Unravelling the prognostic and operative role of intratumoural microbiota in non‐small cell lung cancer: Insights from 16S rRNA and RNA sequencing by Fuling Mao, Zixuan Hu, Ruifeng Shi, Hongbing Zhang, Zihe Zhang, Yongwen Li, Xuanguang Li, Penghu Gao, Jinhui Li, Minghui Liu, Hongyu Liu, Jun Chen

“…We used 16S rRNA sequencing to dissect microbial composition and perform prognosis correlations, and in conjunction with transcriptome sequencing, we determined potential mechanisms underpinning significant microbiota actions. Results In comparing different sample types, we identified more pronounced beta diversity disparity between NSCLC, lung squamous cell carcinoma (LUSC) and corresponding paired normal tissues. …”
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Multimorbidity latent classes in relation to 11-year mortality, risk factors and health-related quality of life in Malaysia: a prospective health and demographic surveillance syste... by Michelle M. C. Tan, Charlotte Hanlon, Graciela Muniz-Terrera, Tatiana Benaglia, Roshidi Ismail, Devi Mohan, Ann Breeze Joseph Konkoth, Daniel Reidpath, Pedro José M. Rebello Pinho, Pascale Allotey, Zaid Kassim, Matthew Prina, Tin Tin Su

“…The complex multimorbidity group had the lowest HRQoL across all domains compared to other groups (p < 0.001), including physical health, psychological, social relationships and environment. …”
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Salmonella pathogenicity Island 1 undergoes decay in serovars adapted to swine and poultry by Martina Tambassi, Melissa Berni, Chiara Bracchi, Ilaria Menozzi, Alessandra Dodi, Laura Mazzera, Marina Morganti, Erika Scaltriti, Stefano Pongolini

“…Similarly, also poultry-adapted Salmonella Kentucky has accumulated deleterious mutations in SPI-1, leading to over 70% of mutated genomes of this serovar compared with negligible proportions of mutated genomes in the generalist serovars from poultry. …”
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The Relationship Between Serum miRNAs and Surgical Prognostic Factors in Gastric Cancers by Çağrı Büyükkasap, Engin Küçükdiler, Mahir Nasirov, Niyazi Samet Yılmaz, Hasan Dağlı, İlke Önen, Furkan Aydoğdu, Aydın Yavuz, Hüseyin Göbüt, Asiye Uğraş Dikmen, Kürşat Dikmen, Hasan Bostancı, Özlem Gülbahar, Abdulkadir Bedirli

“…The objective of this study was to investigate the role of serum microRNA (miRNAs) in diagnosing gastric cancer and their relationship with prognostic factors that impact the choice of surgical approach. Methods: We compared the serum miRNA expression levels of 35 patients who underwent gastrectomy and D2 lymph node dissection for gastric adenocarcinoma between 2015-2018 with those of 33 controls. …”
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Novel and potent MICA/B antibody is therapeutically effective in KRAS LKB1 mutant lung cancer models by Shohei Koyama, Yujiro Naito, John D Minna, David E Gerber, Ryan R Kowash, Manoj Sabnani, Laura T Gray, Qing Deng, Nusrat U A Saleh, Luc Girard, Kentaro Masahiro, Zhiqian Lucy Liu, Hemanta Baruah, Esra A Akbay

“…We show that in two KL mutant NSCLC xenograft models and a KL mutant PDX model, treatment with AHA-1031 monotherapy significantly inhibits tumor growth compared with vehicle-treated animals with no observable toxicity. …”
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Maternal Macronutrient Intake and Associated Risk for Gestational Diabetes Mellitus: Results from the BORN2020 Study by Antigoni Tranidou, Ioannis Tsakiridis, Emmanuela Magriplis, Aikaterini Apostolopoulou, Violeta Chroni, Eirini Tsekitsidi, Ioustini Kalaitzopoulou, Nikolaos Pazaras, Michail Chourdakis, Themistoklis Dagklis

“…Therefore, we evaluated these intakes both before and during pregnancy, comparing macronutrient data against the European Food and Safety Authorities’ (EFSA) Dietary Reference Values (DRVs). …”
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Health care utilization patterns of patients enrolled in an interdisciplinary program for back pain by Sara Davin, Psy.D., MPH, Brittany Lapin, PhD., MPH, Belinda Udeh, PhD, Sarah Rispinto, PhD, Nicolas R. Thompson, MS, Ryan Honomichl, PhD, Andre Machado, MD, Irene L. Katzan, MD

“…Methods: This observational cohort study describes the healthcare utilization of a group of adult patients (N=143) who participated in an IPP for chronic back pain compared to patients who did not complete the entire program (N=112), and those who were eligible for the program but chose not to participate (N=76). …”
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Chichimene field T2 sand: a successful application of cycles in a water injection project on heavy crude oil, enabled by a novel smart selective completion system adapted for water... by Pedro Luis Solorzano, Carlos Emilio Giosa, Carol Stephanny Rojas, Mónica Andrea Satizabal, Amelia Jhoanna Araque, Luisa Fernanda Falla, Walter Enrique Sanchez, Luis Oswaldo Castañeda, Mónica Alexandra Martínez, Diana Patricia Ahmedt

