test formulation and the reference formulation were within the predefined range of 80.00% and 125.00%, bioequivalence of both formulations was demonstrated.ResultsThe 90% confidence intervals of the T/R ratio of the geometric mean of Cmax, AUC0-t, and AUC0-∞ for both formulations were 90.24%–112.68%, 96.99%–112.27% and 96.41%–111.59% respectively, which were all within the bioequivalent range of 80%–125%. …”
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A patient-derived HCC spheroid system to model the tumor microenvironment and treatment response by Emilie Crouchet, Nuno Almeida, Sarah C. Durand, Marie Parnot, Marine A. Oudot, Fabio Giannone, Cloé Gadenne, Natascha Roehlen, Antonio Saviano, Emanuele Felli, Patrick Pessaux, Hong Tuan Duong, Hideki Ohdan, Hiroshi Aikata, Kazuaki Chayama, Thomas F. Baumert, Catherine Schuster

“…The tumor spheroids comprised the main cell compartments, including epithelial cancer cells, as well as all major cell populations of the TME [i.e. cancer-associated fibroblasts (CAFs), macrophages, T cells, and endothelial cells]. …”
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Novel banana lectin CAR-T cells to target pancreatic tumors and tumor-associated stroma by Malcolm K Brenner, Challice Bonifant, Norihiro Watanabe, Mary K McKenna, Daniel Brenner, Ada Ozcan, Maureen Legendre, Dafydd G Thomas, Christopher Ashwood, Richard D Cummings, David M Markovitz

“…Antitumor activity was quantified by caliper measurement and bioluminescence signal and used anti-human vimentin to measure residual PSCs.Results H84T BanLec CAR was successfully transduced and expressed by T cells which had robust expansion and retained central memory phenotype in both CD4 and CD8 compartments. H84T CAR T cells targeted and eliminated PDAC tumor cell lines. …”
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De Novo Acute Myeloid Leukemia with Combined CBFB-MYH11 and BCR-ABL1 Gene Rearrangements: A Case Report and Review of Literature by Venkata Rakesh Sethapati, Ra’ed Jabr, Leyla Shune, Wissam El Atrouni, Patrick R. Gonzales, Wei Cui, Shivani Golem

“…Additionally, inv(16) can cooperate with other genetic aberrations to further increase cell proliferation. …”
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Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy by James Dooley, Bart Neyns, Elizabeth Allen, Frank Tacke, Louis Boon, Damya Laoui, Julia Katharina Schwarze, Helena Van Damme, Bruno Dombrecht, Máté Kiss, Heleen Roose, Eva Van Overmeire, Daliya Kancheva, Liesbet Martens, Aleksandar Murgaski, Pauline Madeleine Rachel Bardet, Gillian Blancke, Maude Jans, Evangelia Bolli, Maria Solange Martins, Yvon Elkrim, Kiavash Movahedi, Niels Vandamme, Sebahat Ocak, Isabelle Scheyltjens, Lars Vereecke, Frank Aboubakar Nana, Pascal Merchiers, Jo Agnes Van Ginderachter

“…Background Modulation and depletion strategies of regulatory T cells (Tregs) constitute valid approaches in antitumor immunotherapy but suffer from severe adverse effects due to their lack of selectivity for the tumor-infiltrating (ti-)Treg population, indicating the need for a ti-Treg specific biomarker.Methods We employed single-cell RNA-sequencing in a mouse model of non-small cell lung carcinoma (NSCLC) to obtain a comprehensive overview of the tumor-infiltrating T-cell compartment, with a focus on ti-Treg subpopulations. …”
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Insights into the effects of biomass feedstock and pyrolysis conditions on the energy storage capacity and durability of standard biochar-based phase-change composites by Dimberu G. Atinafu, Ji Yong Choi, Jihee Nam, Yujin Kang, Sumin Kim

“…The composites demonstrated strong leakage resistance at high heating temperatures (60 °C, above the melting temperature of HXD), good chemical compatibility between the biochar and HXD, and high durability after 500 thermal cycles. …”
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Agricultural Innovation Characteristics and Their Utilisation: A Case of National Agricultural Research Organization by Barekye, Alex

