FORTALECIMIENTO DEL APRENDIZAJE EN ESTUDIANTES CON DISCAPACIDAD INTELECTUAL POR MEDIO DEL SOFTWARE EDUCATIVO ARDORA by Siliana Pallares Santiago, Lisbeth Jackeline López Salazar

“…La muestra intervenida fue de 15 estudiantes de los grados sexto y séptimo de la Institución Educativa Nuestra Señora del Carmen del municipio de Pailitas - Cesar, que presentan necesidades educativas especiales (NEE) una condición de discapacidad que buscó fortalecer el estudio realizado. …”
Get full text

Türk Halk Anlatılarında Ölüme İlişkin Tabu ve Kaçınmalar by Halil Altay Göde, Nezih Tatlıcan

“…Halk anlatılarından hareketle ölüm etrafında oluşan tabu ve kaçınmaların; cesede, ölüyü anma günlerine, ölen kişinin mülkiyetine, ölümün adına anmaya ilişkin tabu ve kaçınmalar olmak üzere dört alt başlık altında değerlendirilmesi uygun görülmüştür. …”
Get full text

Inflammatory changes in the choroid plexus following subarachnoid hemorrhage: the role of innate immune receptors and inflammatory molecules by Peter Solár, Peter Solár, Václav Brázda, Václav Brázda, Martin Bareš, Alemeh Zamani, Parisa EmamiAref, Andrea Joukal, Lucie Kubíčková, Erik Kročka, Klaudia Hašanová, Marek Joukal

“…The aim of the current study was to elucidate the pathophysiological cascades responsible for the inflammatory reaction that is seen in the choroid plexus following subarachnoid hemorrhage.MethodsSubarachnoid hemorrhage was induced in rats by injecting non-heparinized autologous blood to the cisterna magna. …”
Get full text

Oncometabolite D-2HG drives tumor metastasis and protumoral macrophage polarization by targeting FTO/m6A/ANGPTL4/integrin axis in triple-negative breast cancer by Siyue Zhang, Ning Zhang, Tong Wan, Yinqiao He, Jie Hao, Yiwei Liu, Yidong Liu, Bing Chen, Wenjing Zhao, Lijuan Wang, Dan Luo, Chao Gao, Qifeng Yang

“…As a secretory protein, ANGPTL4 subsequently activated the integrin-mediated JAK2/STAT3 signaling cascade in TNBC cells through autocrine signaling. …”
Get full text

IMPACTO DE LOS RECURSOS INSTRUCCIONALES APOYADOS EN REALIDAD AUMENTADA PARA EL APRENDIZAJE DE CIENCIAS NATURALES DEL TERCER GRADO DE EDUCACIÓN PRIMARIA by Msc. Jackson Jaimes, Msc. Yency Gualdron

“…En cuanto a la muestra fue censal, por cuanto se tomó la totalidad de la población.  …”
Get full text

GPR137-RAB8A activation promotes ovarian cancer development via the Hedgehog pathway by Chao Tang, Lin Li, Chongying Zhu, Qiang Xu, Zihao An, Shouying Xu, Chao Lin

“…Conclusions Collectively, this study depicts the role of GPR137-RAB8A-HH cascade in the development of OC, deepening our understanding of tumor biomechanics regarding OC progression and providing novel targets for OC therapy in future.…”
Get full text

Integrative single-cell and bulk RNA-seq analyses identify CD4+ T-cell subpopulation infiltration and biomarkers of regulatory T cells involved in mediating the progression of athe... by Yifeng Zhang, Yifeng Zhang, Shuxian Lu, Shuxian Lu, Liang Qiu, Liang Qiu, Manman Qin, Manman Qin, Dan Shan, Lianhua Xie, Yao Yi, Yao Yi, Jun Yu

“…We also employed high dimensional weighted gene co-expression network analysis (hdWGCNA) and cell-cell communication analysis to elucidate the modules and cascade reaction of Tregs in the progression of AS. …”
Get full text

Evaluation of the Expression of Infection-Related Long Noncoding RNAs among COVID-19 Patients: A Case-Control Study by Zahra Firoozi, Elham Mohammadisoleimani, Farzaneh Bagheri, Atefeh Taheri, Babak Pezeshki, Mohammad Mehdi Naghizadeh, Abdolreza Daraei, Jalal Karimi, Yousef Gholampour, Yaser Mansoori, Zahra Montaseri

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a worldwide pandemic, activates signaling cascades and leads to innate immune responses and secretion of multiple chemokines and cytokines. …”
Get full text

Lipoprotein (a) levels in children with heterozygous familial hypercholesterolemia by Liliya F. Galimova, Dinara I. Sadykova, Evgeniia S. Slastnikova, Chulpan D. Khaliullina, Karina R. Salakhova

“…CONCLUSION: High heritability estimates for Lp(a) highlights the need to measure it in patients with FH and offers an opportunity for reverse cascade screening to identify adult family members with FH at even greater risk of early cardiovascular accidents.…”
Get full text

Culturas en movimiento: migración y difusión-dilución de las creencias en México by Daniel Delaunay

“…El presente trabajo describe la dimensión espacial de tres movimientos en México durante los años noventa, con base en microdatas censales y con ayuida de modelos simples de coefgicientes variables. …”
Get full text

Cerebrospinal fluid β2-microglobulin promotes the tau pathology through microglia–astrocyte communication in Alzheimer's disease by Zehu Sheng, Lanyang Wang, Ming Chen, Fuxin Zhong, Shijing Wu, Shuyu Liang, Jiaqi Song, Lihua Chen, Yingxi Chen, Shiyu Chen, Weihua Yu, Yang Lü

