ACCREDIT: Validation of clinical score for progression of COVID-19 while hospitalized by Vinicius Lins Costa Ok Melo, Pedro Emmanuel Alvarenga Americano do Brasil, PhD

“…They were included if they were adults, with a positive RT-PCR result, history of exposure, or clinical or radiological image findings compatible with COVID-19. The outcome was characterized as either transfer to critical care or death. …”
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The Construction of Smart Chinese Medicine Cloud Health Platform Based on Deep Neural Networks by Yaofeng Miao, Yuan Zhou

“…Some information is not compatible and patient information cannot be shared. …”
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Sleep-Related Respiratory Disorders in Children by Alexander Torres Molina

“…Se asistió en el servicio de enfermedades respiratorias del Hospital Pediátrico Pedro Soto Alba de Moa, a escolares roncadores habituales, que presentaban síntomas y signos compatibles con diferentes grados de obstrucción de las vías respiratorias superiores durante el sueño; sin que se lograra un consenso para su diagnóstico y manejo integral. …”
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Laparoscopic Resection of a Left Upper Quadrant Mass Leading to a Surprise Diagnosis by Hugo J. R. Bonatti, Reinhardt O. Sahmel, Rodrigo B. Erlich

“…He developed left upper quadrant pain, and on CT scan, a 5 cm mass compatible with a sarcoma was found between the tail of the pancreas and the left adrenal gland. …”
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Social Media Marketing for Small and Medium Enterprise Performance in Uganda: A Structural Equation Model by .Kikawa, Cliff R, Kiconco, Charity, Moses, Agaba, Ntirampeba, Dimas, Ssematimba, Amos, Kalema, Billy M.

“…The results indicate that compatibility and perceived ease of use have a positive impact on SMEs to adopt SMM, while perceived usefulness has a negative impact on SMEs to adopt SMM. …”
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Hsa-miR-105-1 Regulates Cisplatin-Resistance in Ovarian Carcinoma Cells by Targeting ANXA9 by Xinxin Kou, Hui Ding, Lei Li, Hongtu Chao

“…Furthermore, the expression levels of several apoptosis-related proteins, including P53, P21, E2F1, Bcl-2, Bax, and caspase-3, were examined by western blot analysis. …”
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供心缺血再灌注损伤与心肌细胞凋亡

“…【目的】 研究供心长时间低温保存后缺血再灌注损伤导致的心肌细胞凋亡,明确抗调亡因子在心脏移植供心缺血再灌注损伤中的保护作用,为心脏保护液药物研究提供帮助65377; 【方法】 24只实验SD大鼠分2组,建立大鼠心脏异位移植模型,在围手术期65380;供心保存过程中使用天冬氨酸特异性半胱氨酸蛋白酶3抑制剂(Ac-DEVD-CHO)干预,使用HTK保存液低温保存供心9 h,监测模型前后,检测凋亡相关因子和病理学指标65377; 【结果】 在异位移植开放后60 min,①实验组的心率恢复率[(71.9 ± 6.9)%]高于对照组[(59.6 ± 10.5)%;P < 0.05]65377;②实验组的心肌Caspase-3活性(0.695 ± 0.040)低于对照组(3.438 ± 0.035;P < 0.01)65377;③实验组的心肌梗死面积(5.29 ± 2.33)低于对照组(22.10 ± 3.00;P < 0.01)65377;④实验组的凋亡指数(5.09 ± 2.31)低于对照组(13.4 ± 2.5;P < 0.01)65377;⑤心肌组织HE染色:对照组的心肌组织损伤较实验组严重65377; 【结论】 ①供心长时间低温保存再灌注后细胞出现明显凋亡,心肌细胞凋亡是心脏移植供心长时间保存缺血再灌注后心功能下降的主要机制之一65377;②使用半胱天冬酶抑制剂能明显抑制心肌细胞凋亡,减轻供心缺血再灌注损伤,改善供心心功能,是提高供心保存时效的良好方法65377;③半胱天冬酶抑制剂Ac-DEVD-CHO对供心保存的时-效和量-效关系仍有待进一步探讨65377;…”
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What does the fox select? Spatial ecology of Rocky Mountain red fox during peaks and troughs of human recreation by Emily N. Burkholder, John Stephenson, Sarah Hegg, David Gustine, Joseph D. Holbrook

