The effectiveness of methanol extract and fractinations fromleaves of mangroveSonneratia albaand Bruguiera gymnorrhizafor the prevention of white spot syndrome virus (WSSV) infecti... by Muliani, Muliani, Endang Susianingsih

“…Mangrove leaves dried approximately for two weeks, made into flour, extracted using 80% methanol, and then evaporated. …”
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Testicular Nitric Oxide and Thiobarbituric Acid Reactive Substances Levels in Obstructive Azoospermia: A Possible Role in Pathophysiology of Infertility

“…Animals were sacrificed 8 weeks after surgery. Testes were removed and used for the evaluation of nitrate/nitrite and TBARS levels and for histology. …”
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Conglomerated Imiquimod and Metronidazole Incorporated Biodegradable Nanofibrous Mats for Potential Therapy of Cervical Cancer by Chen YP, Chiu CF, Wang CN, Lin CC, Shen CR, Yao YC, Kuo YH, Liu SJ

“…In vivo, each membrane consistently released elevated concentrations of imiquimod/metronidazole at the intended site in mice over a four-week period, with minimal systemic drug concentration detected in the bloodstream. …”
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The potential of Trichoderma sp. as antibacterial and immunostimulant on white shrimp (Litopenaeus vannamei) by Catur A. Pebrianto, . Sukenda, . Widanarni

“…A group of shrimp was injected with a minimum inhibitory concentration obtained at first experiment, and a week after, shrimps was challenged with V. harveyi (prophylactic). …”
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Administration of Sex Hormone Preparations as a Risk Factor in the Development of Intrahepatic Cholestasis of Pregnancy and Biliary Sludge in Pregnant Women by Yu. B. Uspenskaya, I. V. Kuznetsova, A. A. Sheptulin, N. V. Goncharenko, A. N. Gerasimov, M. M. Amiraslanova

“…Biochemical laboratory parameters in the ICP group were evaluated after 1 and 2 weeks of treatment.Results.  More than half of patients with BS and ICP were taking sex hormone preparations or had a pregnancy that occurred after the application of ART programs. …”
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Cardiac manifestations of Fabry disease in G3Stg/GlaKO and GlaKO mouse models-Translation to Fabry disease patients. by Abirami Kugadas, Pietro Artoni, Wanida Ruangsiriluk, Meng Zhao, Natalia Boukharov, Rizwana Islam, Dmitri Volfson, Katayoun Derakhchan

“…G3Stg/GlaKO and WT mice were assessed between 27-28 weeks of age due to their shortened lifespan. Several cardiomyopathy characteristics of early Fabry pathology were found in GlaKO mice, including mild cardiomegaly [up-to-25% increase in left ventricular (LV mass)] with no significant LV wall thickening. …”
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When specific exercise is more effective than medication - Sensorimotor training is currently the most promising option to treat and prevent chemotherapy-induced peripheral neuropa... by Fiona Streckmann, Maryam Balke, Céline Hammadou, Bianca Schmidli, Oliver Faude, Sarah Koch

“…Participants in the intervention groups performed supervised sensorimotor training (SMT) or whole-body vibration training (WBV), twice a week, concomitant to medical therapy. The primary end point was the incidence of CIPN. …”
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Athletic Shoulder Test Differences Exist Bilaterally in Healthy Pitchers by Aaron Trunt, Brandon T. Fisher, Lisa N. MacFadden

“…The ASH test was used to assess force production as a proxy for strength bilaterally at four levels of shoulder abduction (0°, 90°, 135°, and 180°), using a force plate. Approximately one-week later subjects returned for a bullpen session where fastball velocity was recorded with a radar gun. …”
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Immune response and growth performance of crayfish Cherax quadricarinatus fed with supplementary diet of synbiotic by Amrullah Amrullah, Wahidah Wahidah

