SPIRIT-DEFINE explanation and elaboration: recommendations for enhancing quality and impact of early phase dose-finding clinical trials protocolsResearch in context by Moreno Ursino, Guillermo Villacampa, Jan Rekowski, Munyaradzi Dimairo, Olga Solovyeva, Deborah Ashby, Jordan Berlin, Oliver Boix, Melanie Calvert, An-Wen Chan, Courtney H. Coschi, Thomas R. Jeffry Evans, Elizabeth Garrett-Mayer, Robert M. Golub, Christina Guo, Kathryn S. Hayward, Sally Hopewell, John D. Isaacs, S. Percy Ivy, Thomas Jaki, Olga Kholmanskikh, Andrew Kightley, Shing Lee, Rong Liu, Adrian Mander, Lynley V. Marshall, James Matcham, Dhrusti Patel, Richard Peck, Khadija Rerhou Rantell, Dawn P. Richards, Mahtab Rouhifard, Lesley Seymour, Yoshiya Tanaka, Christopher J. Weir, Johann de Bono, Christina Yap

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CONSORT-DEFINE explanation and elaboration: recommendations for enhancing reporting quality and impact of early phase dose-finding clinical trialsResearch in context by Jan Rekowski, Christina Guo, Olga Solovyeva, Munyaradzi Dimairo, Mahtab Rouhifard, Dhrusti Patel, Emily Alger, Deborah Ashby, Jordan Berlin, Oliver Boix, Melanie Calvert, An-Wen Chan, Courtney H. Coschi, Johann de Bono, Thomas R. Jeffry Evans, Elizabeth Garrett–Mayer, Robert M. Golub, Kathryn S. Hayward, Sally Hopewell, John D. Isaacs, S. Percy Ivy, Thomas Jaki, Olga Kholmanskikh, Andrew Kightley, Shing Lee, Rong Liu, Israel Maia, Adrian Mander, Lynley V. Marshall, James Matcham, Richard Peck, Khadija Rerhou Rantell, Dawn P. Richards, Lesley Seymour, Yoshiya Tanaka, Moreno Ursino, Christopher J. Weir, Christina Yap

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PROcalcitonin and NEWS2 evaluation for Timely identification of sepsis and Optimal use of antibiotics in the emergency department (PRONTO): protocol for a multicentre, open-label,... by David Taylor-Robinson, Steve Goodacre, Neil French, Richard Body, Kerenza Hood, Emma Thomas-Jones, Jane Daniels, Sarah Walker, Ingeborg Welters, Mike Bradburn, Paul Schmidt, Enitan Carrol, Lucy Brookes-Howell, Sarah Milosevic, Andrew Tabner, Philip Pallmann, Stephen Aston, Gavin Barlow, Emma Richards, Emmanuel Nsutebu, Philip Howard, Matthew Inada-Kim, Stacy Todd, Fiona McGill, Martin Llewelyn, Louis Wihelmus Niessen, Joanne Euden, Julie Carman, Stephanie Gilbert, Sam Clarkstone, Jacqui Hughes, Lena Meister, Angela Brain, Matthew Scarborough, Sian O'Shea, Claire James

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Improving explainability of post-separation suicide attempt prediction models for transitioning service members: insights from the Army Study to Assess Risk and Resilience in Servi... by Emily R. Edwards, Joseph C. Geraci, Sarah M. Gildea, Claire Houtsma, Jacob A. Holdcraft, Chris J. Kennedy, Andrew J. King, Alex Luedtke, Brian P. Marx, James A. Naifeh, Nancy A. Sampson, Murray B. Stein, Robert J. Ursano, Ronald C. Kessler

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Estimating the global cost of vision impairment and its major causes: protocol for a systematic review by Nathan Congdon, Thomas Butt, Peng Tee Khaw, Andrew Bastawrous, Tasanee Braithwaite, Rupert R A Bourne, Matthew J Burton, Serge Resnikoff, Jacqueline Ramke, Kevin Frick, Hugh Taylor, Iris Gordon, Ana Patricia Marques, John Cairns, Justine H Zhang, Hannah B Faal, Iain Jones, Marty Jovic, Allyala Nandakumar

