The values of Hellenic culture as the foundation of Nietzsche's philosophy by Stanković-Pejnović Vesna, Veseli Damir

“…Both responses are the function of such artistic, philosophical visions affected as they were in the age of Greek tragedy. …”
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EHMT2‐mediated R‐loop formation promotes the malignant progression of prostate cancer via activating Aurora B by Yuyang Zhang, Mingqin Su, Yiming Chen, Li Cui, Wei Xia, Renfang Xu, Dong Xue, Xiansheng Zhang, Xingliang Feng

“…Silencing EHMT2 impaired cell division, inducing G2/M‐phase arrest and mitotic catastrophe in PCa cells. Mechanistically, EHMT2 is indispensable to ensure the full activation of Aurora B through centromeric R‐loop‐driven ATR–CHK1 pathway, with EHMT2 protein expression peaking during the G2/M‐phase. …”
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Pengembangan Knowledge Management System Ukiran Kayu Khas Bali Berbasis Artificial Intelligence by I Putu Restu Indrawan Prabawa, Ariq Cahya Wardhana

“…Kata kunci: Artificial Intelligence, Knowledge Management System, Website, Ukiran Bali   Abstract Balinese wood carving art is the work of original Balinese wood carving artists who have extraordinary talent in decades. …”
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Cerebral blood flow change with fluid resuscitation in acute ischemic stroke by Joseph Miller, John Aidan Moloney, Noah Elagamy, Jacob Tuttle, Sam Tirgari, Sean Calo, Richard Thompson, Bashar Nahab, Christopher Lewandowski, Phillip Levy

“…We performed transcranial Doppler (TCD) insonation of the middle cerebral arteries (MCAs) to measure CBF velocity. Each patient received a 500-ml normal saline crystalloid bolus as a standardized intervention, then had hemodynamic and TCD measurements repeated. …”
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The Quality of Life in Heart Failure Reduced Ejection Fraction (HFrEF) Patients: A Phenomenon of Obesity Paradox by Yogi Puji Rachmawan, Witri Pratiwi, Helda Helda

“…Results: A total of 40.3% sample were obese, 9.7% were underweight and 67.5% had central obesity. Coronary artery disease (89.6%), smoking (67.5%) and hypertension (49.4%) were the most common comorbidities and risk factors found. …”
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The effect of pro-inflammatory cytokines on the development of atherosclerosis in systemic lupus erythematosus patients: ultrasonographic assessment of intimal medial thickness and... by Mohamed Nasser, Mary Wadie, Alyaa Farid, Azza El Amir

“…The intimal medial thickness (IMT) of the internal carotid artery (ICA) is a sonographic measurement that assesses the extent of atherosclerosis. …”
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A conserved element in the first intron of Cd4 has a lineage specific, TCR signal-responsive, canonical enhancer function that matches the timing of cell surface CD4 upregulation r... by Gregory A. Swan, Gregory A. Swan, Chika Fujii, Mia E. Guzynski, Sheridan M. Page, Isabelle V. Meyers, Yordan P. Penev, Sejiro Littleton, Sejiro Littleton, Adinda Azzahra, Christine Richardson, Sophia D. Sarafova, Sophia D. Sarafova

“…In this study, we investigate whether a conserved region, here called NCE, that is proximal to the Cd4 silencer and contains E4m has the required developmental-stage-specific canonical enhancer function and TCR responsiveness to mediate the CD4 upregulation required to prevent lineage errors.MethodsTo investigate the role of NCE, transient transfection of reporter plasmids was performed in thymoma cell lines arrested at the double-positive (DP, CD4+CD8+) and intermediate (INT, CD4+CD8lo) stages of development. …”
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Ruthenium(II) Complex with 1-Hydroxy-9,10-Anthraquinone Inhibits Cell Cycle Progression at G0/G1 and Induces Apoptosis in Melanoma Cells by Júlia S. M. Dias, Guilherme A. Ferreira-Silva, Rommel B. Viana, João H. de Araujo Neto, Javier Ellena, Rodrigo S. Corrêa, Marília I. F. Barbosa, Marisa Ionta, Antônio C. Doriguetto