“…Furthermore, the challenge test was performed against the pathogenic bacteria of A. hydrophila and reared for a week. The result showed that synbiotics treatment of Syn300 and Syn200 could improve the immune response and increased the growth rate (P<0.05). …”
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Predictive Validity and Reliability of Frenchay Activities Index by Li TONG, Shanjia CHEN, Guanli XIE, Cai JIANG, Jing TAO, Lidian CHEN

“…Ninety-four subjects were randomly selected within one week and retested by the same assessor.Results:The internal consistency of the Chinese version of the FAI scale was Cronbach's α coefficient of 0.937.The test-retest reliability showed that the intra-group correlation coefficient(ICC)was 0.810(95%<italic>CI</italic>:0.672 to 0.952).In terms of project discrimination, the differences between the high and low group scores of each project were statistically significant(<italic>P</italic>&lt;0.01), and the discrimination of each item in the scale was generally good;the correlation analysis of the entries, dimensions and total scores of the Chinese version of the FAI scale found that the correlation coefficient between the items in the Chinese version of FAI and the total score was in the range of 0.535-0.832(<italic>P</italic>&lt;0.01), and the correlation coefficient of the three dimensions and total scores of household activities, leisure activities and outing activities were 0.867, 0.913, 0.948 respectively(<italic>P</italic>&lt;0.01).The exploratory factor analysis(EFA)was used to test the structural validity of the Chinese version of the FAI scale to a KMO statistic of 0.924 and the Bartlett spherical χ²test to 4535.558(<italic>df</italic>=105, <italic>P</italic>&lt;0.01).Using the principal component analysis method to extract the common factors from the scale, there were three common factors with eigenvalue≥1, the eigenvalue of common factor 1 was 4.776, the contribution rate of variance was 31.842%, and the eigenvalue of common factor 2 was 3.437.The contribution rate of variance was 22.914%, the eigenvalue of common factor 3 was 2.436, the contribution rate of variance was 16.238%, and the cumulative contribution of the three common factors to the total variance was 70.994%.The validity-related validity test showed that the FAI total score was positively correlated with the MBI total score, the correlation was general(<italic>r</italic>=0.322, <italic>P</italic>&lt;0.01), and the three dimensions of FAI(home activities, leisure activities, outing activities)was correlated with the MBI total score, the correlation was general(<italic>r</italic>=0.320, <italic>r</italic>=0.267, <italic>r</italic>=0.319, <italic>P</italic>&lt;0.01).Conclusion:The Chinese version of the Frenchay activities index has good reliability and validity in patients with recovery from stroke hospitalization.…”
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Analysis of the Endocrine Responses to Anti-Diabetes Drugs: An Issue of Elevated Plasma Renin Concentration in Sodium-Glucose Co-Transporter 2 Inhibitor by Lin CW, Hung SY, Chen IW

“…Laboratory measurements of metabolic values and endocrine parameters were assessed after a stable treatment regimen of more than 12 weeks. The differences in various endocrine parameters were compared between subjects with or without certain anti-diabetes drugs, with the administrated anti-diabetes drugs being analyzed to find independent risks associated with elevated endocrine parameters.Results: After maintaining stable treatment, acceptable glycemic control was noted with an average HbA1c of 7.55% in females and 7.43% in males. …”
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Dietary Cinnamaldehyde Enhances Growth Performance, Digestion, Immunity, and Lipid Metabolism in Juvenile Fat Greenling (Hexagrammos otakii) by Yixin Gu, Jian Han, Wenjie Wang, Yu Zhan, Huijie Wang, Wenyuan Hua, Yue Liu, Yafeng Guo, Zhuang Xue, Wei Wang

“…Six experimental diets were formulated containing CNE at levels of 0, 200, 400, 600, 800, and 1000 mg/kg for 8 weeks. The percent weight gain (PWG), specific growth rate (SGR), survival (SR), and feeding rate (FR) were significantly increased by including CNE in fish diets regardless of the inclusion level (P<0.05). …”
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Effects of Duhuo Jisheng Decoction on Calcium Homeostasis and Apoptosis of Chondrocytes under Endoplasmic Reticulum Stress by Qing LIN, Wenyi WANG, Danhong PAN, Yanfeng HUANG, Changlong FU, Jinxia YE

