A European aerosol phenomenology – 9: Light absorption properties of carbonaceous aerosol particles across surface Europe by Jordi Rovira, Marjan Savadkoohi, Gang I. Chen, Griša Močnik, Wenche Aas, Lucas Alados-Arboledas, Begoña Artiñano, Minna Aurela, John Backman, Sujai Banerji, David Beddows, Benjamin Brem, Benjamin Chazeau, Martine Collaud Coen, Cristina Colombi, Sebastien Conil, Francesca Costabile, Esther Coz, Joel F. de Brito, Kostas Eleftheriadis, Olivier Favez, Harald Flentje, Evelyn Freney, Asta Gregorič, Martin Gysel-Beer, Roy Harrison, Christoph Hueglin, Antti Hyvärinen, Matic Ivančič, Athina-Cerise Kalogridis, Hannes Keernik, Granakis Konstantinos, Paolo Laj, Eleni Liakakou, Chunshui Lin, Stefano Listrani, Krista Luoma, Marek Maasikmets, Hanna E. Manninen, Nicolas Marchand, Sebastiao Martins dos Santos, Saliou Mbengue, Nikos Mihalopoulos, Doina Nicolae, Jarkko V. Niemi, Michael Norman, Jurgita Ovadnevaite, Jean-Eudes Petit, Stephen Platt, André S.H. Prévôt, Manuel Pujadas, Jean-Philippe Putaud, Véronique Riffault, Martin Rigler, Matteo Rinaldi, Jaroslav Schwarz, Sanna Silvergren, Erik Teinemaa, Kimmo Teinilä, Hilkka Timonen, Gloria Titos, Anna Tobler, Jeni Vasilescu, Stergios Vratolis, Karl Espen Yttri, Eduardo Yubero, Naděžda Zíková, Andrés Alastuey, Tuukka Petäjä, Xavier Querol, Jesús Yus-Díez, Marco Pandolfi

“…Higher bAbs and AAE were observed in Central/Eastern Europe compared to Western/Northern Europe, due to higher coal and biomass burning emissions in the east. …”
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PD-L1 and IFN-γ modulate Non-Small Cell Lung Cancer (NSCLC) cell plasticity associated to immune checkpoint inhibitor (ICI)-mediated hyperprogressive disease (HPD) by Stefania Angelicola, Francesca Giunchi, Francesca Ruzzi, Mariateresa Frascino, Mary Pitzalis, Laura Scalambra, Maria Sofia Semprini, Olga Maria Pittino, Chiara Cappello, Irene Siracusa, Ilaria Candida Chillico, Martina Di Noia, Cristian Turato, Silvia De Siervi, Francesco Lescai, Teresa Ciavattini, Giulia Lopatriello, Luca Bertoli, Hugo De Jonge, Luisa Iamele, Annalisa Altimari, Elisa Gruppioni, Andrea Ardizzoni, Marzia Rossato, Francesco Gelsomino, Pier-Luigi Lollini, Arianna Palladini

“…Results NSCLC-H exhibited increased expression of specific CD44 isoforms and a more aggressive phenotype, including organoid formation ability, compared to NSCLC-B. Plastic changes in NSCLC-H were well described by a deep transcriptome shift, that also affected IFN-γ–related genes, including PD-L1. …”
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Ice-proximal sea ice reconstruction in the Powell Basin, Antarctica, since the Last Interglacial by W. W. Khoo, J. Müller, J. Müller, J. Müller, O. Esper, W. Xiao, C. Stepanek, P. Gierz, G. Lohmann, G. Lohmann, G. Lohmann, W. Geibert, J. Hefter, G. Mollenhauer, G. Mollenhauer, G. Mollenhauer