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Corrigendum to “Cardiovascular disease outcomes among established cigar users 40 years and older: Findings from the population assessment of tobacco and health (PATH) study, Waves... by Eva Sharma, Zhiqun Tang, Kristin Lauten, Marushka L. Silveira, Cristine D. Delnevo, Kathryn C. Edwards, Daniela Marshall, Diann E. Gaalema, Izabella Zandberg, Bria Graham-Glover, Derick L. Rivers, Omoye E. Imoisili, Kirstie Neal, Raymond Niaura, Maansi Bansal-Travers, Andrew Hyland, K. Michael Cummings

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Therapeutic benefit of the dual ALK/FAK inhibitor ESK440 in ALK-driven neuroblastoma by Seema Chugh, Jean C. Tien, Jennifer Hon, Carson Kenum, Rahul Mannan, Yunhui Cheng, Chi Chiang Li, Zainab I. Taher, Andrew D. Delekta, Pushpinder Singh Bawa, Ingrid J. Apel, Stephanie J. Miner, Xuhong Cao, Rohit Mehra, Saravana M. Dhanasekaran, Yuanyuan Qiao, Rajen Mody, Arul M. Chinnaiyan

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Caregiver worry about COVID-19 as a predictor of social mitigation behaviours and SARS-CoV-2 infection in a 12-city U.S. surveillance study of households with children by Steven M. Brunwasser, Tebeb Gebretsadik, Anisha Satish, Jennifer C. Cole, William D. Dupont, Christine Joseph, Casper G. Bendixsen, Agustin Calatroni, Samuel J. Arbes, Jr, Patricia C. Fulkerson, Joshua Sanders, Leonard B. Bacharier, Carlos A. Camargo, Jr, Christine Cole Johnson, Glenn T. Furuta, Rebecca S. Gruchalla, Ruchi S. Gupta, Gurjit K. Khurana Hershey, Daniel J. Jackson, Meyer Kattan, Andrew Liu, George T. O'Connor, Katherine Rivera-Spoljaric, Wanda Phipatanakul, Marc E. Rothenberg, Max A. Seibold, Christine M. Seroogy, Stephen J. Teach, Edward M. Zoratti, Alkis Togias, Tina V. Hartert

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FERN: is it possible to conduct a randomised controlled trial of intervention or expectant management for early-onset selective fetal growth restriction in monochorionic twin pregn... by Kerry Woolfall, Jamie J Kirkham, Jane Sandall, Mariana Popa, Enrico Lopriore, Mark Turner, Shakila Thangaratinam, Aris T Papageorghiou, Andrew Sharp, Lawrence Impey, Andy Healey, Jessica Mendoza, Asma Khalil, Dharmintra Pasupathy, Brigitte Vollmer, Zarko Alfirevic, Rajeswari Parasuraman, Jan Deprest, Richard Edmund Ashcroft, Kurt Hecher, Smriti Prasad, Baskaran Thilaganathan, Richard J Jackson, Tracy Karen Mitchell, Natasha Fenwick, Monique C Haak, Liesbeth Lewi, Shauna Leven, Fabricio Da Silva Costa, Odai Yaghi, Tracey Ricketts, George Attilakos, Carolyn Bailie, Christine Cornforth, Mark Denbow, Louise Hardman, Jane Harrold, Joel Marsden, Tommy Mousa, Surabhi Nanda, Michelle Watson, Karen Wilding, Dilly Anumba, Edward D Johnstone, Yoav Yinon, Ahmet Baschat

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Functionally important respiratory symptoms and continued cigarette use versus e-cigarette switching: population assessment of tobacco and health study waves 2-6Research in context by James D. Sargent, Kristin Lauten, Kathryn C. Edwards, Susanne E. Tanski, Todd A. MacKenzie, Laura M. Paulin, Mary F. Brunette, Maciej L. Goniewicz, Amanda Malasky, Debra Stark, Fernando B. de Moura, Holly Griffin, Kimberly H. Nguyen, Eric Backlund, Heather L. Kimmel, John H. Kingsbury, Jenny E. Ozga, K Michael Cummings, Andrew Hyland

