Double-Blind Clinical Trial of Arginine Supplementation in the Treatment of Adult Patients with Sickle Cell Anaemia by Renata M. N. Eleutério, Francisco O. Nascimento, Tamara G. Araújo, Marilena F. Castro, Tarcísio P. Almeida Filho, Pedro A. Maia Filho, José Eleutério, Darcielle B. D. Elias, Romélia P. G. Lemes

“…Statistical analysis showed that the levels of NO were increased in the study group, and there was also a reduction in pain frequency using a pain frequency scale by day, week, and month. The levels of nitrite plus nitrate in the group receiving placebo plus HU did not change among the times evaluated (38.27 ± 17.27 mg/L, 39.49 ± 12.84 mg/L, 34.45 ± 11.25 mg/L, p >0.05), but in the patients who received supplementation with L-arginine plus HU, a significant increase in nitrite plus nitrate levels was observed between M0 and M4 (36.55 ± 20.23 mg/L versus 48.64 ± 20.63 mg/L, p =0.001) and M2 and M4 (35.71 ± 15.11 mg/L versus 48.64 ± 20.63 mg/L, p <0.001). …”
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Elucidating the pharmacological foundations and mechanisms of the Sihai Shuyu formula in treating Graves’ disease through integrated serum metabolomics and network pharmacology wit... by Xiaoju Liu, Xingjia Li, Wenbin Huang, Yifan Cui, Fengyun Cheng, Guofang Chen, Guofang Chen, Xiaodong Mao, Chao Liu, Chao Liu, Shuhang Xu

“…A comprehensive analysis of the multi-level bioinformatic analysis, including protein-protein interactions (PPI) and functional pathways of the targets, was conducted, followed by verification through immunohistochemistry (IHC) to clarify SHSY’s pharmacological basis and action mechanisms in treating GD.ResultsAfter 8 weeks of treatment, SHSY significantly reduced serum T4 and TRAb levels in GD mice and enhanced the morphology of thyroid tissues. …”
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Psychometric properties of the Iranian version of the polycystic ovary syndrome quality of life questionnaire for married and unmarried women with PCOS: PCOSQoL-47 and PCOSQoL-42 by Fatemeh Bazarganipour, Seyed Abdolvahab Taghavi, Ali Montazeri, Fazlollah Ahmadi, Zahra Derakhshideh, Zahra Asadikalameh

“…Responsiveness was assessed by comparing two scales scoring in baseline and eight-week follow-up data of prescription contraceptive Daine-35. …”
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Mas Receptor Blockade Promotes Renal Vascular Response to Ang II after Partial Kidney Ischemia/Reperfusion in a Two-Kidney-One-Clip Hypertensive Rats Model by Farzaneh Karimi, Mehdi Nematbakhsh

“…The renal vascular responses to graded Ang II (30, 100, 300, and 1000 ng kg−1.min−1) infusion using A779 or its vehicle were measured at constant renal perfusion pressure. Results. Four weeks after 2K1C implementation, the intravenous infusion of graded Ang II resulted in dose-related increases in mean arterial pressure (MAP) (Pdose < 0.0001) that was not different significantly between the groups. …”
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Evaluation of the diagnostic accuracy of two point-of-care tests for COVID-19 when used in symptomatic patients in community settings in the UK primary care COVID diagnostic accura... by Brian D Nicholson, Philip J Turner, Thomas R Fanshawe, Alice J Williams, Gayatri Amirthalingam, Sharon Tonner, Maria Zambon, Richard Body, Kerrie Davies, Rafael Perera, Simon de Lusignan, Gail N Hayward, F D Richard Hobbs, RAPTOR-C19 Study Group and the CONDOR Steering Committee

“…Tests should not be expected to reliably detect disease more than a week after symptom onset, when viral load may be reduced.…”
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Impact of heavy metal pollution on the use of fishing pond land, a former site of used battery smelting by E. Riani, N.A. Butet, M. Ansori, M.R. Cordova

