The Discriminative Lexicon: A Unified Computational Model for the Lexicon and Lexical Processing in Comprehension and Production Grounded Not in (De)Composition but in Linear Discr... by R. Harald Baayen, Yu-Ying Chuang, Elnaz Shafaei-Bajestan, James P. Blevins

“…The discriminative lexicon also incorporates the insight from machine learning that end-to-end modeling is much more effective than working with a cascade of models targeting individual subtasks. The computational engine at the heart of the discriminative lexicon is linear discriminative learning: simple linear networks are used for mapping form onto meaning and meaning onto form, without requiring the hierarchies of post-Bloomfieldian ‘hidden’ constructs such as phonemes, morphemes, and stems. …”
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Targeting S100A9 attenuates social dysfunction by modulating neuroinflammation and myelination in a mouse model of autism by Hong Gong, Yao Lu, Shi-Long Deng, Ke-Yi Lv, Jing Luo, Yi Luo, Zhu-Lin Du, Ling-Feng Wu, Tian-Yao Liu, Xia-Qing Wang, Jing-Hui Zhao, Lian Wang, Mei-Ling Xia, Dong-Mei Zhu, Li-Wei Wang, Xiao-Tang Fan

“…Our findings indicate that microglia-derived S100A9 triggers the neuroinflammation cascade, myelination deficits, and social dysfunction. …”
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Interdependency classification: a framework for infrastructure resilience by Negin Shamsi, Alysha Helmrich

“…Recent and diverse disturbances worldwide have highlighted that interdependencies within CISs may increase the potential for cascading failures, amplifying the impacts of both large and small-scale disturbances into events of catastrophic proportions. …”
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Macrophages facilitate tumor cell PD‐L1 expression via an IL‐1β‐centered loop to attenuate immune checkpoint blockade by Cheng Xu, Yu Xia, Bai‐Wei Zhang, Emmanuel Kwateng Drokow, Hua‐Yi Li, Sen Xu, Zhen Wang, Si‐Yuan Wang, Ping Jin, Tian Fang, Xiao‐Ming Xiong, Pu Huang, Ning Jin, Jia‐Hong Tan, Qing Zhong, Yu‐Xin Chen, Qi Zhang, Yong Fang, Fei Ye, Qing‐Lei Gao

“…Mechanistically, we demonstrated that IL‐1β significantly boosted programmed death‐ligand 1 (PD‐L1) expression in tumor cells via the activation of the nuclear factor‐κb signaling cascade. Specifically, IL‐1β released from TAMs was triggered by lactate, the anaerobic metabolite of tumor cells, in an inflammasome activation‐dependent manner. …”
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Implicative Statistical Analysis to Identify Prognostic Factors for Mortality from Lymphomas in Children and Adolescents by Mayelyn Rodríguez Estenger, Nelsa María Sagaró del Campo, Larisa Zamora Matamoros, Evelyn Yolanda Fundichely Vázquez

“…<br /><strong>Method:</strong> a case-control study was carried out in children and adolescents diagnosed with Hodgkin and non-Hodgkin lymphoma treated at the Dr. Antonio María Béguez César Sur Pediatric Teaching Hospital in Santiago de Cuba from January 2008 to January 2021. …”
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Epac1 Restores Normal Insulin Signaling through a Reduction in Inflammatory Cytokines by Elizabeth Curtiss, Youde Jiang, Li Liu, Claire Hawthorne, Jessica Zhang, Jena J. Steinle

“…Whole retinal lysates from Epac1 floxed and endothelial cell-specific Epac1 knockout mice were used to investigate proteins involved in the insulin signaling cascade. Primary human REC were cultured in normal and high glucose followed by Epac1 agonist treatment or transfection with IL-1β or TNFα siRNA for protein analyses of insulin signaling proteins. …”
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Targeted allele-specific FGFR2 knockdown via human recombinant ferritin nanoparticles for personalized treatment of Crouzon syndrome by Federica Tiberio, Martina Salvati, Luca Polito, Giada Tisci, Alessia Vita, Ornella Parolini, Luca Massimi, Lorena Di Pietro, Pierpaolo Ceci, Gianpiero Tamburrini, Alessandro Arcovito, Elisabetta Falvo, Wanda Lattanzi

“…The selected therapeutic siRNA mitigated FGFR2 cascade downregulating phosphorylation of FGFR2 (48%) and of its key effector ERK1/2 (77%) as RUNX2 protein levels (34%). …”
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The Effect of Laminin-1-Doped Nanoroughened Implant Surfaces: Gene Expression and Morphological Evaluation by Humberto Osvaldo Schwartz-Filho, Kostas Bougas, Paulo G. Coelho, Ying Xue, Mariko Hayashi, Rafael Silveira Faeda, Rosemary Adriana Chiérici Marcantonio, Daisuke Ono, Fumio Kobayashi, Kamal Mustafa, Ann Wennerberg, Ryo Jimbo

“…The protein-doped surface showed higher gene expression of typical genes involved in the osseointegration cascade than the control surface.…”
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A Review on the Role of Human Solute Carriers Transporters in Cancer by Md. Shafiul Hossen, Mohammed Shafin Ul Islam, Mohammad Yasin, Mohammed Ibrahim, Abhijit Das

