Diagnostics and treatment of cardiac achalasia and cardiospasm: guidelines of the Russian gastroenterological association by V. T. Ivashkin, A. S. Trukhmanov, E. A. Godzhello, I. V. Mayev, Yu. V. Evsyutina, T. L. Lapina, O. A. Storonova

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Mettl3-m6A-NPY axis governing neuron–microglia interaction regulates sleep amount of mice by Qihang Sun, Jinpiao Zhu, Xingsen Zhao, Xiaoli Huang, Wenzheng Qu, Xia Tang, Daqing Ma, Qiang Shu, Xuekun Li

“…However, it remains completely unknown regarding the roles of epitranscriptomics in regulating sleep behavior. …”
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Fasting Leptin Is a Metabolic Determinant of Food Reward in Overweight and Obese Individuals during Chronic Aerobic Exercise Training by Mark Hopkins, Catherine Gibbons, Phillipa Caudwell, Dominic-Luc Webb, Per M. Hellström, Erik Näslund, John E. Blundell, Graham Finlayson

“…However, the underlying mechanisms of food reward, and the physiological correlates of exercise-induced changes in food reward, are unknown. Methods. Forty-six overweight and obese individuals completed 12 weeks of aerobic exercise. …”
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Quality of Life Philosophy III. Towards a New Biology: Understanding the Biological Connection between Quality of Life, Disease, and Healing by Soren Ventegodt, Niels Jørgen Andersen, Joav Merrick

“…How the cell precisely regulates such processes is today a complete mystery. How cells cocreate consciousness is also an enigma. …”
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Effects of royal jelly consumption on clinical outcomes in patients with ischemic stroke: A triple-blind randomized controlled trial by Elham Karimi, Arman Arab, Fariborz Khorvash, Maryam Kazemi, Reza Amani

“…The therapeutic impact of royal jelly (RJ) consumption in patients with ischemic stroke is unknown. Therefore, we conducted a randomized, triple-blind, placebo-controlled clinical trial to evaluate the role of RJ supplementation on clinical and biochemical outcomes in patients recovering from ischemic stroke. …”
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La tranchée supérieure de l’aqueduc du Gier à Saint-Joseph (Loire) : nouvelles données et synthèse by Kilian Blanc, Guillaume Maza

“…While the reasons for its abandonment remain unknown, it would appear that a construction project, even one that has started, does not stand still. …”
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Karel Janeček − a leading figure in Czech Music Theory and Pedagogy: his theoretical writings from the 1930s and 1940s by Miloš Hons

“…The second topic of the study is a critical analysis of Janeček’s completely unknown textbook Kontrapunkt (Counterpoint), which was created in the 1940s and was intended mainly for conservatory students. …”
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A Dual-Hierarchy Synchronization Method for Signal Preambles with High Detection Rates for Satellite-Based ADS-B Receivers with Different Sensitivities by Xinhui Jian, Xuejun Zhang, Jianxiang Ma, Weidong Zhang

“…Existing methods are unable to achieve high detection rates and low false alarm rates of satellite-based Automatic Dependent Surveillance-Broadcast (ADS-B) signal preambles at extremely low signal-to-noise ratios (SNRs) using limited on-star resources. In this paper, a dual-hierarchy synchronization method is proposed, including a first-level coarse synchronization and a second-level fine synchronization. …”
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Microbes and metabolites of a plant-parasite interaction: Deciphering the ecology of Tetrastigma host choice in the world’s largest parasitic flower, Rafflesia by Jeanmaire Molina, Roche C. de Guzman, Rinat Abzalimov, Wenkai Huang, Anusha Guruprasad, Ronniel Pedales, Adhityo Wicaksono, Destiny Davis, John Rey Callado, Hans Bänziger, Piyakaset Suksathan, William Eaton, Pride Yin, Marco Bürger, Mick Erickson, Stephen Jones, James Adams, Susan Pell

“…Completely dependent on its Tetrastigma host plants, Rafflesia grows covertly within its host until flowering, but the ecological factors driving host susceptibility are unknown. …”
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Effect of Footwear Versus Barefoot on Double-Leg Jump-Landing and Jump Height Measures: A Randomized Cross-Over Study by Kim Hébert-Losier, Caleb Boswell-Smith, Ivana Hanzlíková

“… # Methods Eighty healthy individuals (55% male) completed the LESS following standard procedures (i.e., land from a 30-cm box to a distance of 50% of body height and then jump upwards maximally). …”
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Fatigue, pain and faecal incontinence in adult inflammatory bowel disease patients and the unmet need: a national cross-sectional survey by Ailsa Hart, Laura Miller, Fionn Cléirigh Büttner, Thomas Hamborg, Sonia Saxena, Richard C. G. Pollok, Imogen Stagg, Vari Wileman, Qasim Aziz, Wladyslawa Czuber-Dochan, Lesley Dibley, Borislava Mihaylova, Rona Moss-Morris, Chris Roukas, Christine Norton

