Expression and Function of the Homeostatic Molecule Del-1 in Endothelial Cells and the Periodontal Tissue by Jieun Shin, Kavita B. Hosur, Kalyani Pyaram, Ravi Jotwani, Shuang Liang, Triantafyllos Chavakis, George Hajishengallis

“…Treatment of human endothelial cells with Del-1 did not affect the expression of endothelial molecules involved in the leukocyte adhesion cascade (ICAM-1, VCAM-1, and E-selectin). Moreover, genetic or age-associated Del-1 deficiency did not significantly alter the expression of these adhesion molecules in the murine periodontium, further ruling out altered adhesion molecule expression as a mechanism whereby Del-1 regulates leukocyte recruitment. …”
Get full text

Analysis of Single Reservoir Dispatching During a Sudden Accident of Water Pollution in a Long Distance River Channel by FANG Shenguang, HUANG Daizhong, LAN Xiaofeng

“…This paper establishes the hydrodynamic model and mathematical pollutant transport and diffusion model of long distance river channel and cascade reservoir and verifies the models by analytic solutions of pollutant transport and diffusion, and sets up eleven dispatching modes of single reservoir and conducts simulation according to the sudden water pollution accident occurred at different locations at the upper or lower reaches of a reservoir. …”
Get full text

A Hybrid Transformer Architecture for Multiclass Mental Illness Prediction Using Social Media Text by Adnan Karamat, Muhammad Imran, Muhammad Usman Yaseen, Rasool Bukhsh, Sheraz Aslam, Nouman Ashraf

“…In this study, we propose a hybrid transformer architecture, comprising MentalBERT and MelBERT pretrained language models, cascaded with CNN models to generate and concatenate deep features. …”
Get full text

Historical Blurry Video-Based Face Recognition by Lujun Zhai, Suxia Cui, Yonghui Wang, Song Wang, Jun Zhou, Greg Wilsbacher

“…To approach this problem, we first propose a trunk–branch concatenated multi-task cascaded convolutional neural network (TB-MTCNN), which efficiently extracts facial features from blurry historical films by combining the trunk with branch networks and employing various sizes of kernels to enrich the multi-scale receptive field. …”
Get full text

Transcriptomics analysis reveals potential mechanisms underlying mitochondrial dysfunction and T cell exhaustion in astronauts’ blood cells in space by Maria Moreno-Villanueva, Maria Moreno-Villanueva, Luis E. Jimenez-Chavez, Luis E. Jimenez-Chavez, Stephanie Krieger, Liang-Hao Ding, Ye Zhang, Adriana Babiak-Vazquez, Mark Berres, Sandra Splinter, Kristen E. Pauken, Brian C. Schaefer, Brian E. Crucian, Honglu Wu

“…The dysregulated genes and pathways were mostly involved in energy and oxygen metabolism, immune responses, cell adhesion/migration and cell death/survival.DiscussionBased on the DEG and the associated pathways and functions, we propose that mitochondria dysfunction was caused by constant modulation of mechano-sensing receptors in microgravity, which triggered a signaling cascade that led to calcium overloading in mitochondria. …”
Get full text

Mechanistic Insights into the Anticancer Potential of Methoxyflavones Analogs: A Review by Mohammad Aidiel, Maisarah Abdul Mutalib, Rajesh Ramasamy, Nik Nasihah Nik Ramli, Shirley Gee Hoon Tang, Siti Hajar Adam

“…The methoxy group in naturally occurring flavones promotes cytotoxic activity in various cancer cell lines by targeting protein markers, in facilitating ligand–protein binding mechanisms and activating cascading downstream signaling pathways leading to cell death. …”
Get full text

