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  1. 2641
  2. 2642

    Highly selective HPK1 inhibitor NDI-101150 mediates immune cell activation and robust antitumor responses, distinct from immune checkpoint blockade by Samantha Carreiro, Christine Loh, Neelu Kaila, Fu-Shan Kuo, Scott Boiko, David N Ciccone, Joshua J McElwee, Peter J Tummino

    Published 2025-07-01
    “…Genetic HPK1 kinase inactivation or knockout in mice leads to immune cell activation and tumor growth suppression, providing a strong rationale for targeting HPK1 kinase activity as an immuno-oncology therapy.Methods A structure-guided drug design approach was used to identify a highly potent and selective small molecule inhibitor of HPK1 kinase activity, NDI-101150. …”
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  3. 2643

    Epidemiological Aspects of Monitoring the Sensitivity of <i>Staphylococcus aureus</i> Strains by N. Kh. Otamuratova, G. K. Abdukhalilova, D. R. Akhmedova, Yu. A. Tursunova

    Published 2025-04-01
    “…Conclusion. In the general structure of microorganisms of the hospital, Staphylococcus aureus strains prevailed (50%). …”
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  4. 2644

    First rangewide density estimate of the endemic and isolated Luangwa giraffe in Zambia by Catherine Sun, Frederike Otten, Rigardt Hoffman, Courtney Marneweck, Howard Maimbo, Charles-Albert Petre, Dusty Joubert, Tom Riffel, Matthew S. Becker, Stephanie Fennessy, Julian Fennessy, Michael B. Brown

    Published 2025-05-01
    “…However, sparse monitoring since the early 1900s has limited inferences about population size, structure, and range. To address this, we conducted the most spatially extensive and systematic survey to date of Luangwa giraffe across its distribution, extending survey effort 120 km south of their officially recognized extent. …”
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  5. 2645

    Informational and analytical support of planning processes of marketing actions in high-speed trains by E. A. Makarova, K. V. Surzhin, S. S. Morozov, S. V. Muktepavel, I. N. Spesivtseva

    Published 2018-02-01
    “…The functionality created on the basis of ACS “Express” is a flexible system of reports that are formed at the user's request, allowing you to view information on the structure of passenger traffic with varying degrees of detail for compiling programs to stimulate demand and analyze its effectiveness.…”
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  6. 2646

    Clinical and epidemiological characteristic of chronic hepatitis C in the republic of Tyva by A. A. Saryglar, S. O. Dongak, A. D. Ibrohimova, K. E. Novak, E. V. Esaulenko

    Published 2023-04-01
    “…The clinical profile of typical patients with chronic hepatitis C was established; whose share in the total structure of the examined was 38.4%.  Conclusion: There is a tendency to reduce the incidence of chronic hepatitis C in the Republic of Tyva. …”
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  7. 2647

    EPIDEMIOLOGICAL ASPECTS THE INCIDENCE OF CANCER OF THE KIDNEY AND BLADDER IN PRIMORSKY KRAI by G. N. Alexeyeva, P. F. Kiku, V. G. Moreva, L. I. Gurina, M. V. Volkov, S. V. Yudin

    Published 2017-03-01
    “…The incidence of bladder cancer in men tended to rise from the continental bioclimatic zone to the coast in all ecological zones mainly due to differences in the structure of the bioclimate between the coast and continental areas of Primorsky Krai. …”
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  8. 2648
  9. 2649
  10. 2650
  11. 2651

    Knowledge, barriers, and facilitators for promoting cardiovascular health in a Latino community: a qualitative sub-study of the Skills-based Educational Strategies for Reduction of... by Bernadette Boden-Albala, Bernadette Boden-Albala, Bernadette Boden-Albala, Darnisha Draughter-Espinoza, Megan Castro, Desiree Gutierrez, Cassandra Cardenas, Matthew J. Landry, Jeffrey Wing, Bruce Albala, Bruce Albala, Bruce Albala

    Published 2025-06-01
    “…Through these community-engagement methods, SERVE OC can optimize program design and implementation, maximizing the positive impact of the CVD risk reduction initiative.Clinical trial registrationhttp://www.clinicaltrials.gov, NCT05641519.…”
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  12. 2652

    Conceptualizing the Public Component of Green Finance by Horyn Volodymyr P., Sydor Iryna P., Bula Pavlo V., Mudryi Taras P.

