Rational design, synthesis, in vitro, and in-silico studies of pyrazole‑phthalazine hybrids as new α‑glucosidase inhibitors by Mehrdad Roshan, Roghieh Mirzazadeh, Azadeh Tajmir-Riahi, Mohammad Sadegh Asgari

“…Moreover, molecular dynamic simulation and the absorption, distribution, metabolism, and excretion (ADME) have been performed.…”
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Exploring the anticancer potential of Hewittia malabarica through phytochemical analysis and molecular docking study by Shiji Thozhukkad Moosaripparambil, Kannan Vadakkadath Meethal

“…The cytomorphological changes associated with the chloroform extract and AO/EB dual staining indicated apoptotic cell death. An analysis of ADME properties of compounds obtained in GC-MS analysis of the chloroform extract showed that compounds such as Cyclododecanol, Sulfurous acid hexyl octyl ester, 2,4-Ditert-Butylphenol and 1,2-benzenedicarboxylic acid had favourable physicochemical and drug-likeness characteristics. …”
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Synthesis, Molecular Docking Studies, and Antifungal Activity Evaluation of New Benzimidazole-Triazoles as Potential Lanosterol 14α-Demethylase Inhibitors by Nafiz Öncü Can, Ulviye Acar Çevik, Begüm Nurpelin Sağlık, Serkan Levent, Büşra Korkut, Yusuf Özkay, Zafer Asım Kaplancıklı, Ali Savaş Koparal

“…The molecular docking studies were performed to investigate the interaction modes between the compounds and active site of lanosterol 14-α-demethylase (CYP51), which is as a target enzyme for anticandidal azoles. Theoretical ADME predictions were also calculated for final compounds.…”
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Ground-Penetrating Radar Evaluation of Moisture and Frost across Typical Saskatchewan Road Soils by Curtis Berthelot, Diana Podborochynski, Timo Saarenketo, Brent Marjerison, Colin Prang

“…Both laboratory devices, the complex dielectric network analyzer and the Adek Percometer, as well as the field GPR system were used in this study to measure the dielectric constant of soils. …”
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Design, synthesis, and apoptotic antiproliferative action of new benzimidazole/1,2,3-triazole hybrids as EGFR inhibitors by Alshimaa A. Y. Ahmed, Anber F. Mohammed, Zainab M. Almarhoon, Stefan Bräse, Bahaa G. M. Youssif

“…Furthermore, our new study examined the ADME properties of the new hybrids.…”
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Noninvasive Optical Imaging of Ovarian Metastases Using Cy5-labeled RAFT-c(-RGDfK-) by Zhao-hui Jin, Veronique Josserand, Jesus Razkin, Elisabeth Garanger, Didier Boturyn, Marie-Christine Favrot, Pascal Dumy, Jean-luc Coll

“…Human ovarian adenocarcinoma IGROV1 cells expressing low levels of integrin α v β 3 (the main receptor for the cRGD peptide) were used for in vitro and in vivo assays in combination with Cy5-labeled RAFT-c(-RGDfK-) 4 , cRGD, or RAFT-c(-RβADfK-) 4 . In vivo fluorescence imaging was performed on subcutaneous (SC) tumors and intraperitoneal IGROV1 metastases in nude mice. …”
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Investigation of the physicochemical properties and pharmacokinetics of the active compounds in Quercus infectoria gall extract by Roohallah Yousefi

“…The molecular weight, hydrophobicity, polarity, and solubility of these compounds play a key role in their biological activity and pharmacokinetics, which can be evaluated using SwissADME and PubChem. Lipinski's Rule of Five suggests that optimal molecular weights for oral bioavailability fall between 180 and 500 Da. …”
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Secrecy-Constrained UAV-Mounted RIS-Assisted ISAC Networks: Position Optimization and Power Beamforming by Weichao Yang, Yajing Wang, Dawei Wang, Yixin He, Li Li

“…To address this non-convex, multivariate, and coupled problem, we decompose it into three subproblems, which are solved iteratively using particle swarm optimization (PSO), semi-definite relaxation (SDR), majorization–minimization (MM), and alternating direction method of multipliers (ADMM) algorithms. Our numerical results validate the effectiveness of the proposed scheme and demonstrate the potential of employing UAV-mounted RIS in ISAC systems to enhance radar sensing capabilities.…”
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Measuring the Pollutants in a System of Three Interconnecting Lakes by the Semianalytical Method by Indranil Ghosh, M. S. H. Chowdhury, Suazlan Mt Aznam, M. M. Rashid

“…Comparisons with the Adomian decomposition method (ADM) and the well-known purely numerical fourth-order Runge-Kutta method (RK4) suggest that the NIM is a powerful alternative for differential equations providing more realistic series solutions that converge very rapidly in real physical problems.…”
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Cryopreserved human alternatively activated macrophages promote resolution of acetaminophen-induced liver injury in mouse by Maria Elena Candela, Melisande Addison, Rhona Aird, Tak-Yung Man, Jennifer A. Cartwright, Candice Ashmore-Harris, Alastair M. Kilpatrick, Philip J. Starkey Lewis, Anna Drape, Mark Barnett, Donna Mitchell, Colin McLean, Neil McGowan, Marc Turner, James W. Dear, Stuart J. Forbes

