Drug Target Investigation of <i>N</i>-<i>p</i>-Coumaroyl-<i>N</i>’-Caffeoylputrescine, a Naturally-Occurring Alkaloid Derived from <i>Saxifraga tangutica</i> by Chuang Liu, Jun Dang, Minchen Wu

“…An in vitro study on liver (HepG2) cells and breast (MCF-7) cancer cells revealed that PCC modulates HSP90AA1, subsequently affecting Mut-p53 expression, triggering a cascade effect that reduced adriamycin-induced drug resistance in cells. …”
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miR-34a Regulates Multidrug Resistance via Positively Modulating OAZ2 Signaling in Colon Cancer Cells by Yong Li, Ping Gong, Ji-xue Hou, Wei Huang, Xiao-ping Ma, Yu-li Wang, Jing Li, Xiao-bin Cui, Na Li

“…Collectively, our combined analysis reveals a critical role of miR-34a/OAZ2 cascade in conferring a proper cellular response to CCa chemotherapy.…”
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Alpelisib-Induced Diabetic Ketoacidosis and Insulin-Resistant Hyperglycemia by Michael Loke, DO, Vishal Sehgal, MD, Niraj Gupta, MD

“…Background/Objective: Alpelisib is a phosphatidylinositol 3-kinase inhibitor used to treat certain hormone therapy resistant breast cancers that can cause hyperglycemia through inhibition of the insulin signaling cascade. Diabetic ketoacidosis with the initiation of alpelisib remains a rare complication. …”
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Glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide agonists for the treatment of obesity and diabetes mellitus by Alexander C. Martins, Beatriz G. de la Torre, Fernando Albericio

“…Obesity is strongly linked to serious health conditions like cardiovascular disease and insulin resistance, leading to a cascade of health risks. Importantly, the development of effective and safe weight loss medications has been challenging. …”
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Advances in Focal Segmental Glomerulosclerosis Treatment From the Perspective of the Newest Mechanisms of Podocyte Injury by Zhu Y, Xu G

“…Recent research has therefore focused on the development of targeted therapies aimed at disrupting specific pathogenic signaling cascades within podocytes, resulting in noteworthy advancements. …”
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Theoretical and Experimental Comparison Results of Dual-Channel 3D Quasi-Optical Network System between Frequency Selective Surface and Wire Grid Polarizer by Hai Wang, Xiaoming Liu, Junsheng Yu, Zejian Lu, Xiaodong Chen

“…The system structure based on the beam radius is traced by the complex beam parameter and system transfer matrix for deciding the positions of cascade mirrors. The design principles and test results of FSS with perforated hexagonal array and WGP printed on the dielectric substrate are discussed together. …”
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El liberalismo de Friedrich A. Hayek y Judith N. Shklar: una comparación by Paloma De la Nuez Sánchez-Cascado

“…Hayek, además de constituir una empresa intelectual sumamente estimulante, resulta muy útil para comprender la evolución del pensamiento político liberal en el siglo XX.Shklar, cuyo reconocimiento internacional está creciendo sin cesar en los últimos años, escribe que el liberalismo se hace contra el totalitarismo como doctrina política que pone por encima de cualquier otro valor la libertad, principio también fundamental en la obra de F. …”
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Gambaran Missing Cases Tuberkulosis pada Fasilitas Kesehatan Tingkat Pertama (FKTP) di Kota Padang Panjang by Mery Febriyeni, Rizanda Machmud, Finny Fitri Yani

“…Missing cases TB ditelusuri dengan pendekatan Patient Care Cascade. Lokasi missing cases TB diidentifikasi menggunakan Patient Pathway Analysis. …”
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YAP/TAZ-associated cell signaling – at the crossroads of cancer and neurodevelopmental disorders by Aderonke O. Ajongbolo, Aderonke O. Ajongbolo, Sigrid A. Langhans

“…Aside from the canonical Hippo signaling cascade with the key components MST1/2 (mammalian STE20-like kinase 1/2), SAV1 (Salvador homologue 1), MOB1A/B (Mps one binder kinase activator 1A/B) and LATS1/2 (large tumor suppressor kinase 1/2) upstream of YAP/TAZ, YAP/TAZ activation is also influenced by numerous other signaling pathways. …”
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Proapoptotic and Antiangiogenic Activities of Arctium Lappa L. on Breast Cancer Cell Lines by Mohamad Taleb Agha, Hussein M. Baharetha, Majed Ahmed Al-Mansoub, Yasser M. Tabana, Nur Hidayah Kaz Abdul Aziz, Mun Fei Yam, Amin Malik Shah Abdul Majid

“…Furthermore, EHX was found to disrupt the metastatic cascade of breast cancer cells by the inhibition of cell proliferation, migration, invasion, and colonization. …”
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The SIRT5-JIP4 interaction promotes osteoclastogenesis by modulating RANKL-induced signaling transduction by Kecheng Zhu, Chunxiang Sheng, Linlin Zhang, Yuying Yang, Xiaojing Chen, Tao Jiang, Jiaxi Song, Deng Zhang, Xiao Wang, Hongyan Zhao, Lihao Sun, Libin Zhou, Bei Tao, Jianmin Liu

“…Abstract Receptor activator of nuclear factor kappa-B ligand (RANKL) initiates a complex signaling cascade that is crucial for inducing osteoclast differentiation and activation. …”
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Vision-Based Underwater Docking Guidance and Positioning: Enhancing Detection with YOLO-D by Tian Ni, Can Sima, Wenzhong Zhang, Junlin Wang, Jia Guo, Lindan Zhang