“…Our results also unveil a stronger deglacial amplitude and warming during the Last Interglacial (LIG; Marine Isotope Stage (MIS) 5e) compared to the current one (Holocene). A short-term sea ice readvance also occurred towards the end of each deglaciation. …”
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Characterization of feeding damage by tea mosquito bug, Helopeltis theivora Waterhouse (Hemiptera: Miridae) on Hainan Dayezhong tea cultivar by Qi Yao, Qi Yao, Qi Yao, You-Ze Lin, You-Ze Lin, You-Ze Lin, Shuang Qin, Shuang Qin, Shuang Qin, Zhu-Feng Lin, Zhu-Feng Lin, Zhu-Feng Lin, Xun-Cong Ji, Xun-Cong Ji, Xun-Cong Ji

“…More serious infestations of H. theivora were observed in the high-shade HNDYZ tea plantation compared to the medium-shade and no-shade HNDYZ tea plantations. …”
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Exploring the composition of placental microbiome and its potential origin in preterm birth by Marwa Saadaoui, Mohamed Nadhir Djekidel, Selvasankar Murugesan, Manoj Kumar, Duaa Elhag, Parul Singh, Basirudeen Syed Ahamed Kabeer, Basirudeen Syed Ahamed Kabeer, Alexandra Katharina Marr, Tomoshige Kino, Tobias Brummaier, Rose McGready, Rose McGready, François Nosten, François Nosten, Damien Chaussabel, Annalisa Terranegra, Souhaila Al Khodor

“…We leveraged on the multisite microbiome sampling from the MSP participants and on our previously published vaginal microbiome data to investigate the potential origins of the placental microbiome and assess whether its composition varies between healthy and complicated pregnancies.Results and DiscussionOur analysis revealed distinct profiles in the oral microbiome of PTB subjects compared to those who delivered at term. Specifically, we observed an increased abundance of Treponema maltophilum, Bacteroides sp, Mollicutes, Prevotella buccae, Leptotrichia, Prevotella_sp_Alloprevotella, in the PTB group. …”
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Clinical implication of NT-proBNP to predict mortality in patients with acute type A aortic dissection: a retrospective cohort study by Rui Zhang, Hao Wang, Chenxi Song, Rui Fu, Kefei Dou, Shuai Liu, Qianqian Liu, Xiaohui Bian, Weida Liu, Chengang Zhu, Jingjing Gao, Sheng Yuan, Xinming Cui, Sijia Qin, Yumeng Li

“…We aimed to investigate the prognostic value of N-terminal pro-B type natriuretic peptide (NT-proBNP) among this critically ill population.Design The design of this study was a retrospective cohort study.Setting The study population was recruited in the Emergency Department of Fuwai hospital in China from 2018 to 2020.Participants We consecutively enrolled 829 patients with acute type A aortic dissection and measurable baseline NT-proBNP.Primary outcome The primary endpoint was 1-year all-cause death.Results Based on tertiles of NT-proBNP (pg/mL), patients were stratified into low (≤150.3, n=276), intermediate (150.3–667.6, n=277) and high (>667.6, n=276) NT-proBNP groups. Compared with patients with low NT-proBNP, the Kaplan-Meier estimates for primary 1-year mortality were higher in intermediate (32.5% vs 18.1%; HR 1.91, 95% CI 1.35 to 2.69) and high (42.0% vs 18.1%; HR 2.56, 95% CI 1.84 to 3.57) NT-proBNP groups, respectively. …”
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Is first-line treatment with polatuzumab vedotin–rituximab–cyclophosphamide, doxorubicin and prednisone (pola-R-CHP) for previously untreated diffuse large B-cell lymphoma cost-eff... by Lin Yang, Ting Chen, Qiuling Zhao, Liangliang Dong, Wanfu Zhong, Wenbin Liu, Xiuliang Qiu, Ruyi Huang, Shengqiang Huang, Ruixiang Xie

