Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans. by Tammie Bishop, Kah Weng Lau, Andrew C R Epstein, Stuart K Kim, Min Jiang, Delia O'Rourke, Christopher W Pugh, Jonathan M Gleadle, Martin S Taylor, Jonathan Hodgkin, Peter J Ratcliffe

“…Although studies of VHL-defective renal carcinoma cells suggest the existence of other VHL tumor suppressor pathways, dysregulation of the HIF transcriptional cascade has extensive effects that make it difficult to distinguish whether, and to what extent, observed abnormalities in these cells represent effects on pathways that are distinct from HIF. …”
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Pharmacological Inhibition of p38 Mitogen-Activated Protein Kinases Affects KC/CXCL1-Induced Intraluminal Crawling, Transendothelial Migration, and Chemotaxis of Neutrophils In Viv... by Najia Xu, Mokarram Hossain, Lixin Liu

“…Leukocyte recruitment to the site of inflammation is a multistep process governed by specific signalling cascades. After adhesion in the lumen, many leukocytes crawl to optimal sites at endothelial junctions and transmigrate to extravascular tissue in a Mac-1-dependent manner. …”
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Sophocarpine Attenuates LPS-Induced Liver Injury and Improves Survival of Mice through Suppressing Oxidative Stress, Inflammation, and Apoptosis by Zhengyu Jiang, Yan Meng, Lulong Bo, Changli Wang, Jinjun Bian, Xiaoming Deng

“…Mechanistic evidence was also investigated in the present study as sophocarpine inhibited hepatic expression of the CYP2E/Nrf2 pathway during oxidative stress, inactivated p38/JNK cascade and NF-κB pathway, and, meanwhile, suppressed PI3K/AKT signaling that reduced apoptosis. …”
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Post-Translational Modifications of Proteins Orchestrate All Hallmarks of Cancer by Pathea Shawnae Bruno, Aneeta Arshad, Maria-Raluca Gogu, Natalie Waterman, Rylie Flack, Kimberly Dunn, Costel C. Darie, Anca-Narcisa Neagu

“…Aberrant PTMs can be considered as enabling characteristics of cancer as long as they orchestrate all malignant modifications and variability in the proteome of cancer cells, cancer-associated cells, and tumor microenvironment (TME). …”
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The Causative Pathogen Determines the Inflammatory Profile in Cerebrospinal Fluid and Outcome in Patients with Bacterial Meningitis by Denis Grandgirard, Rahel Gäumann, Boubacar Coulibaly, Jean-Pierre Dangy, Ali Sie, Thomas Junghanss, Hans Schudel, Gerd Pluschke, Stephen L. Leib

“…The brain’s inflammatory response to the infecting pathogen determines the outcome of bacterial meningitis (BM), for example, the associated mortality and the extent of brain injury. The inflammatory cascade is initiated by the presence of bacteria in the cerebrospinal fluid (CSF) activating resident immune cells and leading to the influx of blood derived leukocytes. …”
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Transition Effect on the Flow Dynamics in a Compressor Blade Passage by Ryszard Szwaba, Piotr Kaczynski, Janusz Telega

“…An experimental investigation was carried out to study the effect of the boundary layer transition on the flow dynamics in the blade passage of a compressor cascade. A model of a turbine compressor passage was designed and assembled in a transonic wind tunnel for this purpose. …”
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Ekspresi Protein Sitoplasmik SOCs2 pada Adenokarsinoma Kolorektal: Studi Imunohistokimia by Nita Afriani Azmal, Shinta Ayu Intan, Tofrizal Tofrizal

“…SOCs2 protein is a cytoplasmic protein that can inhibit activation of JAK-STAT pathway so that it prevents cascade of signals into the nucleus. This protein is thought to have decreased in adenocarcinoma colorectal. …”
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Audio2DiffuGesture: Generating a diverse co-speech gesture based on a diffusion model by Hongze Yao, Yingting Xu, Weitao WU, Huabin He, Wen Ren, Zhiming Cai

“…Specifically, we employed cascaded 1D convolutions to extract features from the audio waveform and a two-stage attention mechanism to capture features from the Mel-spectrogram. …”
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Tumorigenic and Differentiation Potentials of Embryonic Stem Cells Depend on TGFβ Family Signaling: Lessons from Teratocarcinoma Cells Stimulated to Differentiate with Retinoic Aci... by Olga Gordeeva, Sergey Khaydukov

“…Stimulation of the Activin/Nodal and BMP signaling cascades and inhibition of the MEK/ERK and PI3K/Act signaling pathways resulted in a significant decrease in the number of Oct4-expressing ES cells and a loss of tumorigenicity, similar to retinoic acid-stimulated EC cells. …”
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The EGF Receptor and HER2 Participate in TNF-α-Dependent MAPK Activation and IL-8 Secretion in Intestinal Epithelial Cells by Humberto B. Jijon, Andre Buret, Christina L. Hirota, Morley D. Hollenberg, Paul L. Beck

“…TNF-α activates multiple mitogen-activated protein kinase (MAPK) cascades in intestinal epithelial cells (IECs) leading to the secretion of interleukin 8 (IL-8), a neutrophil chemoattractant and an angiogenic factor with tumor promoting properties. …”
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Responsabilidades civiles, éticas y legales del profesional de enfermería en Caaguazú, Paraguay by Gloria Sebastiana González Vázquez, Guiomar Viveros de Cabello, Julieta Mendez Romero, Cristian Villagra Gonzalez, Deysi Galeano

