Osobnost a dílo Matouše Radouše a tvorba renesančních epitafů v Chrudimi by Ondřej Jakubec, Radka Milotová

“…On the other hand, formal aspect of Radouš's artistic production should not be the only one to appreciate his works of art. …”
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Clustering patients with COVID-19 according to respiratory support requirements, and its impact on short- and long-term outcome (RECOVID study) by Rosario Menéndez, Raúl Méndez, Ana Latorre, Paula González-Jiménez, Germán Peces-Barba, María Molina-Molina, Pedro Pablo España, Estela García, Angélica Consuegra-Vanegas, Marta María García-Clemente, Carolina Panadero, Juan Marco Figueira-Gonçalves, David De la Rosa-Carrillo, Oriol Sibila, María Dolores Martínez-Pitarch, Nuria Toledo-Pons, Cecilia López-Ramírez, Wanda Almonte-Batista, Abigail Macías-Paredes, Mercedes Villamon, Marisol Domínguez-Álvarez, Eli Nancy Pérez-Rodas, Javier Lázaro, Sarai Quirós, Rosa Cordovilla, Irene Cano-Pumarega, Antoni Torres

“…C4 included those without comorbidities except for arterial hypertension, lymphopenia and an intermediate CRP. …”
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Association of Early and Late Contrast-Associated Acute Kidney Injury and Long-Term Mortality in Patients Undergoing Coronary Angiography by Zhubin Lun, Jin Liu, Liwei Liu, Jingjing Liang, Guanzhong Chen, Shiqun Chen, Bo Wang, Qiang Li, Haozhang Huang, Zhidong Huang, Danyuan Xu, Yunzhao Hu, Ning Tan, Jiyan Chen, Yong Liu, Jianfeng Ye

“…The same results were found in patients with coronary artery disease, chronic kidney disease, diabetes mellitus, and percutaneous coronary intervention. …”
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RESISTÊNCIA À INSULINA E EXCESSO DE PESO CORPORAL by Anelise Reis Gaya, Júlia Matzenbacher, Clarice Martins, Adroaldo Gaya, Helena Mansilha, Jorge Mota

“…Os parâmetros metabólicos (colesterol HDL e LDL, triglicerídeos, glicose), a tensão arterial sistólica (TAS) e diastólica (TAD), as variáveis antropométricas e as características físicas foram obtidos durante uma consulta médica. …”
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Circulating miRNAs as Biomarkers for Prostate Cancer Diagnosis in Subjects with Benign Prostatic Hyperplasia by Wei Jin, Xiang Fei, Xia Wang, Fangjie Chen, Yan Song

“…These results are consistent with previous studies regarding the possibility of differentiating between PCa subjects and healthy controls based on the detection of miRNA. The findings attest to a distinctive expression profile of miRNA that is detectable in the blood of PCa subjects, thereby confirming the role of miRNAs as diagnostic biomarkers for PCa.…”
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Isolation and function of a human endothelial cell C1q receptor by M. R. Daha, L. Dunn, R. van den Berg, Y. Muizert-de Lange, A. Gerritsen, L. A. van Es

“…It has been shown previously that cultured human venous and arterial endothelial cells (EC) bind C1q in a time- and dose-dependent manner. …”
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Factores pronósticos de la mortalidad de pacientes con reintervenciones de cirugía abdominal en Unidad de Cuidados Intensivos by Yordany Quintana Dorta, Angel Antonio Urbay Ruiz, Elaine Teresa Gutiérrez Pérez, Mabel Merlán Martínez, Leyla Aurora Rodríguez Pedraza, Isabel Vázquez Curdis

“…Conclusiones: Los factores pronósticos para la mortalidad de pacientes con reintervenciones quirúrgicas abdominales fueron: el Shock séptico, la Neumonía, la conducta antimicrobiana empírica y la Hipertensión Arterial como comorbilidad. Los índices APACHE II y SOFA demostraron una alta sensibilidad y especificidad en la predicción de la muerte.…”
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El artesano y el artista : aspectos de la iconografía de San José by Pierre Civil

