p19Arf suppresses growth, progression, and metastasis of Hras-driven carcinomas through p53-dependent and -independent pathways. by Karen S Kelly-Spratt, Kay E Gurley, Yutaka Yasui, Christopher J Kemp

“…Ectopic expression of oncogenes such as Ras induces expression of p19(Arf), which, in turn, activates p53 and growth arrest. Here, we used a multistage model of squamous cell carcinoma development to investigate the functional interactions between Ras, p19(Arf), and p53 during tumor progression in the mouse. …”
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Evolution of sample-based music authorship network by Dongju Park, Juyong Park

“…First, the community structure in the artist–sample network is identified, and its relationship to distinctive musical styles and flavors is verified. …”
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The Long-Term Outcome Comparison of Different Time-Delayed Kallikrein Treatments in a Mouse Cerebral Ischemic Model by Yaohui Ni, Kefu Cai, Yujie Hu, Chuan-hui Wang, Yuanyuan Zhang, Hua Huang, Xing Su, Jin-hua Gu

“…Human tissue kallikrein was injected through the tail vein daily starting at 8 h, 24 h, or 36 h after right middle cerebral artery occlusion (MCAO) until the 28th day. Three therapeutic regimens all protected against neurological dysfunction, but kallikrein treatment starting at 8 h after MCAO had the best efficacy. …”
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Brain Imaging and Ultrastructural Studies of the Effect of Electroacupuncture on Improving Learning and Memory Impairments in the Focal Cerebral Isch-emia Rats by Ruhui LIN, Kunqiang YU, Xiaojie LI, Congkuai ZHAO, Chunyan LI

“…A modified occlusion method was used to establish the middle cerebral artery occlusion(MCAO)focal cerebral ischemia-reperfusion (I/R) injury model in the IC group and the EA group. …”
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Leclercia adecarboxylata Cholecystitis with Septic Shock in Immunocompetent Patient by Nooraldin Merza, John Lung, Ahmed Taha, Ahmed Qasim, Jill Frost, Tarek Naguib

“…The patient was on the maximum doses of vasopressin, norepinephrine, and epinephrine with a blood pressure of 75/45 and a mean arterial pressure of 51. She passed away on the fourth day of admission.…”
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Radiosensitivity and Induction of Apoptosis by High LET Carbon Ion Beam and Low LET Gamma Radiation: A Comparative Study by Atanu Ghorai, Nitai P. Bhattacharyya, Asitikantha Sarma, Utpal Ghosh

“…Both 12C and gamma induced G2/M arrest although the 12C had greater effect. Unlike the gamma, 12C irradiation affects DNA replication as detected by S-phase delay in cell cycle analysis. …”
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Estimates of Prevalence of Pulmonary Hypertension according to Different International Definitions by Richa Tyagi, Surya Kant, Akshyaya Pradhan, Anupam Wakhlu, Darshan Kumar Bajaj, Jyoti Bajpai

“…The importance of early detection of this complication has been realized worldwide, and recently, the definition of pulmonary hypertension was revised to set the cutoff of mean pulmonary artery pressure (mPAP) at 20 mmHg instead of 25 mmHg at rest. …”
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Overexpression of metalloproteinase PAPPA accelerates cancer progression and correlates with immune cell infiltration in gastric cancer: insights from bioinformatics and in vitro i... by Shiya Yu, Shiyao Zheng, Jinwei Qiu, Hongming Lin, Xiaojuan Yu, Huiyan Chen, Junhong Wu, Weihang Wu, Jiong Chen, Yongyuan Chen, Jianwei Chen, Hu Zhao, Yu Wang

“…Cellular experiments have shown that PAPPA promotes cell proliferation, and its deficiency can inhibit the proliferation of GC cells, inducing cell cycle arrest at the G1/S phase. Conclusions The findings of this investigation suggest that PAPPA serves as a crucial modulator of GC, underscoring its potential as a GC treatment target.…”
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Successful Management of Thyrocervical Trunk Aneurysm Ruptured into the Thoracic Cavity After Cesarean Section in Nonstable Patient with Neurofibromatosis Type I by Nikola Mirković, Marko Prokić, Marija Novčić, Miloš Arsenijević, Snežana Sretenović, Dragan Knežević, Vojin Kovačević, Marija Šorak, Olivera Kostić

“…Urgent computer tomography angiography procedure showed extracranial artery, thyrocervical trunk aneurysm rupture, and vertebral aneurysm without rupture. …”
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Effectiveness of Work and Technology Projects in Acquiring Scientific Skills of First Secondary Students with Emphasis on Fundamental Transformation Document of Education by Mokhtar Zakeri, Marjan Moayeri

“…Five scientific fields are needed to improve students' skills: technology, financial, ethical, motivational, and artistic. The fundamental transformation document of education focuses on work and technology projects. …”
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RNA N4‐acetylcytidine modification and its role in health and diseases by Qiang Wang, Yixiao Yuan, Qiang Zhou, YingDong Jia, Jing Liu, GuangJun Xiao, Chunhong Li, Xiulin Jiang

“…Furthermore, this review delves into the central roles and molecular mechanisms of ac4C modification in regulating malignant proliferation, cell cycle arrest, EMT, drug resistance, cell death, cancer metabolism, and tumor immunotherapy. …”
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A case report of anaplastic thyroid carcinoma transformed from small papillary carcinoma successfully detected by ultrasonography in its early stage with review of literature by Hiroshi Arimitsu, Yui Nishijima, Naoyuki Higaki, Hitoshi Noguchi, Shinya Uchino, Tsukasa Murakami