“…They are crucial for the stimulation of several biological signaling pathways, particularly mTOR kinase activity, which starts a signaling cascade, protein synthesis, cell growth, and proliferation, and inhibits apoptosis of cancerous cells. …”
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Definiendo la cronotipología de los contextos materiales tardorrepublicanos de carácter militar en Hispania by Ángel Morillo Cerdán, Carlos Pereira

“…., pero también los que son típicos en momento postsertoriano, que contempla el pretorado de César y la Guerra Civil entre el Dictador y los pompeyanos.…”
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Reinforcement learning algorithm for improving speed response of a five-phase permanent magnet synchronous motor based model predictive control. by Ahmed M Hassan, Jafar Ababneh, Hani Attar, Tamer Shamseldin, Ahmed Abdelbaset, Mohamed Eladly Metwally

“…This paper proposes a new reinforcement learning (RL) control algorithm based twin-delayed deep deterministic policy gradient (TD3) algorithm to tune two cascaded PI controllers in a five-phase interior permanent magnet synchronous motor (5ph-IPMSM) drive system based model predictive control (MPC). …”
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Targeting Invasion: The Role of MMP-2 and MMP-9 Inhibition in Colorectal Cancer Therapy by Alireza Shoari, Arghavan Ashja Ardalan, Alexandra M. Dimesa, Mathew A. Coban

“…This review provides a comprehensive overview of the pathophysiological roles of gelatinases in CRC, highlighting their contribution to tumor microenvironment modulation, angiogenesis, and the metastatic cascade. We also critically evaluate recent advancements in the development of gelatinase inhibitors, including small molecule inhibitors, natural compounds, and novel therapeutic approaches like gene silencing techniques. …”
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A data-driven group retrosynthesis planning model inspired by neurosymbolic programming by Xuefeng Zhang, Haowei Lin, Muhan Zhang, Yuan Zhou, Jianzhu Ma

“…Inspired by human learning, our algorithm, akin to neurosymbolic programming, builds upon commonly used multi-step concepts such as cascade and complementary reactions and can evolve from practical experiences, enhancing the prediction model for fundamental and compositional reaction templates. …”
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Evaluation of Plaque Stability of Advanced Atherosclerotic Lesions in Apo E-Deficient Mice after Treatment with the Oral Factor Xa Inhibitor Rivaroxaban by Qianxing Zhou, Florian Bea, Michael Preusch, Hongjie Wang, Berend Isermann, Khurrum Shahzad, Hugo A. Katus, Erwin Blessing

“…Activated factor X (FXa) is traditionally known as an important player in the coagulation cascade responsible for thrombin generation. We assessed the hypothesis that rivaroxaban, a direct FXa inhibitor, attenuates plaque progression and promotes stability of advanced atherosclerotic lesions in an in vivo model. …”
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Neonatal Screening for Congenital Hypothyroidism: A Study Conducted in a Tertiary Care Hospital of Gujarat by Shubhangi Rathod, Ramesh Pradhan, Rosy Lekharu, Jaydip Vala, Mehak Kulshrestha

“…Background: Growth and differentiation of the fetal brain largely depend on the thyroidal biochemical cascade. The most common cause of congenital hypothyroidism (CH) is thyroid dysgenesis. …”
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MnGA with multiple enzyme-like properties for acute wound healing by reducing oxidative stress and modulating signaling pathways by Xueting Guo, Wenqi Wang, Liting Lin, Jie Shan, Junyao Zhu, Shipeng Ning, Hanmei Li, Xianwen Wang, Decheng Lu

“…Specifically, MnGA scavenges superoxide anions and produces H2O2 via SOD-like activity and then consumes H2O2 to convert it to nontoxic H2O and O2 via CAT-like activity, resulting in a cascade of catalytic reactions to scavenge reactive oxygen species (ROS). …”
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Multiple Immunosuppressive Effects of CpG-c41 on Intracellular TLR-Mediated Inflammation by Wancheng Liu, Xuejiao Yang, Ning Wang, Shijun Fan, Yuanfeng Zhu, Xinchuan Zheng, Yan Li

“…These results suggest that CpG-c41 acts as an upstream of signaling cascades, perhaps on the processes of ligand internalization and transfer. …”
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Assessing the ecological consequences of crude oil spills on bird communities in an Afrotropical landscape by Iniunam Aniefiok Iniunam, Talatu Tende, Adams Adamanyiwa Chaskda

“…Our study highlights the cascading effects of oil spills on ecosystem services provided by birds, which are vital for human well-being. …”
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Supply risk propagation in international trade networks of the tungsten industry chain by Xinxin Zheng, Huajiao Li, Xiaojie Liu, Xingxing Wang, Yuqi Zhang, Qianyong Tang, Bo Ren

“…Therefore, this paper uses trade data from 2009 to 2020 to construct an international trade network for tungsten products and applies a cascading failure model to simulate the risk propagation process in the trade network of the industry chain. …”
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Two Cysteines in Raf Kinase Inhibitor Protein Make Differential Contributions to Structural Dynamics In Vitro by Hyun Sang Cho, Mohammad Faysal Al Mazid, Eun-Young Lee, Md Abu Rayhan, Hyoun Sook Kim, Byung Il Lee, Hye Jin You

“…As a scaffolding protein, Raf kinase binding protein (RKIP) is involved in a variety of cellular pathways, including the Raf–MEK–ERK-cascade. It acts as a negative regulator by binding to its partners, making it an attractive target in the development of therapeutic strategies for cancer. …”
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