Enhancing glioblastoma therapy: unveiling synergistic anticancer effects of Onalespib - radiotherapy combination therapy by Julia Uffenorde, Mehran Hariri, Eleftherios Papalanis, Annika Staffas, Josefine Berg, Bo Stenerlöw, Hanna Berglund, Christer Malmberg, Diana Spiegelberg, Diana Spiegelberg

“…Moreover, the combination treatment indicated potential for enhancing cell cycle arrest and apoptosis, suggesting promising anti-tumor effects.ConclusionThese findings demonstrate that HSP90 inhibition may be a promising strategy to enhance the efficacy of radiotherapy in the treatment of GBM, potentially leading to improved outcomes for patients battling this challenging disease.…”
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Two-photon NAD(P)H-FLIM reveals unperturbed energy metabolism of Ascaris suum larvae, in contrast to host macrophages upon artemisinin derivatives exposure by Zaneta D. Musimbi, Arkadi Kundik, Jürgen Krücken, Anja E. Hauser, Sebastian Rausch, Peter H. Seeberger, Raluca Niesner, Ruth Leben, Susanne Hartmann

“…Artemisinin derivatives (ARTs)—artesunate, artemether, and dihydroartemisinin—are standard malaria treatments and are also known to influence the energy metabolism of parasites, tumors, and immune cells. …”
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Loss of PKM2 dysregulates inflammatory signaling in the infarcted murine heart by Katie C. Y. Lee, Allison L. Williams, Akitoshi Hara, Vedbar S. Khadka, Jeffrey Hayashi, Ralph V. Shohet

“…We examined the role of PKM2 physiological upregulation after MI, modeled by ligation of the left anterior descending coronary artery, using global PKM2 knockout (PKM2−/−) mice. …”
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Trauma Surgery and War: A Historical Perspective by Kun Hwang

“…In the 16th century, Paré reintroduced ligature of arteries, which had been introduced by Celsus and Galen, instead of cauterization during amputation. …”
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Calculation of Cracks in Partially Steel Fiber Reinforced Concrete Beams with BFRP Bars by Wei Shen, Shengping Chen, Jianbo Zhang

“…For BFRP reinforced concrete beams partially reinforced with steel fibers, the development of the maximum crack width can be effectively suppressed under ultimate load. Its crack arresting effect is more similar to that of full-section steel fiber reinforced concrete beams with BFRP bars; it shows that adding steel fibers only in the compression zone of the beam can not only improve the load capacity of the beam but also obtain good economic benefits. …”
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Pitfalls, Complications, and Necessity of Education about REBOA: A Single Regional Trauma Center Study by Sol Kim, Jae Sik Chung, Sung Woo Jang, Pil Young Jung

“…There are no significant differences between the educated and non-educated groups in sex, age, ISS, shock, injury-to-REBOA time, injury mechanism, injury sites, arrest, access site, type of catheter, type of REBOA, target Zone, mortality, and the result of REBOA. …”
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Ecrire et souffrir : L’inspiration partagée de Constance Fenimore Woolson et de Henry James by Jeannine Hayat

“…Miss Grief is a story by Constance Fenimore Woolson, an American novelist who often wrote about the difficulty a woman had in becoming an artist — a writer or a painter — in the nineteenth century. …”
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Lui, « pour toujours, a embrassé ma bouche, toute frémissante » : Paolo et Francesca dans la peinture préraphaélite et esthétique by Anne-Florence Gillard-Estrada

“…Coupin de la Couperie et J.A.D. Ingres, et par des artistes britanniques, comme William Dyce. Le baiser des amants devient central, mais la réserve féminine est soulignée. …”
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Detecting respiratory diseases using machine learning-based pattern recognition on spirometry data by Ahmed I. Taloba, R.T. Matoog

“…Again, this degree of accuracy attests to the model's effectiveness in distinguishing between healthy and COPD-affected lungs. …”
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Plasma C1q/TNF-Related Protein-9 Levels Are Associated with Atherosclerosis in Patients with Type 2 Diabetes without Renal Dysfunction by Mariko Asada, Tomoaki Morioka, Yuko Yamazaki, Yoshinori Kakutani, Reina Kawarabayashi, Koka Motoyama, Katsuhito Mori, Shinya Fukumoto, Atsushi Shioi, Tetsuo Shoji, Masanori Emoto, Masaaki Inaba

“…The intima-media thickness (IMT) of the common carotid artery was measured with ultrasonography. Results. …”
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Complex biochemical characteristics of <i>Coriandrum sativum</i> L. by T. V. Khmelinskaya, A. E. Smolenskaya, A. E. Solovyeva

