Dual specific STAT3/5 degraders effectively block acute myeloid leukemia and natural killer/T cell lymphoma by Daniel Pölöske, Helena Sorger, Anna Schönbichler, Elvin D. deAraujo, Heidi A. Neubauer, Anna Orlova, Sanna H. Timonen, Diaaeldin I. Abdallah, Aleksandr Ianevski, Heikki Kuusanmäki, Marta Surbek, Elisabeth Heyes, Thomas Eder, Christina Wagner, Tobias Suske, Martin L. Metzelder, Michael Bergmann, Maik Dahlhoff, Florian Grebien, Roman Fleck, Christine Pirker, Walter Berger, Emir Hadzijusufovic, Wolfgang R. Sperr, Lukas Kenner, Peter Valent, Tero Aittokallio, Marco Herling, Satu Mustjoki, Patrick T. Gunning, Richard Moriggl

“…They induced cell death and growth arrest in both AML/NKCL cell lines and primary AML patient blasts. …”
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Surgical planning of small intestine neuroendocrine tumors: the concept of mesenteric tumor deposits by Romain L’Huillier, Gilles Poncet, Arnaud Pasquer, Thomas Walter, Catherine Lombard-Bohas, Valérie Hervieu, Bénédicte Cayot, Pierre-Jean Valette, Helen Cheung, Laurent Milot

“…The mesenteric extension of small neuroendocrine tumors is the surgical limiting factor because of the risk of postoperative short bowel syndrome due to superior mesenteric artery involvement. Recent pathological studies have shown that this vascular involvement is due to mesenteric tumor deposits, differentiated from lymph node metastases. …”
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Risk Factors Related to the in-hospital Evolution of Patients with ST-segment Elevation Acute Coronary Syndrome by Chen Shang, Héctor Pérez Assef, Marlene Ferrer Arrocha

“…<br /><strong>Results:</strong> patients older than 60 years predominated, with a mean age of 63 years and the male sex. Arterial hypertension was the most frequent risk factor, followed by smoking. …”
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Qualidade de vida e nível de atividade física de idosos normotensos e hipertensos cadastrados na estratégia de saúde da família by Paula Silva, Ramires Tibana, Nuno Sousa, Viviane Pinheiro, Renata Santos, Érick Bastos, Eliane Trevisan, Guilherme Peirera, Jonato Prestes

“…Os dois grupos foram classificados como “sedentários” pelo IPAQ, independentemente dos valores de pressão arterial. Em conclusão, idosos hipertensos possuem pior percepção de QV do que idosos normotensos, enquanto que, todos os idosos foram classificados como sedentários. …”
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Reinvigorating South Africa-Sweden Relations: Politics, Economics, And Society by Sven Botha

“…The Digitally Yours Campaign ran from the 4th of April 2020 until the 2nd of May 2020 and hosted a number of virtual exchanges4 whereby both Swedish and South African artists participated in roundtable discussions and cultural performances in the areas of fashion, poetry, and music (Embassy of Sweden in Pretoria, 2020). …”
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Assessment of Cardiovascular Apoptosis in the Isolated Rat Heart by Magnetic Resonance Molecular Imaging by Karl-Heinz Hiller, Christiane Waller, Matthias Nahrendorf, Wolfgang R. Bauer, Peter M. Jakob

“…To this effect, annexin V was linked to gadolinium diethylenetriamine pentaacetate (Gd-DTPA)-coated liposomes. The left coronary artery of perfused isolated rat hearts was ligated for 30 min followed by reperfusion. …”
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What is the Difference Between the Different Types of Thermometers? by Işıl Kübra Savaş, Gülsüm İclal Bayhan

“…The body temperature was measured using a non-contact cutaneous thermometer (NCCT), tympanic thermometer (TT), temporal artery thermometer (TAT), and electronic oral thermometer. …”
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Thermal Analysis of a Casson Boundary Layer Flow over a Penetrable Stretching Porous Wedge by Dur-e-Shehwar Sagheer, Mohammad Alqudah, Nawal A. Alshehri, M. Sabeel Khan, M. Asif Memon, R. Shehzad, Amsalu Fenta

“…The importance of this study is due to its applications in biomedical engineering where the analysis of behavior of non-Newtonian blood flow in arteries and veins is desired. Within the context of blood flow, it is also applicable to many other fields, for instance, radiative therapy, MHD generators, soil machines, melt-spinning, and insulation processes. …”
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Attenuation of Myocardial Injury by HMGB1 Blockade during Ischemia/Reperfusion Is Toll-Like Receptor 2-Dependent by Jan Mersmann, Franziska Iskandar, Kathrina Latsch, Katharina Habeck, Vera Sprunck, René Zimmermann, Ralf R. Schumann, Kai Zacharowski, Alexander Koch

“…HMGB1 plasma levels were measured in patients undergoing coronary artery bypass graft (CABG) surgery. HMGB1 antagonist BoxA reduced cardiomyocyte necrosis during MI/R in WT mice, accompanied by reduced leukocyte infiltration. …”
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Effect of Adiponectin Variant on Lipid Profile and Plasma Adiponectin Levels: A Multicenter Systematic Review and Meta-Analysis by Guiqing Wang, Yufeng Wang, Zhi Luo