“…De los 130 profesionales de Enfermería encuestados el 77,69% eran del sexo femenino, con promedio de edad entre 30 a 36 años y el 63,85% eran casados, el 49,23% (64) tienen nivel de conocimiento deficiente sobre las responsabilidades penales y el 77.69% (101) poseen el nivel de conocimiento excelente en cuanto a responsabilidad civil, el 44.62% (58) de los profesionales tiene nivel de conocimiento regular sobre responsabilidad ética. …”
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The Global RAdical Cystectomy Evaluation and Management (GRACEM) pathway: single‐centre prospective observational cohort study protocol by Bruno Bernardini, Federico Piccioni, Manuele Pastore, Paolo Casale, NicolòMaria Buffi, Giovanni Lughezzani, Massimo Lazzeri, Alberto Saita, Maria Vittoria Fantacci, Stefano Mancon, Filipo Dagnino, Roberto Contieri, Pietro Brin, Stefano Mancin, Andrea Gobbo, Maria Rosaria Martucci, Giovanna Cerina, Sara Ghirmai, Ezio Lanza, Giulia Goretti, Giorgio Ferruccio Guazzoni, Rodolfoi Hurle

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Is lean mass quantity or quality the determinant of maximal fat oxidation capacity? The potential mediating role of cardiorespiratory fitness by Edgardo Opazo-Díaz, Juan Corral-Pérez, Alejandro Pérez-Bey, Alberto Marín-Galindo, Adrián Montes-de-Oca-García, María Rebollo-Ramos, Daniel Velázquez-Díaz, Cristina Casals, Jesús-Gustavo Ponce-González

“…The aim is to analyze the associations of lean-mass, muscle strength and quality with fat oxidation parameters in young adults, considering the mediating role of VO2max.Methods A cross-sectional observational study. …”
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Pathological and Molecular Characterization of Grass Carp Co-Infected with Two <i>Aeromonas</i> Species by Wenyao Lv, Zhijie Zhou, Lingli Xie, Xinyue Wang, Yifei Zhou, Lang Gui, Xiaoyan Xu, Yubang Shen, Jiale Li, Junqiang Qiu

“…Gene ontology and KEGG pathway analyses revealed significant enrichment of immune-related genes primarily associated with Toll-like receptor signaling and TNF signaling cascades. Notably, metabolic pathways showed substantial suppression while immune responses were significantly activated after infected. …”
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<i>shp-2</i> gene knockout upregulates CAR-driven cytotoxicity of YT NK cells by V. G. Subrakova, S. V. Kulemzin, T. N. Belovezhets, A. N. Chikaev, N. A. Chikaev, O. A. Koval, A. A. Gorchakov, A. V. Taranin

“…We hypothesized that stronger cytotoxicity of NK cells could be achieved via gene editing aimed at enhancing the activating signaling cascades and/or weakening the inhibitory ones, thereby shifting the balance of signals towards NK cell activation and target cell lysis. …”
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Blocking TNF-α Reduces <i>Leishmania major</i>-Induced Hyperalgesia and Changes the Cytokine Profile in the Paw Skin of BALB/c Mice with a Potential Positive Effect on Parasite Cle... by Muriel Tahtouh Zaatar, Sara Salman, Reem Hoblos, Rabih Roufayel, Ziad Fajloun, Jean-Marc Sabatier, Marc Karam

“…These and other cytokines also play a major role in <i>Leishmania</i>-induced hyperalgesia via two possible pathways, one involving prostaglandins and the other sympathetic amines as final mediators, preceded by a cascade of cytokines, among which TNF-α seems to play a pivotal role via a still unclear mechanism of action. …”
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Nasal hyperreactivity and inflammation in allergic rhinitis by I. M. Garrelds, C. de Graaf-in't Veld, R. Gerth van Wijk, F. J. Zijlstra

“…The histopathological features of allergic inflammation involve an increase in blood flow and vascular permeability, leading to plasma exudation and the formation of oedema. In addition, a cascade of events occurs which involves a variety of inflammatory cells. …”
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Second-generation anti-amyloid monoclonal antibodies for Alzheimer’s disease: current landscape and future perspectives by Byeong-Hyeon Kim, Sujin Kim, Yunkwon Nam, Yong Ho Park, Seong Min Shin, Minho Moon

“…Notably, lecanemab received traditional approval after demonstrating clinical benefit, supporting the Aβ cascade hypothesis. These MABs targeting Aβ are categorized based on their affinity to diverse conformational features of Aβ, including monomer, fibril, protofibril, and plaque forms of Aβ as well as pyroglutamate Aβ. …”
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Daytime F Region Echoes at Equatorial Ionization Anomaly Crest During Geomagnetic Quiet Period: Observations From Multi‐Instruments by Yi Liu, Zhongxin Deng, Tong Xu, Jian Kong, Chen Zhou, Yibin Yao, Qiong Tang, Zhengyu Zhao

“…Then the large‐scale ionospheric disturbance could further evolve into small‐scale irregularity producing radar echoes through the non‐linear cascade process.…”
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A Rare Case of Post-Partum Hemorrhage with Refractory Thrombotic Microangiopathy, and Hepatic Infarction: A Diagnostic Dilemma with High Mortality by Naved Yousuf Hasan, Asiah Salem Rugaan, Noha Ahmed Mohamed Ali, Masood Iqbal

“…Liver transplantation is the only possible radical therapy in cases with fulminant hepatic failure, worth considering, if clinically possible and applicable. …”
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