Transcriptomic Profile Analysis of Brain Tissue in the Absence of Functional TRPM8 Calcium Channel by Erick B. Saldes, Alexandra Erdmier, Jai Velpula, Timothy E. Koeltzow, Michael X. Zhu, Swapna Asuthkar

“…The activation and deactivation of TRPM8 occur through genetic modifications, channel interactions, and signaling cascades. Recent evidence suggests a significant role of TRPM8 in the hypothalamus and amygdala related to pain sensation and sexual behavior. …”
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Recent Advances in the Mechanisms of Postoperative Neurocognitive Dysfunction: A Narrative Review by Tingting Wang, Xin Huang, Shujun Sun, Yafeng Wang, Linlin Han, Tao Zhang, Tianhao Zhang, Xiangdong Chen

“…Among these, neuroinflammation, mediated by pathways such as the NLRP3 inflammasome and blood–brain barrier disruption, emerges as a pivotal driver, triggering cascades that exacerbate neuronal injury. Oxidative stress and mitochondrial dysfunction synergistically amplify these effects, while neurotransmitter imbalances and microvascular alterations, including white matter lesions, contribute to synaptic dysfunction and cognitive decline. …”
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Evidence in Practice of Tissue Healing with Latex Biomembrane: Integrative Review by Suélia de Siqueira Rodrigues Fleury Rosa, Mário Fabrício Fleury Rosa, Marcos Augusto Moutinho Fonseca, Glécia Virgolino da Silva Luz, Carlos Federico Domínguez Avila, Aldira Guimarães Duarte Domínguez, Aldene Guimarães Duarte Dantas, Von Braun Richter

“…Wound healing is a perfectly coordinated cascade of cellular, molecular, and biochemical events which interact in tissue reconstitution. …”
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Globular-shaped Aβ oligomers have diverse mechanisms for promoting Aβ aggregations with the facilitation of fibril elongation by Hiroto Nakano, Sadao Hikishima, Makoto Mori, Jota Minamikawa, Daiki Muramatsu, Yasuhiro Sakashita, Tokuhei Ikeda, Moeko Noguchi-Shinohara, David B. Teplow, Kenjiro Ono

“…Among the various Aβ species that appear during Aβ aggregation, Aβ oligomers are considered the most neurotoxic form. However, the precise mechanisms of their molecular functions within the Aβ aggregation cascade have not been clarified so far. …”
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Transcriptomic and proteomic analysis of the jejunum revealed the effects and mechanism of protocatechuic acid on alleviating Salmonella typhimurium infection in chickens by Sheng Zhang, Qin Wang, Xiangtian Yao, Jingjing Dong, Guanhuo Li, Yingan Zang, Shouqun Jiang, Yibing Wang

“…Mechanistically, the transcriptomic results showed that dietary protocatechuic acid inhibited acute inflammatory response and activated the signaling pathways of cytokine-cytokine receptor interaction, complement and coagulation cascades. Results of proteomic showed that protocatechuic acid inhibited the positive regulation of dendritic cell cytokine production and I-κB kinase/NF-κB signaling, as well as cytokine-cytokine receptor interaction and MAPK signaling pathways, and activated the mTOR signaling pathways. …”
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Threshold responses of freshwater fish community size spectra to invasive species by Bradley Novak, Brent A. Murry, Jeff S. Wesner, Vojsava Gjoni, Caroline C. Arantes, Erin Shepta, Justin P. F. Pomeranz, James R. Junker, Kathrine Zipfel, Andrew Stump, Levi E. Solomon, Kristopher A. Maxson, Jason A. DeBoer

“…Silver Carp are large‐bodied planktivores that compete with native planktivores, which can cause cascading effects throughout the food web. Our study tested the threshold of abundance beyond which Silver Carp alter fish assemblage structure. …”
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Effects of plant functional group removal on caterpillars (Gynaephora alpherakii) performance and plant production in an alpine meadow by Rui Cao, Han Chen, Jingran Cai, Chen Hang, Ziyu Zhang, Yingchun Miao, Peng Xie

“…Our findings suggest that forb removal disrupts trophic interactions, with potential cascading effects on herbivore populations, plant community structure, and ecosystem productivity. …”
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Feasibility and Safety of Perilla Seed Oil as an Additional Antioxidative Therapy in Patients with Mild to Moderate Dementia by Chuntida Kamalashiran, Junya Pattaraarchachai, Sombat Muengtaweepongsa

“…Oxidative stress plays a major role in the neurodegenerative cascade, leading to the irreversible mechanism in dementia. …”
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Improving health outcomes by strengthening public sector capacity in social and behaviour change programming in Nigeria: a qualitative study by Pooja Sripad, Augustine Ankomah, Amanda Kalamar, Adetayo Adetunji, Bright Addo, Dele Abegunde, Nrupa Jani Tulsiani, Foyeke Oyedokun-Adegbabo

