Systematic Review and Meta-Analysis on Human African Trypanocide Resistance by Keneth Iceland, Kasozi, Ewan Thomas, MacLeod, Susan Christina, Welburn

“…Studies to develop novel chemotherapeutical agents and identify alternative protein targets could help to reduce the emergence and spread of HATr.…”
Get full text

Two-Step Transfer Learning Improves Deep Learning–Based Drug Response Prediction in Small Datasets: A Case Study of Glioblastoma by Jie Ju, Ioannis Ntafoulis, Michelle Klein, Marcel JT Reinders, Martine Lamfers, Andrew P Stubbs, Yunlei Li

“…Our findings support the potential of oxaliplatin being an alternative therapy for patients with GBM and TL facilitating drug repurposing research. …”
Get full text

MnS/MnO heterostructures with dual ion defects for high-performance aqueous magnesium ion capacitors by Minghui Liu, Mudi Li, Siwen Zhang, Yaxi Ding, Ying Sun, Jiazhuo Li, Haixi Gu, Bosi Yin, Hui Li, Tianyi Ma

“…Hence, DID-MnS/MnO offers insightful perspectives for designing alternative clean energy sources and is expected to contribute significantly to the advancement of the clean energy sector.…”
Get full text

Effectiveness of the entomopathogenic fungus Alternaria murispora and the predatory ladybird Harmonia convergens in controlling Phenacoccus solenopsis (Tinsley) by Mohamed El Aalaoui, Said Rammali, Said Rammali, Fatima Zahra Kamal, Fatima Zahra Kamal, Gabriela Calin, Viorica Rarinca, Viorica Rarinca, Viorica Rarinca, Luminita Diana Hritcu, Alin Ciobică, Alin Ciobică, Alin Ciobică, Alin Ciobică, Mohamed Sbaghi

“…In conclusion, AM+HC proved most effective in reducing P. solenopsis densities and maintaining plant health, demonstrating its potential as a sustainable alternative to chemical pesticides.…”
Get full text

IL-33 Mediates Lung Inflammation by the IL-6-Type Cytokine Oncostatin M by Fernando Botelho, Anisha Dubey, Ehab A. Ayaub, Rex Park, Ashley Yip, Allison Humbles, Roland Kolbeck, Carl D. Richards

“…The IL-6-type cytokine Oncostatin M (OSM) elevates lung inflammation, Th2-skewed cytokines, alternatively activated (M2) macrophages, and eosinophils in C57Bl/6 mice in vivo. …”
Get full text

Does the CDC Surgical Wound Classification adequately predict postoperative infection in lower extremity fracture surgery? by Elizabeth Cho, MD, Hanna House, MD, Andrew Marten, BS, Marina Feffer, MPH, Julie Agel, MA, John Scolaro, MD, Meir Marmor, MD, Ashley E. Levack, MD, MAS, OTA Classification & Outcomes Committee, James Kellam, MD, Gillian Soles, MD, Jarrod Dumpe, MD, Kyle Schweser, MD, Geoffrey Maracek, MD

“…While overall SWC is associated with infection, the relationship seems to be confounded by the effect of open versus closed fractures. Alternative classification systems may have improved utility for stratifying risk in orthopaedic patients. …”
Get full text

Prebiotics as an adjunct therapy for posttraumatic stress disorder: a pilot randomized controlled trial by Robin M. Voigt, Robin M. Voigt, Robin M. Voigt, Phillip A. Engen, Michelle Villanueva, Simona A. Bambi, Stefan J. Green, Stefan J. Green, Ankur Naqib, Ankur Naqib, Shohreh Raeisi, Maliha Shaikh, Bruce R. Hamaker, Bruce R. Hamaker, Thaisa M. Cantu-Jungles, Thaisa M. Cantu-Jungles, Sarah A. Pridgen, Philip Held, Ali Keshavarzian, Ali Keshavarzian, Ali Keshavarzian, Ali Keshavarzian

“…., dysbiosis) which can promote neuroinflammation; thus, modulation of the microbiome could be an alternative or adjunct treatment approach for PTSD.MethodsThe current study was a 12-week, double-blind, placebo-controlled trial seeking to understand if CBT combined with a microbiota-modifying, prebiotic fiber intervention would beneficially impact clinical outcomes in veterans with PTSD (n = 70). …”
Get full text

