Serum Soluble ST2 Correlated with Symptom Severity and Clinical Response of Sublingual Immunotherapy for House Dust Mite-Induced Allergic Rhinitis Patients by Kang Zhu, Cui Xia, Jingguo Chen, Chao Yu, Tianxi Gao, Jing Yan, Na Shao, Pin Zhu, Bin Sun, Xiaoyong Ren, Yanni Zhang

“…Serum sST2 levels were increased in HDM-induced AR patients compared to the HC group (P<0.001), and the concentrations were higher in the MSAR group than in the MAR group and HC group (all P<0.05). …”
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Targeting of the G9a, DNMT1 and UHRF1 epigenetic complex as an effective strategy against pancreatic ductal adenocarcinoma by Daniel Oyon, Amaya Lopez-Pascual, Borja Castello-Uribe, Iker Uriarte, Giulia Orsi, Sofia Llorente, Jasmin Elurbide, Elena Adan-Villaescusa, Emiliana Valbuena-Goiricelaya, Ainara Irigaray-Miramon, Maria Ujue Latasa, Luz A. Martinez-Perez, Luca Reggiani Bonetti, Felipe Prosper, Mariano Ponz-Sarvise, Silvestre Vicent, Antonio Pineda-Lucena, David Ruiz-Clavijo, Bruno Sangro, Urko Aguirre Larracoechea, Tian V. Tian, Andrea Casadei-Gardini, Irene Amat, Maria Arechederra, Carmen Berasain, Jesus M. Urman, Matias A. Avila, Maite G. Fernandez-Barrena

“…Results DNMT1, G9a, and UHRF1 were significantly overexpressed in PDAC cells and stroma compared to normal pancreatic tissues. Simultaneous overexpression of the three proteins was associated with significantly reduced survival in resected PDAC patients. …”
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KEAP1 mutations as key crucial prognostic biomarkers for resistance to KRAS-G12C inhibitors by Linyan Tian, Chengming Liu, Sufei Zheng, Huiyang Shi, Fang Wei, Wenxin Jiang, Yucheng Dong, Haiyan Xu, Enzhi Yin, Nan Sun, Jie He, Yan Wang

“…Validation studies in NCI-H358 cells showed a marked increase in IC50 values for AMG510, MRTX849, and JAB-21822 after KEAP1 knockout (P < 0.0001), with IC50 values rising from 27.78 nm, 116.9 nm, and 118.7 nm in controls, respectively. Comparative analysis of differentially expressed genes in KEAP1 knockout cells versus controls, utilizing GO, KEGG, and Reactome pathway analyses, revealed substantial enrichment in pathways linked to extracellular matrix organization and cell adhesion processes. …”
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Heatwave warnings mitigate long-term cardiovascular diseases risk from heat-related illness: a real-world prospective cohort studyResearch in context by Qi Huang, Limei Ke, Linfeng Liu, Yuyang Liu, Yanjun Li, Guoqing Feng, Bo Yin, Wenxin Xiang, Jiarun Li, Keyi Lyu, Miao Wang, Qiannan Tian, Liqun Wu, Xiaofeng He, Wannian Liang, Huatang Zeng, Jiming Zhu, Kuiying Gu, Qian Di

“…Heat-related illness was associated with CVD, with a hazard ratio of CVD 2.526 (95% CI = 2.301–2.773) among patients with heat-related illness compared with those without heat-related illness, and instrumental variable approach analysis suggested causation. …”
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Multi-cancer early detection tests for general population screening: a systematic literature review by Ros Wade, Sarah Nevitt, Yiwen Liu, Melissa Harden, Claire Khouja, Gary Raine, Rachel Churchill, Sofia Dias

“…Where reported, sensitivity was lower for detecting earlier-stage cancers (stages I–II) compared with later-stage cancers (stages III–IV). …”
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Evaluation of the Residues of Rice (Oryza sativa L.), Black-Eyed Pea (Vigna unguiculata L.), Dill (Anethum graveolens L.), and Aubergine (Solanum melongena L.) on Characteristics o... by Einollah Hesami, Mohsen Jahan

“…In the first and second years, respectively, there was a 35 and 29% increase in soil moisture compared to the control. The results of this research showed that the positive effect of plant residues in improving the organic matter of the soil after corn cultivation in wet Planting was much higher than that of dry Planting. …”
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Effects of Temperature and Light Intensity on the Growth and Physiological and Biochemical Characteristics of Young Sporophyte of a Novel Saccharina japonica "Huangguan No.2" by Guiyang SONG, Zhourui LIANG, Xiaoping LU, Yanmin YUAN, Wenjun WANG

