Post-kala-azar dermal leishmaniasis (PKDL) drug efficacy study landscape: A systematic scoping review of clinical trials and observational studies to assess the feasibility of esta... by Sauman Singh-Phulgenda, Rishikesh Kumar, Prabin Dahal, Abdalla Munir, Sumayyah Rashan, Rutuja Chhajed, Caitlin Naylor, Brittany J Maguire, Niyamat Ali Siddiqui, Eli Harriss, Manju Rahi, Fabiana Alves, Shyam Sundar, Kasia Stepniewska, Ahmed Musa, Philippe J Guerin, Krishna Pandey

“…Five (8.9%) studies were published between 1981-1990 (n = 193 patients), 10 (17.9%) between 1991-2000 (n = 230 patients), 10 (17.9%) between 2001-2010 (n = 198 patients), and 31 (55.4%) from 2011 onwards (n = 1,865 patients). …”
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A time for sex: circadian regulation of mammalian sexual and reproductive function by Sydney Aten, Oscar Ramirez-Plascencia, Chiara Blake, Chiara Blake, Gabriel Holder, Gabriel Holder, Emma Fishbein, Emma Fishbein, Adam Vieth, Adam Vieth, Arman Zarghani-Shiraz, Arman Zarghani-Shiraz, Evan Keister, Evan Keister, Shivani Howe, Shivani Howe, Ashley Appo, Ashley Appo, Beatrice Palmer, Carrie E. Mahoney

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CMPK2 promotes NLRP3 inflammasome activation via mtDNA‐STING pathway in house dust mite‐induced allergic rhinitis by YaoMing Zheng, YaDong Xie, JiaYing Li, YuJie Cao, Min Li, Qing Cao, MiaoMiao Han, HongFei Lou, YiLai Shu, Hui Xiao, HuaBin Li

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Advancing tritium self-sufficiency in fusion power plants: insights from the BABY experiment by Rémi Delaporte-Mathurin, Nikola Goles, John Ball, Collin Dunn, Emily Edwards, Sara Ferry, Edward Lamere, Andrew Lanzrath, Rick Leccacorvi, Samuele Meschini, Ethan Peterson, Stefano Segantin, Rui Vieira, Dennis Whyte, Weiyue Zhou, Kevin Woller

“…Here we present the results of the Build A Better Yield blanket experiment, which represents a pioneering effort in tritium research by utilizing high-energy (14 MeV) neutron irradiation of molten salts, a departure from conventional low-energy neutron approaches. …”
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Analysis of Circulating Plasma MicroRNA Profile in Low-Grade and High-Grade Glioma – A Cross-Sectional Study [version 1; peer review: 2 approved, 1 approved with reservations, 1 no... by Sekar Safitri, Rachmat Andi Hartanto, Rusdy Ghazali Malueka, Bo Sun, Ery Kus Dwianingsih, Kusumo Dananjoyo, Ahmad Asmedi, Endro Basuki, Christina Megawimanti Sianipar, Yeshua Putra Krisnugraha

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A Comprehensive Dataset on Microbiome Dynamics in Rheumatoid Arthritis from a Large-Scale Cohort Study by Jing Li, Jun Xu, Jiayang Jin, Congmin Xu, Yuzhou Gan, Yifan Wang, Ruiling Feng, Wenqiang Fan, Yingni Li, Xiaozhen Zhao, Yucui Li, Shushi Gong, Linchong Su, Yueming Cai, Lianjie Shi, Xiaolin Sun, Yang Xiang, Qingwen Wang, Ru Li, Jinxia Zhao, Yulan Liu, Junjie Qin, Zhanguo Li, Jing He

“…Our dataset comprises gut microbiota profiles from 2,238 individuals, including 1,034 RA patients (Ascia Pacific RA cohort, APRAC) and 1,204 healthy controls. …”
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Mendelian randomization analysis of plasma proteins reveals potential novel tumor markers for gastric cancer by Wenhai Fan, Zhenjiang Wu, Shenghao Xu, Zhiheng Liu, Yiming Huang, Pan Wang

“…Specifically, CHST15 (OR = 0.7553, 95% CI = 0.6346 − 0.8988), L1CAM (OR = 0.7230, 95% CI = 0.5876 − 0.8896), FTMT (OR = 0.8246, 95% CI = 0.7241 − 0.9391), and PMM2 (OR = 0.5767, 95% CI = 0.3943 − 0.8433) were negatively correlated with GASTRIC CANCER, whereas ABO (OR = 1.1868, 95% CI = 1.0638 − 1.3240), FAM3D (OR = 1.2109, 95% CI = 1.0850 − 1.3515), FAM3B (OR = 1.2988, 95% CI = 1.0953 − 1.5402), ADH7 (OR = 1.3568, 95% CI = 1.1044 − 1.6670), MAP1LC3A (OR = 1.3704, 95% CI = 1.1194 − 1.6778), PGLYRP1 (OR = 1.4071, 95% CI = 1.1235 − 1.7623), PDE5A (OR = 1.7446, 95% CI = 1.2693 − 2.3978), GLUL (OR = 3.1203, 95% CI = 1.5017 − 6.4839), NFE2L1 (OR = 3.1759, 95% CI = 1.6163 − 6.2402), and MAFG (OR = 3.1945, 95% CI = 1.5329 − 6.6575) were positively correlated. …”
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Health effects of mixed metal exposure on accelerating aging among the elderly population by Chuanli Yang, Jijun Zhang, Haohan Liu, Qin Hong, Yunhe Fan, Jie An, Haijia Zhang, Xiaobing Shen, Xiushan Dong

