Saturated lysing efficiency of CD8+ cells induced monostable, bistable and oscillatory HIV kinetics by Shilian Xu

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Calcineurin, Synaptic Plasticity, and Memory by Carl Weitlauf, Danny Winder

“…A current experimental strategy is to generate genetically altered mice with mutations in genes thought to be involved in LTP and assess the effects of these mutations both on LTP and animal behavior[1,2]. …”
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Age- and sex-related differences in social competence and emotion labeling in pre-adolescence by Elizabeth E.L. Buimer, Pascal Pas, Carlijn van den Boomen, Mathijs Raemaekers, Rachel M. Brouwer, Hilleke E. Hulshoff Pol

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Acute Lymphocytic Leukemia with Skin Infiltration. Case Report and Literature Review by Adrian Isacc Nieto Jiménez

“…Cutaneous leukemia is a very rare pathology and can occur in different types of leukemia associated or not with genetic syndromes. It is a very uncommon form of initial presentation of malignancy. …”
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Progress in immune microenvironment, immunotherapy and prognostic biomarkers in pediatric osteosarcoma by Lin Zhang, Haoming Jiang, Haichao Ma

“…The tumor microenvironment plays a crucial role in osteosarcoma progression, with immune cells such as tumor-associated macrophages and T lymphocytes significantly influencing tumor behavior. …”
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Correlation of sarcopenia and depressive mood in older community dwellers: a cross-sectional observational study in China by Lei Chen, Yunlu Sheng, Hanmei Qi, Tingting Tang, Jing Yu, Shan Lv

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Multiple Roles of the Y Chromosome in the Biology of Drosophila melanogaster by Roberto Piergentili

“…The X and Y chromosomes of Drosophila melanogaster were the first examples of chromosomes associated with genetic information. Thanks to the serendipitous discovery of a male with white eyes in 1910, T.H. …”
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Detection of Elder Abuse Through Emergency Care Technicians Screening Tool Revision for Home-Based Primary Care (DETECT-RPC): a cluster randomised controlled trial study protocol by Melvin D Livingston, Brad Cannell, Jason Burnett, Nicholas Sevey, Kristin Lees Haggerty, Carolyn Pickering

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Refining management strategies for Lennox–Gastaut syndrome: Updated algorithms and practical approaches by Stéphane Auvin, Alexis Arzimanoglou, Mercè Falip, Pasquale Striano, J. Helen Cross

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Novel nonsense mutation in gene CHRNA2 identified by whole-genome sequencing in infant with epilepsy disorder: A case report by Sultan Makhmetov, Kamila Temirkhanova, Saule Rakhimova, Nazerke Satvaldina, Ruslan Kalendar, Ulan Kozhamkulov, Aidos Bolatov, Mirgul Bayanova, Assiya Bazenova, Lyazzat Nazarova, Ainur Akilzhanova, Ulykbek Kairov

“…In this report, we expanded the spectrum of existing variations in the CHRNA2 gene contributing and associated with the development of epilepsy with the important and novel causative genetic variant.…”
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Post-Translational Modifications of Proteins Orchestrate All Hallmarks of Cancer by Pathea Shawnae Bruno, Aneeta Arshad, Maria-Raluca Gogu, Natalie Waterman, Rylie Flack, Kimberly Dunn, Costel C. Darie, Anca-Narcisa Neagu

“…Post-translational modifications (PTMs) of proteins dynamically build the buffering and adapting interface between oncogenic mutations and environmental stressors, on the one hand, and cancer cell structure, functioning, and behavior. Aberrant PTMs can be considered as enabling characteristics of cancer as long as they orchestrate all malignant modifications and variability in the proteome of cancer cells, cancer-associated cells, and tumor microenvironment (TME). …”
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Endothelial and neuronal engagement by AAV-BR1 gene therapy alleviates neurological symptoms and lipid deposition in a mouse model of Niemann-Pick type C2 by Charlotte Laurfelt Munch Rasmussen, Signe Frost Frederiksen, Christian Würtz Heegaard, Maj Schneider Thomsen, Eva Hede, Bartosz Laczek, Jakob Körbelin, Daniel Wüstner, Louiza Bohn Thomsen, Markus Schwaninger, Ole N. Jensen, Torben Moos, Annette Burkhart

