Characterization of Bozitinib as a potential therapeutic agent for MET-amplified gastric cancer by Hang Lin, Lingzhi Qu, Hudie Wei, Ming Guo, Xiaojuan Chen, Qianmeng Lin, Huajun Zhang, Shuyan Dai, Yongheng Chen

“…Bozitinib demonstrates a strong effect on MET-amplified gastric cancer cells by blocking the c-Met signaling pathway, leading to the inhibition of cell proliferation and survival, as well as the induction of G0/G1 phase arrest and apoptosis. Structurally, bozitinib is optimally embedded in the ATP pocket of c-Met and firmly binds via an extensive interaction network. …”
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Dilated Cardiomyopathy in Children and Adults: What is New? by Galal E. Nagib Elkilany, Mustafa A. AL-Qbandi, Khaled A. Sayed, Ibrahim Kabbash

“…Our conclusions were that in children and adults, DCM is a diverse disorder with outcomes that depend largely on cause, age, heart failure status at presentation, and echocardiographic parameters of the heart (systolic and diastolic function of left ventricle, pulmonary artery pressure, global strain, and valvular function of the mitral valve). …”
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Mockery as a special type of laugher in the prose of Leonid Andreev by Alisa V. Mytareva

“…At the end, a conclusion is made about the connection between the themes of death and laughter in the artistic world of L. Andreev, as a distinctive feature of the writer’s work.…”
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Bariatric Surgery in Moderately Obese Patients: A Prospective Study by M. Cerci, M. I. Bellini, F. Russo, D. Benavoli, M. Capperucci, A. L. Gaspari, P. Gentileschi

“…Of the 16 patients with arterial hypertension, 14 (87%) showed remission and 2 (13%) improvement. …”
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Dynamic Spatiotemporal Causality Analysis for Network Traffic Flow Based on Transfer Entropy and Sliding Window Approach by Senyan Yang, Lianju Ning, Xilong Cai, Mingyu Liu

“…Experimental results based on real-world traffic sensor data indicate that the structures of traffic causality graphs are time-varying; the traffic cause-effect interaction among different road segments during the peak time is more significant than that during the nonpeak time; and the critical road segments can be identified, which are mainly located at the intersections of arterial roads, undertaking the convergence and dispersion of large traffic flows.…”
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Validation of Colchicine Assay Method for Therapeutic Drug Monitoring in Human Plasma by Fadime Canbolat

“…Colchicine (COL) reduces the frequency of attacks in Familial Mediterranean Fever (FMF) patients and is effective in preventing and arresting renal amyloidosis in most patients. COL has a narrow therapeutic window. …”
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Sympathetic nervous system inhibition enhances cardiac metabolism and improves hemodynamics and glucose-insulin dynamics in obese and lean rat models by Ionuț Tudorancea, Ionela Lăcrămioara Șerban, Dragomir N. Șerban, Irina-Iuliana Costache-Enache, Caratașu Cătălin, Alexandru Grațian Naum, Radu Iliescu

“…Body weight, food and water intake, blood glucose concentration, blood pressure variability as an index of sympathetic activity and hemodynamic parameters such as mean arterial blood pressure (MAP), systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) were analyzed. …”
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Lawsone encapsulated polylactic‐co‐glycolic acid nanoparticles modified with chitosan‐folic acid successfully inhibited cell growth and triggered apoptosis in Panc‐1 cancer cells... by Helia Ghafaripour, Masoud Homayouni Tabrizi, Ehsan Karimi, Niloofar Barati Naeeni

“…The authors performed acridine orange/propidium iodide staining and flow cytometry to monitor apoptosis induction and cell cycle arrest. The expressions of apoptosis‐related genes (BAX and BCL‐2) were assessed by real time PCR. …”
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Validity of using serum D-dimer titer in prefatory to computed Tomography pulmonary angiography scans in the early identification of pulmonary embolism amid emergency room patients... by Sameh H. Seyam, Hassan Razein, Mohammed Abdelhamid Ali, Islam Elkousy, Shailender Singh, Ihab Gebaly, Rajini Ashok

“…Background and aim Pulmonary embolism emerges when a thrombus forms in the veins or right heart and travels to the pulmonary arteries. The study aims to ascertain the robustness of D-dimer testing for PE compared with CTPA and identify the threshold values to support its use. …”
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Role of calcium overload-mediated disruption of mitochondrial dynamics in offspring neurotoxicity due to methylmercury exposure during pregnancy and lactation by Lingxu Kong, Huajie Yang, Jing Yang, Liujiangshan Jiang, Bin Xu, Tianyao Yang, Wei Liu

“…We found that exposure to MeHg during gestation and lactation resulted in developmental arrest and neurobehavioral dysfunction in the offspring, with calcium overload, disturbed mitochondrial dynamics, and apoptosis. …”
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Robotic-Assisted Transperitoneal Aortic Lymphadenectomy as Part of Staging Procedure for Gynaecological Malignancies: Single Institution Experience by V. Zanagnolo, D. Rollo, T. Tomaselli, P. G. Rosenberg, L. Bocciolone, F. Landoni, G. Aletti, M. Peiretti, F. Sanguineti, A. Maggioni

