Novel primers drive accurate SYBR Green PCR detection of Listeria monocytogenes and Listeria innocua in cultures and mushrooms by Bo-eun Kim, Ravi Jothi, Da woon Kim, Dong Suk Park

“…By performing a comparative analysis of the complete genome sequences of L. monocytogenes (ATCC 12392) and L. innocua (CFSAN044836), a unique gene region encoding a hypothetical protein with an LPXTG cell wall anchor domain (GCF_003031895.1) in L. monocytogenes and leucine-rich repeats (GCF_009648575.1) in L. innocua was identified. …”
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Effects and mechanisms of long-acting glucagon-like peptide-1 receptor agonist semaglutide on microglia phenotypic transformation and neuroinflammation after cerebral ischemia/repe... by Rulin Mi, Huifeng Cheng, Rui Chen, Bo Bai, An Li, Fankai Gao, Guofang Xue

“…Moreover, the results indicated a rise in the levels of CD206 (an indicator of M2 activation) and transforming growth factor beta (an anti-inflammatory mediator), while simultaneously reducing P65 levels in the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling cascade. CONCLUSION: In the CIRI model, semaglutide exhibits notable neuroprotective effects on rats, reducing neuroinflammation through the regulation of microglia phenotype transformation and inhibition of NF-κB activation.…”
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Biomimetic bioreactor for potentiated uricase replacement therapy in hyperuricemia and gout by Bin Yang, Bin Yang, Guihu Luo, Tailei Nie, Zhenglan Ban, Quanxin Ning, Jialin Zhang, Xiangru Liu, Yanhua Lin, Xiaochun Xie, Qianyun Chen, Han Zhong, Ying Huang, Pan Liao, Yan Liu, Chenyang Guo, Chuanxu Cheng, Erwei Sun, Erwei Sun

“…These limitations necessitate innovative strategies to enhance therapeutic efficacy and safety.MethodsWe designed and synthesized RBC@SeMSN@Uri, a red blood cell-coated biomimetic self-cascade bioreactor, which encapsulates uricase (Uri) and a selenium-based nano-scavenger (SeMSN) within RBC membranes. …”
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Multi-Scale Channel Distillation Network for Image Compressive Sensing by Tianyu Zhang, Kuntao Ye, Yue Zhang, Rui Lu

“…One branch extracts features gradually by cascading multiple CDRB modules, thereby supplementing the initial reconstructed image with a large amount of high-frequency content in feature space. …”
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Ir-6: A Novel Iridium (III) Organometallic Derivative for Inhibition of Human Platelet Activation by Ren-Shi Shyu, Themmila Khamrang, Joen-Rong Sheu, Chih-Wei Hsia, Marappan Velusamy, Chih-Hsuan Hsia, Duen-Suey Chou, Chao-Chien Chang

“…In conclusion, Ir-6 plays a crucial role by inhibiting platelet activation through the inhibition of signaling pathways, such as the PLCγ2–PKC cascade and the subsequent suppression of Akt and MAPK activation, thereby ultimately inhibiting platelet aggregation. …”
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Soluble Epoxide Hydrolase Inhibitor and 14,15-Epoxyeicosatrienoic Acid-Facilitated Long-Term Potentiation through cAMP and CaMKII in the Hippocampus by Han-Fang Wu, Yi-Ju Chen, Su-Zhen Wu, Chi-Wei Lee, I-Tuan Chen, Yi-Chao Lee, Chi-Chen Huang, Chung-Hsi Hsing, Chih-Wei Tang, Hui-Ching Lin

“…These results indicated that EETs increased NMDAR- and FSK-mediated synaptic potentiation via the AC-cAMP-PKA signaling cascade and upregulated the ERKs and CaMKII, resulting in increased phosphorylation of NR2B and GluR1 in the hippocampus.…”
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Individual and combined effects of dietary vitamin intake on cognitive function in elderly adults: the potential mediating role of serum neurofilament light chain levels by Zhikui Zhou, Baiyun Fan, Qiang Chen, Xuezhong Li, Xianjin Ke

“…Cognitive performance was assessed according to a composite Z-score of the Animal Fluency Test (AFT), Consortium to Establish a Registry for Alzheimer’s Disease (CERAD), and Digit Symbol Substitution Test (DSST). …”
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Unveiling the link between NADPH oxidase 2 activation and mitochondrial superoxide formation in leukemic cell killing induced by arsenic trioxide by Andrea Spina, Andrea Guidarelli, Gloria Buffi, Mara Fiorani, Orazio Cantoni

“…Consistently, through rescue experiments, we demonstrate that pharmacological stimulation of NOX 2 overcomes resistance in these cells, thereby initiating the same cascade of downstream events observed in APL cells.As a final note, several lines of evidence, including measurement of glutathione, catalase and glutathione peroxidase levels, indicated that the antioxidant machinery was similar in APL and AML cells. …”
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Redistribución espacial y migración interna de la población en Chile en los últimos 35 años (1965-2002): una síntesis de las hipótesis y la evidencia by Daniela González Ollino, Jorge Rodríguez Vignoli

“…La evidencia producida y analizada indica que la migración intrametropolitana desempeña un doble papel, pues mientras reduce la escala de la segregación sigue siendo una fuerza que tiende a ensan char las disparidades socioeconómicas entre comunas. …”
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Bienestar y territorio en los pueblos de la provincia de Buenos Aires, Argentina (2010) by Sofía Estela Ares