“…La figuration du patron des peintres, le pinceau à la main, vient appuyer la revendication corporatiste de la défense de l’artiste et l’affirmation du caractère intellectuel de la peinture.Ces complexes variations sur le travail des deux saints font se croiser bon nombre d’images significatives (œuvres du Greco, Ribalta, Carducho, Murillo, Valdès Leal...) et de textes célébratifs (traités religieux, sermons, comedias ou poésies). …”
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DNA hypomethylation-mediated upregulation of GADD45B facilitates airway inflammation and epithelial cell senescence in COPD by Yuan Zhan, Qian Huang, Zhesong Deng, Shanshan Chen, Ruonan Yang, Jiaheng Zhang, Yating Zhang, Maocuo Peng, Jixing Wu, Yiya Gu, Zhilin Zeng, Jungang Xie

“…Accelerated lung aging and inflammation mutually reinforce each other, creating a detrimental cycle that contributes to disease progression. Growth arrest and DNA damage-inducible (GADD45) family has been reported to involve in multiple biological processes, including inflammation and senescence. …”
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(<i>E</i>)-1-(3-(3-Hydroxy-4-Methoxyphenyl)-1-(3,4,5-Trimethoxyphenyl)allyl)-1<i>H</i>-1,2,4-Triazole and Related Compounds: Their Synthesis and Biological Evaluation as Novel Anti... by Gloria Ana, Azizah M. Malebari, Sara Noorani, Darren Fayne, Niamh M. O’Boyle, Daniela M. Zisterer, Elisangela Flavia Pimentel, Denise Coutinho Endringer, Mary J. Meegan

“…G₂/M phase cell cycle arrest and the induction of apoptosis in MCF-7 cells together with inhibition of tubulin polymerization were demonstrated. …”
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Características de pacientes con diagnóstico de psoriasis y artritis psoriásica by Jessica Magali Herrera Abarca, Luis Medardo Jara Orna, Jhia Vanessa Navarrete Veloz, José Andrés Zaporta Ramos

“…El 57,89 % de los pacientes con artritis psoriásica y el 42,86 % de pacientes con psoriasis presentó al menos una comorbilidad asociada. La hipertensión arterial, el hipotiroidismo y la diabetes mellitus fueron las comorbilidades más frecuentemente reportadas en ambos grupos de personas. …”
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Imaginea lui Narcis în critica literară by Вікторія Фонарь

“… Critica literară abordează imaginea mitică diferit de textul artistic. Perspectivele mitului permit să revendice un traseu explicativ din context care menține vie relația dintre text și autor/scriitor. …”
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Association between Comorbidities and Progression of Transvalvular Pressure Gradients in Patients with Moderate and Severe Aortic Valve Stenosis by Tim Salinger, Kai Hu, Dan Liu, Scharoch Taleh, Sebastian Herrmann, Daniel Oder, Daniel Gensler, Jonas Müntze, Georg Ertl, Kristina Lorenz, Stefan Frantz, Frank Weidemann, Peter Nordbeck

“…Laboratory parameters, medication, and prevalence of eight known cardiac comorbidities and risk factors (hypertension, diabetes, coronary heart disease, peripheral artery occlusive disease, cerebrovascular disease, renal dysfunction, body mass index ≥30 Kg/m2, and history of smoking) were analyzed. …”
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Diagnosis and management of type 2 diabetes mellitus in patients with ischaemic heart disease and acute coronary syndromes - a review of evidence and recommendations by Muhammad Usman Shah, Muhammad Usman Shah, Alun Roebuck, Bala Srinivasan, Joanna Kate Ward, Paul Edward Squires, Claire Elizabeth Hills, Kelvin Lee, Kelvin Lee

“…There is an increased risk of IHD, heart failure, cerebrovascular accidents (CVA), and peripheral artery disease (PVD). These account accounting for 50% of deaths in patients with T2DM. …”
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Caracterización clínica de pacientes fallecidos por enfermedad cerebrovascular by Leonardo Javier Pérez Ponce, Roberto Carlos Barletta Farías, Luis Orlando Iturralde González, Gabriela Castro Vega, Diana Rocío Santana Guerra, Rosa María León Estela

