Heteronemin Suppresses Lymphangiogenesis Through ARF-1 and MMP-9/VE-Cadherin/Vimentin by Hsien-Lin Chen, Yu-Chieh Su, Huang-Chi Chen, Jui-Hsin Su, Chang-Yi Wu, Shih-Wei Wang, In-Pin Lin, Chung-Yi Chen, Chien-Hsing Lee

“…Overall, anti-lymphangiogenic properties of SP-1 occur by downregulating the VEGFR-3 cascade, ARF-1 and MMP-9/VE-cadherin/vimentin. Collectively, these results proposed that SP-1 might be a potential candidate for the treatment of lymphangiogenesis-associated diseases.…”
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Aptitud ecológica de los departamentos castellanos y las colonias, santa fe, para sustentar hipotéticas poblaciones de la garrapata común del vacuno, boophilus microplus (acar... by A. A. Guglielmone, R. Giorgi, A. Sodiro, R. Gay, A. Canal, A.J. Mangold, A. Estrada Peña

“…Para tal fin se utilizaron información censal, datos climáticos históricos y mapas digitales con una resolución de 8 km. …”
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Dioscin pretreatment ameliorates ferroptosis in cardiomyocytes after myocardial infarction via inhibiting endoplasmic reticulum stress by Chang Wu, Xueping Shen, Pan Lou, Dongyan Song

“…Moreover, Dioscin exerted its protective effects by inhibiting ER stress markers, such as the phosphorylation levels of PERK and eIF2α proteins, and the expression levels of BIP and ATF4 proteins, thus disrupting the ER stress-mediated signaling cascade associated with ferroptosis. Conclusion Overall, our findings suggested that Dioscin holds promise as a therapeutic agent against post-MI cardiac injury by mitigating ferroptosis via the suppression of ER stress. …”
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Effectiveness of Centrality Measures for Competitive Influence Diffusion in Social Networks by Fairouz Medjahed, Elisenda Molina, Juan Tejada

“…Firms, as players, aim to maximize the adoption of their products, considering the possible rational choice of their competitors under a competitive diffusion model. …”
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Tearing-mediated Alfvénic Turbulence in a Relativistic Plasma by Stanislav Boldyrev, Nuno F. Loureiro

“…If the opposite inequality holds, the Alfvénic cascade is instead affected by charge starvation at scales below ${a}_{\mathrm{ch}}\sim {d}_{\mathrm{rel}}{\left({d}_{\mathrm{rel}}/{L}_{\perp }\right)}^{1/3}{\tilde{\sigma }}^{2/3}$ , and the energy spectrum becomes steeper than W ( k ) dk ∝ k ^−3 dk . …”
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Tibetan–Chinese speech-to-speech translation based on discrete units by Zairan Gong, Xiaona Xu, Yue Zhao

“…Abstract Speech-to-speech translation (S2ST) has evolved from cascade systems which integrate Automatic Speech Recognition (ASR), Machine Translation (MT), and Text-to-Speech (TTS), to end-to-end models. …”
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Non-Isolated Power Factor Corrected AC/DC Converter with High Step-Down Voltage Ratio for Low-Power Applications by Lalitha T. S. Annambhotla, P. Parthiban

“…In addition, the number of conducting devices during the current path is also the same as the conventional buck converter due to cascading and hence offers lower conduction losses. …”
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Integrated risk analyses as part of national climate risk assessments: lessons learnt from the climate risk assessment of Germany by Walter Kahlenborn, Maike Voss, Luise Porst, Marc Zebisch, Kathrin Renner, Inke Schauser

“…However, existing CRAs oftentimes do not exploit their full potential by means of an integrated assessment, i.e. to illustrate the complexity of cascading risks, provide cross-sectoral results, integrate adaptive capacity and demonstrate spatial patterns. …”
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Reconstruction and analysis of the gene regulatory network for cell wall function in <i>Arabidopsis thaliana</i> L. leaves in response to water deficit by A. R. Volyanskaya, E. A. Antropova, U. S. Zubairova, P. S. Demenkov, A. S. Venzel, Y. L. Orlov, A. A. Makarova, T. V. Ivanisenko, T. A. Gorshkova, A. R. Aglyamova, N. A. Kolchanov, M. Chen, V. A.  Ivanisenko

“…The plant cell wall represents the outer compartment of the plant cell, which provides a physical barrier and triggers signaling cascades under the influence of biotic and abiotic stressors. …”
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The association between short-term apparent temperature exposure and human coagulation: A time-series study from Beijing, 2014–2023 by Yi Zhang, Tiancheng Wang, Jiaqi Shi, Ying Ma, Nairui Yu, Xinyan Zhou, Pai Zheng, Zhangjian Chen, Guang Jia