“…In a mouse model of APAP-induced injury, peripherally injected cryopreserved hAAMs reduced liver necrosis, modulated inflammatory responses, and enhanced liver regeneration. hAAMs were effective even when administered after the therapeutic window for NAC. …”
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Quantifying Patient Demand for Orthopedics Care by Region Through Google Trends Analysis: Descriptive Epidemiology Study by Abram Qiu, Kristopher Meadows, Fei Ye, Osasu Iyawe, Kenneth Kenneth-Nwosa

“…MethodsThe data used were from the US Census Bureau, Association of American Medical Colleges (AAMC) through their 2024 Electronic Residency Application Service (ERAS) directory, AAMC State Physician Workforce Data Report, and Google Trends. …”
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An efficient technique to study of time fractional Whitham–Broer–Kaup equations by Nishant Bhatnagar, Kanak Modi, Lokesh Kumar Yadav, Ravi Shanker Dubey

“…Comparative numerical analyses are conducted with outcomes from the Adomian decomposition method (ADM), variational iteration method (VIM), and optimal homotopy asymptotic method (OHAM), demonstrating the superior accuracy of the proposed method. …”
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SOR-Like New Iterative Method for Solving the Epidemic Model and the Prey and Predator Problem by Atika Radid, Karim Rhofir

“…Our aim in this paper is to propose an SOR-like new iterative method by introducing a relaxation parameter ω to improve the new iterative method proposed by Daftardar-Gejji and Jafari (NIM) [J. …”
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En första kriminologisk inblick i lagen (2007:1150) om tillsyn över hundar och katter by Sirkku Sarenbo, Helena Striwing

“…Not to criminalize Section 1 of the Supervision Act and transfer of responsibility for the law from the Swedish Police Authority to the County Admi- ESSAY nistrative boards have reduced the burden on the Police Authority and the district courts at the expense of an increased burden on the County Administrative boards and the administrative courts. …”
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Meteorological Analysis of Floods in Ghana by S. O. Ansah, M. A. Ahiataku, C. K. Yorke, F. Otu-Larbi, Bashiru Yahaya, P. N. L. Lamptey, M. Tanu

“…A time series of annual daily maximum rainfall (ADMR) showed an increasing trend with a slope of 0.45 over Accra and a decreasing trend and a slope of –0.07 over Kumasi. …”
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Analisis Kadar Timbal (Pb) Air Minum Isi Ulang pada Depot Air Minum (DAM) di Kecamatan Padang Timur Kota Padang Tahun 2017 by Fitri Wahyu Febriwani, Aisyah Elliyanti, Mohamad Reza

“…Air minum isi ulang yang diperoleh dari Depot Air Minum (DAM) menjadi populer karena harganya lebih murah dari Air Minum Dalam Kemasan (AMDK) yang bermerek. …”
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Development of an mPBPK machine learning framework for early target pharmacology assessment of biotherapeutics by Krutika Patidar, Nikhil Pillai, Saroj Dhakal, Lindsay B. Avery, Panteleimon D. Mavroudis

“…By unraveling new design rules for antibody drug properties that are dependent on ML-based TO assessment, we deliver a first-in-class ML-based target pharmacology assessment framework toward better understanding of the biology-specific PK and ADME processes of antibody drug candidate proteins and reduce the overall time for drug development.…”
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In vitro and in silico insights into antimicrobial and anticancer activities of novel imidazo[2,1-b][1,3,4]thiadiazoles by Deepika Dwarakanath, Yogeesha N. Nayak, Ananda Kulal, Samyak Pandey, K Sreedhara Ranganath Pai, Santosh L. Gaonkar

“…Molecular docking was studied to determine the docking poses and binding interaction of the derivatives with the protein bearing PDB: 5BNS and 3ZNR; ADME properties of the derivatives are also inferred which gives insights into the bioavailability. …”
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Biomarker discovery and phytochemical interventions in Alzheimer's disease: A path to therapeutic advances by Mithila Debnath, Mahir Azmal, Rashid Taqui, Moshiul Alam Mishu, Ajit Ghosh

“…Purpose: The study aimed to adopt a new strategy to identify and characterize potential biomarkers and therapeutic phytochemicals for AD by integrating gene expression data and computational analysis. …”
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Binding Mode Investigation of Polyphenols from Scrophularia Targeting Human Aldose Reductase Using Molecular Docking and Molecular Dynamics Simulations by Abinaya Manivannan, Prabhakaran Soundararajan, Yoo Gyeong Park, Sugunadevi Sakkiah, Byoung Ryong Jeong

“…In addition, acacetin also possessed favorable ADME properties and complies with Lipinski’s rule of 5 representing the possible drug-like nature compared to other polyphenols. …”
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