“…At the organisational level, the approach facilitated coordination of SBC activities, enabled training cascades and promoted adherence to health service guidelines. …”
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Drought before fire increases tree mortality after fire by C. Alina Cansler, Micah C. Wright, Phillip J. vanMantgem, Timothy M. Shearman, J. Morgan Varner, Sharon M. Hood

“…The amplifying effects of drought on post‐fire tree mortality and predicted future climates are likely to lead to higher tree mortality following fires in forested landscapes of western North America and may have cascading effects on ecosystem services and future forest resilience.…”
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A DNA-Methylated Sight on Autoimmune Inflammation Network across RA, pSS, and SLE by Xingqiang Wang, Dongyun Lei, Jie Ding, Shuang Liu, Li Tao, Fan Zhang, Jiangyun Peng, Jian Xu

“…Particularly, AZU1 and LTBR with hypomethylated TSS and first exon located in the promoter regions were able to trigger inflammation signaling cascades and play critical roles in autoimmune tautology. …”
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Decoding oral cancer: insights from miRNA expression profiles and their regulatory targets by Xin Wang, Xin Wang, Shuang Zhang, Shuang Zhang, Shuyi Wang, Tao Cao, Tao Cao, Hong Fan, Hong Fan

“…Furthermore, different signaling cascades such as IGF signaling, PDGF signaling and LKB1 signaling and PLK1 signaling pathways were also found associated with DEmiR-related regulation of OC progression. …”
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Parent-of-origin effects on nuclear chromatin organization and behavior in a Drosophila model for Williams–Beuren Syndrome by A. V. Medvedeva, E. V. Tokmatcheva, A. N. Kaminskaya, S. A. Vasileva, E. A. Nikitina, A. V. Zhuravlev, G. A. Zakharov, O. G. Zatsepina, E. V. Savvateeva-Popova

“…These processes are independent and controlled by different signal cascades: the first is cAMPdependent, the second relies on actin remodeling by small GTPase Rac1 – LIMK1 (LIM-kinase 1). …”
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Enabling analytical precision in microplastic analysis: innovative solutions for precise method validation, evaluation and quality control by Jovan Badzoka, Christoph Kappacher, Jakob Lauß, Lisa Obwaller, Anna Pavun, Christian W. Huck

“…Leveraging Fourier Transform Infrared (FT-IR) and Quantum-cascade laser (QCL) imaging, we introduce a method that utilizes potassium bromide (KBr) pellets embedded with microplastics (MPs), facilitating exact particle number determination for method validation and quality control (QC) using FT-IR imaging of formed potassium bromide (KBr) pellets. …”
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Identification of new genes regulating nodule development in Medicago truncatula: an in-silico approach by Mahboobeh Azarakhsh, Sara Eslami, Maryam Moghadas, Zahra Ataei

“…Downstream of Nod factor perception, activation of transcription factor (TF) signaling cascade in root tissue take place. This results in the formation of structure named infection thread and initiation of cell division in root cortex and finally formation of functional nodules. …”
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Fetal Deaths in SARS-CoV-2-Infected Pregnant Women: A Portuguese Case Series by Ana Rita Mira, João Pedro Pereira, Catrine Dahlstedt-Ferreira, Margarida Enes, Hélder Oliveira Coelho, Ana Beatriz Godinho

“…Placental hypoperfusion and inflammation secondary to maternal immune response seem to play a role in the cascade of events that contribute to fetal death. …”
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Modifiable Coronary Risk Factors and Global Cardiovascular Risk by Julio Armando Sánchez Delgado, Nailé Edita Sánchez Lara

“…The universe included the individuals who attended the cardiology consultation belonging to the César Fornet Fruto University Polyclinic health area of the Banes municipality, Holguín province, during June-December 2020. …”
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A Seventeen Multilevel High-Power Application Inverter with Low Total Harmonic Distortion by Ajmal Farooq, Shanshan Tu, Fiaz Ahmad, Muhammad Zeeshan Malik, Obaid U. Rehman, Ghulam Hafeez, Sadaqat ur Rehman

“…The proposed MLI has the advantage of decreasing the output THD by using a modified form of the cascaded H-Bridge structure and sine pulse width modulation technique. …”
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Bivalirudin exerts antiviral activity against respiratory syncytial virus-induced lung infections in neonatal mice by Zhuang Shihao, Tang Qiuyu, Chen Ping, Wang Chengyi, Liu Guanghua

“…The activation of the clotting cascade plays a key role in the progression of disease severity during viral infection. …”
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Validation of the COTENP Code: A Steady-State Thermal-Hydraulic Analysis Code for Nuclear Reactors with Plate Type Fuel Assemblies by Duvan A. Castellanos-Gonzalez, João Manoel Losada Moreira, José Rubens Maiorino, Pedro Carajilescov

“…To solve the conservation equations for mass, momentum, and energy, we adopt the subchannel and control volume methods based on fuel assembly geometric data and thermal-hydraulic conditions. We consider the chain or cascade method in two steps to facilitate the analysis of whole core. …”
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