Knowledge of the ovulatory cycle and its determinants among adolescent females in Ghana by Grace Frempong Afrifa-Anane

“…Adolescent females with secondary/higher education (AOR = 2.36; 95% CI = 1.26–4.43), at least one child (AOR = 2.01; 95% CI = 1.40–2.89), used traditional contraceptives such as rhythm, withdrawal methods (AOR = 2.26; 95% CI = 1.52–3.67), menstruated in the last six weeks (AOR = 2.01; 95% CI = 1.08–3.57) and media exposure to family planning messages (AOR = 1.89; 95% CI = 1.52–2.35) had higher odds of having good knowledge about the ovulation cycle. …”
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CitySEIRCast: an agent-based city digital twin for pandemic analysis and simulation by Shakir Bilal, Wajdi Zaatour, Yilian Alonso Otano, Arindam Saha, Ken Newcomb, Soo Kim, Jun Kim, Raveena Ginjala, Derek Groen, Edwin Michael

“…This work arose in response to requests from county agencies to support their work on COVID-19 monitoring, risk assessment, and planning, and using the described workflows, we were able to provide uninterrupted bi-weekly simulations to guide their efforts for over a year from late 2021 to 2023. …”
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Emotion regulation-based internet-delivered cognitive behavioural therapy for premenstrual dysphoric disorder: study protocol for a randomised controlled trial in Sweden by Filipa Sampaio, Alkistis Skalkidou, Gerhard Andersson, Cornelia Weise, Johanna M. Hoppe, Maria Kleinstaeuber, Johan Vegelius, Erika Comasco, Maria Gröndal, Elisavet Kaltsouni, Felicia Sundström, Monica Buhrman

“…The current study aims to evaluate the effects and cost-effectiveness of an internet-delivered CBT (ICBT) intervention for PMDD incorporating skills training in emotion regulation and interpersonal effectiveness.Methods and analysis The study is a parallel two-group randomised controlled trial with 1:1 allocation to 8 weeks of therapist-guided ICBT or a waitlist control condition. …”
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Intravesical BCG in patients with non-muscle invasive bladder cancer induces trained immunity and decreases respiratory infections by J Alfred Witjes, Alina Vrieling, Mihai G Netea, Leo A B Joosten, Katja K H Aben, Sita H Vermeulen, Joost L Boormans, Antoine G van der Heijden, Boris Novakovic, Jelmer H van Puffelen, Liesbeth van Emst, Denise Kooper, Tahlita C M Zuiverloon, Ursula T H Oldenhof, Tessel E Galesloot, Lambertus A L M Kiemeney, Egbert Oosterwijk

“…Gene-based association analysis of genetic variants in candidate trained immunity genes and their association with recurrence-free survival and progression-free survival after BCG therapy was performed to investigate the hypothesized link between trained immunity and clinical response.Results We found that intravesical BCG does induce trained immunity based on an increased production of TNF and IL-1β after heterologous ex vivo stimulation of circulating monocytes 6–12 weeks after intravesical BCG treatment; and a 37% decreased risk (OR 0.63 (95% CI 0.40 to 1.01)) for respiratory infections in BCG-treated versus non-BCG-treated NMIBC patients. …”
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Protective Effect of Exercise Preconditioning on Myocardial Ischemia-Reperfusion Injury in Rats Based on Autophagy by Qiang TANG, Jiyao ZHANG, Hongyu LI, Xue WANG, Xia YIN, Xuedong WANG, Zichen MU, Luwen ZHU

“…Before modeling the Sham group and MIRI group didn't receive intervention, and the EP group was given electric treadmill training for four weeks. The ultrastructure and autophagic bodies of rat cardiac myocytes were observed by transmission electron microscopy, the infarct size was measured by Evans blue-TTC double staining, and the expression ofPI3K-Akt-mTOR signal pathway related proteins was detected by Western blot.Results:In the Sham group, the nuclear membrane was intact and continuous, the myofibrillar bundles arranged orderly, the structure of mitochondria was intact and no edema, the morphology of myocardial cells was normal, and no autophagic bodies were found; in the MIRI group, the myofibrillar bundles were loose and disordered with interstitial edema, mitochondria and myocardial cells were damaged seriously, the structure of cells was disordered, and autophagy was observed in the field of vision; in the EP group, some of sarcoplasmic reticulum was edema and expanding, mitochondrial structure was more complete with slight edema, myocardial cell was less damaged, and autophagy was less. …”
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Peptide-based vaccine targeting IL17A attenuates experimental spondyloarthritis in HLA-B27 transgenic rats by Tetsuya Tomita, Hiromi Rakugi, Hiroki Hayashi, Ryuichi Morishita, Jiao Sun, Yuka Yanagida, Shota Yoshida, Satoshi Baba, Akiko Tenma, Masayoshi Toyoura, Sotaro Kawabata, Takako Ehara, Ryoko Asaki, Makoto Sakaguchi, Hideki Tomioka, Munehisa Shimamura, Hironori Nakagami

