Early Markers of Liver Fibrosis in Children with Beta-thalassaemia Major: A Cross-sectional Study by Himani Aggarwal, Monica Verma, Shuchi Bhalla, Dinkar Yadav, Kapil Bhalla, Abhishek Soni

“…Early markers for liver fibrosis were evaluated using serum YKL-40 levels, APRI, and FIB-4 scores, which were then compared to fibrosis scores obtained from TE. Statistical analysis was performed using Statistical Package for Social Sciences (SPSS) software version 20.0. …”
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P Wave Duration/P Wave Voltage Ratio Plays a Promising Role in the Prediction of Atrial Fibrillation: A New Player in the Game by E. Karacop, A. Enhos, N. Bakhshaliyev, R. Ozdemir

“…P wave duration (123.27 ± 12.87 vs. 119.33 ± 17.39 ms, p=0.024) and P wave duration/P wave voltage (1284.70 ± 508.03 vs. 924.14 ± 462.06 ms/mV, p<0.001) were higher, and P wave voltage (0.12 ± 0.04 vs. 0.13 ± 0.04 mV, p<0.001) was significantly lower in the new-onset AF group compared with non-AFs. P wave duration/P wave voltage, with a cut off of 854.5 ms/mV, had 83.3% sensitivity and 62.0% specificity in a receiver operating characteristic curve (AUC 0.728, 95% CI 0.687–0.769; p<0.001). …”
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Hypoxic BMSC-derived exosomal miR-210-3p promotes progression of triple-negative breast cancer cells via NFIX-Wnt/β-catenin signaling axis by Meng Wang, Yi Zheng, Qian Hao, Guochao Mao, Zhijun Dai, Zhen Zhai, Shuai Lin, Baobao Liang, Huafeng Kang, Xiaobin Ma

“…Moreover, we notably observed a marked downregulation of NFIX expression levels in cancerous tissues compared to paracancerous tissues. Conclusions Hypoxic BMSC-derived exosomal miR-210-3p promotes TNBC progression via NFIX-Wnt/β-catenin signaling axis.…”
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Accurate phenotype-to-genotype mapping of high-diversity yeast libraries by heat-shock-electroporation (HEEL) by Marcus Wäneskog, Emma Elise Hoch-Schneider, Shilpa Garg, Christian Kronborg Cantalapiedra, Elena Schäfer, Michael Krogh Jensen, Emil Damgaard Jensen

“…HEEL also allows more than 107 yeast cells per reaction to be transformed with a circular plasmid molecule, which corresponds to an almost 100-fold improvement compared with current yeast transformation methods. …”
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Identification of a 5-Gene-Based Scoring System by WGCNA and LASSO to Predict Prognosis for Rectal Cancer Patients by He Huang, Shilei Xu, Aidong Chen, Fen Li, Jiezhong Wu, Xusheng Tu, Kunpeng Hu

“…HPA analysis supported the downregulation of PRPH, RNASE7, CASQ2, EPHA6, and PDK4 in RC compared with normal controls. Conclusion. Our immune-related signature panel may be a promising prognostic indicator for RC.…”
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Progression of the faecal microbiome in preweaning dairy calves that develop cryptosporidiosis by M. F. Hares, B. E. Griffiths, L. Barningham, E. E. Vamos, R. Gregory, J. S. Duncan, G. Oikonomou, C. J. Stewart, J. L. Coombes

“…Whilst Firmicutes were elevated in the Cp+ group at W5 compared to the H group, no other significant differences were detected between H and Cp+ groups. …”
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A first study on sperm sexing in water buffalo through magnetic nanoparticles by Syed Murtaza Hassan Andrabi, Muhammad Hammad Fayyaz, Muhammad Shafiq Haider, Ghulam Muhammad Ali

“…The mean fold expression of the PLP gene (X chromosome bearing sperm) was higher (p<0.05) in all sexed groups (average: 15.34-fold = 91.09% X chromosome bearing sperm) as compared to control (1.60- fold). In conclusion, the MNPs-based technique appeared to be an effective method for water buffalo sperm sexing as validated by RT PCR. …”
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Spinal neuromodulation using ultra low frequency waveform inhibits sensory signaling to the thalamus and preferentially reduces aberrant firing of thalamic neurons in a model of ne... by Martyn G. Jones, Martyn G. Jones, Liam A. Matthews, Liam A. Matthews, Scott Lempka, Scott Lempka, Scott Lempka, Nishant Verma, James P. Harris, Stephen B. McMahon

