BRD4 silencing attenuates hemin-induced neuronal ferroptosis and inflammation via the H3K27ac–ATF3 axis in an in vitro model of cerebral hemorrhage by Jing Yi, Hua Tang, Siwei Que, Tao Zheng, Hu Zeng, Xiaoming Xie, Hua Chen

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MYC Binding Near Transcriptional End Sites Regulates Basal Gene Expression, Read‐Through Transcription, and Intragenic Contacts by Huabo Wang, Bingwei Ma, Taylor Stevens, Jessica Knapp, Jie Lu, Edward V. Prochownik

Subjects: “…BRD4…”
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Bromodomain-containing protein 4 contributes to chronic postsurgical pain via activating TLR4/NF-kappaB-dependent neuroinflammation by Ruichen Shu, Yuan Li, Zengli Zhang, Xuan Zhang, Shan Guan, Kaiyuan Wang, Yiqing Yin

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The novel BET‐CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild‐type prostate cancer by Yuqian Yan, Jian Ma, Dejie Wang, Dong Lin, Xiaodong Pang, Shangqian Wang, Yu Zhao, Lei Shi, Hui Xue, Yunqian Pan, Jun Zhang, Claes Wahlestedt, Francis J Giles, Yu Chen, Martin E Gleave, Collin C Collins, Dingwei Ye, Yuzhuo Wang, Haojie Huang

Subjects: “…BRD4…”
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(+)-JQ-1 alleviates cardiac injury in myocardial infarction by inhibiting ferroptosis through the NAMPT/SIRT1 pathway by Mengxue Yang, Ting Wang, Jingrong Shao, Xinna Ran, Rui Xiao, Rui Zhao, Chunyan Wu, Ming Ji, Weiping Tian, Huabing Sun, Jiao Liu, Shengkai Zuo

“…Bromodomain-containing protein 4 (BRD4) is an epigenetic reader and a key regulator of cell survival. …”
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SPATIO-TEMPORAL ORGANIZATION OF THE SUPER-ENHANCER STRUCTURE IN CANCER CELLS

“…Mass spectrometry revealed the RNA-dependent PIP2-associated (RDPA) nuclear proteome, enriched for intrinsically disordered regions and polybasic motifs, supporting LLPS. Among RDPA proteins, BRD4 undergoes PIP2- and RNA-dependent condensation. …”
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A methyl-to-acetyl switch in H3K27 drives metabolic reprogramming and resistance to BRAFV600E inhibition in melanoma by Jiang Zhou, Xinxin Chai, Yi Zhu, Zhi Huang, Tingting Lin, Zhen Hu, Guangdi Chen, Chi Luo, Rutao Cui, Jinghao Sheng

“…This H3K27 methyl-to-acetyl conversion shifts chromatin from a repressive to an active state, thereby promoting gene transcription through the acetylation reader BRD4. Specifically, the KDM6A-H3K27ac-BRD4 axis upregulates PGC1α, a master regulator of mitochondrial metabolism, enabling melanoma cells to sustain oxidative metabolism and survive BRAFV600E-targeted therapies. …”
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Advances in KEAP1-based PROTACs as emerging therapeutic modalities: Structural basis and progress by Jing Chen, Disheng Feng, Rui Zhu, Hua Li, Lixia Chen

“…Recent progress in developing KEAP1-based PROTACs targeting BRD4, CDK9, FAK, Tau and KEAP1 itself is highlighted, with particular emphasis on ligand optimization strategies employed to enhance degradation efficacy and specificity. …”
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