“…Objective:To observe the effect of Duhuo Jisheng decoction on the balance of calcium homeostasis and apoptosis of chondrocytes under endoplasmic reticulum stress(ERS), and to preliminarily explore its mechanism of preventing and treating osteoarthritis.Methods:A steady chondrocyte in vitro culture system was established by using 4-week-old SD rat knee cartilage, and identify the third generation chondrocyte by toluidine blue staining.The 25 μmol/L Thapsigargin(TG)was used to induce chondrocyte in vitro culture to produce endoplasmic reticulum stress(ERS), incubate it in Duhuo Jisheng Decoction(100, 200, 400 μg/mL)for 24 hours after induction.The cells were divided into the blank group, the model group, the low-dose Duhuo Jisheng decoction group, the medium-dose Duhuo Jisheng decoction group, and the high-dose Duhuo Jisheng decoction group.Then morphological changes of chondrocytes were observed respectively by inverted microscope, viability of chondrocyte in each group was examined by CCK-8 method, chondrocyte apoptosis was observed by Hoechst 33342 staining and real-time dynamic changes of intracellular Ca²⁺concentration was examined by double turntable laser confocal microscope.Results:①The morphology of chondrocytes: the cells in the blank group grew in a single-layer paving stone shape, while the cells in the model group increased in a polygonal shape, the pseudopodia increased, the gaps widened, and the number of cells decreased significantly.Compared with the model group, the number of cells in the three dose groups of Duhuo Jisheng decoction(100, 200, 400 μg/mL)increased significantly and the cytoplasm was uniform.The activity of chondrocytes in each group: compared with the blank group, the survival rate of the model group was lower, and the difference was statistically significant(<italic>P</italic>&lt;0.05).The absorbance of each concentration group of Duhuo Jisheng decoction increased with the increase of concentration, and the difference was statistically significant compared with the model group(<italic>P</italic>&lt;0.05).③Apoptosis of chondrocytes: the number of apoptosis in the model group was significantly increased, and the degree of pyknosis of the nucleus was obvious, and some of them were a high density of bright blue or half moon-shaped.The number of apoptotic cells in each dose group of Duhuo Jisheng decoction was significantly reduced, only a few apoptotic cells showed a high density of bright blue or half-moon shape, and the number of apoptosis decreased with the increase of the concentration of Duhuo Jisheng decoction, showing a certain dose-effect relationship.④The changes of intracellular calcium ion concentration: the calcium ion fluorescence intensity of the cells in the blank group was weaker and more uniform, maintaining a stable state.The calcium ion release of the model group was significantly increased, and the fluorescence intensity was enhanced.The fluorescence spectrum showed that calcium sparks were more frequent.Compared with the blank group, the difference was statistically significant(<italic>P</italic>&lt;0.05).Chondrocytes in the medium and high-dose Duhuo Jisheng decoction groups could quickly return to calcium homeostasis, and calcium sparks were significantly reduced.Although there were still some calcium sparks in the low-concentration Duhuo Jisheng decoction group, the fluorescence intensity was significantly weaker than the model group.Conclusion:Duhuo Jisheng decoction has an inhibitory effect on the apoptosis of chondrocyte induced by TG, the mechanism may be that Duhuo Jisheng decoction can alleviate endoplasmic reticulum stress by regulating calcium balance, thus inhibiting the apoptosis of chondrocyte.…”
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Interaction of dietary protein and energy-protein ratio on growth performance of snakehead Channa striata by Hani Wijianti, Muhammad Agus Suprayudi, Nur Bambang Priyo Utomo, Dedi Jusadi

“…Snakehead with average weight of 6.21 ± 0.03 g were reared for 8 weeks. The treatments showed significant results. …”
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Efek Pemberian Vitamin C Terhadap Aktifitas Katalase Hati Tikus Galur Wistar yang Terpapar Ion Pb by Elmatris Sy, Husnil Kadri, Eti Yerizel