“…In addition, regression results indicated that innovation characteristics such as relative xii advantage, compatibility, triability and, other variables such as gender, age, education had a significant effect (p<0.05) on innovation utilization by farming communities. …”
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Real-world effectiveness and causal mediation study of BNT162b2 on long COVID risks in children and adolescentsResearch in context by Qiong Wu, Bingyu Zhang, Jiayi Tong, L. Charles Bailey, H. Timothy Bunnell, Jiajie Chen, Elizabeth A. Chrischilles, Dimitri A. Christakis, Stephen M. Downs, Kathryn Hirabayashi, Aaron D. Mishkin, Abu S.M. Mosa, Nathan M. Pajor, Suchitra Rao, Hanieh Razzaghi, Hayden T. Schwenk, Marion R. Sills, Huiyuan Wang, Linbo Wang, Yudong Wang, Dazheng Zhang, Ting Zhou, Ravi Jhaveri, Eric J. Tchetgen Tchetgen, Jeffrey S. Morris, Christopher B. Forrest, Yong Chen

“…We aim to assess the effectiveness of BNT162b2 on long COVID risks with various strains of the SARS-CoV-2 virus in children and adolescents, using comparative effectiveness methods. We further explore if such pre-infection vaccination can mitigate the risk of long COVID beyond its established protective benefits against SARS-CoV-2 infection using causal mediation analysis. …”
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Global, regional, and national trends in drug use disorder mortality rates across 73 countries from 1990 to 2021, with projections up to 2040: a global time-series analysis and mod... by Soeun Kim, Hayeon Lee, Selin Woo, Hyeri Lee, Jaeyu Park, Tae Kim, Guillaume Fond, Laurent Boyer, Masoud Rahmati, Lee Smith, Guillermo F. López Sánchez, Elena Dragioti, Christa J. Nehs, Jinseok Lee, Hyeon Jin Kim, Jiseung Kang, Dong Keon Yon

“…In HICs, the impacts of epidemiological changes for increasing DUD mortality rates were particularly prominent compared to other factors. In the Bayesian age-period-cohort models, the predicted number of global DUD deaths up to 2040 were estimated to increase from 25.95 deaths per 1,000,000 people (95% credible interval [CrI], 24.72–27.28) in 2021 to 38.45 (95% CrI, 30.48–49.33) in 2030, and 42.43 (95% CrI, 23.67–77.77) in 2040. …”
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Effects of stress hyperglycemia ratio upon long-lasting prognosis in coronary artery disease patients with or lacking chronic renal impairment: findings from a Chinese multi-center... by Jielan Wu, Jin Liu, Ziyao Yuan, Shangyi Tang, Weipeng Zhang, Yulong Xiang, Jinming Chen, Qiqiang Lin, Wei Guo, Yibo He, Haozhang Huang, Xiaozhao Lu, Jingru Deng, Huangtao Ruan, Rengui Jiang, Shiqun Chen, Yong Liu

“…In cohorts with CKD, patients with high SHR had higher all-cause mortality (30.2% vs. 27.6%; adjusted hazard ratio HR 1.13, 95% CI 1.04–1.22; P = 0.003) and cardiovascular mortality (18.2% vs. 15.6%; HR adjusted 1.17, 95% CI 1.06–1.30; P = 0.002) compared to the individuals in low SHR. However, this was not the case in CAD cohorts without CKD [all-cause mortality (12.9% vs. 11.9%; HR adjusted 1.04, 95%CI 0.98–1.10, P = 0.206); cardiovascular mortality (5.1% vs. 4.4%; HR adjusted 1.09, 95%CI 0.99–1.20, P = 0.084)]. …”
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COLLABORAZIONE INTERPROFESSIONALE E ORGANIZZAZIONE SANITARIA: uno studio esplorativo sulle sfide e opportunità per i professionisti della riabilitazione. by Simone Sottana, Andrea Vianello, Matteo Tognin, Deborah Mazzarotto, Marco Ceccato, Daria Visintin, Riccardo Martignon, Francesca Magaton Rizzi, Noemi Pasquon, Lucia Savietto

“…OBIETTIVO Questo studio mira a colmare questo vuoto esplorando la percezione della collaborazione interprofessionale tra i professionisti sanitari, identificando barriere e facilitatori alla collaborazione efficace e valutando l'impatto dell'educazione al lavoro in team previsto nel modello di cura interprofessionale. …”
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Cooling and Sterile Inflammation in an Oxygen-Glucose-Deprivation/Reperfusion Injury Model in BV-2 Microglia by Jana Lücht, Nele Rolfs, Sylvia J. Wowro, Felix Berger, Katharina R. L. Schmitt, Giang Tong

