Early Endoscopic Outcomes After Risankizumab Are Associated With Fewer Hospitalizations and Surgeries in Crohn’s Disease by Brian G. Feagan, Jean-Frederic Colombel, Remo Panaccione, Stefan Schreiber, Marc Ferrante, Koji Kamikozuru, Christopher Ma, Wan-Ju Lee, Jenny Griffith, Namita Joshi, Kristina Kligys, Jasmina Kalabic, Si Xuan, Marla Dubinsky

“…Background and Aims: We evaluated the association between endoscopic outcomes following risankizumab induction and subsequent rates of hospitalization and surgery through 52 weeks of risankizumab (both doses) maintenance therapy in patients with Crohn’s disease (CD). …”
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Dynamic Expression of HDAC3 in db/db Mouse RGCs and Its Relationship with Apoptosis and Autophagy by Yuhong Fu, Ying Wang, Xinyuan Gao, Huiyao Li, Yue Yuan

“…To investigate the chronological sequence of the abnormalities of retinal ganglion cells in diabetic retinopathy, we choose 15 male db/db mice (aged 8 weeks, 12 weeks, 16 weeks, 18 weeks, and 25 weeks; each group had 3 mice) as diabetic groups and 3 male db/m mice (aged 8 weeks) as the control group. …”
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Feasibility and acceptability of an integrated mind-body intervention for depression: whole-body hyperthermia (WBH) and cognitive behavioral therapy (CBT) by Ashley E. Mason, Anoushka Chowdhary, Wendy Hartogensis, Chelsea J. Siwik, Osnat Lupesko-Persky, Leena S. Pandya, Stefanie Roberts, Claudine Anglo, Patricia J. Moran, J. Craig Nelson, Christopher A. Lowry, Rhonda P. Patrick, Charles L. Raison, Frederick M. Hecht

“…Background: There is a pressing need for effective treatments for major depressive disorder (MDD).Objective To examine the feasibility of an integrated mind-body MDD treatment combining cognitive behavioral therapy (CBT) and whole-body hyperthermia (WBH).Methods In this single-arm trial, 16 adults with MDD initially received 8 weekly CBT sessions and 8 weekly WBH sessions. Outcomes included WBH sessions completed (primary), self-report depression assessments completed (secondary), and pre-post intervention changes in depression symptoms (secondary). …”
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Microscale bone interlocking enhances osseointegration strength on the rough surface of 3D-printed titanium implants: experimental and finite element analysis by Tianyu Shu, Haoyu Shi, Meng Li, Yu-Chia Lin, Ang Li, Dandan Pei

“…Histological osseointegration assessments revealed equal levels of SLM and CNC-SLA implants at weeks 1, 2, and 8. Notably, after week 2, bone interlocking phenomenon appeared on the SLM implants. …”
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TIGIT inhibitor M6223 as monotherapy or in combination with bintrafusp alfa in patients with advanced solid tumors: a first-in-human, phase 1, dose-escalation trial by Wei Gao, Ping Hu, Aung Naing, Meredith McKean, Anthony Tolcher, Lillian L Siu, Keyvan Tadjalli-Mehr, Anja Victor, Emilia Richter, Marco A F Nogueira Filho, Thomas Kitzing, Stephan Gleicher, Daniel Holland

“…Bintrafusp alfa (BA) is a bifunctional fusion protein that simultaneously blocks nonredundant immunosuppressive TGF-β and PD-(L)1 pathways.Methods This first-in-human, dose-escalation study in patients with advanced solid tumors (N=58; aged ≥18 years, ECOG PS≤1) evaluated M6223 alone (Part 1A, n=40; M6223 10–2400 mg every 2 weeks, n=32; M6223 2400 mg every 3 weeks, n=8) or with BA (Part 1B, n=18; M6223 300–1600 mg with BA 1200 mg; both every 2 weeks, intravenous). …”
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Efficacy and Safety of Risankizumab in Patients with Psoriasis Showing Suboptimal Response to Secukinumab or Ixekizumab: Results from a Phase 3b, Open-Label, Single-Arm (aIMM) Stud... by Richard B. Warren, Lev Pavlovsky, Antonio Costanzo, Michael Bukhalo, Neil J. Korman, Yu-Huei Huang, Georgios Kokolakis, Andreas Pinter, Nadia Ibrahim, Yanbing Zheng, Leonidas Drogaris, Vassilis Stakias, Ahmed M. Soliman, Simone Rubant, Diamant Thaçi