“…Composite phenotype scores and behavioral tests were assessed for the following 6 weeks and visually documented. …”
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Genomic Introgression Between Critically Endangered and Stable Species of Darwin's Tree Finches on the Galapagos Islands by Rachael Y. Dudaniec, Sonu Yadav, Julian Catchen, Sonia Kleindorfer

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Volt/VAr Regulation of the West Mediterranean Regional Electrical Grids Using SVC/STATCOM Devices With Neural Network Algorithms by H. Feza Carlak, Ergin Kayar

“…Many researchers have focused on the behavior of voltage in the unbalanced state, and the majority of the studies have been done with STATCOM. …”
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A randomized, placebo-controlled, cross-over trial of ketamine in Rett syndrome by Kathleen Campbell, Jeffrey L. Neul, David N. Lieberman, Elizabeth Berry-Kravis, Tim A. Benke, Cary Fu, Alan Percy, Bernhard Suter, David Morris, Randall L. Carpenter, Eric D. Marsh, Jana von Hehn

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Hepatitis B prevalence in an endemic area of hepatitis C virus: A population-based study implicated in hepatitis elimination in Thailand by Nawarat Posuwan, Rujipat Wasitthankasem, Napaporn Pimsing, Wijittra Phaengkha, Saranya Ngamnimit, Preeyaporn Vichaiwattana, Sirapa Klinfueng, Maneerat Raksayod, Yong Poovorawan

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Gene mutation, clinical characteristics and pathology in resectable lung adenocarcinoma by Ji’an Zou, Wei Han, Yan Hu, Chao Zeng, Jina Li, Weixuan Lei, Jieming Cao, Quanming Fei, Mengqi Shao, Junqi Yi, Zeyu Cheng, Li Wang, Fang Wu, Wenliang Liu

“…Pathological examination and genetic testing have become a routine procedure for lung adenocarcinoma following radical resection. …”
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Expression of Wnt signaling proteins LEF1, β-catenin, GSK3β, DVL1, and N-myc varies across retinoblastoma subtypes and pRb phosphorylation status by Leon Marković, Anja Bukovac, Ana Maria Varošanec, Antonia Jakovčević, Davor Tomas, Zdenko Sonicki, Borna Puljko, Fran Dumančić, Reno Hrašćan, Nives Pećina-Šlaus

“…While TNM classification helps in prognosis, understanding molecular mechanisms is vital for the clinical behavior of retinoblastoma prediction. Our study aimed to analyze the expression levels of key Wnt pathway proteins, GSK3β, LEF1, β-catenin, and DVL1, and associate them to non-phosphorylated active form (pRb) and the phosphorylated inactive form (ppRb) and N-myc expression, in retinoblastoma cells and healthy retinal cells, in order to elucidate their roles in retinoblastoma and identify potential targets that could help to improve diagnostic and therapy. …”
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CD2AP deficiency aggravates Alzheimer’s disease phenotypes and pathology through p38 MAPK activation by Yan-Yan Xue, Zhe-Sheng Zhang, Rong-Rong Lin, Hui-Fen Huang, Ke-Qing Zhu, Dian-Fu Chen, Zhi-Ying Wu, Qing-Qing Tao

“…Abstract Background Alzheimer’s disease (AD) is the most common form of neurodegenerative disorder, which is characterized by a decline in cognitive abilities. Genome-wide association and clinicopathological studies have demonstrated that the CD2-associated protein (CD2AP) gene is one of the most important genetic risk factors for AD. …”
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Molecular architecture of the altered cortical complexity in autism by Makliya Mamat, Yiyong Chen, Wenwen Shen, Lin Li

“…Cell-specific analyses, protein–protein interaction network analysis and gene temporal expression profiling further elucidated the dynamic molecular landscape associated with these alterations. These findings indicate that ASD-related alterations in cortical complexity are closely linked to specific genetic pathways. …”
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