“…Adults are only allowed 3 grams per week, while children may not consume goldfish from this fishing pond. …”
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Predicting the effectiveness of omalizumab in patients with refractory chronic rhinosinusitis with nasal polyps comorbid with asthma based on inflammatory biomarkers by Yutong Sima, MD, Ming Zheng, MD, Yan Zhao, PhD, Siqi Ge, PhD, Chengyao Liu, MD, Ping Wang, BS, Xiangdong Wang, MD, PhD, Luo Zhang, MD, PhD

“…Forty-eight biomarkers involving type 1 (T1), type 2 (T2), and type 3 (T3) inflammatory factors, chemokines, and remodeling factors were detected in nasal secretion and serum samples at baseline and after 24 weeks of omalizumab treatment. Results: Eighteen patients with CRSwNP and 16 patients as control were enrolled. …”
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Precise Acetabular Prosthesis Positioning Using a Novel Robot‐Assisted Total Hip Arthroplasty System: A Multicenter, Randomized Controlled Trial by Xiao Geng, Ziyang Dong, Yang Li, Minwei Zhao, Yanqing Liu, Zijian Li, Hong Cai, Ming Zhang, Xinfeng Yan, Zhiwen Sun, Xin Lv, Feng Guo, Feng Li, Hua Tian

“…There was no significant difference in WOMAC score, Harris score, and SF‐36 between the two groups (6 ± 2) weeks after operation (p > 0.05). The dislocation rate of hip joint in the experimental group and control group were 3.0% and 1.5%, respectively, without significant difference (p > 0.05). …”
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THE EFFECT OF ADDING 25-HYDROXYCHOLECALCIFEROL TO THE DIET ON SOME BIOCHEMICAL CHARACTERISTICS OF JAPANESE QUAIL by M. S. Dawod, M. A. Al-Bayar

“…This experiment was conducted in the quail breeding hall of the Department of Animal Production at the College of Agriculture / Anbar University for the period from 11/23/2022 until 1/25/2023 (8 weeks) with the aim of studying the effect of adding different levels of 25-hydroxycholecalciferol to the diet on some blood biochemical characteristics. …”
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Effects of on-farm hatching versus hatchery hatching on growth performance, gut development, and intestinal health and function in broiler chickens by Muhammad Zeeshan Akram, Ester Arévalo Sureda, Matthias Corion, Luke Comer, Nadia Everaert

“…HOF chicks had higher d1 body weights than HH chicks (P < 001), but this advantage disappeared within first week, with no subsequent performance differences. …”
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A Study of Combined Onabotulinumtoxin A and Hyaluronic Acid Filler for the Treatment of Enlarged Facial Pores by Vasanop Vachiramon, Sonphet Chirasuthat, Suphagan Boonpethkaew, Nawara Sakpuwadol, Tanat Yongpisarn, Natthachat Jurairattanaporn

“…The outcomes were measured by pore volume, visual assessment, pain score, improvement score, and side effects at various time intervals up to 24 weeks. Results: This study investigated the effects of onaBoNT-A monotherapy or in combination with HA filler on facial pore size and skin roughness. …”
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CLP-Net: an advanced artificial intelligence technique for localizing standard planes of cleft lip and palate by three-dimensional ultrasound in the first trimester by Guangzhi He, Zhou Li, Zhiyuan Zhu, Tong Han, Yan Cao, Chaoyu Chen, Yuhao Huang, Haoran Dou, Lianying Liang, Fangmei Zhang, Jin Peng, Tao Tan, Hongmei Liu, Xin Yang, Dong Ni

“…Methods This retrospective study included 418 (394 normal, 24 CLP) 3D ultrasound from 288 pregnant woman between July 2022 to October 2024 from Shenzhen Guangming District People’s Hospital during the 11–13+ 6 weeks of pregnancy. 320 normal volumes were used for training and validation, while 74 normal and 24 CLP volumes were used for testing. …”
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Coinfection of severe acute respiratory syndrome coronavirus 2 and polyomavirus in a patient with coronavirus disease 2019 detected by enrichment next-generation sequencing: a case... by Gunadi, Esensi Tarian Geometri, Pramana Adhityo, Ali Zainal Abidin, Marcellus, Dyah Ayu Puspitarani, Fadila Dyah Trie Utami, Kristy Iskandar, Hendra Wibawa, Mohamad Saifudin Hakim