“…The findings support that both cold and heat can augment blood coagulability through distinct stages of the coagulation cascade, thereby leading to an elevated risk of thromboembolic diseases.…”
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Anti-Inflammatory Activity of Diterpenoids from Celastrus orbiculatus in Lipopolysaccharide-Stimulated RAW264.7 Cells by Hyun-Jae Jang, Kang-Hoon Kim, Eun-Jae Park, Jeong A. Kang, Bong-Sik Yun, Seung-Jae Lee, Chan Sun Park, Soyoung Lee, Seung Woong Lee, Mun-Chual Rho

“…Therefore, these results demonstrated that diterpenoids 1 and 3 obtained from C. orbiculatus may be considered a potential candidate for the treatment of inflammatory diseases.…”
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Sevuparin strongly reduces hepcidin expression in cells, mice, and healthy human volunteers by Michela Asperti, Andrea Denardo, Magdalena Gryzik, Kristina E. M. Persson, Göran Westerberg, John Öhd, Maura Poli

“…Sevuparin strongly suppressed basal, BMP6‐, and IL6‐dependent hepcidin expression in HepG2 cells in a dose‐ and time‐dependent manner, modulating the essential BMP6/SMAD cascade. These effects were evident in C57BL/6J mice after intravenous injection of a single dose of sevuparin (20 mg/kg) with a 70% reduction of hepcidin mRNA. …”
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Membrane-bound model of the ternary complex between factor VIIa/tissue factor and factor X by Melanie P. Muller, Alex Mortenson, Josepha C. Sedzro, Po-Chao Wen, James H. Morrissey, Emad Tajkhorshid

“…Abstract: Formation of the extrinsic complex (EC) on cell surfaces is the event that triggers the coagulation cascade. Tissue factor (TF) and factor VIIa (FVIIa) form the EC together with FX on phosphatidylserine-containing membranes, leading to FX activation by TF:FVIIa. …”
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Approbation of the mechanism of economic reliability on the example of an industrial enterprise by A. R. Terentyeva

“…The article considers the operation of the cascade model of the mechanism of economic reliability based on the process-technological approach. …”
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In vitro Release of Eosinophil Proteins in Allergic and Atopic Dermatitis Patients by L. K. Poulsen, C. M. Reimert, C. Bindslev-Jensen

“…To investigate whether eosinophils are stimulated in vivo or have acquired an increased susceptibility to stimuli from the coagulation cascade, the release of eosinophil proteins was compared for three groups of donors with different levels of serum IgE. (1) with atopic dermatitis (s-IgE > 5000 IU/ml, n = 11); (2) with inhalant allergy (200 < s-IgE < 2 000 IU/ml, n = 10); and (3) non-allergic (s- IgE < 100 IU/ml, n = 10). …”
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Clinical profile of stress hyperglycemia in medical intensive care units by Geethanjali Ganesan, Sudha Vidyasagar, Nandakrishna Bolanthakodi, Cynthia Amrutha Sukumar

“…In the setting of medical intensive care units (ICU), it significantly contributes to patient morbidity and mortality.It initates a cascade of pathophysiological responses that in turn increase blood glucose and insulin resistance. …”
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Bisphenol A induces apoptosis and disrupts testosterone synthesis in TM3 cells via reactive oxygen species-mediated mitochondrial pathway and autophagic flux inhibition by Wenzhe Yang, Feilong Pan, Tong Zhao, Fangfang Chen, Wenqi Shao, Jinhao Wang, Shirui Wang, Zichen Zhao, Kexiang Liu, Shuchen Zhao, Lijia Zhao

“…The release of cytochrome C from damaged mitochondria into the cytoplasm activated a Caspase cascade reaction. In addition, excessive ROS levels impaired autophagic degradation by inhibiting the fusion of autophagosomes with lysosomes. …”
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REENCONTRO COM O NORDESTE: Itinerários de pesquisa e construção do campo intelectual dos estudos rurais. by Maria de Nazareth Baudel Wanderley

“…Outrora fizeram este mesmo esforço de síntese, entre eles, Jose Vicente Tavares dos Santos, Jose Cesar Gnaccarini e Margarida Maria Moura.1 Neste meu trabalho, assumo o risco de propor minha leitura pessoal. …”
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Mesenchymal stem cell‐derived exosomes mitigate amyloid β‐induced retinal toxicity: Insights from rat model and cellular studies by Amanda Qarawani, Efrat Naaman, Rony Ben‐Zvi Elimelech, Michal Harel, Shahaf Sigal‐Dror, Tali Ben‐Zur, Tamar Ziv, Daniel Offen, Shiri Zayit‐Soudry

“…The multifaceted nature of AMD pathophysiology, presumably involving diverse retinal cascades, corresponds with the complexity of Aβ‐induced retinopathy. …”
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Volumetric alterations in auditory and visual subcortical nuclei following perinatal deafness in felines by Alessandra Sacco, Stephen G. Gordon, Stephen G. Lomber

“…A mechanism that has been proposed to contribute to this plasticity involves adaptations within subcortical nuclei that trigger cascading effects throughout the brain. The current study uses 7T MRI to investigate the effect of perinatal deafness on the volumes of subcortical structures in felines, focusing on key sensory nuclei within the brainstem and thalamus. …”
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