“…As a result of the study, the feasibility of using C. sativum as a source of bioactive compounds was theoretically justified and experimentally confirmed, thus attesting to the prospects of coriander accessions from the VIR collection for quality-targeted breeding programs. …”
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Intravenous Transplantation of Mesenchymal Stem Cells Reduces the Number of Infiltrated Ly6C+ Cells but Enhances the Proportions Positive for BDNF, TNF-1α, and IL-1β in the Infarct... by Yunqian Guan, Xiaobo Li, Wenxiu Yu, Zhaohui Liang, Min Huang, Renchao Zhao, Chunsong Zhao, Yao Liu, Haiqiang Zou, Yanli Hao, Zhiguo Chen

“…The ischemic brain injury was induced by distal middle cerebral artery occlusion (dMCAO) in SD rats, with or without MSC infusion in the same day following dMCAO. …”
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Livourne, ville de la diversité : un concours d’idées pour l’aménagement d’une zone portuaire by Simona Corradini, Francesca Morucci, Francesca Pichi

“…This led to the association organising a competition for the best artistic ideas for the development of a port area through the installation of a work of art in the port of Livorno. …”
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Whistler et l’esthétisme avant l’ouverture de laGrosvenor Gallery by Isabelle Énaud-Lechien

“…Aussi chercherons-nous ici établir ce qui, avant même cette date, motive à associer l’artiste à l’Esthétisme, en particulier dans les journaux caricaturaux. …”
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Gabriele Wohmann, une joyeuse anticonformiste by Benoît Pivert

“…Au fil des décennies, on a vu naître ainsi un portrait grinçant de la République fédérale, avec ses soixante-huitards à l’intarissable logorrhée, ses écrivains engagés, ses artistes s’essoufflant à courir après la dernière mode, ses donneurs de leçons de morale hypocrites et ses pasteurs ayant succombé aux sirènes du bouddhisme. …”
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Changes in Glucose Metabolism and Atherogenic Risk Factors in Diabetic Patients’ First-degree Relatives by María Teresa González Pedroso, Elizabeth Remis Rodríguez, Marlene Ferrer Arrocha, Marisela Nuez Villar, Ingrid Rodríguez Crespo, Héctor Pérez Assef

“…The most frequent risk factor was dyslipidemia, present in 43,4 % followed by arterial hypertension and overweight/obesity. Alterations in glucose metabolism occurred in 74,6 % of the patients, with a predominance of altered fasting glycemia in 30,3 % and 11,5 % diagnosed with diabetes mellitus. …”
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GV1001, hTERT Peptide Fragment, Prevents Doxorubicin-Induced Endothelial-to-Mesenchymal Transition in Human Endothelial Cells and Atherosclerosis in Mice by Wei Chen, Seojin Kim, Sharon Y. Kim, Cheyenne Beheshtian, Naryung Kim, Ki-Hyuk Shin, Reuben H. Kim, Sangjae Kim, No-Hee Park

“…Additionally, GV1001 reduced systemic and vascular inflammation, lipid accumulation, and monocyte/macrophage infiltration within arterial walls in mice. In conclusion, GV1001 appears to prevent doxorubicin-induced atherosclerosis by safeguarding vascular endothelial cells from mitochondrial dysfunction, inflammation, and phenotypic changes. …”
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REPAIR OF SCIATIC NERVE LESION AUGMENTED WITH AMNION MEMBRANE COMPOSITE AND MESENCHYMAL STEM CELL by Heri Suroto, R. Taufan Mulyo Wibisono

“…The patient underwent emergency surgery to repair the right Femoral artery and the Sciatic nerve. Discussion: After six months since the first operation, flail foot and anesthesia were persisting with a FADI score of 47.1. …”
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Gridlocked Streets or Simply Disinterested? Urban Youth and Unconventional Political Participation in Zimbabwe’s Second Republic by Octavious Masunda

“…Utilising focus groups conducted in Harare and Bulawayo, findings reveal how young people engage with political issues through internet-based platforms and novel artistic expressions. While internet participation offers a space to the largely digitally savvy youth for critique and dialogue, it often fails to translate into tangible policy changes or meaningful impact, highlighting a sense of futility among the youth. …”
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Le complexe monumental suburbain et l’ensemble funéraire de Saint-Martin-au-Val (Chartres, Eure-et-Loir) : état de la recherche (2006-2011) by Bruno Bazin, Emmanuel Bouilly, Vincent Drost, Isabelle Godin, Stéphane Hérouin, Christophe Loiseau, Apolline Louis, Stéphanie Raux, Julie Rivière, Jonathan Simon, Stéphane Willerval

“…AD 120-130, the construction of rectangular, apsidal exedrae is attested on the eastern facade. Between the middle and the second half of the 2nd c. …”
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