“…From 2016 to 2021, we captured and GPS‐collared 18 individuals (11 males, 7 females) and evaluated spatiotemporal shifts in home range characteristics and habitat selection. …”
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The Combined Use of Platelet-Rich Plasma Clot Releasate and Allogeneic Human Umbilical Cord Mesenchymal Stem Cells Rescue Glucocorticoid-Induced Osteonecrosis of the Femoral Head by Yanxue Wang, Shuo Luan, Ze Yuan, Shaoling Wang, Shengnuo Fan, Chao Ma, Shaoling Wu

“…Western blotting was conducted to evaluate the expression levels of RUNX2, VEGF, caspase-3, and Bcl-2 in the coculture systems. Ultrasound-guided intra-articular PRCR, UC-MSCs, and PRCR + UC-MSC injections were performed on the ONFH model rats. …”
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Kojic Acid Derivative as an Antimitotic Agent That Selectively Kills Tumour Cells by Giuseppina Pichiri, Marco Piludu, Terenzio Congiu, Nicole Grandi, Pierpaolo Coni, Monica Piras, Mariusz Jaremko, Joanna Izabela Lachowicz

“…Mitotic exit into apoptosis was further conformed by the cytoflow of early/late apoptosis stages and caspase-3 analysis. NGS investigation showed differentiated expressions of genes involved in mitosis and apoptosis processes. …”
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BMSC-Derived Exosomes Ameliorate Osteoarthritis by Inhibiting Pyroptosis of Cartilage via Delivering miR-326 Targeting HDAC3 and STAT1//NF-κB p65 to Chondrocytes by Honggang Xu, Bin Xu

“…Incubation with BMSC-Exos could significantly improve the survival rate, migration ability, and chondrocyte-specific genes (COL2A1, SOX9, Agg, and Prg4) and miR-326 expression of OA chondrocytes and significantly inhibit pyroptosis of chondrocytes by downregulation of the levels of inflammatory cytokines, Caspase-1 activity, and pyroptosis-related proteins such as GSDMD, NLRP3, ASC, IL-1β, and IL-18 (P<0.01). …”
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Betaine Inhibits NLRP3 Inflammasome Hyperactivation and Regulates Microglial M1/M2 Phenotypic Differentiation, Thereby Attenuating Lipopolysaccharide-Induced Depression-Like Behavi... by Man Zhang, Xiao-Long Wang, Hui Shi, Lan-Qing Meng, Hong-Feng Quan, Lin Yan, Hui-Fang Yang, Xiao-Dong Peng

“…Western blotting was used to detect the protein expression levels of the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3), caspase-1, and ASC, the protein expression levels of the microglial polarization markers COX-2, inducible nitric oxide synthase (iNOS), and CD206. …”
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Preparation, structural property, and antioxidant activities of a novel pectin polysaccharide from the flowers of Hibiscus syriacus Linn. by Jialong Chen, Chaojun Ye, Lu Zhang, Zhiliang Xie, Jianjun Zhu, Zhi Zhang

“…Notably, HFPS upregulated the expression of antioxidant-related genes, including B-cell lymphoma-2 (Bcl-2), heme oxygenase 1 (HO-1), NAD(P)H quinone oxidoreductase 1 (NQO1), and nuclear factor erythroid 2-related factor 2 (Nrf2), while downregulating pro-apoptotic genes like Bcl-2-associated X protein (Bax) and Caspase-3. These findings suggest that HFPS exerts its antioxidant effects by modulating the Nrf2/HO-1 pathway and redox homeostasis.DiscussionThis study contributes to the understanding of the structure-function relationships and antioxidant mechanisms of HFPS, highlighting its potential applications as a natural antioxidant in various fields.…”
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Dexmedetomidine Attenuates Myocardial Ischemia-Reperfusion Injury in Diabetes Mellitus by Inhibiting Endoplasmic Reticulum Stress by Jinjie Li, Ying Zhao, Nan Zhou, Longyun Li, Kai Li

“…The apoptosis of heart tissue cells was also tested through the expressions of cleaved caspase-3, Bcl-2, and Bax proteins. The expression of endoplasmic reticulum stress-related proteins GRP78, CHOP, ERO1α, ERO1β, and PDI was examined. …”
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Palmitic acid-induced cell death: impact of endoplasmic reticulum and oxidative stress, mitigated by L-citrulline by Md. Rezwanul Habib, Yukako Tokutake, Shinichi Yonekura

“…Moreover, L-citrulline pretreatment significantly downregulated the PA-induced upregulation of GRP78, ATF4, and CHOP mRNA expression, and protein expression of p-PERK and cleaved caspase-3. PA increased intracellular ROS levels and NRF2 mRNA expression, whereas L-citrulline pretreatment remarkably reduced these levels. …”
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The temporal scale of energy maximization explains allometric variations in movement decisions of large herbivores by Daniel Fortin, Christopher F. Brooke, Hervé Fritz, Jan A. Venter