“…The primary endpoint was the proportion of patients achieving sPGA of 0/1 at week 16. Secondary endpoints included sPGA 0/1 at week 52, sPGA 0, Dermatology Life Quality Index (DLQI) 0/1, and Psoriasis Symptoms Scale (PSS) 0 at weeks 16 and 52. …”
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The dose–effect relationship between acupuncture and its effect on primary insomnia: a systematic review and meta-analysis by Xiaoni Zhang, Xiaoni Zhang, Yue Wang, Chengyong Liu, Shan Qin, Liyu Lin, Liyu Lin, Can Dong, Wenzhong Wu, Wenzhong Wu, Zhaoming Chen

“…For the acupuncture course, there were no differences in the short course (≤2 weeks) and the long course (>4 weeks) between the acupuncture group and the control group. …”
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FAecal micRobiota transplantation in primary sclerosinG chOlangitis (FARGO): study protocol for a randomised, multicentre, phase IIa, placebo-controlled trial by Laith Alrubaiy, Rachel Cooney, Tariq Iqbal, Mohammed Nabil Quraishi, Susan Manzoor, Christopher Quince, Palak J Trivedi, Andrew D Beggs, Alexandra Vince, Chris Weston, Benjamin Mullish, Sahida Shabir, Nicola Jackson, Anna Rowe, Victoria Homer, Willem van Schaik, Peter Rimmer, Sarah Al-Shakhshir, Arzoo Patel, Derick Gyimah, Miriam Hares, Elena Efstathiou

“…Participants will then be followed on a 12-weekly basis until week 48 from the first treatment visit. …”
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Synergistic Effect of Quercetin and α-Lipoic Acid on Aluminium Chloride Induced Neurotoxicity in Rats by Sooad Saud Al-Otaibi, Maha Mohamad Arafah, Bechan Sharma, Abdullah Salih Alhomida, Nikhat Jamal Siddiqi

“…The study consisted of eight groups, namely, Group 1: control rats, Group 2: rats receiving aluminium chloride 7 mg/kg body weight intraperitoneal route (i.p) for two weeks, Group 3: rats receiving quercetin 50 mg/kg body weight i.p. for two weeks, Group 4: rats receiving quercetin 50 mg/kg body weight followed by aluminium chloride 7 mg/kg body weight i.p. for two weeks, Group 5: rats receiving α-lipoic acid 20 mg/kg body weight i.p. for two weeks, Group 6: rats receiving lipoic acid 20 mg/kg body weight followed by aluminium chloride 7 mg/kg body weight i.p. for two weeks, Group 7: rats receiving α-lipoic acid 20 mg/kg body weight and quercetin 50 mg/kg body weight i.p. for two weeks, and Group 8: rats receiving α-lipoic acid 20 mg/kg body weight and quercetin 50 mg/kg body weight followed by aluminium chloride 7 mg/kg body weight i.p. for two weeks. …”
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Effect of Cluster Acupuncture of Scalp-point combined with Rehabilitation Training for Daily Living Ability of Patients with Parkinson's Disease by Linjing WANG, Yuan TIAN, Chunying WANG, Lu WANG, Lili SHANG, Wei AN, Hong CHANG

“…The control group was given simple rehabilitation training, loosening-up activities for 10 min a time first, and 30 minutes'Pavel rehabilitation training in preparation period,3 times a week, continuous training for two weeks. During the training period, six movements including leg kicking, leg flexion and extension, chest, rowing, hip and body extension were request, thirty times each movement, sixty minutes for tainning, once every other day, continuous training for four weeks. …”
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Pulmonary and systemic immune alterations in rats exposed to airborne lunar dust by Brian E. Crucian, Heather Quiriarte, Chiu-wing Lam, Mayra Nelman, Audrie A. Colorado, Douglass M. Diak, John T. James