Fufang E’jiao Jiang’s effect on immunity, hematopoiesis, and angiogenesis via a systematic “compound-effect-target” analysis by Xiang Li, Xiao Xu, Ying Dong, Shusheng Fan, Xueyang Ren, Yuan Zheng, Jiamu Ma, Feng Zhang, Qingyue Deng, Xianxian Li, Yingyu He, Mengyu Sun, Wei Liu, Mengxia Li, Qing Xia, Yan Zhang, Gaimei She

“…Transcriptome data showed that several pathways such as complement and coagulation cascades, ECM-receptor interaction, and PI3K-Akt signaling pathway were associated with proangiogenic effect of FEJ. 19 common targets were obtained through combined analysis of network pharmacology and transcriptomics, and 5 targets of them were verified by PCR. …”
Get full text

La ayahuasca como tema y recurso narrativo en dos novelas peruanas: "Las tres mitades de Ino Moxo y otros brujos de la Amazonía y Puka Allpa. Viaje hacia la selva invisible" by Julio Penenrey Navarro

“…Las tres mitades de Ino Moxo y otros brujos de la Amazonía, de César Calvo (1981), y Puka Allpa. Viaje hacia la selva invisible (2015), de Pedro Favaron, contribuyen a la conformación de un corpus cada vez más emergente de obras de ficción en las que la ayahuasca ocupa un lugar protagónico como tema y como elemento de experimentación narrativa. …”
Get full text

Cross-Linking Mast Cell Specific Gangliosides Stimulates the Release of Newly Formed Lipid Mediators and Newly Synthesized Cytokines by Edismauro Garcia Freitas Filho, Elaine Zayas Marcelino da Silva, Camila Ziliotto Zanotto, Constance Oliver, Maria Célia Jamur

“…The effect of cross-linking these gangliosides on the activation of enzymes in the arachidonate cascade was then investigated. Ganglioside cross-linking resulted in phosphorylation of cytosolic phospholipase A2 and increased expression of cyclooxygenase-2. …”
Get full text

mTOR Inhibitor Everolimus Modulates Tumor Growth in Small-Cell Carcinoma of the Ovary, Hypercalcemic Type and Augments the Drug Sensitivity of Cancer Cells to Cisplatin by Kewei Zheng, Yi Gao, Jing Xu, Mingyi Kang, Ranran Chai, Guanqin Jin, Yu Kang

“…This indicates that everolimus enhances cisplatin efficacy by disrupting survival-promoting signaling cascades and inducing cell cycle arrest. Furthermore, it points to potential biomarkers for predicting therapeutic response.…”
Get full text

Thrombotic Complications in Inflammatory Bowel Disease by A. V. Borota, A. A. Borota, E. V. Onishchenko

“…In turn, the activation of the coagulation cascade may trigger the inflammatory response, which eventually leads to the formation of a vicious circle between chronic inflammation and thrombosis. …”
Get full text

Personal glucose meter-based portable method for creatine kinase assay by Jinhwan Lee, Yejin Oh, Hyoyong Kim, Sangmo Lee, Hyun Gyu Park

“…This method relies on the target-induced consumption of glucose by the cascade enzymatic reaction (CER) promoted by the combined activities of CK and hexokinase (HK). …”
Get full text

Autoimmune and Neoplastic Thyroid Diseases Associated with Hepatitis C Chronic Infection by Poupak Fallahi, Silvia Martina Ferrari, Ugo Politti, Dilia Giuggioli, Clodoveo Ferri, Alessandro Antonelli

“…These cytokines might induce a further CXCL10 secretion by thyrocytes, thus perpetuating the immune cascade, which may lead to the appearance of autoimmune thyroid disorders in genetically predisposed subjects. …”
Get full text

Construction of Multi-Scale Fusion Attention Unified Perceptual Parsing Networks for Semantic Segmentation of Mangrove Remote Sensing Images by Xin Wang, Yu Zhang, Wenquan Xu, Hanxi Wang, Jingye Cai, Qin Qin, Qin Wang, Jing Zeng