Evaluation of Treatment Outcomes Using dNLR and GNRI in Combination Therapy With Atezolizumab and Bevacizumab for Hepatocellular Carcinoma by Atsushi Naganuma, Satoru Kakizaki, Atsushi Hiraoka, Toshifumi Tada, Takeshi Hatanaka, Kazuya Kariyama, Joji Tani, Masanori Atsukawa, Koichi Takaguchi, Ei Itobayashi, Shinya Fukunishi, Kunihiko Tsuji, Toru Ishikawa, Kazuto Tajiri, Hidenori Toyoda, Chikara Ogawa, Hiroki Nishikawa, Takashi Nishimura, Kazuhito Kawata, Hisashi Kosaka, Masashi Hirooka, Yutaka Yata, Hideko Ohama, Hidekatsu Kuroda, Tomomitsu Matono, Tomoko Aoki, Yuki Kanayama, Kazunari Tanaka, Fujimasa Tada, Kazuhiro Nouso, Asahiro Morishita, Akemi Tsutsui, Takuya Nagano, Norio Itokawa, Tomomi Okubo, Taeang Arai, Michitaka Imai, Shinichiro Nakamura, Hirayuki Enomoto, Masaki Kaibori, Yoichi Hiasa, Masatoshi Kudo, Takashi Kumada

“…It offers a feasible alternative for databases lacking lymphocyte count information, ensuring comprehensive patient stratification and outcome prediction. …”
Get full text

Evaluation of cumulative rainfall and rainfall event–duration threshold based on triggering and non-triggering rainfalls: Northern Thailand case by Chinkulkijniwat Avirut, Salee Rattana, Yubonchit Somjai, La Duong Hai, Horpibulsuk Suksun, Hoy Menglim

“…However, the establishment of the CED threshold was based on a frequentist approach which required an adequate number of landslide-triggering rainfall data. An alternative to the use of landslide-triggering rainfall data is the use of non-triggering rainfall data. …”
Get full text

Multi-centre comparison between device-independent web-browser perimetry (Melbourne Rapid Fields-web) and SITA-Faster for glaucoma by Joyce Tiang, Algis J. Vingrys, Algis J. Vingrys, Sarah Lin, Selwyn M. Prea, Adam Ahmed Moktar, Allan Bank, Ashish Agar, Ashish Agar, Yu Xiang George Kong, Yu Xiang George Kong, Yu Xiang George Kong

“…Its portability and cost-effectiveness suggest suitability as an alternative method for visual field testing where a standard perimeter is not easily accessible.…”
Get full text

Polycaprolactone for Hard Tissue Regeneration: Scaffold Design and In Vivo Implications by Fernanda Ramírez-Ruiz, Israel Núñez-Tapia, María Cristina Piña-Barba, Marco Antonio Alvarez-Pérez, Vincenzo Guarino, Janeth Serrano-Bello

“…In the last thirty years, tissue engineering (TI) has emerged as an alternative method to regenerate tissues and organs and restore their function by implanting specific lineage cells, growth factors, or biomolecules functionalizing a matrix scaffold. …”
Get full text

Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability by Wei-Ching Liang, Hongkang Xi, Dawei Sun, Luigi D’Ascenzo, Jonathan Zarzar, Nicole Stephens, Ryan Cook, Yinyin Li, Zhengmao Ye, Marissa Matsumoto, Jian Payandeh, Matthieu Masureel, Yan Wu

“…Rabbits produce robust antibody responses and have unique features in their antibody repertoire that make them an attractive alternative to rodents for in vivo discovery. However, the frequent occurrence of a non-canonical disulfide bond between complementarity-determining region (CDR) H1 (C35a) and CDRH2 (C50) is often seen as a liability for therapeutic antibody development, despite limited reports of its effect on antibody binding, function, and stability. …”
Get full text

Computerized QT and QTc Measurements From Bedside ICU Monitors Are Similar to Those Derived From a Standard 12‐Lead ECG by Arthur Murray, Karolina Ho, Thomas J. Hoffmann, Gopika K. Ganesh, Shelvin Prasad, Sarah Berger, Cass Sandoval, Amy Larsen, Hildy Schell‐Chaple, Michele M. Pelter

“…These pilot data are promising and suggest QT/QTc measurements from bedside monitors (four leads) may be an acceptable alternative to obtaining additional standard 12‐lead ECGs. …”
Get full text