“…Under the same light intensity, compared to 10–13 ℃, the contents of soluble protein decreased in the high temperature group; whereas the contents of MDA and H2O2 significantly increased. …”
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Potential role of dietary white poplar (Populus alba L.) in stimulating growth, digestion, and antioxidant/immune status of Nile tilapia (Oreochromis niloticus) by Rowida E. Ibrahim, Mohamed Shaalan, Mohamed ElHady, Hanan A. Ghetas, Faten I. Elsayed, Elsayed M. Younis, Abdelwahab A. Abdelwarith, Mohamed F. Badran, Simon J. Davies, Afaf N. Abdel Rahman

“…During the A. sobria challenge, the survival of fish was improved in a level-dependent manner (2–6 g/kg) (80%, 85%, 95%, respectively) compared to the control (70%), where the WP6 group recorded the highest survival. …”
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Modeling feed efficiency over productive lifetime and integrating a submodel for body reserve management in Nordic dairy cattle by R.B. Stephansen, J. Lassen, V.M. Thorup, B.G. Poulsen, J. Jensen, G. Sahana, O.F. Christensen

“…We demonstrated the feasibility of incorporating EBbody into gRFI. Comparing gRFI calculated with EBbody or changes in BW as an energy sink trait for body reserve management were highly genetically correlated (>0.95). …”
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Radiological safety assessment of sugar consumption in South Africa—a study of 226Ra, 228Ra, and 40K levels by Samuel Odumu Ogana John, Stephen Friday Olukotun, Stephen Friday Olukotun, Moses Mpofana Radebe, Manny Mathuthu

“…In this study, the measured activity levels are comparable to those reported in other similar studies. …”
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Immune Cell-Based versus Albumin-Based Ratios as Outcome Predictors in Critically Ill COVID-19 Patients by Zeba S, Surbatovic M, Udovicic I, Stanojevic I, Vojvodic D, Rondovic G, Mladenovic K, Abazovic T, Hasanovic A, Ilic AN, Abazovic D, Khan W, Djordjevic D

“…All the measured and calculated parameters were compared between survivors and nonsurvivors, with the outcome measure being hospital mortality.Results: Immune cell-based ratios [NLR - Neutrophil-to-Lymphocyte Ratio, MLR - Monocyte-to-Lymphocyte Ratio, PLR - Platelet-to-Lymphocyte Ratio, MPV - Mean Platelet Volume, MPV/PC - Mean Platelet Volume-to-Platelet Count Ratio, Derived (d-)NLR ratio - neutrophil count divided by the result of white blood cell (WBC) count – neutrophil count), N/LP - Neutrophil count x 100/Lymphocyte count x Platelet count, CLR – C-reactive protein (CRP)-to-Lymphocyte Ratio, CPR - CRP-to-Platelet Ratio, LLR - Lactate dehydrogenase (LDH)-to-Lymphocyte Ratio, Systemic Immune Inflammation Index (SII) - platelet x neutrophil/lymphocyte count, Systemic Inflammation Response Index (SIRI) - neutrophil x monocyte/lymphocyte count] were investigated. …”
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Preliminary effectiveness of social prescription and virtual patient information in increasing tertiary prevention among cancer patients (ESPRIT): protocol for a single-centre, ran... by Karen Steindorf, Michael Koller, Michael Leitzmann, Wolfgang Herr, Daniel Heudobler, Lisa Boyer, Anne Herrmann, Tobias Pukrop, Christine Bernardi, Sabine Einhell

“…Regarding the analysis of primary endpoints, the average number of steps per day, as well as the summary score of the social activity log and self-report on the use of psychosocial support, will be compared between the groups (A, B and C) using analysis of variance, followed by Dunnett’s test for pairwise comparisons of the intervention groups against the control group. …”
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Human health risk assessment of drinking water using heavy metal pollution index: a GIS-based investigation in mega city by Maria Latif, Iqra Nasim, Mubeen Ahmad, Rab Nawaz, Arifa Tahir, Muhammad Atif Irshad, Aamal A. Al-Mutairi, Ali Irfan, Sami A. Al-Hussain, Magdi E. A. Zaki

“…Through exposure to drinking water, heavy metals had a significant impact on non-carcinogenic risk (HI > 1), according to the hazard index values determined by the human health risk analysis for children, infants, and adults. As compared with metals carcinogenic risk values, lead posed high risks to adults than children and infants as mean CR values for adults, children, and infants were 1.48E + 00, 1.40E + 00, and 7.60E-01, respectively. …”
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Application of mind mapping-based health education in perioperative nursing of glioma patients undergoing awake surgery (基于思维导图的宣教模式在脑胶质瘤患者唤醒手术围手术期中的应用效果)... by ZHANG Fuli (张富丽), ZHONG Liyun (仲丽芸), DENG Lan (邓岚), ZHANG Aifang (张爱芳), SHANG Wuyi (尚无怡)

“…The patient satisfaction, readiness for hospital discharge and anxiety state were measured and compared between two groups. Results Score of Hamilton Anxiety Scale(HAMA) in the intervention group was lower than that in the control group (P＜0. 05). …”
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Quality of Life and Related Factors in Discharged Patients with COVID-19 by Jinzhuo HU, Wenhuan WU, Jinwen SUN, Wei ZHANG, Shu CHENG, Zicheng GAO, Jinghua QIAN