“…The scenario analyses were also conducted.Setting Chinese healthcare system perspective.Participants A hypothetical cohort of adult patients presenting with CD20-positive, patients with previously untreated DLBCL.Interventions Pola-R-CHP versus R-CHOP.Main outcome measures The main outcomes of the study were QALYs, incremental cost-effectiveness ratio (ICER) and incremental net-health benefit (INHB).Results In China, the ICER and INHB of pola-R-CHP compared with R-CHOP were US$77 036.33/QALY and −1.11 QALYs, respectively. …”
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Prognostic nutritional index as a predictor of cardiovascular and all-cause mortality in American adults with hypertension: results from the NHANES database by Jing Tang, Jing Tang, Long Yang, Guan-Ying Yang, Yan-Hong Li, You-Sen Zhu, Hui Li, Xiao-Ming Gao, Xiao-Ming Gao, Xiao-Ming Gao

“…Multifactorial COX regression analysis showed all-cause mortality [hazard ratio (HR): 0.584, 95% CI: 0.523–0.652, p < 0.001] and cardiovascular mortality (HR: 0.435, 95% CI: 0.349–0.541, p < 0.001) associated with Q4 group risk of malnutrition in PNI compared to Q1 group. RCS curves showed a nonlinear relationship between PNI and all-cause mortality and cardiovascular mortality (both non-linear p < 0.001).ConclusionsLower PNI levels are associated with mortality in patients with hypertension. …”
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Outcome of critically ill patients receiving systemic chemotherapy on the intensive care unit by Panagiotis Karagiannis, Felix Klingler, Viktor Arelin, Winfried Alsdorf, Christina König, Kevin Roedl, Walter Fiedler, Katja Weisel, Stefan Kluge, Carsten Bokemeyer, Dominic Wichmann

“…Hematological patients had a significantly higher median Simplified Acute Physiology Score II (47 vs. 39 points; p=0.013), a higher need for invasive mechanical ventilation (59% vs. 50%; p=0.3), renal replacement therapy (54% vs. 24%; p < 0.001), and a higher 1-year mortality rate (64% vs. 53%; p=0.2) compared to solid tumor patients. The hazard ratio for 1 year survival for male sex was 2.34 (1.31–3.49), for mechanical ventilation 2.01 (1.33–3.04), for vasopressor therapy 1.98 (1.27–3.10), and for renal replacement therapy 1.51 (1.03–2.23), respectively.ConclusionAdministering intravenous chemotherapy in an ICU setting remains challenging, and the experience to establish an indication for systemic chemotherapy is still challenging. …”
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Dual role of ramR mutation in enhancing immune activation and elevating eravacycline resistance in Klebsiella pneumoniae by Wei Yu, Peiyao Jia, Xiaobing Chu, Shengjie Li, Xinmiao Jia, Ying Zhu, Xiaoyu Liu, Yingchun Xu, Qiwen Yang

“…Then, the CRISPR‐Cas9 technology was employed to construct specific ramR mutations into K. pneumoniae, which were then subjected to phenotypic and functional assays in both in vitro and in vivo (mouse models, macrophage, and blood‐killing experiment) settings. ramR L58P and F165L genetic alterations disrupt the binding affinity of RamR to the ramA promoter, thereby upregulating the efflux pump expression and increasing ERV minimum inhibitory concentration values up to 64‐fold compared to the wild‐type. Concurrently, these mutations modulate lipid A structure by increasing 2‐hydroxy fatty acid chain abundance. …”
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Appropriate Timing of Gestational Diabetes Mellitus Diagnosis in Medium- and Low-Risk Women: Effectiveness of the Italian NHS Recommendations in Preventing Fetal Macrosomia by Paola Quaresima, Federica Visconti, Eusebio Chiefari, Maria Mirabelli, Massimo Borelli, Patrizia Caroleo, Daniela Foti, Luigi Puccio, Roberta Venturella, Costantino Di Carlo, Antonio Brunetti