“…This network integrates Cascade Pyramid Fusion Modules, a Multi-scale Selective Kernel Attention Module, and an Auxiliary Edge Neck to process the unique characteristics of mangrove remote sensing images, particularly addressing issues of scale variation, complex backgrounds, and boundary accuracy. …”
Get full text

Nε-carboxyethyl-lysin influences atherosclerotic plaque stability through ZKSCAN3 acetylation-regulated macrophage autophagy via the RAGE/LKB1/AMPK1/SIRT1 pathway by Zhongwei Liu, Jing Liu, Xiqiang Wang, Yong Zhang, Yanpeng Ma, Gongchang Guan, Ya Yuwen, Ni He, Hanxiu Liu, Xingfeng Yu, Sen Ma, Junkui Wang, Jin Zhang, Ling Zhu, Yulian Zhang

“…Mechanistically, CEL disrupted macrophage autophagy and plaque stability by perturbing the Receptor for Advanced Glycation End products (RAGE)/Liver Kinase B1 (LKB1)/AMP-activated Protein Kinase 1 (AMPK1)/Sirtuin 1 (SIRT1) signaling cascade. This pathway further regulated autophagic activity through SIRT1-mediated acetylation of Zinc Finger with KRAB and SCAN Domains 3 (ZKSCAN3). …”
Get full text

Transient activation of YAP/TAZ confers resistance to morusin-induced apoptosis by Hoyeon Lee, Sang Woo Cho, Hyo Sun Cha, Kun Tae, Cheol Yong Choi

“…Abstract Background The Hippo signaling pathway involves a kinase cascade that controls phosphorylation of the effector proteins YAP and TAZ, leading to regulation of cell growth, tissue homeostasis, and apoptosis. …”
Get full text

Liquid biopsy approaches to capture tumor evolution and clinical outcomes during cancer immunotherapy by Susan Scott, Mark Sausen, Valsamo Anagnostou, Jennifer Jackson, Vincent Lam, Joseph C Murray, Lavanya Sivapalan, Jenna Vanliere Canzoniero, Blair Landon, Benjamin P. Levy

“…Tracking the landscape of genomic alterations detected in ctDNA may reveal the clonal architecture of the metastatic cascade and thus improve our understanding of the molecular wiring of therapeutic responses. …”
Get full text

B-CD8+ T Cell Interactions in the Anti-Idiotypic Response against a Self-Antibody by Darel Martínez, Amaury Pupo, Lianet Cabrera, Judith Raymond, Nichol E. Holodick, Ana María Hernández

“…This antibody is able to induce an anti-idiotypic IgG response and B-T idiotypic cascade, even in the absence of any adjuvant or carrier protein. …”
Get full text

The Effect of Diabetes-Associated Autoantigens on Cell Processes in Human PBMCs and Their Relevance to Autoimmune Diabetes Development by Jana Vcelakova, Radek Blatny, Zbynek Halbhuber, Michal Kolar, Ales Neuwirth, Lenka Petruzelkova, Tereza Ulmannova, Stanislava Kolouskova, Zdenek Sumnik, Pavlina Pithova, Maria Krivjanska, Dominik Filipp, Katerina Stechova

“…Type 1 Diabetes (T1D) is considered to be a T-helper- (Th-) 1 autoimmune disease; however, T1D pathogenesis likely involves many factors, and sufficient tools for autoreactive T cell detection for the study of this disease are currently lacking. …”
Get full text

Simulation investigation of a Ka-band phase-locked klystron-type coaxial relativistic Cherenkov generator by Yunxiao Zhou, Jinchuan Ju, Wei Zhang, Dian Zhang, Ying Li, Tengfang Wang, Fugui Zhou, Zhuang Yu, Hongtao Yao, Jun Zhang

“…Specially designed reflectors and cascaded single-gap bunching cavities with active suppression of asymmetric TM mode are employed in the pre-modulation region to suppress energy coupling and achieve a lower input power ratio. …”
Get full text