“…Third, this novel form of neuromodulation preferentially attenuates pathological thalamic activity in this neuropathic model compared to normal activity in naïve and sham-operated animals. …”
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Impact of post-breeding administration of hCG and flunixin meglumine on luteal function and pregnancy rates in anestrous Nili-Ravi buffaloes by Ejaz Ahmad, Muhammad Muzammal Niaz, Muhammad Saleem Akhtar, Muhammad Rizwan Yousuf, Muhammad Zahid Tahir, Tanveer Ahmad

“…The pregnancy rates were higher (p<0.05) in T1 and T3 compared to T2 and Control Group. It is concluded that post-breeding administration of hCG improved luteal functions and pregnancy rate. …”
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Effect of pelvic floor muscle training combined with hydrotherapy on postoperative rehabilitation of patients undergoing for sphincter preservation rectal cancer (盆底肌锻炼联合水疗促进直肠癌患者保... by HUANG Liming (黄丽明), WU Lifang (吴丽芳)

“…The degree of low anterior resection syndrome(LARS)and incontinence dermatitis were measured and compared between two groups. Results There were 9 (27. 27%)patients with mild to severe LARS in the observation group and 20 (60. 61%)patients with mild to severe LARS in the control group at 6 month after operation(P＜0. 05). …”
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Effect of Soft Rehabilitation Robot Gloves on Upper Limb and Hand Function of Stroke Patients：A Meta-Analysis by YU Tingting, SHEN Yuwei, WAN Guomeng, LI Jianan

“…Meta-analysis results showed that, compared with the control group, FMA-UE score [<italic>MD</italic>=8.05, 95% <italic>CI </italic>(7.01,9.09), <italic>Z</italic>=15.20, <italic>P</italic>&lt;0.000 01], MBI score [<italic>MD</italic>=9.91, 95% <italic>CI</italic> (2.65,17.17), <italic>Z</italic>=2.68, <italic>P</italic>=0.007], WMFT score [<italic>MD</italic>=8.39, 95% <italic>CI</italic> (6.99,9.78), <italic>Z</italic>=11.81，<italic>P</italic>&lt;0.000 01], grip strength [<italic>SMD</italic>=0.39, 95% <italic>CI</italic> (0.11,0.67), <italic>Z</italic>=2.75, <italic>P</italic>=0.006], and ARAT score [<italic>MD</italic>=11.18, 95% <italic>CI</italic> (9.10, 13.26), <italic>Z</italic>=10.53, <italic>P</italic>&lt;0.000 01] were significantly higher in the experimental group, but there was no significant difference in BBT score between two groups [<italic>MD</italic>=0.53, 95% <italic>CI</italic> (-1.47, 2.53), <italic>Z</italic>=0.52, <italic>P</italic>=0.60].ConclusionSRG can improve the upper limb and hand motor function and activities of daily living of stroke patients, but more large-sample and high-quality RCTs would be needed to further verify its efficacy.…”
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Early Electroacupuncture Extends the rtPA Time Window to 6 h in a Male Rat Model of Embolic Stroke via the ERK1/2-MMP9 Pathway by Xin-chang Zhang, Ya-hui Gu, Wen-tao Xu, Yang-yang Song, Ao Zhang, Zhi-hui Zhang, Si-yuan Jiang, Si-qi Chang, Guang-xia Ni

“…However, treatment with EA plus rtPA significantly improved neurological function and reduced the infarct volume, hemorrhagic transformation, brain edema, and EB leakage in rats compared with rtPA alone. EA increased the levels of tight junction proteins, inhibited the activation of the ERK1/2 signaling pathway, and reduced MMP9 overexpression induced by delayed rtPA thrombolysis. …”
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Addition of Vitamin C on Diet to Improve Immunity on Tiger Grouper, Epinephelus fuscoguttatus to Infection Viral Nervous Necrosis by F. Johnny, K. Mahardika, I.N.A. Giri, D. Roza

“…Attempt result indicated that addition of vitamin C in diet dose between 600-1,200 mg/kg after 60 treatment day yield highest survival rate, PA and LA compared to other treatments. Keywords:  Immunity, tiger grouper, viral nervous necrosis, vitamin C   ABSTRAK Suatu percobaan dengan tujuan meningkatkan imunitas benih ikan kerapu macan, Epinephelus fuscoguttatus terhadap infeksi viral nervous necrosis (VNN) dengan penambahan vitamin C telah dilakukan di Balai Besar Riset Perikanan Budidaya Laut Gondol, Bali.  …”
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Exploring anticancer, antioxidant, and antimicrobial potential of Aspergillus flavus, a fungal endophyte isolated from Dillenia indica leaf callus by Ashish Gupta, Brajesh Chandra Pandey, Mohd Yaseen, Renu Kushwaha, Madhavenda Shukla, Pratima Chaudhary, Partha Pratim Manna, Aparna Singh, Ida Tiwari, Gopal Nath, Nishi Kumari