    Published 2025-03-01
    “…The generalization of scientific viewpoints from domestic and foreign economic science regarding the essence and structure of green finance has enabled the distinction of both public and private components within it. …”
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  13. 2653

    Development of intelligent monitoring system for tension overhead line construction based on multi-parameter sensing by Liu-Huo Wang, Qi Xiao, Feng Wang, Xiao-Bin Li, Hua-Shen Guan, Bao-Jun Liu

    Published 2025-07-01
    “…., and then it builds up the overall structure of the system’s monitoring points. Aiming at the characteristics of field construction of tension wire, a real-time data collection and processing model is designed, and LoRa communication technology and 4G communication technology are selected to interconnect the self constructed local area network and 4G wide area network, so as to complete the on-site interaction and long distance transmission of data. …”
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  14. 2654

    Demographic and socioeconomic factors affecting relative poverty level of older adults in Türkiye by Hüseyin Doğan, Kenan Özmen, Ceyhun Serçemeli, Ömer Alkan

    Published 2025-07-01
    “…Policies addressing older adults should incorporate flexible solutions based on household structure, prioritize health issues, and enhance community support. …”
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  15. 2655

    Radiation-hygienic monitoring and assessment of the doses of the public residing on the radioactively contaminated territories of the Tula region by A. E. Lomovtsev, T. E. Sheveleva, A. S. Karpukhin, A. I. Volodicheva

    Published 2019-09-01
    “…Additionally, it included the assessment of the dynamics of concentration of 137Cs and 90Sr in food products, maximal values of mean annual effective doses of the public and contribution of the collective dose from medical exposure into the structure of the annual collective dose of the public. …”
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  16. 2656

    Coronavirus Anxiety Inventory’s (CAI) Turkish Adaptation: Testing its Validity and Reliability by Esra Asıcı, Halil İbrahim Sarı, Abdi Güngör

    Published 2021-08-01
    “…The results of the confirmatory factor analysis showed that the single-factor structure of the CAI with nine items had adequate fit indices, that is, it showed good features in terms of measuring coronavirus-related anxiety. …”
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  17. 2657

    Fault current limiting dynamic voltage restorer for power quality improvement in distribution system (case study: air force feeder) by Yechale Amogne, Efrata Admas, Wondifraw Asmare Alemu

    Published 2025-07-01
    “…In this paper, dual-function fault current limiter dynamic voltage restorer (FCL-DVR) topology is proposed. The proposed structure can perform both compensate supply voltage fluctuations and limit fault current. …”
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  18. 2658

    The stomatologic status of the population of the Far Eastern region

    Published 2020-04-01
    “…The authors carried out a comparative analysis of the frequency and structure of the dental diseases in different age groups of local and migrant adult population of the Far East. …”
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  19. 2659

    The scale of zebrafish pectoral fin buds is determined by intercellular K+ levels and consequent Ca2+-mediated signaling via retinoic acid regulation of Rcan2 and Kcnk5b. by Xiaowen Jiang, Kun Zhao, Yi Sun, Xinyue Song, Chao Yi, Tianlong Xiong, Sen Wang, Yi Yu, Xiduo Chen, Run Liu, Xin Yan, Christopher L Antos

    Published 2024-03-01
    “…Using the zebrafish pectoral fin bud as a model for early vertebrate fin/limb development, we found that K+ channels also scale this anatomical structure, and we determined how one K+-leak channel, Kcnk5b, integrates into its developmental program. …”
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  20. 2660

    Cryptic species and hybridisation in corals: challenges and opportunities for conservation and restoration by Riginos, Cynthia, Popovic, Iva, Meziere, Zoe, Garcia, Vhon, Byrne, Ilha, Howitt, Samantha M., Ishida, Hisatake, Bairos-Novak, Kevin, Humanes, Adriana, Scharfenstein, Hugo, Richards, Thomas, Briggs, Ethan, Clark, Vanessa, Lei, Chuan, Khan, Mariam, Prata, Katharine E.

    Published 2024-11-01
    “…Here, we investigate the prevalence of cryptic coral groups and assess evidence for their permeability to gene flow (hybridisation) via a structured literature review of genomic studies. Using reproducible criteria to detect distinct genetic groups that are sympatric, we find that 68% of nominal species represented in population genomic studies show evidence for comprising partially reproductively isolated groups and that these distinct groups are often linked by gene flow. …”
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