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  1. 1001

    Heart-on-a-chip: a revolutionary organ-on-chip platform for cardiovascular disease modeling by Beiqin Liu, Shuyue Wang, Hong Ma, Yulin Deng, Jichen Du, Yimeng Zhao, Yu Chen

    Published 2025-01-01
    “…Traditional preclinical models, such as 2D cell cultures model and animal model, have limitations in accurately predicting human response to cardiovascular diseases and treatments. …”
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  5. 1005

    The Opportunistic Pathogen Listeria monocytogenes: Pathogenicity and Interaction with the Mucosal Immune System by Markus Schuppler, Martin J. Loessner

    Published 2010-01-01
    “…It was recently found that the bacterium can also cause acute, self-limiting febrile gastroenteritis in healthy individuals. …”
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  6. 1006
  7. 1007

    Enhancing human ACE2 expression in mouse models to improve COVID‐19 research by Sun Jiaoyang, Cheng Shaofei, Hong Guangliang, Quan Xiongzhi, Lin Haofeng, Mao Rui, Johannes Grillari, Shi Zheng‐Li, Chen Jiekai, Liu Meiqin, Wu Haoyu, Wu Guangming

    Published 2025-02-01
    “…Although mice with human ACE2 (hACE2) driven by Ace2 promoter reflect its tissue specificity, these animals exhibit low ACE2 expression, potentially limiting their fidelity in mimicking COVID‐19 manifestations and their utility in viral studies. …”
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  8. 1008
  9. 1009

    Temperature and repeated catecholamine surges modulate regional wall motion abnormalities in a rodent takotsubo syndrome model by Ermir Zulfaj, AmirAli Nejat, Abdulhussain Haamid, Aaron Espinosa, Ahmed Elmahdy, Tetiana Pylova, Sandeep Jha, Björn Redfors, Elmir Omerovic

    Published 2025-01-01
    “…This study validates the small-animal TS model by replicating patient findings, and emphasizing the importance of controlling body temperature and limiting adrenergic drug use in managing TS. …”
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    Carbon-Based Materials as Effective Adsorbents for the Removal of Pharmaceutical Compounds from Aqueous Solution by Chian Ying Teo, Jim Sii Jack Jong, Yee Qian Chan

    Published 2022-01-01
    “…Antibiotics are generally released via hospital effluents, industrial production waste, animal manure, and irrigated agricultural land. Antibiotic residues can harm all living organisms, with the most detrimental consequence being the generation of antibiotic-resistant microorganisms, commonly known as “superbugs.” …”
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  13. 1013

    When Shepherds Mine Mountains: The Impact of Artisanal Mining on Agropastoral Systems in Kyrgyzstan. Case Study of Naryn Province by Irène Mestre

    Published 2017-03-01
    “…Thus, the co-existence of high income–generating activities and traditional activities such as agropastoralism does not limit community-based management and can even be a lever for a dynamic process that helps to support the creation of management rules.…”
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  14. 1014

    An optimized method for counting viral particles using electron microscopy by B. N. Zaitsev, O. S. Taranov, N. B. Rudometova, N. S. Shcherbakova, A. A. Ilyichev, L. I. Karpenko

    Published 2019-05-01
    “…Viruses can infect all types of life forms, from animals and plants to microorganisms, including bacteria and archaea. …”
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  15. 1015

    Brain targeting based nanocarriers loaded with resveratrol in Alzheimer's disease: A review by Cyrus Jalili, Amir Kiani, Mohammadreza Gholami, Fariborz Bahrehmand, Sajad Fakhri, Somayeh Kakehbaraei, Seyran Kakebaraei

    Published 2023-05-01
    “…This antioxidant compound, however, barely crosses the blood–brain barrier (BBB), thereby limiting its bioavailability and stability at the target sites in the brain. …”
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  16. 1016

    Early life gut microbiome and its impact on childhood health and chronic conditions by Harold Nunez, Pamela A. Nieto, Ruben A. Mars, Maryam Ghavami, Cheryl Sew Hoy, Kimberley Sukhum

    Published 2025-12-01
    “…Other challenges are methodological: small sample sizes, lack of longitudinal studies, and poor control of confounding variables. To address these limitations, we advocate for more robust research methodologies to better understand the microbiome’s role in health and disease. …”
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  17. 1017

    Multifaceted neuroprotective effects of (-)-epigallocatechin-3-gallate (EGCG) in Alzheimer’s disease: an overview of pre-clinical studies focused on β-amyloid peptide by Kumju Youn, Chi-Tang Ho, Mira Jun

    Published 2022-05-01
    “…AD has a complex pathogenic mechanism, and a single-target approach for anti-AD strategy is thus full of challenges. To overcome these limitations, the present study focused to review on one of multiple target-compounds, (–)-epigallocatechin-3-gallate (EGCG) for the prevention and treatment of AD. …”
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  18. 1018

    Enhanced antitumor efficacy through sustained release of 5-fluorouracil from poly(trimethylene carbonate) membranes by Zongheng Wang, Zhipeng Hou, Shuguang Zhang, Shuangyi Ren, Liqun Yang, Qianshi Zhang

    Published 2025-01-01
    “…IntroductionCancer remains one of the deadliest diseases worldwide. 5-Fluorouracil (5-FU) is one of the most commonly used chemotherapeutic agents in clinical practice today, but its effectiveness is often hampered by rapid drug metabolism and systemic toxicity. To address these limitations, the development of novel drug delivery systems for sustained drug release is essential to improve therapeutic outcomes.MethodsThis study aimed to develop a poly(trimethylene carbonate) (PTMC) membrane capable of sustained drug release of 5-FU to enhance its antitumor activity. …”
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  19. 1019

    Versatility of Chitosan-Based Biomaterials and Their Use as Scaffolds for Tissue Regeneration by José Carlos Viana Ribeiro, Rodrigo Silveira Vieira, Iracema Matos Melo, Vilana Maria Adriano Araújo, Vilma Lima

    Published 2017-01-01
    “…The results demonstrated the effectiveness of chitosan-based biomaterials in 93.4% of the studies reviewed, whether or not combined with cells and growth factors, in the regeneration of various types of tissues in animals. However, the absence of clinical studies in humans, the inadequate experimental designs, and the lack of information concerning chitosan’s characteristics limit the reproducibility and relevance of studies and the clinical applicability of chitosan.…”
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  20. 1020

    Validation of a triiodothyronine (T3) ELISA for mouse fecal samples by Lucia M. Thompson, Brailey M. Coulter, Cinnamon L. VanPutte

    Published 2024-11-01
    “…Because there are interactions between glucocorticoids and thyroid hormones (T3 and T4), reducing the animal's “distress” during sample collection is imperative. …”
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