Multiple Myeloma and B Cell Lymphoma. Investigation of IL-6, IL-6 Receptor Antagonist (IL-6RA), and GP130 Antagonist (GP130A) Using Various Parameters in an In Vitro Model by Eva Kovacs

“…This means that gp130 is not absolutely necessary for the cellular signalling cascade via JAK/STAT and RAS/MAPK pathways involved in proliferation and viability. …”
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0.5 V Digitally-Tunable Filters for Biomedical Applications Exploiting Segmented Duty-Cycled Resistors by Alessandro Fava, Francesco Centurelli, Giuseppe Scotti

“…The 8th-order filter, implemented with 4 cascaded instances of the proposed biquad filter, guarantees an attenuation higher than 30 dB at <inline-formula> <tex-math notation="LaTeX">$f_{0}$ </tex-math></inline-formula>/2 and 2f0 with a power consumption of 480 nW, and an area footprint of 0.152 mm2, thus satisfying the requirements to extract the epilepsy biomarker in closed-loop deep brain stimulation systems.…”
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NLRP3 inflammasome-modulated angiogenic function of EPC via PI3K/ Akt/mTOR pathway in diabetic myocardial infarction by Jia-Peng Li, Shu Qiu, Guang-Jie Tai, Yi-Ming Liu, Wei Wei, Meng-Meng Fu, Pan-Qi Fang, Joseph Nicolao Otieno, Tungalag Battulga, Xiao-Xue Li, Ming Xu

“…Furthermore, KEGG enrichment and validation at the protein levels revealed PI3K/ Akt/mTOR cascade might be a downstream signal for NLRP3 inflammasome. …”
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Concatenated Vertical Channel Modeling and Performance Analysis for HAP-Based Optical Networks by Neha Tiwari, Swades De, Dharmaraja Selvamuthu

“…We develop a VFSO channel model built upon the cascaded structure of fading coefficients. Correlated phase screen simulation method is used to verify the accuracy of the proposed channel model. …”
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‘They went for the test together but came back separately’: a constructivist grounded theory perspective on male engagement in antenatal HIV testing in Bamenda, Cameroon by Lily Haritu Foglabenchi, Nancy Manigha Nyahkeh, Heidi Stöckl, Tanya Marchant

“…Despite this, men especially the male partners of pregnant women have been consistently missing in the HIV prevention cascade. The factors accounting for sub-optimal levels in male engagement intersect but reasons for this are poorly understood. …”
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Post-traumatic patellar tendon ossification in children: a case series by Kirill A. Kartavenko, Vyacheslav I. Zorin, Sergey A. Lukyanov

“…The clinical picture of pediatric patients with patellar tendon ossification manifests in the form of a chronic cascade of symptoms and functional and topographic disorders: patellar tendon ossification, patella alta, anterior knee pain, flexion contracture and rectus femoris muscle hypotrophy. …”
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Wnt signaling as a translational target in rheumatoid and psoriatic arthritis by Gloria Riitano, Francesca Spinelli, Valeria Manganelli, Daniela Caissutti, Antonella Capozzi, Cristina Garufi, Tina Garofalo, Roberta Misasi, Maurizio Sorice, Fabrizio Conti, Agostina Longo, Cristiano Alessandri

“…Furthermore, a significant positive correlation was found between β-catenin and IL-6 levels in RA, indicating that β-catenin may be involved in the inflammatory cascade. Conclusion This study compares the involvement of Wnt signaling in RA and PsA, suggesting that Wnt signaling may represent a possible mechanism of disease activity. …”
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Anti-VEGF therapy for proliferative diabetic retinopathy: translating research evidence into clinical practice by E.A. Abdulaeva, E.L. Minkhuzina, A.N. Kuskov

“…DR pathogenesis is mediated by alterations in many metabolic cascades, production of pro-inflammatory cytokines and growth factors, increased vascular leakage resulting from the loss of blood-retinal barrier integrity, and pathological neovascularization (which indicates increasing severity of DR). …”
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Pregnancy and Childbirth Outcomes of Gestational Diabetes Mellitus: A Retrospective Cohort Study by Fatemeh Darsareh, Malihe Shirzadfard Jahromi, Amene Ranjbar, Mitra Shekari, Vahid Mehrnoush, Nasibeh Roozbeh

“…Background: Understanding the various outcomes of gestational diabetes mellitus (GDM) is essential for initiating a cascade of preparatory steps to address them. Therefore, this study aimed to evaluate the pregnancy and childbirth outcomes of GDM. …”
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Integration of artificial intelligence and advanced optimization techniques for continuous gas lift under restricted gas supply: A case study by Leila Zeinolabedini, Forough Ameli, Abdolhossein Hemmati-Sarapardeh

“…To optimize the selected input variables, including tubing inside diameter, gas injection rate, and separator pressure, various optimization algorithms such as particle swarm optimization (PSO), ant colony optimization (ACO), genetic algorithm (GA), and a Novel optimization algorithm in a gas-lift study called grey wolf optimization (GWO), were utilized considering the constraint of the limited available gas. …”
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Targeting Toll-like receptor 4 and microbiota dysregulation: a new frontier in nonalcoholic fatty liver disease management by K.B. Kvit