“…The result was exposure of Pb ions 0.05 mg / g BW / day for four weeks decreases catalase activity rat’s-wistar-strain liver. …”
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Effect of Exercise Preconditioning on Protein Expression of VEGF and NeuN in Rats with Cerebral Ischemia-reperfusion by Fei PEI, Xuedong WANG, Baolong LI, Qiang TANG, Luwen ZHU

“…Before the model was built, the exercise sham-operation group and the exercise model group were trained on the treadmill for 3 weeks. In the model group and exercise model group, the modified Longa suture method was used to prepare the rat middle cerebral artery occlusion (MCAO) model. …”
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Pengaruh Pemberian Glutamin pada Kemampuan Fagositosis Makrofag terhadap Pseudomonas Aeruginosa by Daslina , Eryati Darwin, Aziz Djamal

“…Experimental research with post test only control group design was conducted on 24 male minutes 6-8 weeks of age weighing 30 grams. Mice were divided into two groups: control (K) and treatment (P) are given glutamine at a dose of 30 mg / kg / day for 14 days. …”
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An interpretable machine learning tool for in-home monitoring of agitation episodes in people living with dementia: a proof-of-concept studyResearch in context by Marirena Bafaloukou, Ann-Kathrin Schalkamp, Nan Fletcher-Lloyd, Alex Capstick, Chloe Walsh, Cynthia Sandor, Samaneh Kouchaki, Ramin Nilforooshan, Payam Barnaghi

“…Employing machine learning techniques, we developed a monitoring tool to identify the presence of agitation during the week. We incorporated a traffic-light system to stratify agitation probability estimates supporting clinical decision-making, and employed the SHapley Additive exPlanations (SHAP) framework to enhance interpretability. …”
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Immune responses and resistance of white shrimp (Litopenaeus vannamei) fed Probiotic Bacillus sp NP5 and prebiotic honey against White Spot Syndrome Virus infection by Widanarni Widanarni, Dewi Rahmi, Muhamad Gustilatov, Sukenda Sukenda, Diah Ayu Satyari Utami

“…White shrimp with an average weight of 1.8±0.06 gram/shrimp were reared at a density of 15 shrimps per aquarium (60 cm x 30 cm x 30 cm and water height of 20 cm) for eight weeks, then challenge against WSSV at lethal dose (LD50) dose as much as 0.1 ml per shrimp. …”
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FERN: is it possible to conduct a randomised controlled trial of intervention or expectant management for early-onset selective fetal growth restriction in monochorionic twin pregn... by Kerry Woolfall, Jamie J Kirkham, Jane Sandall, Mariana Popa, Enrico Lopriore, Mark Turner, Shakila Thangaratinam, Aris T Papageorghiou, Andrew Sharp, Lawrence Impey, Andy Healey, Jessica Mendoza, Asma Khalil, Dharmintra Pasupathy, Brigitte Vollmer, Zarko Alfirevic, Rajeswari Parasuraman, Jan Deprest, Richard Edmund Ashcroft, Kurt Hecher, Smriti Prasad, Baskaran Thilaganathan, Richard J Jackson, Tracy Karen Mitchell, Natasha Fenwick, Monique C Haak, Liesbeth Lewi, Shauna Leven, Fabricio Da Silva Costa, Odai Yaghi, Tracey Ricketts, George Attilakos, Carolyn Bailie, Christine Cornforth, Mark Denbow, Louise Hardman, Jane Harrold, Joel Marsden, Tommy Mousa, Surabhi Nanda, Michelle Watson, Karen Wilding, Dilly Anumba, Edward D Johnstone, Yoav Yinon, Ahmet Baschat

“…Therefore, the main objective of the FERN study is to assess the feasibility of conducting an RCT of active intervention vs expectant management in monochorionic twin pregnancies with early-onset (prior to 24 weeks) sFGR.Methods and analysis The FERN study is a prospective mixed-methods feasibility study. …”
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