“…San Fernando). The results were compared with conventional water injection, technology that utilizes a simple selective completion system, in the aspects of recovery factor, water consumption, operation style, and others. …”
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Genomic selection strategies to overcome genotype by environment interactions in biosecurity-based aquaculture breeding programs by Ziyi Kang, Jie Kong, Qi Li, Juan Sui, Ping Dai, Kun Luo, Xianhong Meng, Baolong Chen, Jiawang Cao, Jian Tan, Qiang Fu, Qun Xing, Sheng Luan

“…However, these programs may exhibit a reduced genetic gain in the presence of a genotype by environment interactions (G × E) when employing biosecurity-based breeding schemes (BS), compared to non-biosecurity-based breeding schemes (NBS). …”
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Effects of dietary amylose/amylopectin ratio on antioxidant ability and amino metabolism in the liver of weaned piglets undergoing feed transition and challenged with lipopolysacch... by Can Yang, Can Yang, Xiaowu Tang, Min Wang, Han Yang, Huansheng Yang, Yancan Wang, Yulong Yin, Yulong Yin

“…Serum immunoglobulin G (IgG) concentration increased in DAR 0.80 but decreased in other groups after LPS stress (p &lt; 0.05). Compared with the control group, concentrations of Ile, Leu, Phe, Val, Thr, Arg decreased in serum but increased in liver after LPS stress (p &lt; 0.05). …”
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System-Technology Co-Optimization for Dense Edge Architectures Using 3-D Integration and Nonvolatile Memory by Leandro M. Giacomini Rocha, Mohamed Naeim, Guilherme Paim, Moritz Brunion, Priya Venugopal, Dragomir Milojevic, James Myers, Mustafa Badaroglu, Marian Verhelst, Julien Ryckaert, Dwaipayan Biswas

“…Three-dimensional nonvolatile memory (NVM)-VGSOT allows <inline-formula> <tex-math notation="LaTeX">$4\times $ </tex-math></inline-formula> memory capacity increase with 30% footprint reduction at iso-power compared with 2-D SRAM <inline-formula> <tex-math notation="LaTeX">$1\times $ </tex-math></inline-formula>. …”
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Sonograms of perineal muscles as a noninvasive diagnosis of pyometra and endometritis in beef cows: a preliminary study by Amrozi, S. Y. Hayanti, Aryogi, D. Pamungkas, D. M. Dikman, E. Handiwirawan, F. A. Pamungkas, Herdis, Jakaria, M. F. Ulum

“…In the control group, only the levator ani muscle of pregnant Bali beef cows had a significant intensity compared to nonpregnant postpartum Bali beef cows (<span class="inline-formula"><i>P</i>&lt;0.05</span>). …”
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First report of serological, molecular detection, and characterization of human parvovirus B19 infections among sickle cell anaemia patients in Khartoum State, Sudan by Khalid Salman, Sittna Hayder El Nagar, Abdel Rahim M. El Hussein, Mohammed A. El Hussein, Hadi M. Yassine, Hebah A. Al Khatib, Mashael Ali Al- Badr, Ibrahim Farah, Khalid A. Enan

“…Children under 5 years of age exhibited a higher nucleic acid detection rate compared to older age groups, suggesting the importance of molecular testing in younger patients particularly in the early detection of Parvovirus B19 during the acute phase of infection, before the body has developed detectable antibodies and also in immunocompromised children, who may not mount an antibody response detectable by serological methods. …”
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Modulatory effect of Echium plantagineum oil on the n-3 LC-PUFA biosynthetic capacity of chicken (Gallus gallus) by Jesús Villora, José Antonio Pérez, Nieves Guadalupe Acosta, Deiene Rodríguez-Barreto, Pedro Juan Alonso, Mónica B. Betancor, Alexandr Torres, Sergio Álvarez, Covadonga Rodríguez

“…However, the inclusion of LO and EO equally increased n-3 polyunsaturated fatty acids (PUFA) levels in the brain, liver, and intestine compared to animals fed with SO (p<0.05). Moreover, EO increased hepatic relative expressions of the fatty acid elongases (elovl2 and elovl5). …”
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Eosinophil is a predictor of severe immune-related adverse events induced by ipilimumab plus nivolumab therapy in patients with renal cell carcinoma: a retrospective multicenter co... by Yoshihiko Tasaki, Shuzo Hamamoto, Shimpei Yamashita, Junya Furukawa, Kazutoshi Fujita, Ryotaro Tomida, Makito Miyake, Noriyuki Ito, Hideto Iwamoto, Yoshihisa Mimura, Yosuke Sugiyama, Rei Unno, Atsushi Okada, Takahiro Yasui, Yoko Furukawa-Hibi