“…Results: We found that blood cadmium (Cd) concentration was positively associated with an increased risk of AgeAccelGrim in both females and males, with odds ratios (OR) of 5.73 (95 % confidence interval (95 % CI): 1.88–17.41, P trend = 0.008) and 14.25 (95 % CI: 4.88–41.62, P trend < 0.001), respectively. …”
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Establishment and evaluation of a UPLC-MS/MS method for simultaneous determination of bongkrekic acid and dehydroacetic acid in rice noodles by Lingguo Zhao, Ronggui Lv, Ronggui Lv, Jiang Song, Xi Chen, Lei Lei, Weixian Zeng, Miaowen She, Miaowen She, Dabing Li, Xiaxia Yu, Zhanguo Liu, Xiao Wang, Yong Liu

“…Additionally, the method exhibited good recovery of 90.1%∼105.4% for BA and 80.4%∼102% for DHA. Meanwhile, the method also exhibited good precision with RSD of 0.4%∼7.5% for BA, and with RSD of 4.5%∼11.4% for DHA. …”
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Harmful newborn cord care practices and associated factors among mothers who gave birth in the last six months in Chencha town, Southern Ethiopia: a mixed-methods study by Misgana Seifu, Sultan Hassen, Mekdim Kassa, Yosef Haile, Zeleke Girma, Temesgen Mohammed Toma, Agune Ashole, Mintesinot Melka Gujo, Wondimagegn Taye Dema, Aleme Mekuriya, Endashaw Shibru

“…Factors such as husband's educational status (AOR = 3.09, 95% CI: 1.11, 8.67), communication on cord care within the community (AOR = 10.24, 95% CI: 5.44, 19.28), and discussions with health workers regarding cord care (AOR = 7.26, 95% CI: 3.59, 14.64) demonstrated significant associations with harmful newborn cord care practice (p &lt; 0.05). …”
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Global trends in surgical approach to neonatal brachial plexus palsy: a systematic review by Michael F. Levidy, Amanda Azer, Jasmine Shafei, Nivetha Srinivasan, Jasmine Mahajan, Shivani Gupta, George Abdelmalek, Krittika Pant, Kunj Jain, Yash Shah, Zheshi Zheng, Johnny Chuieng-Yi Lu, Tommy Nai-Jen Chang, Alice Chu, Aleksandra McGrath, Aleksandra McGrath

“…Age at EBP was 7.2 ± 5.77 months, and age at NTwoRE was 15.85 ± 13.18 months (p &lt; 0.05). The incidence of NTwoRE is increasing time.ConclusionsAge at NBPP surgery is increasing over time. …”
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Evaluating the Benefit of Home Support Provider Services for Positive Airway Pressure Therapy in Patients With Obstructive Sleep Apnea: Protocol for an Ambispective International R... by Sarah Alami, Manuella Schaller, Sylvie Blais, Henry Taupin, Marta Hernández González, Frédéric Gagnadoux, Paula Pinto, Irene Cano-Pumarega, Lieven Bedert, Ben Braithwaite, Hervé Servy, Stéphane Ouary, Céline Fabre, Fabienne Bazin, Joëlle Texereau

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Digital technologies for water use and management in agriculture: Recent applications and future outlook by Carlos Parra-López, Saker Ben Abdallah, Guillermo Garcia-Garcia, Abdo Hassoun, Hana Trollman, Sandeep Jagtap, Sumit Gupta, Abderrahmane Aït-Kaddour, Sureerat Makmuang, Carmen Carmona-Torres

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Age-related features of some plasminogen activation system components content and activity in the blood of benign and malignant uterine body tumors by I. V. Kaplieva, G. V. Zhukova, V. R. Zakharchenko, E. M. Frantsiyants, E. V. Verenikina, Yu. A. Pogorelova, P. S. Kachesova, Yu. Yu. Kozel, N. A. Maximova, M. G. Ilchenko, E. I. Agarkova, A. S. Egorova

“…There was an increase in the calculated t-PA index (activity per unit mass) by 1.4–2.8 times (p &lt; 0.05) in the most patients. …”
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Noninvasive Oral Hyperspectral Imaging–Driven Digital Diagnosis of Heart Failure With Preserved Ejection Fraction: Model Development and Validation Study by Xiaomeng Yang, Zeyan Li, Lei Lei, Xiaoyu Shi, Dingming Zhang, Fei Zhou, Wenjing Li, Tianyou Xu, Xinyu Liu, Songyun Wang, Quan Yuan, Jian Yang, Xinyu Wang, Yanfei Zhong, Lilei Yu