“…AC and EFW percentiles, as well as neonates’ BW percentiles, were significantly higher in HR women diagnosed with GDM at 24-28 weeks of gestation with respect to normal glucose-tolerant women, as well as MR and LR women who tested positive for GDM. Comparative analysis between MR and LR women with GDM and women with normal glucose tolerance revealed significant differences in both AC and EFW percentiles (P<0.05), while there was no significant difference in neonatal BW percentiles. …”
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Processing tomato (Lycopersicon esculentum Miller) yield and quality in arid regions through micro-nano aerated drip irrigation coupled with humic acid application by Jiaying Ma, Rui Chen, Yue Wen, Jinzhu Zhang, Feihu Yin, Tehseen Javed, Jiliang Zheng, Zhenhua Wang

“…The finding of the study revealed that compared to the conventional treatment (W1H1A1), the synergistic application of 0.5 % HA combined with micro-nano aeration significantly improved both the yield and quality (vitamin C, soluble sugars, lycopene, and soluble solids, increased by 102.97 %, 38.95 %, 104.69 %, and 21.16 %, respectively) of processing tomatoes under low irrigation stress (380 mm) in the first year. …”
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Severe obesity, high inflammation, insulin resistance with risks of all-cause mortality and all-site cancers, and potential modification by healthy lifestyles by Qianyun Jin, Siwen Liu, Yunmeng Zhang, Yuting Ji, Jie Wu, Hongyuan Duan, Xiaomin Liu, Jingjing Li, Yacong Zhang, Zhangyan Lyu, Fangfang Song, Fengju Song, Hua Li, Yubei Huang

“…Further analyses showed stronger interaction between severe obesity, inflammation, IR and lifestyles, with similar associations observed in both males and females. Additionally, compared with unfavorable lifestyles, favorable lifestyles attenuated the risks of both all-cause mortality [the highest HRs(95%CIs) 2.35(1.75–3.15) vs. 3.72(2.86–4.84) for favorable vs. unfavorable lifestyles] and all-site cancers [1.16(0.89–1.53) vs. 1.63(1.26–2.10)]. …”
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Effects of Mixing Tree Species on Soil Enzyme Activity and Carbon-Use Efficiency in Eroded Masson Pine Forest by WANG Man, JIANG Yongmeng, ZHANG Shiliang, ZHANG Jinxiu, ZHENG Linmin, ZENG Zhiwei, LYU Maokui, XIE Jinsheng

“…[Results] (1) With the increase of restoration years, soil acid phosphatase (AP) and β-glucosidase (βG) activities were significantly reduced, while C∶NEEA (βG∶NAG), vector length (VL) and vector angle (VA) of the mixed forest were lower than that of pure forest, while C∶PEEA (βG∶AP) and N∶PEEA (NAG∶AP) showed the opposite trend, indicating that long-term mixing is beneficial to alleviate the carbon limitation and phosphorus limitation of microorganisms. (2) Mixing was beneficial to improve CUE and significantly increased with the increase of forest age. Specifically, compared with that of Y39-CF and Y19-MF, CUE of Y39-MF significantly increased by 200.00% and 136.84%, respectively. (3) By analyzing the characteristics of soil enzyme activity and the relationship between CUE and environmental factors, it was found that soil carbon, nitrogen and phosphorus availability was an important influencing factor, mainly affecting AP activity, C∶PEEA, N∶PEEA, VL, VA and CUE, while the stoichiometric ratio of soil nutrients mainly affected βG activity and C∶NEEA. (4) The results of redundancy analysis (RDA) showed that the ratio of fungi and bacteria mainly affected the characteristics of soil enzyme activity and CUE in the mixed forest, while the main influencing factors in pure forest were actinomyces and Gram-negative bacteria. …”
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Delivery of dendritic cells targeting 3M2e-HA2 nanoparticles with a CpG adjuvant via lysosomal escape of Salmonella enhances protection against H9N2 avian influenza virus by Futing Jia, Wenfeng Wang, Yawen Tian, Ainul Zahra, Yingkai He, Chongbo Ge, Tongyu Zhang, Mingyue Wang, Jingshuo Gong, Gerui Zhang, Guilian Yang, Wentao Yang, Chunwei Shi, Jianzhong Wang, Haibin Huang, Xin Cao, Yang Zeng, Nan Wang, Zhannan Wang, Chunfeng Wang, Yanlong Jiang