“…Endophyte extract prepared in chloroform showed both antioxidant (IC50 430.23) and antibacterial (maximum inhibition of E. coli:15 ± 0.62 mm) potential compared to other solvents. Cell viability decreased at high concentrations of endophyte extract prepared in chloroform and ethyl acetate solvents. …”
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Post-training breakdown: acute effects of different training types on body hydration status and performance by Erkan Demirkan, Mehmet İsmail Tosun, Abdurrahim Kaplan, Mert Ayrancı, Damian George Cosmin, Mustafa Arıcı, Mehmet Kutlu, Veysi Aslan, Michael Favre

“…In contrast, the strength training improved the reaction time before the next day’s session (+5.6 ± 1.3%, p &lt; 0.05), while the attention remained unaffected across all training types.ConclusionEndurance training—commonly used for rapid weight loss—can acutely compromise hydration and reduce key performance measures, with recovery taking more time compared to strength or wrestling sessions. Given these findings, endurance sessions should be strategically scheduled before rest days or low-intensity technical training to minimize their negative effects on subsequent performance. …”
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Biomimetic polydopamine loaded with janus kinase inhibitor for synergistic vitiligo therapy via hydrogel microneedles by Chunying Li, Wenwen Wang, Junyi Shao, Sen Zhou, Xiaolin Ji, Youxia Xi, Qiuyang Xu, Yuhan Huang, Jingle Wang, Yilin Wan, Zhiming Li

“…We precisely deliver this therapeutic agent to the dermis using microneedle (MN) patches, aiming to enhance therapeutic efficacy compared to traditional drug administration methods. …”
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Clinical characteristics and frailty status in heart failure with preserved vs. reduced ejection fraction by Tomoyuki Hamada, Toru Kubo, Kazuya Kawai, Yoko Nakaoka, Toshikazu Yabe, Takashi Furuno, Eisuke Yamada, Hiroaki Kitaoka, Kochi YOSACOI study

“…Conclusions In a super‐aged population of HF patients in Japan, HFpEF patients are more likely to be frail/have a high frailty status compared with HFrEF patients. The results suggested that physical frailty is associated with extracardiac factors in both HFpEF patients and HFrEF patients.…”
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Overexpression of multiple cytochrome P450 genes with and without knockdown resistance mutations confers high resistance to deltamethrin in Culex quinquefasciatus by Saowanee Chamnanya, Benyapa Kiddela, Jassada Saingamsook, Woottichai Nachaiwieng, Nongkran Lumjuan, Pradya Somboon, Jintana Yanola

“…All eight cytochrome P450 genes were significantly overexpressed in larvae of Cq_NiH-R strain compared to the parent and susceptible Cq_Sus strains. …”
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The effects of growth hormone on the outcomes of in vitro fertilization and embryo transfer in age-grouped patients with decreased ovarian reserve: a prospective cohort study by Jiexiu Chen, Xumei Kong, Zonghui Luan, Yu Qiu, Yu Qiu, Shiqi Chen, Jesse Li−Ling, Yan Gong

“…The quality of oocytes and embryos and the outcome of pregnancy were compared.ResultsIn group B, the number (1.16 ± 0.12 vs. 0.74 ± 0.09) and rate (34.27% vs. 23.90%) of high-quality cleavage embryos, rate of implantation (32.37% vs. 22.35%), clinical pregnancy (48.98% vs. 33.67%), and live birth (44.90% vs. 29.59%) were significantly higher, whereas the canceled oocyte retrieval rate was significantly lower (1.49% vs. 6.58%) in the GH part than those of the control part (P &lt; 0.05). …”
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Diagnostic criteria for asthenic accommodative asthenopia in patients with computer vision syndrome by I.G. Ovechkin, I.S. Gadzhiev, Kozhukhov A.A, E.I. Belikova

“…Additionally, patients with asthenic accommodative asthenopia were characterized by the lowest score of the quality of visual life and subjective psychophysiological status compared to HEAS patients and controls.</i> </p> <p> <i><b>Conclusion</b>: asthenic accommodative asthenopia is characterized by specific clinical functional and diagnostic criteria identified by both conventional and modern methods of the examination of visual accommodative system. …”
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