“…All the para-aortic lymphadenectomies were carried out to the level of the renal veinl but 6 cases were carried out to the level of the inferior mesenteric artery. Hysterectomy was performed in 24 patiens (47%). …”
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Multi-tissue characterization of the constitutive heterochromatin proteome in Drosophila identifies a link between satellite DNA organization and transposon repression. by Ankita Chavan, Lena Skrutl, Federico Uliana, Melanie Pfister, Franziska Brändle, Laszlo Tirian, Delora Baptista, Dominik Handler, David Burke, Anna Sintsova, Pedro Beltrao, Julius Brennecke, Madhav Jagannathan

“…We further demonstrate that this gonadal atrophy can be rescued by mutating the checkpoint kinase, Chk2, which mediates germ cell arrest in response to transposon mobilization. Thus, we reveal that a satellite DNA-binding protein functions during embryogenesis to silence transposons, in a manner that is heritable across later stages of development.…”
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Effects of Physical Exercise Breaks on Executive Function in a Simulated Classroom Setting: Uncovering a Window into the Brain by Qian Yu, Zhihao Zhang, Sebastian Ludyga, Kirk I. Erickson, Boris Cheval, Meijun Hou, Dominika M. Pindus, Charles H. Hillman, Arthur F. Kramer, Ryan S. Falck, Teresa Liu‐Ambrose, Jin Kuang, Sean P. Mullen, Keita Kamijo, Toru Ishihara, David A. Raichlen, Matthew Heath, David Moreau, André O. Werneck, Fabian Herold, Liye Zou

“…Behavioral outcomes, retinal vessel diameters (central retinal artery equivalents [CRAE], retinal vein equivalents [CRVE], arteriovenous ratio [AVR]), cortical activation, and effective connectivity were evaluated. …”
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Federal Deep Learning Approach of Intrusion Detection System for In-Vehicle Communication Network Security by In-Seop Na, Anandakumar Haldorai, Nithesh Naik

“…Additionally, it is capable of arresting temporal dependencies over time in the information. …”
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Captopril Pretreatment Produces an Additive Cardioprotection to Isoflurane Preconditioning in Attenuating Myocardial Ischemia Reperfusion Injury in Rabbits and in Humans by Yi Tian, Haobo Li, Peiyu Liu, Jun-mei Xu, Michael G. Irwin, Zhengyuan Xia, Guogang Tian

“…Rabbit MI/R model was induced by occluding coronary artery for 30 min followed by 2-hour reperfusion. …”
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Halofuginone prevents inflammation and proliferation of high-altitude pulmonary hypertension by inhibiting the TGF-β1/Smad signaling pathway by Jiangtao Wang, Lina Guan, Jian Yu, Bohua Ma, Huihua Shen, Guozhu Xing, Yawei Xu, Qiufang Li, Juan Liu, Qin Xu, Wenhui Shi, Jia He, Yixuan Huang, Dongfeng Yin, Wu Li, Rui Wang

“…Abstract The inflammatory response of lung tissue and abnormal proliferation of pulmonary artery smooth muscle cells are involved in the pathogenesis of high-altitude pulmonary hypertension (HAPH). …”
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Gender-affirming hormone therapy: effects on cardiovascular risk and vascular function by Kirsty A McGinley, Angela K Lucas-Herald, Paul Connelly, Christian Delles

“…In transgender men, there was evidence of negative changes in CVD risk profile, including atherogenic changes in lipids and increased haemoglobin, arterial stiffness and pro-inflammatory markers. Conclusions: There is a paucity of research across non-traditional measures of CVD risk, which in combination with heterogeneous study design, loss of follow-up, low sample sizes and lack of diversity in age and ethnicity requires the results to be interpreted with caution. …”
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Paciente con carcinoma papilar de mama ulcerado by Leyanis González Baigorría, Ilian Esteban Tarife Romero, Luis Manuel Abreu Pereira, Adriel Herrero Díaz

“…Caso Clínico: Paciente femenina de 84 años con antecedentes de hipertensión arterial, acudió a la consulta de mastología donde se detectó una masa palpable de 8 cm ulcerada, sangrante y con cambios de coloración de la piel. …”
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Early Poststroke Rehabilitation Using a Robotic Tilt-Table Stepper and Functional Electrical Stimulation by Alexey N. Kuznetsov, Natalia V. Rybalko, Vadim D. Daminov, Andreas R. Luft

“…In 52% of controls mean arterial pressure decreased by %. ROBO-FES increased leg strength by points, ROBO by more than control (, ). …”
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In-stent chronic coronary occlusion. Efficiency of revascularization and recanalization technique by S.M. Furkalo

“…Most often (38.2 %), stent occlusion was recorded in the left anterior descending artery. Results. Our results indicate that in the presence of conical (typed) proximal and distal occlusion cups, the recanalization efficiency was the greatest (86.6 %), providing intraluminal guidewire advancement both with antegrade access and in the case of a retrograde approach for recanalization of chronic occlusions in the stent. …”
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