Inotodiol induces hepatocellular carcinoma apoptosis by activation of MAPK/ERK pathway. by Yushuang Xing, Di Jia, Xinping Zhu, Jialu Yang, Zhipeng Gao, Nana Meng, Haohao Xu, Mengxiao Wang, Shijun Chang, Mingqian Zhao, Shanbo Zhang, Zichen Mu, Qiang Tang, Weiming Zhao

“…These results showed that inotodiol has the ability to promote apoptosis, as well as inhibit the ability of cell proliferation, migration, and clonogenic ability. The cell cycle was arrested in G1 phase, when the expression of CDK2, CDK4, CDK6 and Cyclin D were inhibited. …”
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Inhibitory effects of limonin on the proliferation of non-small cell lung cancer cells via targeting S-phase kinase-associated protein 2 by Zhu Jiaxian, Zhang Mengting, Li Shengqing, Liu Yongqiang

“…Results Limonin inhibited NSCLC cell proliferation in a dose-dependent manner by inducing cell cycle G0/G1 phase arrest while significantly attenuating NSCLC stem cell-like properties. …”
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A Retrospective Analysis of Thromboembolic Phenomena in Mechanically Ventilated Patients with COVID-19 by Fahad Faqihi, Abdulrahman Alharthy, Abdullah Balhamar, Nasir Nasim, Khaled Alanezi, Feisal Alaklobi, Ziad A. Memish, Mike Blaivas, Saleh A. Alqahtani, Dimitrios Karakitsos

“…Sixty patients (37.5%) developed TEP including thirty patients with deep vein thrombosis, 55 patients with pulmonary embolism, and 7 patients with arterial thromboembolism. Cardiac arrhythmias, lymphocytopenia, and increased D-dimers were more frequently observed in the TEP group compared to the non-TEP group of patients (all p<0.05). …”
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Elevated levels of serum alpha-2-macroglobulin associate with diabetes status and incident CVD in type 1 diabetes by Baohai Shao, Janet K. Snell-Bergeon, Ian H. de Boer, W. Sean Davidson, Karin E. Bornfeldt, Jay W. Heinecke

“…We used isotope dilution-MS/MS to quantify 28 serum proteins in 228 subjects participating in the prospective Coronary Artery Calcification in Type 1 Diabetes study. We used linear regression to analyze the association between serum protein levels and T1DM status using 47 healthy controls and 134 T1DM patients without CVD and Cox proportional hazards regression to assess their prediction for incident CVD by a case-cohort study using a subcohort of 145 T1DM subjects and a total of 47 CVD events. …”
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Relationship between skin temperature and blood flow during exposure to radio frequency energy: implications for device development by Georgia E. H. Robles, David A. Nelson

“…We are developing an REFLO device to screen for peripheral artery disease (PAD). PAD is characterized by impaired blood flow to the legs, as reflected in the skin microcirculation. …”
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Varying pixel resolution significantly improves deep learning-based carotid plaque histology segmentation by Yurim Lee, Rashid Al Mukaddim, Tenzin Ngawang, Shahriar Salamat, Carol C. Mitchell, Jenna Maybock, Stephanie M. Wilbrand, Robert J. Dempsey, Tomy Varghese

“…Abstract Carotid plaques—the buildup of cholesterol, calcium, cellular debris, and fibrous tissues in carotid arteries—can rupture, release microemboli into the cerebral vasculature and cause strokes. …”
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Tasks of the National Police of Ukraine as a subject of implementation of the preventive function of the state by I. V. Ishchenko

“…It is emphasized that the main tasks of the Department of Preventive Activities of the National Police of Ukraine are to organize and ensure within the competence of the National Police of Ukraine the functions of Ukrainian legislation to maintain public safety and order, protect human rights and freedoms, and individual preventive work aimed at preventing the commission of administrative and criminal offenses, preventing and combating domestic violence, escorting persons detained on suspicion of committing a criminal offense, taken into custody, accused, sentenced to arrest or imprisonment, and for a term of imprisonment in the courtroom. …”
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In vitro antitumor effects of methanolic extracts of three Ganoderema mushrooms by Elshahat A. Toson, Amira A. El-Fallal, Marwa A. Oransa, Hoda M. El-Gharabawy

“…On the other hand, the IC50 of T-47D were 221.95 and 236.45 µg/mL, respectively. The three extracts arrested the cell life cycle at the G1 phase in each case. …”
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Safety of Colonoscopies in Patients on Advanced Heart Failure Therapies Who Received a Heart Transplant by Zaid Ansari, Akram Ahmad, Osama Sharjeel Khan, Vuha Reddi, Fernando Castro

“…Only four patients had a complication of bleeding requiring clips after polypectomy during the index procedure, with no anesthesia‐related adverse events (such as hypotension, arrhythmias, or cardiac arrest) or addition of inotropes, vasopressors, or MCS. …”
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The SpxA1-TenA toxin-antitoxin system regulates epigenetic variations of Streptococcus pneumoniae by targeting protein synthesis. by Shaomeng Wang, Xiu-Yuan Li, Mengran Zhu, Haiteng Deng, Juanjuan Wang, Jing-Ren Zhang

