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    Long-Term Therapeutic Effects of <sup>225</sup>Ac-DOTA-E[c(RGDfK)]<sub>2</sub> Induced by Radiosensitization via G2/M Arrest in Pancreatic Ductal Adenocarcinoma by Mitsuyoshi Yoshimoto, Kohshin Washiyama, Kazunobu Ohnuki, Ayano Doi, Miki Inokuchi, Motohiro Kojima, Brian W. Miller, Yukie Yoshii, Anri Inaki, Hirofumi Fujii

    Published 2024-12-01
    “…Biodistribution and therapeutic studies were carried out in BxPC-3-bearing mice. <b>Results</b>: <sup>225</sup>Ac-DOTA-RGD<sub>2</sub> demonstrated potent cytotoxicity against cells expressing α<sub>v</sub>β<sub>3</sub> or α<sub>v</sub>β<sub>6</sub> integrins and induced G2/M arrest and γH2AX expression as a marker of double-stranded DNA breaks. …”
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