“…Subsequent studies showed that (<b>1</b>) inhibits the proliferation of CHL-1 cells and induces apoptosis, associated at least in part with the pro-oxidant effect and cell cycle arrest at the G1/S transition.…”
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Mas Receptor Blockade Promotes Renal Vascular Response to Ang II after Partial Kidney Ischemia/Reperfusion in a Two-Kidney-One-Clip Hypertensive Rats Model by Farzaneh Karimi, Mehdi Nematbakhsh

“…Four weeks after 2K1C implementation, the intravenous infusion of graded Ang II resulted in dose-related increases in mean arterial pressure (MAP) (Pdose < 0.0001) that was not different significantly between the groups. …”
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Impact of Postshock Transcutaneous Pacing on Chest Compression Quality during Resuscitation: A Simulation-Based Pilot Study by Wojciech Telec, Tomasz Kłosiewicz, Radosław Zalewski, Julia Żukowska-Karolak, Artur Baszko, Mateusz Puślecki

“…Participants were asked to take part in a 10-minute adult cardiac arrest scenario with ventricular fibrillation. In the first simulation, paramedics had to resume compressions after each shock (control group). …”
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Celastrol promotes DNA damage and apoptosis in uterine corpus endometrial carcinoma via promotion of KAT2B-mediated RBPJ acetylation and repression of MCM4 transcription by Lipeng Pei, Yan Zhu, Wenpeng Li, Bin Xu, Jingli Sun

“…Results Treatment of Celastrol inhibited cell viability in a dose-dependent manner, and caused cell cycle arrest, accompanied by the downregulation of CDK2 and cyclin E expression and the upregulation of p21. …”
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Perinatal consequences of a category 1 caesarean section at term by Sailesh Kumar, Leah Grace, Ristan M Greer

“…Significantly higher (p&lt;0.001) perinatal complications were seen in the category 1 CS cohort—Apgar scores &lt;7 at 1 min (20.4%, 241/1179 vs 10.7%, 377/3527) and 5 min (5.8%, 68/1179 vs 1.9%, 67/3527), umbilical arterial pH&lt;7.2 (23.7%, 279/1179 vs 9.1%, 321/3527), neonatal resuscitation (59.9%, 706/1179 vs 51.8%, 1828/3527), neonatal intensive care unit admission (9.8%, 116/1179 vs 2.5%, 87/3527) and seizures (0.8%, 10/1179 vs 0.3%, 9/3527), respectively.Conclusions These results demonstrate significantly poorer outcomes associated with term category 1 CS compared with non-category 1 emergency CS.…”
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Comparative evaluation of non-contrast MRI versus gadoxetic acid-enhanced abbreviated protocols in detecting colorectal liver metastases by Haoran Dai, Cheng Yan, Xi Jia, Yuyao Xiao, Xinyue Liang, Chun Yang, Kai Liu, Mengsu Zeng

“…Protocol 3 utilized the standard Gadoxetic Acid-enhanced MRI sequence, which included pre-contrast T1-weighted imaging, T1-weighted Dixon sequences, post-contrast T1-weighted imaging (including arterial, portal venous, transitional and hepatobiliary phases), and additional T2-weighted and DWI sequences. …”
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A systematic analysis of the contribution of genetics to multimorbidity and comparisons with primary care dataResearch in context by Olivia Murrin, Ninon Mounier, Bethany Voller, Linus Tata, Carlos Gallego-Moll, Albert Roso-Llorach, Lucía A. Carrasco-Ribelles, Chris Fox, Louise M. Allan, Ruby M. Woodward, Xiaoran Liang, Jose M. Valderas, Sara M. Khalid, Frank Dudbridge, Sally E. Lamb, Mary Mancini, Leon Farmer, Kate Boddy, Jack Bowden, David Melzer, Timothy M. Frayling, Jane A.H. Masoli, Luke C. Pilling, Concepción Violán, João Delgado