“…This study proposed a vision-based underwater vertical docking guidance and positioning method to address docking control challenges for human-operated vehicles (HOVs) and unmanned underwater vehicles (UUVs) under complex underwater visual conditions. A cascaded detection and positioning strategy incorporating fused active and passive markers enabled real-time detection of the relative position and pose between the UUV and docking station (DS). …”
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Multiscale Adaptively Spatial Feature Fusion Network for Spacecraft Component Recognition by Wuxia Zhang, Xiaoxiao Shao, Chao Mei, Xiaoying Pan, Xiaoqiang Lu

“…Second, the multi-scale adaptively spatial feature fusion module within the Multi-ASFFD cascades four adaptively spatial feature fusion blocks to fuse low-level, middle-level, and high-level features at various scales to enrich the semantic information for different spacecraft components. …”
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Desarrollo y utilización de habilidades: el caso de los migrantes en León, Guanajuato, procedentes de la Ciudad de México by Ricardo Sabatés Aysa

“…Esto nos lleva a investigar si la experiencia laboral en los grandes centros urbanos está relacionada con el desarrollo de habilidades que ocasionan la diferenciación socioeconómica obtenida por los datos censales. Tras un estudio de campo que se llevó a cabo en la ciudad de León se identificó que la eficiencia, la eficacia, la resilencia, y la seguridad son las principales habilidades desarrolladas por los migrantes que proceden de la Ciudad de México. …”
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Plant Coping with Cold Stress: Molecular and Physiological Adaptive Mechanisms with Future Perspectives by Yan Feng, Zengqiang Li, Xiangjun Kong, Aziz Khan, Najeeb Ullah, Xin Zhang

“…This review summarizes the mechanisms of how plants respond to cold stress, covering four main signal transduction pathways, including the abscisic acid (ABA) signal transduction pathway, Ca²⁺ signal transduction pathway, ROS signal transduction pathway, and mitogen-activated protein kinase (MAPK/MPK) cascade pathway. Some transcription factors, such as AP2/ERF, MYB, WRKY, NAC, and bZIP, not only act as calmodulin-binding proteins during cold perception but can also play important roles in the downstream chilling-signaling pathway. …”
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The Effects of Hyperacute Serum on the Elements of the Human Subchondral Bone Marrow Niche by Melinda Simon, Bálint Major, Gabriella Vácz, Olga Kuten, István Hornyák, Adél Hinsenkamp, Dorottya Kardos, Marcell Bagó, Domonkos Cseh, Adrienn Sárközi, Denes Horvathy, Stefan Nehrer, Zsombor Lacza

“…Hyperacute serum (HAS), a new serum derivative, has been designed to approximate the natural coagulation cascade with a single-step, additive-free preparation method. …”
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A multi-stage deep learning network toward multi-classification of polyps in colorectal images by Shilong Chang, Kun Yang, Yucheng Wang, Yufeng Sun, Chaoyi Qi, Wenlong Fan, Ying Zhang, Shuang Liu, Wenshan Gao, Jie Meng, Linyan Xue

“…Drawing inspiration from the sequential procedure of colonoscopy, where endoscopists first locate polyps and then proceed to detailed observations and diagnoses, we developed a novel multi-stage classification network. This network cascades several convolutional neural networks (CNNs) to mimic the gradual increase in diagnostic specificity seen in clinical settings. …”
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Impaired peroxisomal beta-oxidation in microglia triggers oxidative stress and impacts neurons and oligodendrocytes by Ali Tawbeh, Catherine Gondcaille, Fatima-Ezzahra Saih, Quentin Raas, Damien Loichot, Yannick Hamon, Céline Keime, Alexandre Benani, Francesca Di Cara, Mustapha Cherkaoui-Malki, Pierre Andreoletti, Stéphane Savary

“…This dysfunction might contribute to the early neurodegenerative events in X-ALD by triggering and sustaining neuroinflammatory cascades. Therapeutic strategies that target microglial activation and secretion profiles could hold promise in managing peroxisomal disorders such as X-ALD.…”
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Revealing enhanced dilution effect of conjugated polymers in partially miscible blends by Hongbo Chen, Ming Hu, Yuehua Zhao, Kaixuan Lyu, Yushuai Xu, Yuansheng Sun, Zhiyuan Xie, Jinying Huang, Dapeng Wang

“…In this work, we propose a cascade analysis by combining multiple fluorescence microscopic techniques and all‐atom molecular dynamics simulations to study the solid‐to‐solid dilution of poly[2‐methoxy‐5‐(2‐ethylhexyloxy)‐1,4‐phenylenevinylene] (MEH‐PPV) in MEH‐PPV/polystyrene (PS) blends and MEH‐PPV/poly(vinylcarbazole) (PVK) blends. …”
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Analysis of Inflammatory Mediator Profiles in Sepsis Patients Reveals That Extracellular Histones Are Strongly Elevated in Nonsurvivors by Tanja Eichhorn, Ingrid Linsberger, Lucia Lauková, Carla Tripisciano, Birgit Fendl, René Weiss, Franz König, Gerhard Valicek, Georg Miestinger, Christoph Hörmann, Viktoria Weber

“…Treatment strategies relying on a “one-fits-all” approach have failed to reduce mortality, suggesting that therapeutic targets differ between patient subgroups and highlighting the need for accurate analysis of the molecular cascades to assess the highly variable host response. …”
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