“…After 23 months, the preexisting nodule had expanded toward the common carotid artery. The expanded portion was round and well demarcated. …”
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Application of dynamic enhanced scanning with GD-EOB-DTPA MRI based on deep learning algorithm for lesion diagnosis in liver cancer patients by Bo Liu, Jinhua Yang, Yifei Wu, Xi Chen, Xueru Wu

“…Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI) technology is in high demand.ObjectivesThe purpose of the study is to segment the liver using an enhanced multi-gradient deep convolution neural network (EMGDCNN) and to identify and categorize a localized liver lesion using a Gd-EOB-DTPA-enhanced MRI.MethodsWe provided the classifier images of the liver in five states (unenhanced, arterial, portal venous, equilibrium, and hepatobiliary) and labeled them with localized liver diseases (hepatocellular carcinoma, metastasis, hemangiomas, cysts, and scarring). …”
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The Change of Left Ventricular Function in Rats with Subclinical Hypothyroid and the Effects of Thyroxine Replacement by Xuedi Chen, Cuixia Gao, Ningning Gong, Yu Wang, Limin Tian

“…Serum TT4, TSH, APN, chemerin, and TNF-α were detected by radioimmunoassay kits and ELISA kits; left ventricular function was measured by PowerLab system via subclavian artery catheter. The expression of Serca2a, Ryr2, APN, chemerin, and TNF-α were detected by RT-PCR, Western blot, and immunohistochemistry. …”
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Hostility Modifies the Association between TV Viewing and Cardiometabolic Risk by Anthony Fabio, Chung-Yu Chen, Kevin H. Kim, Darin Erickson, David R. Jacobs, Janice C. Zgibor, Tammy Chung, Karen A. Matthews, Steven Sidney, Carlos Iribarren, Mark A. Pereira

“…A total of 3,269 Black and White participants in the coronary artery risk development in young adults (CARDIA) study were assessed from age 23 to age 35. …”
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Prophylactic Subacute Administration of Zinc Increases CCL2, CCR2, FGF2, and IGF-1 Expression and Prevents the Long-Term Memory Loss in a Rat Model of Cerebral Hypoxia-Ischemia by Victor Manuel Blanco-Alvarez, Guadalupe Soto-Rodriguez, Juan Antonio Gonzalez-Barrios, Daniel Martinez-Fong, Eduardo Brambila, Maricela Torres-Soto, Ana Karina Aguilar-Peralta, Alejandro Gonzalez-Vazquez, Constantino Tomás-Sanchez, I. Daniel Limón, Jose R. Eguibar, Araceli Ugarte, Jeanett Hernandez-Castillo, Bertha Alicia Leon-Chavez

“…We explored whether zinc prevents the cerebral cortex-hippocampus injury through regulation of CCL2, CCR2, FGF2, and IGF-1 expression following a 10 min of common carotid artery occlusion (CCAO). Male rats were grouped as follows: (1) Zn96h, rats injected with ZnCl2 (one dose every 24 h during four days); (2) Zn96h + CCAO, rats treated with ZnCl2 before CCAO; (3) CCAO, rats with CCAO only; (4) Sham group, rats with mock CCAO; and (5) untreated rats. …”
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Más de 2350 años de dinámica lacustre en la Cuenca de Magdalena, Jalisco. Un hallazgo en La isla de Atitlán que hace evidente a una población hacedora de tumbas de tiro by Ericka Sofia Blanco Morales, Axl Eduardo Rosales Rodríguez, Valeria Montserrat Sauza Nuñez

“… En la Cuenca de Magdalena en el estado de Jalisco se reconocen arqueológicamente, por lo menos, cinco culturas o tradiciones que representan a grupos sedentarios que desde hace 4000 años basaron su economía en la agricultura, aprovechamiento de recursos, trabajo artesanal e intercambio. Una de las tradiciones arqueológicas más tempranas es la tradición Teuchitlán y/o Tumba de tiro, la cual se caracterizó, entre otras cosas, por sus construcciones mortuorias. …”
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Assessment and zoning of the geomorphological quality of Vardavard river in Tehran by negar mirzaii, ali ahmadabadi, Seyed morovat eftekhari, elaheh lofti

“…Rivers are always vital arteries of the earth and naturally, they have a gradual and continuous development process which has undergone fundamental changes after the expansion of human settlements and urban development and they have lost some of their natural functions. …”
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Part 3. Clinical Practice Guideline for Airway Management and Emergency Thoracotomy for Trauma Patients from the Korean Society of Traumatology by Chan Yong Park, O Hyun Kim, Sung Wook Chang, Kang Kook Choi, Kyung Hak Lee, Seong Yup Kim, Maru Kim, Gil Jae Lee, Korean Society of Traumatology (KST) Clinical Research Group

“…Resuscitative thoracotomy is recommended for trauma patients with penetrating injuries undergoing cardiac arrest or shock in the emergency room (1B).…”
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Bioinspired hierarchical porous tough adhesive to promote sealing of high-pressure bleeding by Yinghao Li, Dongling Xiao, Weixi Yan, Meilin Jiang, Ju Tan, Zhongliang Qin, Jingting Zhou, Yue Sun, Mingcan Yang, Guanyuan Yang, Yawei Gu, Yong Liu, Chuhong Zhu

“…The currently widely used hemostatic bioadhesives are ineffective for hemorrhage from major arteries and the heart due to the absence of biologically compatible flexible structures capable of simultaneously ensuring conformal tough adhesion and biomechanical support. …”
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