“…This study assessed airborne lunar dust exposure in rats on localized pulmonary and systemic immune parameters.MethodsRats were exposed to 0 (air only), 20.8 (low), and 60.6 (high) mg/m3 of respirable-size lunar dust for 4 weeks (6 h/day, 5 days/week). Rats were then euthanized either 1 day, 7 days, 4 weeks, or 13 weeks after the last exposure. …”
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Levels of apoptosis factors in mitochondria of brain cortex cells in female С57ВL/6 mice in dynamics of B16/F10 melanoma growth combined with comorbidity by E. M. Frantsiyants, I. V. Neskubina, N. D. Cheryarina, E. I. Surikova, A. I. Shikhlyarova, V. A. Bandovkina, L. A. Nemashkalova, I. V. Kaplieva, L. K. Trepitaki, P. S. Kachesova

“…CNP, levels of calcium in murine brain cortex mitochondria were 1.4 times higher (p < 0.05) than in the comparison group at the same time; in 2 weeks the levels declined by 80.1 times and after 3 weeks declined by 37.7 times. …”
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Supervised pulmonary tele-rehabilitation and individualized home-based pulmonary rehabilitation for patients with COPD, unable to participate in center-based programs. The protocol... by Christina Nielsen, Nina Godtfredsen, Stig Molsted, Charlotte Ulrik, Thomas Kallemose, Henrik Hansen

“…After completion of the intervention, the PTR and HPR groups are offered 65-weeks groupbased maintance program supervised once a week online via tablet. …”
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Effect on Movement and Balance Function with Robot Training for Stroke Patients in Lower Limb Rehabilitation by Zhiyuan WU, Kunbin LI, Shuwei LOU, Xianli YAO, Pingge SUN, Xiaoxing LI

“…The control group received routine rehabilitation training,30 min per day, once a day, five days a week, continuous treatment for eight weeks. The observation group received lower limb rehabilitation robot training based on the control group, and the standing angle, step mode, left/right leg movement range were choosed according to the patient's physical condition, set the walking frequency about 20 to 30 steps per minute, the training frequency was 30 min per day, once a day, five days a week, continuous treatment for eight weeks. …”
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The use of immunostimulant from phycocyanin of Spirulina platensis to control motile aeromonad septicaemia (MAS) disease in common carp Cyprinus carpio by Muthahharah Muchtar, Sukenda Sukenda, Sri Nuryati, Dendi Hidayatullah

“…Second phase was conducted by applying the best dose obtained from the first phase added in the feed for feeding the fish in one week/month, two weeks/month, three weeks /month, and two weeks/month with one week interval. …”
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SARS-CoV-2 Viral Shedding and Associated Factors among COVID-19 Inpatients and Outpatients by Masoomeh Sofian, Behzad Khansarinejad, Ehsanollah Ghaznavi-Rad, Farzaneh Shokoohi, Hossein Mazaherpour, Farzane Farmani, Mona Sadat Larijani, Leila Pakpour, Amitis Ramezani

“…The RT-PCR tests were done two and three weeks after the symptoms initiation. Results. Viral eradication occurred in 44.8% two weeks after illness initiation whereas in 71% who achieved a negative PCR test in the third week. …”
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The effect of muscle energy technique on pain, kinesiophobia, and quality of life in patients with COPD with chronic pain by Serpil Mıhçıoğlu, Mehtap Malkoç

“…The intervention group received MET 3 times a week for 4 weeks, while the control group was given a home exercise program. …”
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Evaluation of the Effects of Charged Amino Acids on Uncontrolled Seizures by Hossein Ali Ebrahimi, Saeed Ebrahimi

“…The patients used amino acid powder dissolved in water (three times the daily need) every day for two weeks before breakfast. The number of seizures was recorded one week prior to commencing amino acid use, as well as the first and the second weeks subsequent to use. …”
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Study of Postprandial Lipaemia in Type 2 Diabetes Mellitus: Exenatide versus Liraglutide by Maria Voukali, Irene Kastrinelli, Sapfo Stragalinou, Dimitra Tasiopoulou, Pinelopi Paraskevopoulou, Nicholas Katsilambros, Alexandros Kokkinos, Nicholas Tentolouris, Ioannis Ioannidis

“…This study was a single-center, two-armed, randomized, controlled 2-week prospective intervention trial in 20 subjects with T2DM. …”
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Health-Related Quality of Life in the Gender, Race, And Clinical Experience Trial by Judith Feinberg, Michael Saag, Kathleen Squires, Judith Currier, Robert Ryan, Bruce Coate, Joseph Mrus

“…Total FAHI of the entire population improved by Week 4 (𝑃<.05); near-maximum changes obtained by Week 12 were maintained through Week 48. …”
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