Economic feasibility, perception of farmers, and environmental sustainability index of sorghum-eucalyptus agroforestry by . Komalawati, S. Hidayat, R.H. Praptana, M.D. Pertiwi, A.S. Romdon, Y. Hidayat, R.P. Ramadhan, D. Yuniati, . Saptana, . Syahyuti, N. Khaririyatun, S. Ika, R.K. Jatuningtyas, . Subiharta, R.N. Hayati, S. Sudarto, M.P. Yufdy, B. Nuryanto, A. Prasetyo

“…BACKGROUND AND OBJECTIVES: The Indonesian Government is promoting sorghum as an alternative commodity to substitute wheat. The cultivation of this commodity on dryland is initiated in forestry areas through social programs. …”
Get full text

Generation of Insulin-Producing Cells from Canine Adipose Tissue-Derived Mesenchymal Stem Cells by Takahiro Teshima, Keiji Okamoto, Kazuho Dairaku, Tomokazu Nagashima, Masaki Michishita, Ryohei Suzuki, Hirotaka Matsumoto, Hidekazu Koyama

“…New cell-based therapy using MSCs for diabetes mellitus is anticipated as an alternative treatment option to insulin injection or islet transplantation in both human and veterinary medicine. …”
Get full text

Peculiarities of the blood system of animals under the conditions of consumption of drinking water containing chlorates by T.E. Kravchun, L.A. Tomashevskaya, L.A. Tomashevskaya, V.A. Prokopov, T.V. Kulish, V.S. Tsytsyruk

“…Chlorine dioxide can be an alternative reagent for disinfecting drinking water. …”
Get full text

Evaluation of Expanded Clay and Tuff as Lightweight Agents in Concrete Stabilized with Nopal Mucilage and Aloe Vera by Daniel Mendoza-Goden, Rocio Rafaela Gallegos-Villela, Pedro Flores-Becerra, Josue Francisco Perez-Sanchez, Edgardo Jonathan Suarez-Dominguez, Arturo Palacio-Perez

“…The findings provide valuable insights into optimizing eco-friendly concrete mixtures with improved thermal retention, workability, and mechanical properties, offering a sustainable alternative for modern construction.…”
Get full text

Ellagic Acid from <i>Geranium thunbergii</i> and Antimalarial Activity of Korean Medicinal Plants by Hojong Jun, Joon-Hee Han, Min Hong, Fadhila Fitriana, Jadidan Hada Syahada, Wang-Jong Lee, Ernest Mazigo, Johnsy Mary Louis, Van-Truong Nguyen, Seok Ho Cha, Wanjoo Chun, Won Sun Park, Se Jin Lee, Sunghun Na, Soo-Ung Lee, Eun-Taek Han, Tae-Hyung Kwon, Jin-Hee Han

“…This study highlights the importance of exploring plant-based compounds as alternative strategies against drug-resistant malaria. …”
Get full text

Provocative tests of anal sphincter function correlate with symptoms and subtypes of faecal incontinence by John McLaughlin, Dipesh H Vasant, Asbjørn Mohr Drewes, Abhiram Sharma, Matthew Davenport, Edward Kiff, Karen Telford, Alexander O'Connor, Donghua Liao, Niels Klarskov

“…However, provocative tests (functional lumen imaging probe (FLIP) and anal acoustic reflectometry (AAR)) have been proposed as alternatives. This study uniquely explores all three methods in correlation with FI symptoms and subtypes.Methods This was a prospective observational study of patients with FI attending a tertiary pelvic floor unit between August 2022 and January 2024. …”
Get full text

Development and cross-validation of predictive equations for fat-free mass estimation by bioelectrical impedance analysis in Brazilian subjects with overweight and obesity by Kalina Veruska Da Silva Bezerra Masset, Analiza M. Silva, Analiza M. Silva, Gerson Ferrari, Gerson Ferrari, Breno Guilherme De Araújo Tinoco Cabral, Paulo Moreira Silva Dantas, Roberto Fernandes Da Costa

“…The criterion technique was dual-energy-x-ray absorptiometry (DXA), whereas a tetrapolar single-frequency BIA equipment was used as the alternative method. Paired t-test, multiple regression, concordance correlation coefficient, and Bland–Altman analysis were used.ResultsMost existing equations were not valid and new equations were derived: (1) for individuals with overweight or obesity: CCC = 0.982; r2 = 0.95; standard error of estimate (SEE) = 2.50 kg; limits of agreement (LOA) = -5.0 to 4.8; and (2) specific for individuals with obesity: CCC = 0.968; r2 = 0.94; SEE = 2.53 kg; LOA = -5.3 to 5.2. …”
Get full text