“…The patient was given acetaminophen, vitamin C, vitamin D, and zinc for the treatment and discharged uneventfully from the hospital 4 days after admission. Then, 2 weeks after discharge, she visited the outpatient clinic without any further concerns. …”
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Performance evaluation and stability analysis of malt barley (Hordeum vulgare L.) varieties for yield and quality traits in Eastern Amhara, Ethiopia by Abebe Assefa, Getawey Girmay, Tesfaye Alemayehu, Alemu Lakew

“…Field experiments were conducted using eight improved malt barely varieties during the main cropping seasons (from the first week of July to end of October) in 2016 and 2017 at two selected sites Dehana (Amede work) and Lalibela (Medagai)) in north east Ethiopia. …”
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Spatial and social relevance perceptions by pre-service teachers of learning about oil palm management as a local or nonlocal socioscientific issue by Finn Kristen Matthiesen, Gina Nolte, Finn Rehling, I Gede Arjana, Lola Utama Sitompul, Upik Yelianti, Susanne Bögeholz, Susanne Bögeholz

“…We specifically investigated Indonesian PST' relevance perceptions of learning about oil palm management (OPM), a local SSI for PST of one university and a nonlocal SSI for PST of two other universities.MethodsThe PST participated in a 5-week socioscientific inquiry-based educational unit on OPM in curricular courses (N = 111). …”
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Psychometric characteristics and feasibility of microinteraction-based Ecological Momentary Assessment in audiology research by Yu-Hsiang Wu, Elizabeth Stangl, Samuel Smith, Jacob Oleson, Christi Miller, Octav Chipara

“…Correlation analysis revealed that over two visits 1 week apart, the 2-point scale had the poorest test-retest reliability, while the 5-point scale had the highest. …”
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Swiss Orthopaedics Minimal Dataset: First Pilot Report of Reliability and Validity by Thorsten Jentzsch, Claudio Dora, Urs Müller, Mazda Farshad

“…It is a standardized, generic, and patient-reported outcome questionnaire, comprising ten items (location of disease, pain within the past four weeks, limitations at work/leisure/sleep/autonomy, subjective value of a body part, employment status, work disability (sick leave/pension), and household support). …”
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Owners’ perceptions of dog treat management in Western Romania by Sorana Daina, Anamaria Blaga-Petrean, Silvana Popescu, Ioana Delia Pop, Daniel Mierlita, Adrian Macri

“…Owners who provided treats less frequently, 'seldom' (80.7%) or 'a few times a week' (87.8%), were more likely to have dogs with an ideal weight, while higher treat frequencies – 'once daily' (40.0%) or 'multiple times daily' (52.7%), were significantly associated with overweight or obese dogs (p&lt;0.003).DiscussionThese findings underscore the importance of educating dog owners on aligning treat provision with caloric requirements and promoting responsible feeding practices. …”
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Exploration of effects of galvanic vestibular stimulation on circadian rhythms and its associations with sleep and spatial memory in patients with breast cancer: The ICANSLEEP-2 pr... by Melvin Galin, Laura de Girolamo, Bénédicte Clarisse, Carine Segura-Djezzar, Franka Glöckner, Clara Elia, Stéphane Réhel, Patrice Clochon, Franck Doidy, Julien Chavant, Olivier Etard, Fausto Viader, Jean-Michel Grellard, Justine Lequesne, Florence Joly, Francis Eustache, Tristan Martin, Bénédicte Giffard, Gaëlle Quarck, Joy Perrier

“…There will be two assessment sessions, before and after 2 weeks of GVS. Patients will be randomly assigned to either a GVS group or a sham group (noneffective stimulation). …”
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Validation study of synthetic models for esophageal atresia with tracheoesophageal fistula (EA/TEF): A simulation-based training in pediatric surgery by Zahradníková Petra, Hnilicová Silvia, Lindák Martin, Pechanová Rebeka, Števková Dominika, Vitovič Pavol, Laurovičová Miroslava, Horn František, Tvrdoň Tomáš, Babala Jozef

“…Eight participants (18 %) declared weekly access to simulation training, while 49 % had none. …”
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