“…Strikingly, after oral immunization with χYL56 (pYL331), chickens were protected against challenge with the G57 genotype H9N2 virus, which presented similar or even better levels of virus shedding and body weight gain compared with the commercial inactivated vaccine, providing a new option for controlling H9N2 virus infection in the future.…”
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Mechanical Ventilator-Associated Pneumonia in the COVID-19 Pandemic Era: A Critical Challenge in the Intensive Care Units by Mircea Stoian, Adina Andone, Sergiu Rareș Bândilă, Danusia Onișor, Sergiu Ștefan Laszlo, Gabriela Lupu, Alina Danielescu, Dragoș-Florin Baba, Anca Meda Văsieșiu, Andrei Manea, Adina Stoian

“…<b>Materials and Methods</b>: This study was a single-center, cross-sectional, retrospective analysis involving 122 patients who were hospitalized in the ICU of Târgu Mureș County Clinical Hospital from 1 April 2021, to 1 April 2023. This study compares patients with VAP in COVID-19 and non-COVID-19 groups, examining the clinical progression, duration of ventilation and hospitalization, mortality, pathogen distribution, and the emergence of multidrug-resistant strains. …”
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Medication related osteonecrosis (MRONJ) in the management of CTIBL in breast and prostate cancer patients. Joint report by SIPMO AND SIOMMMS by Francesco Bertoldo, Cristina Eller-Vainicher, Vittorio Fusco, Rodolfo Mauceri, Jessica Pepe, Alberto Bedogni, Andrea Palermo, Umberto Romeo, Giuseppe Guglielmi, Giuseppina Campisi

“…Background: Low-doses of bone modifying agents (LD-BMAs) compared to those used to treat bone metastases are used in breast or prostate cancer patients on adjuvant endocrine therapy to prevent Cancer Treatment Induced Bone Loss (CTIBL). …”
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Effect of trilaciclib administered before chemotherapy in patients with extensive-stage small-cell lung cancer: A pooled analysis of four randomized studies by Ying Liu, Lin Wu, Dingzhi Huang, Qiming Wang, Chen Yang, Li Zhou, Shuguang Sun, Xiaomei Jiang, Ying Cheng

“…Trilaciclib showed better capability of reducing CIMs incidence compared with prophylactic G-CSF in the overall and 1 L population. …”
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Col1A1 as a new decoder of clinical features and immune microenvironment in ovarian cancer by Xiao Xiao, Fangyi Long, Shaolan Yu, Wengjuan Wu, Dayan Nie, Xiaoyan Ren, Wen Li, Xujuan Wang, Ling Yu, Pinghan Wang, Gang Wang

“…The LinkedOmics and INPUT2 databases were used to analyze differential gene expression in OC, This was followed by enrichment analysis using the Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) annotations to identify and predict potential signaling pathways associated with COL1A1.ResultsOur study demonstrated that COL1A1 expression was significantly elevated in OC tissues compared to normal ovarian tissues. This elevated expression was closely associated with tumor metastasis, poor prognosis, and advanced pathological stages in OC patients. …”
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The Effect of Heat-treated Poultry Pellets and Composted Poultry Litter on E. coli Survival in Southeastern US Soils: Florida and Georgia by Karuna Kharel, Cameron A. Bardsley, Charles Bency Appolon, Laurel L. Dunn, Govindaraj Dev Kumar, Krishna Prabha, Manan Sharma, Michelle D. Danyluk, Keith R. Schneider

“…In FL, HTPP-amended soils supported higher levels of E. coli compared to PL-amended soils; in Georgia, similar survival was observed between PL- and HTPP-amended soils, both of which were higher (P < 0.05) than in UN soils. …”
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