“…Furthermore, the astrocyte cascade also partially mediated the pathological relationship between CSF β2M and tau pathology (β2M → GFAP → YKL-40 → P-tau/T-tau, IE: 0.424—0.435, all P < 0.001). …”
Get full text

Assessing the Future ODYSEA Satellite Mission for the Estimation of Ocean Surface Currents, Wind Stress, Energy Fluxes, and the Mechanical Coupling Between the Ocean and the Atmosp... by Marco Larrañaga, Lionel Renault, Alexander Wineteer, Marcela Contreras, Brian K. Arbic, Mark A. Bourassa, Ernesto Rodriguez

“…Our results indicate that ODYSEA would significantly improve the monitoring of eddy kinetic energy, the kinetic energy cascade, and air–sea kinetic energy flux in the Gulf Stream region. …”
Get full text

Unveiling the Effect of Age and IgE Level on Alopecia Areata: Insights from Comparative RNAseq Analysis by Liu H, Yang S, Xian H, Liu Y, Zhang Y, Chen Y, Xu Y, Liu J, Yang B, Luo Y

“…Pediatric AA was characterized by an upregulation of genes controlling inflammatory responses, such as the IFN-γ pathway and JAK-STAT cascade, contrasting to adult AA. Compared to age-matched healthy controls, pediatric AA patients exhibited a significant increase in the infiltration of B cell subtypes, mast cells, and regulatory T cells. …”
Get full text

Deciphering the oncogenic network: how C1QTNF1-AS1 modulates osteosarcoma through miR-34a-5p and glycolytic pathways by Yu Zhang, Hailong Lun, Naiqiang Zhu, Naiqiang Zhu, Ning Yang, Kaikai Ding, Bin Chen, Chengbing Chang, Haipeng Gu, Yanqi Liu

“…We discovered that the downregulation of C1QTNF1-AS1 indirectly upregulates the expression of LDHA and PDK3 by suppressing miR-34a-5p, which functions as a regulator of the Warburg effect. This cascade of events promotes OS progression by enhancing glycolytic metabolism and supplying energy for cancer cell growth, migration, and invasion. …”
Get full text

EL CORREDOR BIOCEÁNICO NORPATAGÓNICO, UNA ALTERNATIVA DE DESARROLLO LOCAL EN EL MARCO DEL PROCESO DE GLOBALIZACIÓN by Pablo Andrés Forgia

“…Desde el punto de vista metodológico, se preve un revisión bibliográfica de diversas publicaciones académicas, elaboración de cartografía del área de estudio y análisis de datos censales desde el inicio de la actividad minera en la ciudad hasta la actualidad.…”
Get full text

<i>Cichorium intybus</i> L. Oligo-Polysaccharides (CIO) Exerts Antianxiety and Antidepressant Effects on Mice Experiencing Behavioral Despair and Chronic Unpredicted Mild Stress by Yanqin Luo, Xueyi Bei, Yiwen Zhang, Xinran Sun, Yongzhi Zhao, Fang Chen, Ruile Pan, Qi Chang, Qinghu He, Xinmin Liu, Ning Jiang

“…Moreover, CIO therapy was facilitated by increasing the 5-HT content, alleviating the damage of hippocampal neurons, and upregulating the BDNF/ERK and PI3K/AKT/mTOR cascade. Thus, CIO is a substance with the potential to treat anxiety and depression.…”
Get full text

Empirična preveritev obstoja in delovanja notranjih kontrol pri pripravi konsolidirane premoženjske bilance države in občin v Sloveniji by Jasna Ida Zafred

“…Ugotovili smo, da so formalnopravno sicer dopustne razlike hkrati tudi neprave razlike, zaradi česar je verodostojnost skupinskega računovodskega izkaza lahko vprašljiva. …”
Get full text

‘Gaedhilg Chúige Uladh a shábhailt’: An phleanáil teanga in An tUltach [‘Gaedhilg Chúige Uladh a shábhailt’: Language planning in An tUltach] by Duane Long

“…Is cosúil go raibh sé mar aidhm thosaigh ag An tUltach díriú ar phleanáil an chorpais nó tá sé luaite go ndéanfar iarracht Gaeilge “a chur síos i leabhraibh” sa chéad eagrán den iris agus gairm ar scríbhneoirí ann. …”
Get full text

The global impact of COVID-19 on tuberculosis: A thematic scoping review, 2020-2023. by Michael H Marco, Sevim Ahmedov, Kenneth G Castro

“…The themes encompassed TB's care cascade, patient-centered care, psychosocial issues, and health services: 1) case-finding and notification (n = 45; 26%); 2) diagnosis and laboratory systems (n = 19; 10.7%) 3) prevention, treatment, and care (n = 22; 12.2%); 4) telemedicine/telehealth (n = 12; 6.8%); 5) social determinants of health (n = 14; 8%); 6) airborne infection prevention and control (n = 8; 4.6%); 7) health system strengthening (n = 22; 13%); 8) mental health (n = 13; 7.4%); 9) stigma (n = 11; 6.3%); and 10) health education (n = 10; 5.7%).…”
Get full text

Resveratrol contributes to NK cell-mediated breast cancer cytotoxicity by upregulating ULBP2 through miR-17-5p downmodulation and activation of MINK1/JNK/c-Jun signaling by Bisha Ding, Jie Li, Jia-Lin Yan, Chun-Yan Jiang, Ling-Bo Qian, Jie Pan

“…Furthermore, treatment with sp600125, a JNK inhibitor, resulted in the suppression of ULBP2 expression.Conclusions：RES potentiates ULBP2-mediated immune eradication of BC cells by NK cells through the downregulation of miR-17-5p and concurrent activation of the MINK1/JNK/c-Jun cascade. This finding identifies RES as a potentially effective therapeutic agent for inhibiting BC progression and optimizing NK cell-based cancer immunotherapy.…”
Get full text