Oxytocin ameliorates lipopolysaccharide-induced acute orchitis model: interplay of oxidative stress and inflammatory pathways by Mohamed El-Sherbiny, Hany A. Elkattawy, Shimaa Hadhoud, Ahmed N. Nasr, Ateya M. Ibrahim, Ateya M. Ibrahim, Omar Z. Ameer, Noorhan Alsaleebi, Joud Asfari, Madaniah O. Zakari, Moaz A. Mojaddidi, Ehab K. Ali, Hailah M. Almohaimeed, Ahmed Abdeen, Sahar K. Ali, Mamdouh Eldesoqui, Mamdouh Eldesoqui

“…Besides, LPS increased the malondialdehyde (MDA) and decreased the glutathione (GSH) levels, inducing an oxidative stress cascade. In addition, there are dramatic increases in the TLR4, MyD88, NF-κB, and PK2/PKR1 protein expression levels. …”
Get full text

Efficacy And Safety Of Low Dose Tofacitinib As Induction Therapy In Moderate To Severe Ulcerative Colitis: A Pilot Study by Sadia Ahmed, Muhammad Umar, Muhammad Kamran, Misbah Noureen, Iqra Ashraf, Javeria Khan

“… Objective: The Inflammatory cascade has been the root cause of ulcerative colitis's pathogenesis, and its treatment would centre upon reducing its intensity. …”
Get full text

KAI2-dependent signaling controls vegetative reproduction in Marchantia polymorpha through activation of LOG-mediated cytokinin synthesis (14) by Aino Komatsu, Mizuki Fujibayashi, Kazato Kumagai, Hidemasa Suzuki, Yuki Hata, Yumiko Takebayashi, Mikiko Kojima, Hitoshi Sakakibara, Junko Kyozuka

“…We propose a genetic cascade, starting from KAI2-dependent signaling, that promotes vegetative reproduction through the induction of MpLOG and GCAM1. …”
Get full text

An improved TDM-based controller for a multilevel three-phase active frontend with variable DC ratios: The extended Negev rectifier by Eli Barbie, Dmitry Baimel

“…This allows UDCS-based voltage and current THD minimization, traditionally limited to cascaded H-bridge MLIs, to be adapted into AC-source-fed MLIs of the MPC topologies, better suited for 3ɸ applications. …”
Get full text

Tgfbr1 regulates lateral plate mesoderm and endoderm reorganization during the trunk to tail transition by Anastasiia Lozovska, Ana Casaca, Ana Novoa, Ying-Yi Kuo, Arnon D Jurberg, Gabriel G Martins, Anna-Katerina Hadjantonakis, Moises Mallo

“…Similar alterations in the LPM and vascular system were also observed in Isl1 null mutants, indicating that this factor acts in the regulatory cascade downstream of Tgfbr1 in LPM-derived tissues. …”
Get full text

Early Transcriptional Changes Induced by Wnt/β-Catenin Signaling in Hippocampal Neurons by Eduardo Pérez-Palma, Víctor Andrade, Mario O. Caracci, Bernabé I. Bustos, Camilo Villaman, Matías A. Medina, Miguel E. Ávila, Giorgia D. Ugarte, Giancarlo V. De Ferrari

“…Likewise, following activation of the signaling cascade, the expression of a significant number of genes with transcription factor activity (GO:0043565, p-adjusted = 4.1 × 10−6) was induced. …”
Get full text

Saberes y prácticas alimentarias: familias migrantes entre tierras altas y bajas en Argentina by Mora Castro, Giorgina Fabron

“…Limitaciones: se basan en los datos censales públicos nacionales de población y agropecuarios de ambas zonas están desactualizados y, en la ampliación de entrevistas a familias migrantes para la muestra. …”
Get full text

Intelligent Electronic Device-in-the-Loop: A Real-Time Simulation as Modern Educational Aid by Francisco Gonzalez-Longatt, LE Nam Hai Pham

“…However, incorrect configuration settings in IEDs can trigger malfunctions, such as unintended circuit breaker trips, leading to cascading failures, widespread outages, and reduced power system reliability. …”
Get full text

Autoimmune Factor V Deficiency That Took 16 Years to Diagnose due to Pseudodeficiency of Multiple Coagulation Factors by Takaaki Kato, Takaya Hanawa, Mea Asou, Tomohiko Asakawa, Hisashi Sakamaki, Makoto Araki

“…When factor V, which is downstream of the coagulation cascade, is inhibited, coagulation test using the one-stage clotting method shows a pseudolow value. …”
Get full text

Association of polymorphism <i>TP53</i> Arg72Pro with radon-induced lung cancer in the Kazakh population by O. Bulgakova, A. Kussainova, A. Kakabayev, А. Kausbekova, R. Bersimbaev

“…The tumor suppressor gene TP53 is a key mediator of the DNA damage response cascade following cell exposure to ionizing radiation. …”
Get full text