“…Among the 28 algorithms tested, the random forest algorithm demonstrated superior performance with an area under the receiver operating characteristic curve (AUC) of 0.884 and an accuracy of 82.9% in the internal testing group, as well as an AUC of 0.812 and an accuracy of 85.7% in the external testing group. …”
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Mudanças percebidas no estilo de vida no distanciamento social: validade preliminar do questionário by Sueyla Ferreira da Silva dos Santos, Thiago Ferreira de Sousa, Silvio Aparecido Fonseca, Ana Maria Alvarenga, Karine Moraes Pereira, Gildeene Silva Farias, Luiz Rodrigo Augustemak de Lima, Fernanda Carneiro Mussi

“…Participaram da reprodutibilidade 83 estudantes e servidores de instituições de ensino superior brasileiras e o nível de concordância variou de K de 0,182 a 0,584. Conclui-se que o questionário PERMEV apresentou validade de face e conteúdo e de clareza excelente (≥ 90%), bem como a validade de reprodutibilidade foi razoável para avaliar as mudanças no estilo de vida de adultos durante períodos de distanciamento social, a exemplo, a pandemia da COVID-19. …”
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Associations of health literacy with metabolic status and quality of life among comunity patients with type 2 diabetes in Shanghai by YANG Liping, SONG Haihong, SHEN Jue, GAO Jinli, ZHANG Zhiping, QIAN Liuyu, GONG Huan

“…Logistic regression models were used to estimate the odds ratios (OR) and 95% confidence intervals (CI) for the associations between patients’ health literacy levels, metabolic status, and QoL.ResultsAmong the 932 diabetic patients surveyed, the health literacy level was low, with an average score of (65.2±13.4) points of which (62.6±13.8) points for males and (67.9±12.5) points for females. …”
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Burden of alopecia areata in China, 1990–2021: Global Burden of Disease Study 2021 by Xiangqian Li, Huixin Liu, Wenhui Ren, Qijiong Zhu, Peng Yin, Lijun Wang, Jianzhong Zhang, Jinlei Qi, Cheng Zhou, Lishao Guo

“…This large number of patients with AA resulted in a total of 114,431.25 DALYs (95% UI, 74,780.27–160,318.96 DALYs). …”
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Development and validation of a nomogram model for prolonged length of stay in spinal fusion patients: a retrospective analysis by Linghong Wu, Xiaozhong Peng, Yao Lu, Cuiping Fu, Liujun She, Guangwei Zhu, Xianglong Zhuo, Wei Hu, Xiangtao Xie

“…The diagnostic performance of the nomogram model was satisfactory, with AUC values of 0.784 and 0.795 for the internal and external validation sets, respectively. …”
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多囊卵巢综合征及不同受孕方式对妊娠结局的影响

“…【目的】 探讨多囊卵巢综合征(PCOS)患者与普通孕妇妊娠结局的差别及不同受孕方式与妊娠结局的关系【方法】 选择2007年1月至2010年12月在中山大学孙逸仙纪念医院妇产科确诊为PCOS并通过不同方式受孕的220例孕妇为PCOS组,同时期在本院就诊有妊娠结局(包括自然流产人工流产活产及死胎畸形引产)无PCOS史的普通孕产妇11 778例为对照组,比较两组孕妇的妊娠并发症及妊娠结局同时对PCOS组中三种受孕方式(自然促排卵及体外受精胚胎移植受孕)的妊娠结局进行比较 【结果】 PCOS组与对照组妊娠并发症发生率分别为自然流产34.54% vs 8.86%,妊娠期糖代谢异常49.31% vs 8.22%,妊娠期高血压疾病10.42% vs 2.17%,早产18.75% vs 10.13%,双胎22.92% vs 4.26%,胎儿生长受限7.64% vs 2.11%新生儿黄疸17.36% vs 8.95%,PCOS孕妇高于普通孕妇,差异有统计学意义(P < 0.05)两组巨大胎儿胎儿畸形及新生儿窒息的发生率分别为4.17% vs 2.46%,2.08% vs 2.52%,10.42% vs 7.84%,无明显差异PCOS患者体外受精胚胎移植(IVF-ET)组及促排卵组与自然受孕组相比,双胎发生率分别为45.24% vs 2.90%,36.36% vs 2.90%;胎儿生长受限发生率分别为11.90% % vs 1.45%,15.15%% vs 1.45%,IVF-ET组及促排卵组大于自然受孕组,差别有统计学意义;IVF-ET组促排卵组自然受孕组早产发生率分别为26.19%27.27%10.14%,三组相比差别有统计学意义,但两两比较时任意两组相比差别均无统计学意义;其余妊娠并发症在3种不同方式受孕组无显著差别【结论】 PCOS患者妊娠后自然流产妊娠期糖代谢异常妊娠期高血压疾病早产双胎胎儿生长受限及新生儿黄疸的发病率显著升高,两组巨大胎儿畸形及窒息的发生率无明显差异除双胎胎儿生长受限及早产外不同受孕方式对妊娠并发症及妊娠结局无明显影响…”
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