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Optimal timing of organs-at-risk-sparing adaptive radiation therapy for head-and-neck cancer under re-planning resource constraints by Fatemeh Nosrat, Cem Dede, Lucas B. McCullum, Raul Garcia, Abdallah S.R. Mohamed, Jacob G. Scott, James E. Bates, Brigid A. McDonald, Kareem A. Wahid, Mohamed A. Naser, Renjie He, Aysenur Karagoz, Amy C. Moreno, Lisanne V. van Dijk, Kristy K. Brock, Jolien Heukelom, Seyedmohammadhossein Hosseinian, Mehdi Hemmati, Andrew J. Schaefer, Clifton D. Fuller

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Cluster randomised controlled trial of screening for atrial fibrillation in people aged 70 years and over to reduce stroke: protocol for the pilot study for the SAFER trial by Martin R Cowie, Stephen Morris, Gregory Lip, Richard J McManus, Stephen Sutton, Jonathan Mant, Simon J Griffin, Sarah Hoare, Jenni Burt, Rachel Johnson, Mark Lown, Alison Powell, Natalie Armstrong, FD Richard Hobbs, Trudie Lobban, Rakesh Narendra Modi, Ben Freedman, David A Fitzmaurice, Stephen Kaptoge, Jenny Lund, Duncan Edwards, Kate Williams, H Thom, Francesco Fusco, Michael J Sweeting, Andrew Dymond, The SAFER Authorship Group

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Pancreaticoduodenectomy in trauma patients with grade IV–V duodenal or pancreatic injuries: a post hoc analysis of an EAST multicenter trial by Jeffry Nahmias, Daniel N Holena, Bellal Joseph, Martin Schreiber, Lisa M Kodadek, Mayur Narayan, Grace Chang, Joe Patton, Abid Khan, Mark Seamon, Jessica H Beard, Michelle T Bover Manderski, Michael A Vella, Ryan Peter Dumas, Haytham Kaafarani, Alison A Smith, Rachel Leah Choron, Christopher Bargoud, Amanda L Teichman, Francesk Mulita, Christine T Trankiem, Hashim Ahmed, Aaron Anderson, Odessa Pulido, Caleb Mentzer, Jane Keating, Mira Ghneim, Reynold Henry, Dane R Scantling, Andrew Benjamin, Christopher W Foote, Carlos H Palacio, Randi N Smith, Meghan Jonikas, Dias Argandykov, Jason D Sciarretta, Joshua P Hazelton, Pascal Udekwu, Jordan Michael Kirsch, Charoo Piplani, Julia Kuzinar, Dustin Hanos, Iman N Afif, Navpreet Kaur Dhillon, Ashling Zhang, Rebekah Devasahayam, Oliver Gunter, Brandi Sun, Chloe S Cao, Jessica K Reynolds, Lauren A Hilt, Karla Echeverria-Rosario, Nathaniel S Fung, Caitlin A Fitzgerald, Jeremy H Levin, JaeHee Yoon, Jacqueline Blank, Christopher J McLaughlin, Rami Al-Aref, Daniel S Howard, Kate Dellonte, Brent Hopkins, Chloe Shell, Evan G Wong, Howard Lieberman, Walter A Ramsey, Collin H Stewart, Claudia Alvarez, John D Berne, Ivan Puente, Ilya Rakitin, Lindsey Perea, Jason Wade, Laura K Mann, Vasileios Mousafeiris, Shari Reid-Gruner, Erica Sais, Lilamarie Moko

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MERS-CoV spike vaccine-induced N-terminal domain-specific antibodies are more protective than receptor binding domain-specific antibodies by Olubukola M. Abiona, Nianshuang Wang, Sarah R. Leist, Alexandra Schäfer, Adam S. Cockrell, Lingshu Wang, Sandhya Bangaru, Laura Stevens, Rachel L. Graham, Jacob F. Kocher, Yaroslav Tsybovsky, Masaru Kanekiyo, Azad Kumar, Kaitlyn M. Morabito, Osnat Rosen, Wei Shi, Anne Werner, Yi Zhang, Cynthia Ziwawo, Christian K.O. Dzuvor, Charis Palandjian, Connor Eastman, Hannah R. Matthews, Jeswin Joseph, James D. Chappell, Wing-Pui Kong, John R. Mascola, Andrew B. Ward, Mark R. Denison, Ralph Baric, Jason S. McLellan, Barney S. Graham, Kizzmekia S. Corbett-Helaire