“…En la Geografía argentina hay una producción académica importante sobre calidad de vida y bienestar, desarrollada en distintas escalas de análisis, como son provincias, partidos/ departamentos o radios censales. En este artículo el objetivo es analizar el bienestar de la población residente en los pueblos pequeños y grandes de la provincia de Buenos Aires en 2010 y explorar su asociación con otras variables, como la tasa anual de crecimiento intercensal y la accesibilidad a una ciudad de 50.000 habitantes o más. …”
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Influence of Test Protocol on Filtration Efficiency of Medical Face Mask Material by Aurélie Joubert, Ala Bouhanguel, Yves Andrès, Laurence Le Coq

“…Several polydisperse test aerosols were used - DEHS, alumina, HOLI, NaCl, Staphylococcus epidermidis and Emesvirus zinderi (MS2) - produced by liquid atomization and/or powder dispersion, and sized by optical and aerodynamic counters or cascade impactors. The results have shown that the particle size distribution and charges for a given type of aerosol can differ depending on the generator used, in particular the wet or dry nature of generation. …”
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Identification of signaling networks associated with lactate modulation of macrophages and dendritic cells by Rapeepat Sangsuwan, Bhasirie Thuamsang, Noah Pacifici, Phum Tachachartvanich, Devan Murphy, Abhineet Ram, John Albeck, Jamal S. Lewis

“…While lactate mainly altered STAT3, ERK, and p38 MAPK signaling cascades in DCs, the STAT1 and GSK-3β signaling in MΦs were the major pathways significantly impacted by lactate. …”
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Pathway Analysis of Metabolic Syndrome Using a Genome-Wide Association Study of Korea Associated Resource (KARE) Cohorts by Unjin Shim, Han-Na Kim, Yeon-Ah Sung, Hyung-Lae Kim

“…Through pathway analysis, biological pathways, including electron carrier activity, signaling by platelet-derived growth factor (PDGF), the mitogen-activated protein kinase kinase kinase cascade, PDGF binding, peroxisome proliferator-activated receptor (PPAR) signaling, and DNA repair, were associated with MetS. …”
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Polarization conversion in soft glass fluoride and chalcogenide fibers for mid-infrared applications by Md Moinul Islam Khan, Md Hosne Mobarok Shamim, Jean-Luc Delarosbil, Younes Messaddeq, Frederic Smektala, Martin Rochette

“…Our experiments using a single PC show a polarization extinction ratio (PER) of 20.7 dB in a ZBLAN fiber (FiberLabs) with a coating of urethane acrylic resin. Cascading two PCs enhances the PER to 39.1 dB while reducing the required compressive force and, thus, increasing the fiber lifetime. …”
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Effect of celecoxib and paracetamol on the functional state of the central nervous system, pain sensitivity, and physical endurance of rats with acute heat injury by P.O. Chuikova, S.Yu. Shtrygol’

“…Since the effectiveness of drugs for the treatment of thermal injuries has not been proven, the search for new thermoprotective agents with different mechanisms of action, in particular inhibitors of the arachidonic acid cascade, is urgent. In a preliminary screening study on the AHI model in rats, it was found that among cyclooxygenase (COX) inhibitors, the highly selective COX-2 inhibitor celecoxib and the analgesic-antipyretic para­cetamol are the most effective in preventing hyperthermia and improving the course of the recovery period. …”
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Oxyberberine alleviates lipopolysaccharide-induced intestinal barrier disruption and inflammation in human colonic Caco-2 cells in vitro by Cailan Li, Cailan Li, Cailan Li, Jiahao Wang, Hongmei Yang, Shuang Luo, Qiang Lu

“…The levels of proinflammatory cytokines, reactive oxygen species (ROS), Nrf2, and NF-κB signaling cascade were analyzed via ELISA, qRT-PCR, immunofluorescence, or Western blotting.ResultsOBB was found to mitigate the effects of LPS on Caco-2 cell monolayers, as evidenced by the improvement in TEER and the decrease in FITC-dextran flux. …”
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Effect of Acetyl tributyl citrate on bone metabolism based on network toxicology and molecular docking technology by Xuan Lin, Kun Lin, Yue Lai, Qingping Peng, Miao Xu, Yiting Xu, Jialin Yang, Huan Liu, Jianlin Shen

“…In-depth Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses, conducted within the Metascape database, revealed that the core targets of ATBC’s influence on bone metabolism are predominantly concentrated within vital signaling cascades, including thyroid hormone signaling, FOXO signaling, glucagon signaling, AMPK signaling, insulin signaling, adipocytokine signaling, and Notch signaling pathways. …”
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Understanding the risks for post-disaster infectious disease outbreaks: a systematic review protocol by Ilan Kelman, Gina E C Charnley, Katy Gaythorpe, Kris Murray

“…The risks and drivers for these outbreaks and their ability to form cascades are somewhat contested. Despite evidence for post-disaster outbreaks, reviews quantifying them have been on short time scales, specific geographic areas or specific hazards. …”
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Induced resistance to the greenbug aphid Schizaphis graminum Rond. in species of the genus Triticum by S. D. Rumyantsev, S. V. Veselova, G. F. Burkhanova, I. V. Maksimov

“…We assume that the oxidative burst in the resistant forms of wheat was induced via the activation of the SA signaling pathway, which was of crucial importance in the further cascade of chemical reactions leading to the development of resistance.…”
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Exploring the Association Between Overactive Bladder (OAB) and Cognitive decline: mediation by depression in elderly adults,   a NHANES weighted analysis by Ling Liu

“…Cognitive health was assessed using the Consortium to Establish a Registry for Alzheimer’s Disease-Word Learning (CERAD W-L), Animal Fluency Test (AFT), and Digit Symbol Substitution Test (DSST). …”
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