“…The IL17A antibody titre was assessed using ELISA, and arthritis score and joint thickness were monitored two times a week. Enzyme-linked immunospot (ELISpot) assays for IL4- and interferon-γ-secreting splenocytes were conducted to evaluate IL17A-specific T cell activation. …”
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Immunogenicity in humans of a transdermal multipeptide melanoma vaccine administered with or without a TLR7 agonist by Craig L Slingluff, Gina R Petroni, Walter C Olson, Kimberly A Chianese-bullock, Donna Deacon, Mark Smolkin, William W Grosh, Max O Meneveau, Kevin T Lynch, Elise P Salerno, Elizabeth Woodson, James W Patterson

“…We hypothesized that: (1) applying melanoma-derived peptides topically, in proximity to LC, could be immunogenic and safe, with low vaccine-site toxicity and (2) topical toll-like receptor 7 (TLR7) agonist would increase immunogenicity of the peptide vaccine.Methods Twelve melanoma peptides plus a tetanus helper peptide were combined with granulocyte macrophage colony stimulating factor (GM-CSF) and were administered topically on days 1, 8, and 15, to 28 patients randomized to one of four adjuvant preparations: (1) incomplete Freund’s adjuvant (IFA); (2) IFA plus a TLR7 agonist (imiquimod) administered on days 0, 7, 14; (3) dimethyl sulfoxide (DMSO) or (4) DMSO+ imiquimod administered on day 0, 7, 14. Every 3 weeks thereafter (x 6), the peptides were combined with GM-CSF and were injected into the dermis and subcutis in an emulsion with IFA. …”
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Dim blue light at night worsens high-fat diet-induced kidney damage via increasing corticosterone levels and modulating the expression of circadian clock genes by Wenji Ren, Zixu Wang, Yulan Dong, Jing Cao, Ting Gao, Qingyun Guo, Yaoxing Chen

“…Herein, we fed mice a high-fat diet and gave them dim white (dWL), blue (dBL), green (dGL), and red (dRL) light for 12 weeks. Our results showed that both dWL and dBL tended to be more susceptible to damage to kidney dysfunction caused by a high-fat diet compared to LD, with more pronounced changes in dBL. …”
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Performance and quality of eggs of laying hens fed with Moringa Oleifera leaf flour. by Rogério Ventura da Silva Junior, Carlos Bôa-Viagem Rabello, Maria do Carmo Mohaupt Marques Ludke, Cláudia da Costa Lopes, Waleska Rocha Leite de Medeiros Ventura, Elayne de Souza Rocha Soares, Patricia Maria Guedes Paiva, Thiago Henrique Napoleão, Apolonio Gomes Ribeiro, Júlio Cézar Dos Santos Nascimento, Lilian Francisco Arantes de Souza, Helia Sharlane de Holanda Oliveira

“…For this purpose, 150 laying hens of the Dekalb White lineage, at 62 weeks of age, and with an initial average weight of 1.458 kg ± 8.70g, were used. …”
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Residue depletion profile and withdrawal interval estimation of ivermectin in eggs following topical administration of injectable ivermectin to domestic chickens (Gallus domesticus... by Melissa A. Mercer, Jennifer L. Davis, Scott E. Wetzlich, Maaike O. Clapham, Lisa A. Tell

“…IntroductionTopical ivermectin is commonly prescribed extra-label for the control of mite infestations in backyard chicken flocks in the US.MethodsDomestic laying hens (n = 8; 78 weeks of age, weight 1.7–2.2 kg) were administered injectable ivermectin solution topically over the jugular vein (0.4 mg/kg every 7 days for 2 doses). …”
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Urban and Rural Differences in Cancer Treatment Disruption Among Patients With COVID‐19: An Analysis of the US ASCO COVID‐19 in Oncology Registry by Yu Chen Lin, Kea Turner, Oliver T. Nguyen, Emma Hume, Marlene Camacho‐Rivera, Jessica Y. Islam

“…Cancer TDD was defined as any scheduled treatment by more than 2 weeks. Rurality was examined through both patient residence and oncology practice. …”
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Eosinophilic Asthma Secondary to Adjuvant Anti-PD-1 Immune Checkpoint Inhibitor Treatment in a Melanoma Patient by P. Kissoonsingh, B. Sutton, Syed U. Iqbal, Lalit Pallan, Neil Steven, L. Khoja

“…The patient experienced episodes of breathlessness 4 weeks after cycle 1. These episodes were nocturnal and caused acute respiratory distress and cough, occasionally waking him up. …”
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Effects of Dietary Yeast, Saccharomyces cerevisiae, and Costmary, Tanacetum balsamita, Essential Oil on Growth Performance, Digestive Enzymes, Biochemical Parameters, and Disease R... by Hossein Adineh, Morteza Yousefi, Basim S. A. Al Sulivany, Ehsan Ahmadifar, Mohammad Farhangi, Seyyed Morteza Hoseini