“…Although the mPFS did not differ between the severe and non-severe irAE groups (9.2 vs 14.2 months, P = 0.45), notably, mPFS2 and mOS in the former group tended to be shorter than those in the latter group (mPFS2: 29.2 vs not reached, P = 0.10; mOS: 36.9 vs 52.3 months, P = 0.06).DiscussionAn increased eosinophil 2 weeks after ipilimumab plus nivolumab therapy may be a predictor of severe irAEs, which are associated with poor prognoses, compared with non-severe irAEs among patients with RCC. …”
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Mobile Toolbox sequences task: development and validation of a remote, smartphone-based working memory test by Jerry Slotkin, Aaron J. Kaat, Stephanie Ruth Young, Elizabeth M. Dworak, Miriam A. Novack, Yusuke Shono, Hubert Adam, Cindy J. Nowinski, Sarah Pila, Zahra Hosseinian, Maria Varela Diaz, Anyelo Almonte-Correa, Keith Alperin, Monica R. Camacho, Monica R. Camacho, Bernard Landavazo, Bernard Landavazo, Rachel L. Nosheny, Rachel L. Nosheny, Michael W. Weiner, Michael W. Weiner, Richard C. Gershon

“…In Study 3 (N = 147), participants completed MTB measures twice, remotely on their own devices, with a 2–week interval between sessions.ResultsSequences exhibited moderately high correlations with a comparable NIHTB test and external measures of a similar construct, while exhibiting a lower correlation with an unrelated test, as hypothesized. …”
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Integrating pharmacogenomics and cheminformatics with diverse disease phenotypes for cell type-guided drug discovery by Arda Halu, Sarvesh Chelvanambi, Julius L. Decano, Joan T. Matamalas, Mary Whelan, Takaharu Asano, Namitra Kalicharran, Sasha A. Singh, Joseph Loscalzo, Masanori Aikawa

“…We benchmark our approach by calculating area under the receiver operating characteristic curves (AUROC) for 73 gene sets from the Molecular Signatures Database (MSigDB) using target gene expression profiles from the Comparative Toxicogenomics Database (CTD). We validate the drugs predicted in our proofs-of-concept using real-time polymerase chain reaction (qPCR) experiments. …”
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Four-dimensional flow magnetic resonance imaging for noninvasive diagnosis of clinically significant portal hypertension and high-risk gastroesophageal varices in patients with cir... by Jiachen Ji, Yi Xiang, Jinghui Dong, Hanyu Jiang, Tianyi Xia, Yunduo Li, Mengmeng Zhang, Changchun Liu, Xijun Gong, Bo Jin, Wen Shen, Gangfeng Zhu, Jianming Cai, Rui Li, Xiaolong Qi

“…Hemodynamic parameters within the portal vein, including the average and peak flow velocities, normalized flow volume (Qnormal), and regurgitant fraction (R%), were extracted and compared between healthy individuals and patients with CSPH and between participants with high- and low-risk varices. …”
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A Meta-analysis of the effect of functional dressing in nursing of pressure injury (功能性敷料在压力性损伤护理中应用效果的Meta分析) by WU Qian (吴倩), NING Yuyin (宁余音), BAI Zhiyu (柏志玉), HUANG Jie (黄洁), LU Junchen (陆俊辰), LIU Rui (刘芮), LIAO Zipeng (廖子鹏)

“…The results of Meta analysis showed that functional dressings were superior to the control group in terms of nursing satisfaction, healing status, and healing time except for the number of dressing changes (P<0. 05). Conclusion Compared with traditional dressings, functional dressings can reduce the number of dressing changes, shorten the healing time, increase the cure rate, and thus improve the patient's nursing satisfaction. …”
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Effect of a high dose atorvastatin as adjuvant therapy to mesalamine in attenuating inflammation and symptoms in patients with ulcerative colitis: a randomized controlled pilot stu... by Sumaiah J. Alarfaj, Sahar M. El-Haggar, Sahar K. Hegazy, Sahar K. Hegazy, Maha M. Maher, Maha M. Maher, Monir M. Bahgat, Thanaa A. Elmasry, Sarah Alrubia, Amsha S. Alsegiani, Mostafa M. Bahaa

“…Clinical remission was defined as a PMS of less than 2 and the absence of any single sub score greater than 1.Primary outcomeDecreased PMS and improved quality of life.Secondary outcomeChange in the level of measured biomarkers.ResultsCompared to the placebo group (n = 24), the atorvastatin group (n = 23) exhibited a significant decrease in the level of IL-6 (p = 0.001), S1P (p = 0.0001), TNF-α (p = 0.003), NO (p = 0.0001), CRP (p = 0.015), ESR (p = 0.012), PMS (p = 0.013), and fecal calprotectin (p = 0.0003), and improved SF-36 (p = 0.006). …”
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