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Correction: Surgical stabilization of rib fractures (SSRF): the WSES and CWIS position paper by Giacomo Sermonesi, Riccardo Bertelli, Fredric M. Pieracci, Zsolt J. Balogh, Raul Coimbra, Joseph M. Galante, Andreas Hecker, Dieter Weber, Zachary M. Bauman, Susan Kartiko, Bhavik Patel, SarahAnn S. Whitbeck, Thomas W. White, Kevin N. Harrell, Daniele Perrina, Alessia Rampini, Brian Tian, Francesco Amico, Solomon G. Beka, Luigi Bonavina, Marco Ceresoli, Lorenzo Cobianchi, Federico Coccolini, Yunfeng Cui, Francesca Dal Mas, Belinda De Simone, Isidoro Di Carlo, Salomone Di Saverio, Agron Dogjani, Andreas Fette, Gustavo P. Fraga, Carlos Augusto Gomes, Jim S. Khan, Andrew W. Kirkpatrick, Vitor F. Kruger, Ari Leppäniemi, Andrey Litvin, Andrea Mingoli, David Costa Navarro, Eliseo Passera, Michele Pisano, Mauro Podda, Emanuele Russo, Boris Sakakushev, Domenico Santonastaso, Massimo Sartelli, Vishal G. Shelat, Edward Tan, Imtiaz Wani, Fikri M. Abu-Zidan, Walter L. Biffl, Ian Civil, Rifat Latifi, Ingo Marzi, Edoardo Picetti, Manos Pikoulis, Vanni Agnoletti, Francesca Bravi, Carlo Vallicelli, Luca Ansaloni, Ernest E. Moore, Fausto Catena

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Surgical stabilization of rib fractures (SSRF): the WSES and CWIS position paper by Giacomo Sermonesi, Riccardo Bertelli, Fredric M. Pieracci, Zsolt J. Balogh, Raul Coimbra, Joseph M. Galante, Andreas Hecker, Dieter Weber, Zachary M. Bauman, Susan Kartiko, Bhavik Patel, SarahAnn S. Whitbeck, Thomas W. White, Kevin N. Harrell, Daniele Perrina, Alessia Rampini, Brian Tian, Francesco Amico, Solomon G. Beka, Luigi Bonavina, Marco Ceresoli, Lorenzo Cobianchi, Federico Coccolini, Yunfeng Cui, Francesca Dal Mas, Belinda De Simone, Isidoro Di Carlo, Salomone Di Saverio, Agron Dogjani, Andreas Fette, Gustavo P. Fraga, Carlos Augusto Gomes, Jim S. Khan, Andrew W. Kirkpatrick, Vitor F. Kruger, Ari Leppäniemi, Andrey Litvin, Andrea Mingoli, David Costa Navarro, Eliseo Passera, Michele Pisano, Mauro Podda, Emanuele Russo, Boris Sakakushev, Domenico Santonastaso, Massimo Sartelli, Vishal G. Shelat, Edward Tan, Imtiaz Wani, Fikri M. Abu-Zidan, Walter L. Biffl, Ian Civil, Rifat Latifi, Ingo Marzi, Edoardo Picetti, Manos Pikoulis, Vanni Agnoletti, Francesca Bravi, Carlo Vallicelli, Luca Ansaloni, Ernest E. Moore, Fausto Catena

