Constitutive inflammation and epithelial-mesenchymal transition dictate sensitivity to nivolumab in CONFIRM: a placebo-controlled, randomised phase III trial by Dean A. Fennell, Kayleigh Hill, Min Zhang, Charlotte Poile, Sean Ewings, Essa Y. Baitei, Joanna Dzialo, Nada Nusrat, Jan Rogel, Daniel Faulkner, Christian Ottensmeier, Raffaele Califano, Gerard G. Hanna, Sarah Danson, Nicola Steele, Mavis Nye, Lucy Johnson, Kim Mallard, Joanne Lord, Calley Middleton, Peter Szlosarek, Sam Chan, Liz Darlison, Peter Wells-Jordan, Cathy Richards, James Harber, Aleksandra Bzura, Jake Spicer, Catrin Pritchard, Tamihiro Kamata, Jens C. Hahne, Maymun Jama, Edward J. Hollox, Jason F. Lester, Jin-Li Luo, Zisen Zhou, Hongji Yang, Huiyu Zhou, Astero Klampatsa, Gareth O. Griffiths

“…Non-synonymous and neoantigen mutation burden were no different between groups, however R-mesotheliomas were infiltrated with activated CD8+ T- and CD19+ B-lymphocytes, organised into tertiary lymphoid structures. B-cell infiltration correlated with pro-inflammatory chemokines including IL24 and CCL19. …”
Get full text

Citizen Science Identification of Isolated Blue Stellar Systems in the Virgo Cluster by Swapnaneel Dey, Michael G. Jones, David J. Sand, Nicolas Mazziotti, Steven Janowiecki, Gregory R. Zeimann, Paul Bennet

“…Most candidates are concentrated in relatively dense regions, roughly following filamentary structures within the cluster, but avoiding its center. …”
Get full text

FOXA1 enhances antitumor immunity via repressing interferon-induced PD-L1 expression in nasopharyngeal carcinoma by Ying Liu, Bo Xiang, Wei Xiong, Pan Chen, Zhaoyang Zeng, Junshang Ge, Guiyuan Li, Mei Yi

“…Forkhead box A1 (FOXA1) is one of the earliest discovered pioneer factors, which can open up compact chromatin structures to facilitate the binding of other proteins to chromatin.Methods By using RNA sequencing, it was discovered that FOXA1 suppresses the activation of the interferon signaling pathway and the expression of the related interferon-responsive genes in NPC cells. …”
Get full text

Mediating roles of rumination and emotional intelligence in the relationship between resilience and professional efficacy in pharmacy practice by Shazia Rehman, Nadia Rehman, Ali Altalbe, Muhammad Nasir Khan, Ahsan Riaz Khan, Muhammad Akhlaq, Dan Liu, Mi Wang

“…Methods We employed a cross-sectional design and structural equation modeling to analyze data from a sample of 576 pharmacists conducted in the Punjab province between September 2023 and January 2024. …”
Get full text

Knowledge, attitudes, and practices of oxygen therapy among emergency nurses by Yazhu Zhao, Linshan Li, Yi Liu, Yongli Gao, Wei Zhang

“…Notable knowledge gaps emerged regarding two critical aspects: 21.95% of respondents expressed uncertainty about oxygen administration in myocardial infarction patients with SpO2 > 93% without respiratory distress, while 14.88% demonstrated unclear understanding of Venturi mask applications for hypercapnic patients. Structural equation modeling (SEM) analysis demonstrated good model fit (CMIN/DF = 3.323, RMSEA = 0.075, IFI = 0.881, TLI = 0.870, CFI = 0.881). …”
Get full text

The effects of decentralisation on patient and service outcomes: a case of the 2018 decentralisation of multidrug-resistant tuberculosis in Zambia by Tulani Francis L. Matenga, Malizgani Paul Chavula, Joseph Mumba Zulu, Adam Silumbwe, Patricia Maritim, Margarate N. Munakampe, Batuli Habib, Namakando Liusha, Jeremiah Banda, Ntazana N. Sinyangwe, Chris Mweemba, Angel Mubanga, Patrick Kaonga, Mwiche Musukuma, Henry Phiri, Hikabasa Halwiindi

“…Abstract Introduction The Zambian government decentralised tuberculosis control programs by transferring responsibility for the care and treatment of multidrug-resistant tuberculosis (MDR-TB) patients from a two-national hospital model to provincial hospitals and other lower-level healthcare structures. …”
Get full text

A matter of choice: a cross-sectional study examining the impact of the overturning of Roe v Wade on U.S. medical students’ perceptions and career decisions [version 2; peer review... by Zeb Saeed, Alissa Conklin, Sacha Sharp

“…We emphasize the role that abortion laws have in shaping the landscape of healthcare workforce and the need for a more nuanced understanding of how societal structures impact women's reproductive decisions and career paths in medicine.…”
Get full text