“…Gut-derived lipopolysaccharides activate TLR4, initiating inflammatory cascades that exacerbate liver injury. This study purposed to evaluate the relationship between gut microbiota composition, TLR4 levels, and biochemical markers in NAFLD and to assess the efficacy of microbiome-targeted therapy in modulating these factors. …”
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A Small-Area 2nd-Order Adder-Less Continuous-Time &#x0394;&#x03A3; Modulator With Pulse Shaping FIR DAC for Magnetic Sensing by Manish Srivastava, Alessandro Ferro, Aleksandr Sidun, Jose M. De La Rosa, Kilian O'Donoghue, Padraig Cantillon-Murphy, Daniel O'Hare

“…The CT<inline-formula> <tex-math notation="LaTeX">$\Delta \Sigma \text{M}$ </tex-math></inline-formula> is used for digitising very low amplitude signals in applications such as magnetic tracking for image-guided and robotic surgery. A cascade of integrators in a feed-forward architecture implemented with an adder-less architecture has been proposed to minimise the silicon area. …”
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Pore fracture structure evolution and damage failure mechanism of hot dry rock induced by temperature impact effect by Yong SUN, Cheng ZHAI, Yuzhou CONG, Yangfeng ZHENG, Wei TANG, Shuai WANG, Yongshuai LAI, Yu WANG, Aikun CHEN

“…The changes in temperature distribution, pore structure, and mechanical characteristics were tested and the cascade failure mechanism of “temperature shock-pore development-mechanical damage” was analyzed. …”
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Wnt/β-catenin signalling underpins juvenile Fasciola hepatica growth and development. by Rebecca Armstrong, Nikki J Marks, Timothy G Geary, John Harrington, Paul M Selzer, Aaron G Maule

“…Notably, silencing FhCTNNB1, the key effector of the Wnt/β-catenin signal cascade led to aberrant development of the neuromuscular system which ultimately proved lethal - the first report of a lethal RNAi-induced phenotype in F. hepatica. …”
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NEODUALISMO VERSUS HETEROGEIDAD: el caso de la pequena producción agraria em la Argentina by Pedro Tsakoumagkos

“…Así pues, uma imagen alternativa del sector agropecuário argentino es caracterizada por tres rasgos: a) La pequena producción agraria em la Argentina – entendida como unidades familiares conacesso limitado al capital y estimado mediante la categoria censal de pequena explotación agropecuária – tiene uma presencia significatica em el agro del país. b) Las escalas económicas de las unidades familiares em la Argentina tienen uma pluri-insertabilidad em la producción agropecuária porque tienen tres tipos de inserción: unidades familiares capaces de autosostener um proceso de capitalización y modernizarse, unidades familiares com acceso limitado al capital aunque estén em el mercado o se capitalicen y se modernicen em forma parcial; y unidades familiares que aunque estén em el mercado se limitan a repoducir la família y la unidade u aún están em la pobreza. …”
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Plasmid-free production of the plant lignan pinoresinol in growing Escherichia coli cells by U. Joost Luelf, Alexander Wassing, Lisa M. Böhmer, Vlada B. Urlacher

“…In addition, the simultaneous expression of multiple heterologous genes from different plasmids for a multi-enzyme cascade can be challenging and limits large-scale use. …”
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Prediction of Immune Infiltration Diagnostic Gene Biomarkers in Kawasaki Disease by Hongjun Ba, Yao Wang, Lili Zhang, Huishen Wang, Zhan-Peng Huang, Youzhen Qin

“…Gene sets related to complement and coagulation cascades, Toll-like receptor signaling pathway, Fc gamma R-mediated phagocytosis, NOD-like receptor signaling pathway, and regulation of actin cytoskeleton underwent differential activation in KD as opposed to the controls. …”
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Gene expression analysis reveals mir-29 as a linker regulatory molecule among rheumatoid arthritis, inflammatory bowel disease, and dementia: Insights from systems biology approach... by Devi Soorya Narayana S, Vino Sundararajan

“…These hub genes were mostly enriched in significant processes and pathways like tissue development, collagen binding, cell adhesion, regulation of ERK1/2 cascade, PI3K-AKT signaling, and cell surface receptor signaling. …”
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Comprehensive computational analysis of differentially expressed miRNAs and their influence on transcriptomic signatures in prostate cancer by Fahad M. Aldakheel, Hadeel Alnajran, Ayesha Mateen, Shatha A. Alduraywish, Mohammed S. Alqahtani, Rabbani Syed

“…This analysis uncovered their substantial impact on critical biological processes and molecular functions, such as cyclin-dependent protein kinase activity, mitotic DNA damage checkpoint signalling, stress-activated MAPK cascade, regulation of extrinsic apoptotic signalling pathway, and positive regulation of cell adhesion. …”
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Delayed Supplementation Strategy of Extracellular Vesicles from Adipose-Derived Mesenchymal Stromal Cells with Improved Proregenerative Efficiency in a Fat Transplantation Model by Shan Mou, Yuan Li, Di Sun, Muran Zhou, Jialun Li, Lifeng Chen, Shaokai Liu, Jie Yang, Peng Xiao, Jing Tong, Zhenxing Wang, Jiaming Sun

“…Besides, the inflammatory cascade is incited, providing an unfavorable environment for target cells. …”
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