“…Intracellular cold-shock proteins CIRBP and RNA-binding motif 3 (RBM3) as well as caspases 9, 8, and 3 were also analyzed via Western blot analysis. …”
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Teneur nutritionnelle des aliments « préférés » et « non-préférés » du Mangabey de Sanje (Cercocebus sanjei). Test du modèle «fallback foods » et choix saisonnier de nourriture... by Guillaume Pagès

“…Un indice de préférence, calculé sur la base de L = (% utilisation aliment dans la prise alimentaire ̶ abondance relative aliment dans l’environnement), permit de reconnaitre 12 aliments dis « préférés », dont l’indice positif indique une sur-utilisation comparée à l’abondance de l’aliment dans l’environnement, et six aliments « non-préférés », dont l’indice négatif indique une sous-utilisation comparée à l’abondance. …”
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Application of evidence-based nursing combined with individualized health education intervention for patients undergoing gynecological surgery (循证护理联合个性化健康教育干预在妇科手术患者中的应用)... by FAN Ying (范莹), ZHANG Hong (张宏), LIU Li (刘莉), ZHEN Qiao (郑巧), GAO Huiyun (高灰云), CHEN Cheng (陈程)

“…The self-management ability ［self-care ability measurement scale (ESCA)］, DVT related knowledge (self-made DVT-related knowledge questionnaire), incidence of DVT and discharge readiness level ［Discharge Readiness Assessment Scale (RHDS)］ were compared between the two groups. Results After intervention, the total score and dimensional scores of ESCA in the two groups were increased (P<0. 01), and scores in the observation group were higher than those in the control group(P<0. 01). …”
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Evaluation of the Chemical Properties and Absorption Capacity of Different Manganese Sources using Everted Gut Sacs Technique and Their Effects on the Performance and Immune Respon... by Farogh Kargar, Hasan Kermanshahi, Ali Javadmanesh, Reza Majidzadeh Heravi

“…In general, manganese sulfate had the highest solubility in deionized water compared to the other two sources. Also, the highest solubility of organic manganese in 2% citric acid was 96.12% in the whole experiment. …”
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Determining the Heterotic Groups of Selected Grain Maize (Zea mays L.) Inbred Lines using Morphological and Phenological Traits by Mahnaz Oroojloo, Sara Dezhsetan, Behzad Ahmadi, Mohammadreza Shiri, Ali Moghaddam

“…The highest days to physiological ripening trait for the lines was recorded in the second cluster) late ripening), it was medium in the first, third, fourth, and sixth clusters (medium ripening), and the lowest value belonged to the fifth cluster (early ripening) compared to the other clusters. Furthermore, the distribution of the lines based on the first and second principle component analysis and cluster analysis were in significant agreement with each other. …”
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Editorial by Michael Rose, Jonathan M. Hoffmann

“…However, he points out that the C-NIP is only a problem to moral theories that employ a comparative personal view. Referring to Rawls’s veil of ignorance, Jonathan M. …”
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Serum NFL and neuropsychological performance over ∼8 years in women with and without HIV: a longitudinal repeated measures studyResearch in context by Deborah R. Gustafson, Xuantao Li, Alison E. Baird, Henrik Zetterberg, Kaj Blennow, Jinbing Zhang, Amanda Blair Spence, Pauline Maki, Anjali Sharma, Kathleen Weber, Recai Yucel

“…Findings: 417 participants (290 WLWH, 127 WLWOH), African American/Black (55%), ≥high school education (69%), current/former smokers (79%), and overweight/obese (BMI ≥25.0 kg/m2, 74%) were included. Compared to WLWOH at baseline, WLWH performed worse on memory and global NP. …”
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Nécropoles multipolaires et élaboration d’un nouveau modèle socio-politique au premier âge du Fer : réflexions à partir des sites du Camp de l’Église Sud à Flaujac-Poujols (Lot) et... by Antoine Dumas

“…In order to confirm this spatial hypothesis, the typological and stylistic profiles of each group of graves were then compared, using specifically adapted typological tools and basic numerical methods. …”
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Prevalence and determinants of home delivery among pregnant women in Somaliland: Insights from SLDHS 2020 data by Hodo Abdikarim, Abdisalam Hassan Muse, Mukhtar Abdi Hassan, Yahye Hassan Muse

“…Significant regional variations were observed, with certain regions showing higher rates of home deliveries compared to others. Conclusions: The findings highlight the importance of targeted interventions to address sociodemographic and regional disparities in the utilization of institutional delivery services in Somaliland. …”
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