“…Methods Adults with IBD in the UK, recruited from clinics, the national IBD-BioResource, a patient charity and social media sources, completed PROMIS validated patient-reported questionnaires to identify fatigue, pain and faecal incontinence, in addition to symptom severity and impact, disease activity, anxiety and depression questionnaires and questions about their desire for help with these symptoms. …”
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Exploratory profiling of metabolites in cerebrospinal fluid using a commercially available targeted LC-MS based metabolomics kit to discriminate leptomeningeal metastasis by Soojin Jang, Ho-Shin Gwak, Kyue-Yim Lee, Jun Hwa Lee, Kyung-Hee Kim, Jong Heon Kim, Jong Bae Park, Sang Hoon Shin, Heon Yoo, Yun-Sik Dho, Kyu-Chang Wang, Byong Chul Yoo

“…Long-chain AC level in PBT was lower than in LM or HC. A regression model including Ala, PC (42:7), PC (30:3), PC (37:0), and Tyr achieved complete discrimination (AUC = 1.0) between LM and HC. …”
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Usability and Usefulness of a Symptom Management Coaching System for Patients With Cancer Treated With Immune Checkpoint Inhibitors: Comparative Mixed Methods Study by Savannah Lucia Caterina Glaser, Itske Fraterman, Noah van Brummelen, Valentina Tibollo, Laura Maria Del Campo, Henk Mallo, Sofie Wilgenhof, Szymon Wilk, Vitali Gisko, Vadzim Khadakou, Ronald Cornet, Manuel Ottaviano, Stephanie Medlock

“…Participants were asked to review the concept of the tool, perform think-aloud tasks, and complete the System Usability Scale and a Perceived Usefulness questionnaire. …”
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Your period and your pregnancy, a cohort study of pregnant patients investigating the associations between menstruation and birth outcomes in Australia: study protocol by Miranda Davies-Tuck, Billie Bradford, Adrienne Gordon, Beverley Vollenhoven, Kirsten Rebecca Palmer, Kirstin Tindal, Caroline E Gargett, Fiona Cousins, Stacey Ellery

“…Whether AUB is associated with pregnancy outcomes in the absence of a diagnosed endometrial pathology, however, remains unknown. …”
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Prospects of Using Microbiota Correction Methods in the Treatment of Inflammatory Bowel Disease by A. I. Akinshina, D. V. Smirnova, A. V. Zagainova, V. V. Makarov, S. M. Yudin

“…Inflammatory bowel disease (IBD) is an umbrella term used to describe a group of chronic diseases of unknown aetiology. …”
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Estimating the Effect of Adhering to the Recommendations of the 2019 Canada’s Food Guide on Health Outcomes in Older Adults: Protocol for a Target Trial Emulation by Didier Brassard, Nancy Presse, Stéphanie Chevalier

“…However, the extent to which these recommendations are appropriate for older adults is unknown. Although ideal, conducting a large randomized controlled trial is unrealistic in the short term. …”
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Improvement of Quality of Life after Surgical Treatment of Patients with MRONJ: A Prospective Analysis Using the SF-12 and OHIP-14 Questionnaires by Georg Hoene, Nikolaus von Hahn, Denise Sievers, Lukas Schuffelen, Susanne Wolfer, Kathi Goldstein, Boris Schminke, Phillipp Brockmeyer, Philipp Kauffmann

“…Medication-related osteonecrosis of the jaw (MRONJ) is a rare, serious, and debilitating disease of unknown cause that can be associated with significant health-related quality of life (HRQOL) impairment. …”
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La gestion de l’eau à Bibracte (Saône-et-Loire), avant et après la Conquête romaine by Laetitia Borau

“…As a matter of fact, this second type of hydraulic structure, the reservoir, can be observed on the site and it completes the hydraulic equipment of the oppidum: there are five excavated structures which are rather enigmatic and which can be considered as being reservoirs. …”
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Physical health in young males and risk of chronic musculoskeletal, cardiovascular, and respiratory diseases by middle age: A population-based cohort study. by Aleksandra Turkiewicz, Karin Magnusson, Simon Timpka, Ali Kiadaliri, Andrea Dell'Isola, Martin Englund

“…Health and lifestyle factors in youth have known associations with cardiovascular or respiratory disease in adulthood, but largely unknown associations with musculoskeletal disease.…”
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Group B streptococcus colonization in pregnancy and neonatal outcomes: a three-year monocentric retrospective study during and after the COVID-19 pandemic by Gregorio Serra, Lucia Lo Scalzo, Maria Giordano, Mario Giuffrè, Pietro Trupiano, Renato Venezia, Giovanni Corsello

“…Comparing the frequency of performing vaginal-rectal swabs in the women admitted in the two time periods, the quote of those screened out of the total in the pandemic period (years 2020–2021) was higher than that of those undergoing GBS screening out of the total admitted in the year 2022 (75.65% vs. 70.38%, p = 0.009), while a greater number (not statistically significant, p = 0.12) of adequate and complete IAP was conducted in 2022, than in the previous biennium (26.36 vs. 18.62%). …”
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