“…The quality of life of discharged patients with COVID-19 with different characteristics was compared. The correlation between the quality of life of patients and anxiety, depression and dyspnea and the related factors were analyzed.Results:A total of 57 questionnaires were distributed, and three duplicate and invalid questionnaires were eliminated, 54 valid questionnaires were obtained, with an effective questionnaire of 94.74%.①Quality of life of discharged patients with COVID-19: the physical component summary (PCS) scores and mental component summary (MCS) scores were (37.02±12.32) and (38.46±14.42) respectively; there were 3 cases (5.56%), 45 cases (83.33%), 5 cases (9.26%), and 1 case (1.85%) with dyspnea grade 0 to 3 respectively; 19 cases (35.19%) had an anxiety state (SAS≥50), and 19 cases (35.19%) had an anxiety state (SDS≥53). ②Comparison of quality of life of COVID-19 patients with different characteristics: patients with different disease types showed statistically significant differences in the SF-12V2 PCS(<italic>P</italic>&lt; 0.05). ③Correlation analysis between quality of life, anxiety, depression and dyspnea: Pearson's correlation indicated that, anxiety (<italic>r</italic>=-0.34, <italic>P</italic>=0.011) and dyspnea (<italic>r</italic>=-0.39, <italic>P</italic>=0.003) were negatively correlated with the PCS scores, anxiety (<italic>r</italic>=-0.46, <italic>P</italic>=0.001) and depression (<italic>r</italic>=-0.40, <italic>P</italic>=0.002) were negatively correlated with the MCS scores.④Analysis of influencing factors on the quality of life of COVID-19 patients: multiple linear regression indicated that, sex (β=8.27), depression (β=-0.34) and severity of illness (β=-11.68) were significant predictors of the SF-12V2 PCS scores (<italic>P</italic>&lt; 0.05). …”
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Kinerja probiotik Bacillus sp. pada pendederan benih ikan lele Clarias sp. yang diinfeksi Aeromonas hydrophila by , Sukenda, Muhammad Mufthi Rafsyanzani, , Rahman, Dendi Hidayatullah

“…The results of the blood profile showed significantly better results in the treatment of probiotics compared to the positive control after challenge test A. hydrophila. …”
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Cardiovascular risk factors and markers of myocardial injury and inflammation in people living with HIV in Nairobi, Kenya: a pilot cross-sectional study by Pablo Perel, Kuan Ken Lee, Anoop SV Shah, Mohammed K Ali, Shirjel R Alam, Jasmit Shah, Hassan Adan Ahmed, Jeilan Mohamed, Isaiah G Akuku, Sherry Eskander, Michael H Chung

“…Older age (adjusted OR (aOR) per year increase 1.05, 95% CI 1.01 to 1.08) and systolic blood pressure (140–159 mm Hg (aOR 2.96; 95% CI 1.09 to 7.90) and &gt;160 mm Hg (aOR 4.68, 95% CI 1.55 to 14) compared with &lt;140 mm Hg) were associated with hscTnI levels. …”
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Inflammatory and Redox Blood Gene Expression Fingerprint of Severe Obstructive Sleep Apnoea in Patients With Mild Alzheimer&rsquo;s Disease by Romero-ElKhayat L, Dakterzada F, Huerto R, Carnes-Vendrell A, Mínguez O, Pujol Sabaté M, Targa A, Barbé F, Milanesi E, Dobre M, Manda G, Cuadrado A, Piñol-Ripoll G

“…We aimed to identify inflammatory and redox genes differentially expressed in the blood from AD patients with severe OSA compared with those with nonsevere OSA.Methods: We included 40 AD patients diagnosed based on clinical manifestations and AD biomarker levels in cerebrospinal fluid (CSF). …”
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Understanding phage BX-1 resistance in Vibrio alginolyticus AP-1 and the role of quorum-sensing regulation by Xiaoyu Li, Xin Liu, Tianyi Ma, Haochen Su, Bingrui Sui, Lili Wang, Bilal Murtaza, Yongping Xu, Na Li, Demeng Tan

“…Conversely, cells in a low-density state (ΔhapR) exhibit reduced susceptibility to phage BX-1 while still producing comparable phage progenies. This population density-dependent response is primarily enhanced by the predicted quorum-sensing autoinducer CAI-1, synthesized by the gene cqsA. …”
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Explorando el potencial de la inteligencia artificial en traumatología: respuestas conversacionales a preguntas específicas by F. Canillas del Rey, M. Canillas Arias

“…Material and methods: Three «chatbot» models (ChatGPT, Bard and Perplexity) were analyzed by answering 114 questions from the MIR. Their accuracy was compared, the readability of their responses was evaluated, and their dependence on logical reasoning and internal and external information was examined. …”
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