“…Four diets containing 1 g/kg yeast (Sc), 0.1 g/kg costmary essential oil (Tb), 1 g/kg yeast + 0.1 g/kg costmary essential oil (Sc + Tb), and without Sc and Tb (control) were formulated and fed (2.5% per day) to triplicate groups of fish (average: 9.8 g; SD : 0.12) for 8 weeks. Each replicate was a 70-L tank, stocked with 25 fish. …”
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Older adults’ Internet use behavior and its association with accelerometer-derived physical activity by Yen-Yu Chung, Jiaren Chen, Mei-Chun Lin, Ruo-Lan Liu, Jenn-Bang Wu, Hsin-Chang Tsai, Ting-Fu Lai, Ting-Fu Lai, Yung Liao, Yung Liao, Jong-Hwan Park, Jong-Hwan Park, Jong-Hwan Park

“…., those who used the Internet less than once a week or not at all, respectively) were less likely to meet the WHO’s recommended levels for PA than older adults who used the Internet with moderate frequency. …”
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Effects of Synthetic Astaxanthin on the Growth Performance, Pigmentation, Antioxidant Capacity, and Immune Response in Black Tiger Prawn (Penaeus monodon) by Qiang Chen, Shuting Huang, Jieyu Dai, Congcong Wang, Songming Chen, Yuanxin Qian, Yangyang Gong, Tao Han

“…In the present study, five diets containing different doses of synthetic astaxanthin (0% (CON), 0.02% (AX0.02), 0.04% (AX0.04), 0.08% (AX0.08), and 0.16% (AX0.16)) were administered to Penaeus monodon (initial body weight: 0.3 ± 0.03 g) for 8 weeks. With an increase in astaxanthin content in feed, weight gain and specific growth rate increased initially and subsequently decreased, with the highest value appearing at AX0.08. …”
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Exploring the impact and mechanisms of behavioral activation on sleep disorders in colorectal cancer: a randomized controlled trial by Anlong Li, Runze Huang, Han Ge, Dajie Liu, Shaochun Liu, Yingxue Jia, Jiaying Chai, Xinyi Zheng, Lijun Liu, Chen Gan, Jian Xu, Ling Cheng, Mingjun Zhang, Huaidong Cheng

“…Assessments of quality of life, sleep disturbances, psychological distress, activation, avoidance, and physical activity levels were conducted at baseline (T0), four weeks later (T1), and post-intervention (T2). Generalized estimating equation (GEE) analysis was used to evaluate the intervention’s impact and potential mediating effects. …”
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Telaprevir: options of application in separate patient groups by M. V. Mayevskaya, I. N. Tikhonov, V. T. Ivashkin

“…The potential of decreasing of antiviral therapy (AVT) duration to 24 wks is proved, based on dynamics of viral load at AVT, at week 4 and 12 of treatment in patients who receiving no AVTs earlier, and in groups, representing as a rule, difficulty for treatment (patients with CHC relapse or absence the response/incomplete response to previous AVT). …”
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Extensible lateral approach versus sinus tarsi approach for sanders type II and III calcaneal fractures osteosynthesis: a randomized controlled trial of 186 fractures by Amr A. Fadle, Ahmed A. Khalifa, Peter Mamdouh Shehata, Wael EL-Adly, Ahmed Ekram Osman

“…The time to fracture union was significantly shorter in STA (6.33 ± 0.8 vs. 7.13 ± 0.7 weeks, p = 0.000). Skin complications (superficial or deep infection) and Subtalar osteoarthritis were significantly higher in ELA (18.9% vs. 3.3%, p = 0.001) and (32.6% vs. 9.9%, p = 0.001), respectively. …”
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Role of B7H4 and Fas in regulation of trophoblast cells and development of pre-eclampsia: a cross-sectional study by Xiujuan Dong, Cuicui Nie, Yanli Yin, Haixia Xu, Yanxia Zhang, Lihua Han, Congcong Xu

“…In addition, the clinical characteristics of all participants were collected, including age, gestational weeks at delivery, gestational time, number of births, systolic blood pressure, diastolic blood pressure and foetal weight. …”
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Comparison of the Efficiency of Lepidium sativum, Ficus carica, and Punica granatum Methanolic Extracts in Relieving Hyperglycemia and Hyperlipidemia of Streptozotocin-Induced Diab... by Shimaa Ramadan, Amany Mohamed Hegab, Yahya S. Al-Awthan, Mohammed Ali Al-Duais, Ahmed A. Tayel, Mahmoud A. Al-Saman

“…To induce diabetes, all animals were administered with STZ intraperitoneal injection at a dose of 60 mg/kg body weight. For five weeks, the crude plant extracts were given orally to various groups of rats at doses of one hundred and two hundred mg/kg body weight. …”
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