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Towards a common approach for managing food allergy and serious allergic reactions (anaphylaxis) at school. GA2LEN and EFA consensus statement by Antoine Deschildre, Montserrat Alvaro‐Lozano, Antonella Muraro, Marcia Podesta, Debra deSilva, Mattia Giovannini, Simona Barni, Timothy E. Dribin, Mónica Sandoval‐Ruballos, Aikaterini Anagnostou, Alessandro Fiocchi, Alice Toniolo, Andrew Bird, Angel Sánchez Sanz, Anna Asarnoj, Anna Nowak‐Wegrzyn, Berber Vlieg‐Boerstra, Brian P. Vickery, Carina Venter, Caroline Nilsson, Cecilia Parente, Céline Demoulin, David M. Fleischer, Diola Bijlhout, Edward F. Knol, Eleanor Garrow, Emma E. Cook, Fallon Schultz, Francesca Lazzarotto, Francesca Mori, Gary Wong, Gideon Lack, Graham Roberts, Gustavo Andres Marino, H. N. G. Oude Elberink, Helen A. Brough, Hugh A. Sampson, Jay Lieberman, Jennifer Gerdts, Jing Zhao, Josefine Gradman, Julia E. M. Upton, Julie Wang, Kati Palosuo, Kirsi M. Järvinen, Kirsten Beyer, Kunling Shen, Laura Polloni, Lianne Mandelbaum, Luciana Kase Tanno, Lucy A. Bilaver, Marcus S. Shaker, Margitta Worm, Maria Said, Mary Kelly, Mary Jane Marchisotto, Michael Makris, Mikaela Odemyr, Montserrat Fernandez‐Rivas, Motohiro Ebisawa, Nandinee Patel, Pablo Rodríguez del Río, Pakit Vichyanond, Paul Turner, Pete Smith, Pilar Morón Gaspar, R. Sharon Chinthrajah, Rima Rachid, Roberta Bonaguro, Ruchi Gupta, Sabine Schnadt, Sakura Sato, Stefania Arasi, Stephanie Leonard, Sung Poblete, Susanne Halken, Thuy‐My Le, Guillaume Pouessel, Tracey Dunn, Victoria Cardona, Torsten Zuberbier

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Association of glycemic control with Long COVID in patients with type 2 diabetes: findings from the National COVID Cohort Collaborative (N3C) by Jane E B Reusch, Rachel Wong, Nasia Safdar, Harold Lehmann, Brijesh Patel, Til Stürmer, Hongfang Liu, Peter Robinson, Elaine Hill, Richard Moffitt, Justin Guinney, Joel Gagnier, Cavin Ward-Caviness, Noha Sharafeldin, Justin Starren, Amit Saha, Lesley Cottrell, Melissa A Haendel, Margaret A Hall, Vignesh Subbian, Kristin Kostka, Farrukh M Koraishy, Andrew E Williams, Robert Hurley, Steve Johnson, Usman Sheikh, Rishi Kamaleswaran, Christopher Dillon, Michele Morris, Randeep Jawa, Hemalkumar Mehta, Benjamin Bates, Tellen D Bennett, Nabeel Qureshi, Katie Rebecca Bradwell, Federico Mariona, Adam B Wilcox, Adam M Lee, Alexis Graves, Amin Manna, Amy Olex, Andrea Zhou, Andrew Southerland, Andrew T Girvin, Anita Walden, Anjali A Sharathkumar, Benjamin Amor, Brian Hendricks, Caleb Alexander, Carolyn Bramante, Charisse Madlock-Brown, Christine Suver, Christopher Chute, Chunlei Wu, Clare Schmitt, Cliff Takemoto, Dan Housman, Davera Gabriel, David A Eichmann, Diego Mazzotti, Eilis Boudreau Don Brown, Elizabeth Zampino, Emily Carlson Marti, Emily R Pfaff, Evan French, Fred Prior, George Sokos, Greg Martin, Heidi Spratt, Hythem Sidky, JW Awori Hayanga, Jami Pincavitch, Jaylyn Clark, Jeremy Richard Harper, Jessica Islam, Jin Ge, Joel H Saltz, Joel Saltz, Johanna Loomba, John Buse, Jomol Mathew, Joni L Rutter, Julie A McMurry, Karen Crowley, Kellie M Walters, Ken Wilkins, Kenneth R Gersing, Kenrick Dwain Cato, Kimberly Murray, Lavance Northington, Lee Allan Pyles, Leonie Misquitta, Lili Portilla, Mariam Deacy, Mark M Bissell, Marshall Clark, Mary Emmett, Mary Morrison Saltz, Matvey B Palchuk, Meredith Adams, Meredith Temple-O'Connor, Michael G Kurilla, Nicole Garbarini, Ofer Sadan, Patricia A Francis, Penny Wung Burgoon, Rafael Fuentes, Rebecca Erwin-Cohen, Richard A Moffitt, Richard L Zhu, Robert T Miller, Saiju Pyarajan, Sam G Michael, Samuel Bozzette, Sandeep Mallipattu, Satyanarayana Vedula, Scott Chapman, T Shawn, Soko Setoguchi O'Neil, Stephanie S Hong, Tiffany Callahan, Umit Topaloglu, Valery Gordon, Warren A Kibbe, Wenndy Hernandez, Will Beasley, Will Cooper, William Hillegass, Xiaohan Tanner Zhang, Samuel Soff, Yun Jae Yoo, Jared Davis Huling, Daniel Brannock, Zachary Butzin-Dozier, Alfred Jerrod Anzalone, Philip RO. Payne, Rena Patel