“…., iron deficiency anaemia and peripheral arterial disease: genetic correlation Rg = 0.45 [95% Confidence Intervals 0.27:0.64]). 33 pairs displayed negative genetic correlations, such as skin cancer and rheumatoid arthritis (Rg = −0.14 [−0.21:−0.06]), due to potential adverse drug effects. …”
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The effect of the fenugreek hydrolyzed protein on lipid profile in patients with mild-to-moderate hypercholesterolemia: A confirmatory triple-blind randomized-controlled clinical t... by Mahdi Badiee Gavarti, Ali Askari, Hamidreza Roohafza, Mozhde Askari, Zahra Teimouri Jervekani, Shima Kaveh, Mohammad Kermanialghoraishi, Alireza Sadeghimahoonak, Masoumeh Sadeghi

“…Background: The risk of coronary artery disease in people with high serum cholesterol is more than twice as high as in those with moderate serum cholesterol. …”
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Emergency Endovascular Interventions on Descending Thoracic Aorta: A Single-Center Experience by Piotr Buczkowski, Mateusz Puslecki, Marcin Ligowski, Marek Dabrowski, Sebastian Stefaniak, Zuzanna Fryska, Jerzy Kulesza, Robert Juszkat, Marek Jemielity, Bartlomiej Perek

“…All procedures were done through surgically exposed femoral arteries while 2 hybrid procedures required additional approaches. …”
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Prediction of mortality and prioritisation to tertiary care using the 'OUR-ARCad' risk score gleaned from the second wave of COVID-19 pandemic-A retrospective cohort study from Sou... by Narendran Gopalan, Vinod Kumar Viswanathan, Vignes Anand Srinivasalu, Saranya Arumugam, Adhin Bhaskar, Tamizhselvan Manoharan, Santosh Kishor Chandrasekar, Divya Bujagaruban, Ramya Arumugham, Gopi Jagadeeswaran, Saravanan Madurai Pandian, Arunalatha Ponniah, Thirumaran Senguttuvan, Ponnuraja Chinnaiyan, Baskaran Dhanraj, Vineet Kumar Chadha, Balaji Purushotham, Manoj Vasanth Murhekar

“…The 'OUR-ARCad' risk score components were-Oxygen saturation SaO2<94%-23, Urea > 40mg/dL-15, Neutrophil/Lymphocytic ratio >3-23, Age > 50 years-8, Pulse Rate >100-8 and Coronary Artery disease-15. A summated score above 50, mandated tertiary care management (sensitivity-90%, specificity-75%; AUC-0.89), validated in 2000 bootstrap dataset.…”
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HMGB1 lactylation drives neutrophil extracellular trap formation in lactate-induced acute kidney injury by Li Zhu, Li Zhu, Qiang Zheng, Xiaodong Liu, Xiaodong Liu, Hao Ding, Mengqing Ma, Jiaxin Bao, Yawen Cai, Changchun Cao

“…Elevated lactate levels are implicated in sepsis-induced AKI; however, it remains unclear whether increased lactate directly induces AKI or elucidates the underlying mechanisms.MethodsFor human, the measurement of lactate in arterial blood gas is performed using the direct determination of L-lactate through an electrode oxidation method by a blood gas analyzer. …”
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Argonaute2 and Argonaute4 Involved in the Pathogenesis of Kawasaki Disease via mRNA Expression Profiles by Zon-Min Lee, Hui-Chuan Chang, Shih-Feng Liu, Ying-Hsien Huang, Ho-Chang Kuo

“…There were no significant differences between AGO(s) and coronary artery lesions or intravenous immunoglobulin resistance. …”
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Causal Effects of Sleep Traits on Angina Pectoris: Mediation by Cardiovascular Risk Factors by Zeng C, Ke Y, Li H, Zhang C, Chen J, Chen M

“…Chuanfei Zeng,&ast; Yujia Ke,&ast; Huan Li, Chi Zhang, Jian Chen, Mingkai Chen Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430000, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Mingkai Chen, Email kaimingchen@163.comPurpose: Angina pectoris (AP) is a major factor in heightened risk of cardiac arrest and has been previously linked to sleep patterns. …”
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