“…We found that resource partitioning was achieved through a synergy of spatial segregation and interspecies differences in habitat selection and in the temporal scale of energy maximization. Radio‐collared individuals of the three species spent 95% of their time >850 m from one another. …”
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外源性SHIP基因表达抑制生长因子介导的 K562细胞增殖及Akt磷酸化

“…【目的】 探讨SHIP基因对IL-3诱导K562细胞系增殖的抑制作用,阐明SHIP对K562细胞作用的机制65377;【方法】 将慢病毒质粒pReceiver-Lv31-FIV和pReceiver-Lv31-SHIP转染K562细胞;转染细胞与IL-3共培养,Western blot法检测K562细胞Akt磷酸化;观察转染野生型SHIP基因对K562细胞增殖的影响;末端脱氧核苷酸转移酶介导的dUTP缺失末端标记(TUNEL)法检测细胞凋亡65377;【结果】 重组慢病毒载体pReceiver-Lv31-FIV和pReceiver-Lv31-SHIP转染K562细胞,GFP阳性率为74.6%65377;野生型SHIP基因阻断了IL-3对K562细胞的增殖作用,对照组(K562/FIV)细胞增殖抑制率(3.26%)明显低于转染SHIP基因组细胞增殖抑制率(26.42%,P < 0.05);集落形成实验显示SHIP能显著抑制K562细胞集落形成能力[IL-3作用组K562/SHIP细胞形成集落为60.3 ± 6.6,明显低于IL-3诱导的K562/FIV组(91.7 ± 4.2)](P < 0.01)65377;细胞形态观察发现凋亡增加,Western blot检测发现转染SHIP基因组前凋亡酶pro-caspase-3降解增加,TUNEL法证实SHIP蛋白促进细胞凋亡65377;IL-3作用不同时间段(3 h, 6 h, 12 h),转染野生型SHIP组细胞增殖明显减弱,且Akt磷酸化水平均低于对照组(P < 0.05)65377;【结论】 SHIP基因负调控生长因子(IL-3)介导的K562细胞增殖及其蛋白激酶活化65377;…”
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Alpha B-crystallin Ameliorates Imbalance of Redox Homeostasis, Inflammation and Apoptosis in an Acute Lung Injury Model with Rats by Seda KOCAK, İbrahim GUNER, Muhittin Onur YAMAN, Tugba EKIZ YILMAZ, Emine Elif GUZEL MEYDANLI, Nermin YELMEN, Gulderen SAHIN

“…Results: The levels of malondialdehyde, reactive oxygen species, total oxidant status, tumor necrosis factor-alpha (TNF-&#945;), interleukin-1 beta (IL-1&#946;), nuclear factor kappa B (NFK&#946;), caspase-9 (CASP-9), 8-hydroxy-2'-deoxyguanosine, total antioxidant status, superoxide dismutase, and interleukin-10 levels in lung tissues, plasma, and BAL fluid (p&lt;0.05 versus control) increased in Aortic IR. …”
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Application of integrated traditional Chinese and western medicine nursing in rehabilitation of patients with hemiplegia after ischemic stroke (中西医结合护理干预在缺血性脑卒中偏瘫患者康复中的应用)... by HUANG Chaoping (黄朝萍), WANG Li (王丽), LI Yanmin (李艳敏), ZHANG Shuai (张帅), CHENG Jiangyan (程江艳), WANG Jing (王晶), QIU Yajiao (邱亚娇), LIANG Hui (梁慧)

“…The Fugl-Meyer Assessment (FMA) scale and Brathel Index were measured and compared between two groups. The effect of rehabilitation nursing was evaluated by self-made rating scale. …”
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A pharmacoinformatic approach for studying Atractylodes Lancea DC’s anticancer potential and control ROS-mediated apoptosis against prostate cancer cells by Chi-Hoon Ahn, Ji Soo Myong, Kazi Rejvee Ahmed, Md Ataur Rahman, Md. Maharub Hossain Fahim, Min Choi, Muntajin Rahman, Jinwon Choi, Kiryang Kim, Seungjoon Moon, Seungjoon Moon, Mohammed Dalli, Mohammed Dalli, Rony Abdi Syahputra, Sang-Won Shin, Abdel Halim Harrath, Moon Nyeo Park, Bonglee Kim, Hwa-Seung Yoo

“…These findings suggest that ALD may exert a synergistic effect comparable to or greater than that of enzalutamide (ENZ) in inhibiting AR. …”
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