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Obesity is South Africa’s new HIV epidemic by Nomathemba Chandiwana, Willem Venter, Jennifer Manne-Goehler, Alisha Wade, Carel le Roux, Nzama Mbalati, Angelika Grimbeek, Petronell Kruger, Eunice Montsho, Zukiswa Zimela, Anele Yawa, Sibongile Tshabalala, Ndivhuwo Rambau, Ngqabutho Mpofu, Sasha Stevenson, Bridget McNulty, Ntobeko Ntusi, Yogan Pillay, Joel Dave, Angela Murphy, Sue Goldstein, Karen Hfman, Sameera Mahomedy, Elizabeth Thomas, Busi Mrara, Jeff Wing, Jeanne Lubbe, Zack Koto, Marli Conradie-Smit, Sean Wharton, Wayne May, Ian Marr, Hilton Kaplan, Mariam Forgan, Graham Alexander, John Turner, V R Fourie, Jocelyn Hellig, Mandy Banks, Kim Ragsdale, Marisa Noeth, Farzahna Mohamed, Landon Myer, Limakatso Lebina, Salome Maswime, Yunus Moosa, Sumy Thomas, Mzamo Mbelle, Phumla Sinxadi, Linda-Gail Bekker, Sindeep Bhana, June Fabian, Eric Decloedt, Zaheer Bayat, Reyna Daya, Bilal Bobat, Fiona Storie, Julia Goedecke, Kathleen Kahn, Stephen Tollman, Brett Mansfield, Mark Siedner, Vincent Marconi, Aaloke Mody, Ntombifikile Mtshali, Elvin Geng, Suman Srinivasa, Mohammed Ali, Samanta Lalla-Edwards, Alison Bentley, Gustaaf Wolvaardt, Andrew Hill, Jeremy Nel

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History and Habitability of the LP 890-9 Planetary System by Rory Barnes, Laura N. R. do Amaral, Jessica Birky, Ludmila Carone, Peter Driscoll, Joseph R. Livesey, David Graham, Juliette Becker, Kaiming Cui, Martin Schlecker, Rodolfo Garcia, Megan Gialluca, Arthur Adams, MD Redyan Ahmed, Paul Bonney, Wynter Broussard, Chetan Chawla, Mario Damasso, William C. Danchi, Russell Deitrick, Elsa Ducrot, Emeline F. Fromont, Brandt A. L. Gaches, Sakshi Gupta, Michelle L. Hill, James A. G. Jackman, Estelle M. Janin, Mikołaj Karawacki, Matheus Daniel Koren, Roberto La Greca, Michaela Leung, Arturo Miranda-Rosete, Michael Kent A. Olohoy, Cecelia Ngo, Daria Paul, Chandan Kumar Sahu, Debajyoti Basu Sarkar, Mohammad Afzal Shadab, Edward W. Schwieterman, Melissa Sedler, Katie Texeira, Allona Vazan, Karen N. Delgado Vega, Rohit Vijayakumar, Jonathan T. Wojack

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