“…SpxA1 and TenA were found to constitute a highly conserved type II TA system in S. pneumoniae, primarily based on the observation that overexpressing toxin TenA led to growth arrest in E. coli and enhanced autolysis in S. pneumoniae, and the antitoxin SpxA1 repressed the transcription of the spxA1-tenA operon. …”
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Open Medial Meniscus Centralization With Arthroscopic Root Repair by Nicholas Newcomb MD, Jared Sanderford MD, Tyag Patel MD, Price Sessums MD, Ryan Price MD, William Curtis MD, Gehron Treme MD, Christopher Shultz MD

“…Patient Consent Disclosure Statement: The author(s) attests that consent has been obtained from any patient(s) appearing in this publication. …”
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Primary Mechanism Study of Panax notoginseng Flower (Herb) on Myocardial Infarction in Rats by Xin Zhou, Zhi-Cheng Li, Pei-Pei Chen, Rui-Fang Xie

“…The proximal left anterior descending coronary artery in rats was ligated to induce acute myocardial infarction. …”
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The Effect of a 12-Week Plyometric and Tabata Training Program with Three Weekly Sessions on Cardiovascular Efficiency in Elite Soccer Players by Nidhin Muthrathiparambil Narayanan, Kayambu Sundar, Nirmal Michael Salvi, Yashpal, Debajit Karmakar, Sohom Saha, Bekir Erhan Orhan, Farjana Akter Boby, Yuni Astuti

“…Cardiovascular metrics, including vital capacity, resting heart rate, mean arterial blood pressure, breath-holding time, and respiratory rate, were assessed before and after the program. …”
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Long-chain chlorinated paraffins (LCCPs) exposure induces apoptosis in primary chicken embryo hepatocytes through oxidative stress by Haochu Deng, Yezi Taishi, Guoxia Wang, Yuebing Kong, Ruoting Zhang, Xin Zheng

“…Our findings indicate that the proliferation capacity of primary chicken embryo hepatocytes exposed to LCCPs at concentrations of 1, 10, and 100 μg/L was significantly diminished, with an observed arrest in the G0/G1 phase and a notable reduction in the proportion of cells in the G2/M phase. …”
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KAMU KURUMLARININ ÇAĞRI MERKEZLERİ ÜZERİNE BİR ANALİZ by Yener Lütfü Mert

“…Bu sektörlerden en çok istihdam artışı kamu çağrı merkezlerinde gerçekleşmektedir. …”
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Discovery of phloridzin as a new antagonist for Di(2-ethylhexyl) phthalate-induced male reproductive toxicity based on the adverse outcome pathway network and drug-target gene set... by Huan Gao, Xue Zhang, Ziqi Liu, Xiaoge Yang, Yajie Li, Mengxing Cui, Han Wang, Xiaoyu Chen, Weiying Zhang, Zhihan Liu, Yongjiang Yu, Liping Chen, Daochuan Li, Yongmei Xiao, Wen Chen, Qing Wang

“…After functional enrichment analyses and mapping to the global AOP network, we found that the increased ROS level, cell cycle arrest, and increased apoptosis are key events (KEs) involved in DEHP-mediated MRT, which was validated in TM3 Leydig cell model. …”
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Políticas, estrategias y tecnologías ambientales en las empresas mineras de yeso para una gestión sostenible en la Guajira, Colombia by Nohora Cecilia Lozada Medina, Tatiana Andrea Ruiz Arrieta, Danny Daniel López Juvinao

“…., Yesos Colombia S.A.S., y la mina artesanal de yeso en Manaure. Los resultados revelaron en lo que concierne a las políticas ambientales dentro de las empresas existen una carencia en la aplicación de las mismas; en cuanto a la implementación de estrategias y tecnologías ambientales las empresas han tomado la iniciativa para mejorar en sus actividades mineras. …”
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Surgical techniques and prognostic nomogram for patients with supravalvular aortic stenosis by Yuekun Sun, Lizhi Lv, Xinyue Lang, Aihua Zhi, Simeng Zhang, Cheng Wang, Qiang Wang

“…Age, gender, SVAS type, pulmonary artery stenosis, aortic valve stenosis, sinotubular junction z-score and gradient were considered independent risk factors by Lasso regression and were included in the nomogram. …”
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Transanal Hemorrhoidal Dearterialization (THD): A Single Center Experience on 100 Consecutive Cases by Aleksandar Mitevski, Vladko Cvetanovski, Petar Markov, Ilija Milev

“…Morphological and hemodynamic changes that occur in patients with hemorrhoidal disease is the finding of an increased diameter of the terminal branches of the superior rectal artery that supplies the hemorrhoidal nodes. These branches are 10–11 in number, of which ligation of up to six is allowed for effective treatment with the THD method. …”
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Sex Differences in the Renal Vascular Responses of AT1 and Mas Receptors in Two-Kidney-One-Clip Hypertension by Zahra Pezeshki, Mehdi Nematbakhsh

“…Male and female 2K1C rats were divided into 8 experimental groups (4 of each sex) treated with vehicle, losartan, A779, or A779+losartan. Responses of mean arterial pressure (MAP), renal blood flow (RBF), and renal vascular resistance (RVR) to Ang II were determined. …”
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