PYRUS ZANGEZURA (ROSACEAE) AT SAINT PETERSBURG by K. G. Tkachenko, G. A. Firsov, L. F. Yandovka, A. V. Volchanskaya, N. E. Staroverov, Yu. A. Gryaznov

“…The reasons for the low flower setting may be variable: impaired pollination processes and insufficient fertility of pollen, underdevelopment of the flower morphological structures, or lack of pollinating insects due to adverse weather conditions. …”
Get full text

The role of evaluation in iterative learning and implementation of quality of care interventions by Nikhil Shah, Sharon Mathew, Amanda Pereira, April Nakaima, Sanjeev Sridharan

“…This, of course, implies taking stock of areas of incompleteness in knowledge of context, theory of change, support structures needed in order for the program to succeed in specific settings. …”
Get full text

Electrochemical sensing of 3,3’-Dichlorobiphenyl using green-synthesized gold nanoparticles and Polyvinylpyrrolidone composite by Nahid Rehman, Shraddha Shukla, Ashutosh Pandey, Anjana Pandey

“…Characterization via UV, XRD, FTIR, and TEM confirmed the structural integrity and nanoscale dimensions of the AuNPs. …”
Get full text

In silico screening of naturally derived dietary compounds as potential butyrylcholinesterase inhibitors for Alzheimer’s disease treatment by Md. Tarikul Islam, Md. Aktaruzzaman, Chandan Barai, Farhan Ishrak Rafi, Al Riyad Hasan, Tasfiah Tasnim, Parvej Sarder, Ghadeer M. Albadrani, Muath Q. Al-Ghadi, Amany A. Sayed, Mohamed M. Abdel-Daim, Humayra Afroz Dona, Kishore Kumar Sarkar, Md. Obayed Raihan

Get full text

Everyday stressors questionnaire for students by Buzina, Darya Olegovna, Petrash, Marina D.

“…An obvious, meaningful, convergent validity was carried out, and the structural validity of the scales has been confi rmed by the confi rmatory factor analysis. …”
Get full text

A cross-national analysis of demographic variation in self-rated mental health across 22 countries by Chukwuemeka N. Okafor, Ducel Jean-Berluche, Jason Paltzer, Elizabeth Kwon, Nikolitsa Grigoropoulou, Tyler J. VanderWeele, Byron R. Johnson

Get full text

CASCADE: a community-engaged action model for generating rapid, patient-engaged decisions in clinical research by Bridgette L. Kelleher

“…Opportunities for further development will include exploring best-practice structural procedures, enhancing greater opportunities for pre-panel input by community interest-holders, and determining how to best standardize CASCADE outputs. …”
Get full text

Morphogenesis of Penile Cavernous Fibrosis in Hypotestosteronemia: an Experimental Study by M. I. Kogan, S. S. Todorov, I. V. Popov, I. V. Popov, M. A. Kulishova, A. M. Ermakov, D. V. Sizyakin

“…Morphological signs of the restructuring of smooth muscle cells, sinuses and connective tissue structures in the cavernous bodies of the penis are clearly defined by the day 7 after castration. …”
Get full text

Project Management in the Tourism Industry: the Basics of TMBOK by O. A. Burukina

“…An attempt was made to prove the applicability of the project management methodology and tools to the tourism industry and the dependence of the sustainable development of the tourism industry, both at the local and national levels, on more effective management of processes, programs and portfolios based on a systems approach and project management as a method to improve tourism firms’ operations. …”
Get full text

PERAN PRODUCT CUES AND RISK AVERSION PADA PURCHASE INTENTION DAN POST PURCHASE FEELINGS by Sri Rejeki Ekasasi, Ayu Hema Ajeng Diwasasri

Get full text

Are depression, anxiety, and fear-avoidance predictors of outcomes after digital care for chronic musculoskeletal pain? by Dora Janela, Xin Tong, Anabela C. Areias, Diogo Pires, Fabíola Costa, Hélder Fonseca

“…To assess whether fear-avoidance beliefs, depression, and anxiety predict pain outcomes after a digital care program (DCP) for chronic musculoskeletal pain (CMP). …”
Get full text

The Use of 3D Printing as an Educational Tool in Orthopaedics by Peter Joseph Mounsef, Pasquale Mulé, MSc, Mitchell Bernstein, MD, FRCSC, Reggie Hamdy, MD, FRCSC

“…Despite its increasing use in surgical programs, reviews evaluating its educational impact are sparse. …”
Get full text

Searching for genes determining the APR phenotype in rye by Joanna Szewińska, Mateusz Matuszkiewicz, Monika Rakoczy-Trojanowska, Magdalena Święcicka, Marianna Krysińska, Wojciech Wakuliński

“…However, ScLr_SUG1, a putative ortholog of Lr67, and ScLr_ABC25, which shows high 3D structural similarity to Lr34, could potentially be involved in APR of rye. …”
Get full text