“…The present study indicated that Chinese with the rs2241766 and rs266729 variants were at high risk of dyslipidemia, atherosclerosis, or coronary artery disease (CAD). Males with the rs2241766 variant were at high risk of CAD. …”
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Use of Artemisinin- Combination Therapies in Port Harcourt by OA Shorinwa, OO Ebong

“…The respondents that took artemisinin based combination drugs were 230 (32.1%), those that took artesunate only were 174 (24.3%), those that took chloroquine were 101 (14.1%) while those that took sulphadoxine/pyrimethamine were 140 (19.5%) while 72 (10%) took other antimalarial drugs. …”
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Single-cell transcriptomics identify a novel macrophage population associated with bone invasion in pituitary neuroendocrine tumors by Xinzhi Wu, Xueshuai Han, Haibo Zhu, Mingxuan Li, Lei Gong, Sicheng Jing, Weiyan Xie, Zhaoqi Liu, Chuzhong Li, Yazhuo Zhang

“…This infiltration poses a significant surgical risk due to potential damage to vital nerves and arteries. However, the mechanisms underlying bone invasion caused by PitNETs remain elusive, and effective interventions for PitNET-induced bone invasion are lacking in clinical practice. …”
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Silicon-mediated modulation of maize growth, metabolic responses, and antioxidant mechanisms under saline conditions by Muhammad Saad Ullah, Athar Mahmood, Hussam F. Najeeb Alawadi, Mahmoud F. Seleiman, Bilal Ahmad Khan, Muhammad Mansoor Javaid, Abdul Wahid, Fnu Abdullah, Daniel O. Wasonga

“…Soil salinity triggers a range of physiochemical abnormalities, often leading to growth arrest and, eventually, the demise of susceptible plants. …”
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Fulminant Diabetes in a Patient with Advanced Melanoma on Nivolumab by Nora Chokr, Hafsa Farooq, Elizabeth Guadalupe

“…Labs revealed potassium 9.5 mmol/L, sodium 127 mmol/L, bicarbonate <10 mmol/L, blood glucose 1211 mg/dL, anion gap >31 mmol, arterial blood pH 7.14, and beta-hydroxybutyrate 13.7 mmol/L. …”
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Cardioembolic but Not Other Stroke Subtypes Predict Mortality Independent of Stroke Severity at Presentation by Latha Ganti Stead, Rachel M. Gilmore, M. Fernanda Bellolio, Anunaya Jain, Alejandro A. Rabinstein, Wyatt W. Decker, Dipti Agarwal, Robert D. Brown

“…Subtypes were as follows: large artery atherosclerosis 97 (19.4%), cardioembolic 144 (28.8%), small vessel disease 75 (15%), other causes 19 (3.8%), and unknown 165 (33%). …”
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3D Fusion Framework for Infarction and Angiogenesis Analysis in a Myocardial Infarct Minipig Model by Xu Zhenzhen PhD, Bo Tao PhD, MD, Yu Li MSc, Jun Zhang PhD, Xiaochao Qu PhD, Feng Cao PhD, Jimin Liang PhD

“…The presented framework is helpful in facilitating the study of the relationship between infarct territories and blocked coronary arteries as well as angiogenesis.…”
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Ekphrasis, Description and Realism in Ahmad Mahmoud’s The Pilgrim under the Rain by Alireza Omidbakhsh, Razieh Aran, hesam khaloee

“…By pondering in this collection of stories, we correctly understand that description is one of the main essences of this work; And the way events happen, the state of characters and situations with the author's descriptive pen creates an artistic world. These descriptions give the story a drama and are realistic. …”
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Intratesticular Angiolipoma: A Rare Case of Adipose Tissue Presence in the Testis by V. Kalyvas, C. Gkekas, D. Papadopoulos, A. Malioris, S. Milias, M. Papathanasiou, N. Kalinderis, K. Moysidis, K. Hatzimouratidis

“…Testicular ultrasound however depicted an isoechoic lesion on the upper pole of the right testis measuring 1.8 cm×0.8 cm×1 cm and exhibiting intense arterial flow. After sonographic and MRI investigation, the patient was referred for semen analysis and cryopreservation. …”
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Spontaneous Ruptured Pyomyoma in a Nulligravid Female: A Case Report and Review of the Literature by S. Read, J. Mullins

“…It may also arise after recent uterine instrumentation, after uterine artery embolization, or in immunocompromised patients. …”
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El contexto actual de un cambio regulatorio de cannabis: análisis de un curso peruano by Pedro Wong-Salgado, Marcia M. Moya-Salazar, Eliane Goicochea-Palomino, Jeel Moya-Salazar

“…La nueva regulación debe incluir a la producción artesanal de cannabis y derivados, a través de las asociaciones de pacientes, según el mandato de la Ley 31312, que modifica a la Ley 30681, incluyendo así esta actividad. …”
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