“…La principal patología asociada fue la hipertensión arterial (34,6 %). <br /><strong>Conclusiones:</strong> la mortalidad por enfermedad cerebrovascular se presentó principalmente en pacientes de edades avanzadas, varones e hipertensos. …”
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Multiple Myeloma and B Cell Lymphoma. Investigation of IL-6, IL-6 Receptor Antagonist (IL-6RA), and GP130 Antagonist (GP130A) Using Various Parameters in an In Vitro Model by Eva Kovacs

“…Our results showed that (1) all five MM cell lines (OPM-2, RPMI-8226, U-266, KMS-12-BM, MOLP-8) expressed surface IL-6R and gp130, the B cell lymphomas (WSU-1, DOHH-2, U-698) expressed only gp130; (2) exogenous IL-6 markedly up-regulated the expression of membrane IL-6R (up to 186%) and down-regulated the gp130 receptor (down to 4%) in MM cell lines, the membrane expression of gp130 in B cell lymphomas was not altered; (3) IL-6 markedly increased the spontaneous proliferation (up to 151%) in all MM cell lines, that of B cell lymphomas was not affected; (4) IL-6 increased the DNA synthesis in the S cell cycle phase of MM cells and arrested the stage G2/M, IL-6 was ineffective in any cell cycle phase of B cell lymphoma; (5) IL-6RA inhibited the membrane IL-6R partially, the proliferation was decreased only slightly; and (6) although gp130A inhibited the membrane gp130 completely, the proliferation was decreased 81—78% in MM and B cell lymphoma cell lines. …”
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Phase I trial of hydroxychloroquine to enhance palbociclib and letrozole efficacy in ER+/HER2− breast cancer by Akshara Singareeka Raghavendra, Nicole M. Kettner, Danielle Kwiatkowski, Senthil Damodaran, Yan Wang, David Ramirez, Dan S. Gombos, Kelly K. Hunt, Yu Shen, Khandan Keyomarsi, Debu Tripathy

“…Previously, we demonstrated that low doses of palbociclib activate autophagy, reversing initial G1 cell cycle arrest, while high concentrations induce off-target senescence. …”
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Cardiovascular events observed among patients in the etrasimod clinical programme: an integrated safety analysis of patients with moderately to severely active ulcerative colitis by Xiang Guo, Peter M Irving, Laurent Peyrin-Biroulet, Séverine Vermeire, Joseph Wu, Irene Modesto, David T Rubin, Marla C Dubinsky, Andres J Yarur, Miguel Regueiro, Martina Goetsch, Krisztina Lazin, Guibao Gu, Aoibhinn McDonnell, Jesse Green, Alexis B Dalam

“…Incidence rates (IRs, per 100 patient-years) of cardiovascular-related TEAEs associated with S1P receptor modulators, including bradycardia/atrioventricular (AV) block and hypertension, and other cardiovascular events, including coronary artery disease (CAD) and cerebrovascular disease (CVD), were analysed.Results In patients receiving etrasimod, cardiovascular-related TEAEs were infrequent (≤2.6% per AE). …”
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Volumen plaquetario medio y posible valor pronóstico en pacientes con infarto agudo de miocardio by Daniel Lázaro Núñez Garlobo, Roger Ravelo Dopico, Birsy Suárez Rivero, Carmen Rosa Perera Lombillo, Liz Odelnis Cruz Rodríguez, Osvaldo Miranda Gómez

“…Se asoció además a la hipertensión arterial, tabaquismo y diabetes mellitus. …”
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Biomarkers to predict the outcomes of surgical intervention for aortic dissection by Abanob G. Hanna, Fabian Jimenez Contreras, Omar M. Sharaf, Griffin P. Stinson, Philip J. Hess

“…A combination of elevated preoperative and postoperative SII values was again predictive of in-hospital adverse outcomes and follow-up complications, including endoleaks, branch artery stenosis, distal aortic expansion, aortic rupture, and death (p = 0.0016). …”
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