Peroxiredoxin 6 maintains mitochondrial homeostasis and promotes tumor progression through ROS/JNK/p38 MAPK signaling pathway in multiple myeloma by Dandan Gao, Yang Lv, Fei Hong, Dong Wu, Ting Wang, Gongzhizi Gao, Zujie Lin, Ruoyu Yang, Jinsong Hu, Aili He, Pengyu Zhang

“…Then, the expression of BAX and Bcl2 was imbalance, and the cascade cleavage of PARP and caspase 3 was increased, ultimately triggering cell apoptosis. …”
Get full text

Application of new external cooling cycles in technological scheme of helium extraction and natural gas liquefaction by M. Mehrpooya, A. V. Zaitsev, A. O. Lisovtsov

“…The most common and effective way to ensure cooling capacity in the natural gas liquefaction process is to use a cascade cycle on mixed refrigerant (MFC) as external cooling. …”
Get full text

Musique et perception de la montagne à travers les poèmes symphoniques de Liszt, Franck et Strauss by Adrià San José Plana, Jordi Martí-Henneberg, Justino Losada Gómez

“…C'est un processus qui a commencé et s'est développé en Europe au cours du XIXe siècle.Pour ce faire, nous proposons une étude de deux poèmes symphoniques que César Franck (1822-1890) et Ferenc Liszt (1811-1866) ont composé sous le même tire, « Ce qu’on entend sur la montagne », et de « Eine Alpensinfonie » de Richard Strauss (1864-1949). …”
Get full text

Fall detection method based on spatio-temporal coordinate attention for high-resolution networks by Xiaorui Zhang, Qijian Xie, Wei Sun, Ting Wang

“…Then the long-range relationships and channel correlations among features are captured by cascading and slicing operations. Finally, the key information is effectively highlighted by performing dot-multiplication operations between the feature maps from the horizontal, vertical and temporal directions and the input feature maps. …”
Get full text

Real Time Operation Simulation Model with Early Release Reservoir Storage by Ida W. Amitaba, Pitojo T. Juwono, Lily M. Limantara, Runi Asmaranto

“…This research intends to build an optimal curve model of reservoir water level fluctuation for real-time water supply operation and to build an information system of gate opening operation due to the real-time release of reservoir storage by considering water demand and flood capacity in the downstream. …”
Get full text

A Novel Role for Brain Natriuretic Peptide: Inhibition of IL-1β Secretion via Downregulation of NF-kB/Erk 1/2 and NALP3/ASC/Caspase-1 Activation in Human THP-1 Monocyte by Letizia Mezzasoma, Cinzia Antognelli, Vincenzo Nicola Talesa

“…Here, we newly demonstrated that, in human THP-1 monocytes, LPS/ATP-induced IL-1β secretion is strongly inhibited by BNP/NPR-1/cGMP axis at all the molecular mechanisms that tightly control its production and release, NF-kB, ERK 1/2, and all the elements of NALP3/ASC/Caspase-1 inflammasome cascade, and that NALP3 inflammasome inhibition is directly related to BNP deregulatory effect on NF-kB/ERK 1/2 activation. …”
Get full text

Personal Identification Using Embedded Raspberry Pi-Based Face Recognition Systems by Sebastian Pecolt, Andrzej Błażejewski, Tomasz Królikowski, Igor Maciejewski, Kacper Gierula, Sebastian Glowinski

“…This study focuses on the development and validation of a facial recognition system utilizing a Haar cascade classifier and the AdaBoost machine learning algorithm. …”
Get full text

Galectin-1-Dependent Mitochondria Apoptosis Plays an Essential Role in the Potential Protein Targets of DBDCT-Induced Hepatotoxicity as Revealed by Quantitative Proteomic Analyses by Jiayu Song, Yuan Ren, Lihua Liu, Yixin Wang, Chuandao Shi, Xiaoqing Ji, Yunlan Li, Qingshan Li

“…As a result of these modulations, caspase cascades were finally activated, which executed apoptosis in HL7702 liver cells. …”
Get full text

Social media warfare: investigating human-bot engagement in English, Japanese and German during the Russo-Ukrainian war on Twitter and Reddit by Wentao Xu, Kazutoshi Sasahara, Jianxun Chu, Bin Wang, Wenlu Fan, Zhiwen Hu

“…Moreover, we found that English content demonstrated Granger causality with cascade size and depth in minor languages like Japanese and German (p < 0.05), with temporal correlations between human and bot posting frequencies significantly heightening toxicity in English compared to the other languages. …”
Get full text

Using an Artificial Neural Network to Validate and Predict the Physical Properties of Self-Compacting Concrete by K. Thirumalai Raja, N. Jayanthi, Jule Leta Tesfaye, N. Nagaprasad, R. Krishnaraj, V. S. Kaushik

“…Specialist systems based on the fully connected cascade (FCC) architecture in artificial neural networks (ANN) are used to estimate the compressive toughness of SCC. …”
Get full text