Targeting MARCO in combination with anti-CTLA-4 leads to enhanced melanoma regression and immune cell infiltration via macrophage reprogramming by Hidenori Takahashi, Rana Falahat, Patricio Perez-Villarroel, James J Mulé

“…Macrophage Receptor with Collagenous Structure (MARCO) is one of a family of class-A scavenger receptors expressed by Mφ in the TME and is one of the most upregulated transcripts in dendritic cells (DC) following their ex vivo uptake of dead tumor cells. …”
Get full text

Flipping the curriculum for resident didactics: In-Training and certifying examination scores in an internal medicine residency. by Luke McCoy, Ronald Markert, Elysha Thoms, Olivia Noall, Kathryn Burtson

“…The curriculum followed a 13-block annual structure aligned with ABIM content areas. We compared IM-ITE and IM-CE scores of residents who completed the full flipped curriculum to those trained under the prior LB model.…”
Get full text

The role of Universal Grammar and crosslinguistic influence in the interpretation of recursive set-subset adjectives in adult Romanian L1-English L2 bilinguals by Adina Camelia Bleotu, Adina Camelia Bleotu, Deborah Foucault, Tom Roeper, Usha Lakshmanan

Get full text

Functional annotation of the Hippo pathway somatic mutations in human cancers by Han Han, Zhen Huang, Congsheng Xu, Gayoung Seo, Jeongmin An, Bing Yang, Yuhan Liu, Tian Lan, Jiachen Yan, Shanshan Ren, Yue Xu, Di Xiao, Jonathan K. Yan, Claire Ahn, Dmitry A. Fishman, Zhipeng Meng, Kun-Liang Guan, Ruxi Qi, Ray Luo, Wenqi Wang

Get full text

Discovery of Cyclopentane-Based Phospholipids as Miltefosine Analogs with Superior Potency and Enhanced Selectivity Against <i>Naegleria fowleri</i> by Ahmed H. E. Hassan, Hương Giang Lê, Tuấn Cường Võ, Minji Kim, Joo Hwan No, Mohamed H. Aboutaleb, Jaehoon Sim, Byoung-Kuk Na, Yong Sup Lee

Get full text

Clinical and Epidemiological Characteristics of Hepatocellular Carcinoma in the Republic of Saha (Yakutia) by S. S. Sleptsova, S. I. Malov, E. D. Savilov, S. I. Semenov, V. K. Semenova, L. A. Stepanenko, O. B. Ogarkov, I. V. Malov

“…The Republic of Sakha (Yakutia) is a hyperendemic region of the Russian Federation in terms of the incidence of hepatocellular carcinoma with a predominance of the male population in its structure. The rate of decrease in the incidence of liver cancer in the country will depend on the effectiveness of the regional program for the elimination of viral hepatitis and the decrease in the incidence of cirrhosis of the liver of non-infectious etiology.…”
Get full text

CanvasHero: The role of artificial intelligence in cultivating resilience among children and youth using the 6-part story method in mass war trauma by Yuval Haber, Inbar Levkovich, Iftach Tzafrir, Karny Gigi, Dror Yinon, Dorit Hadar Shoval, Zohar Elyoseph

Get full text

Cartilage loss is greater in knees with virtual joint replacement status than in matched controls without by Felix Eckstein, Wolfgang Wirth, Ali Guermazi, Frank Roemer, Michael Nevitt, Christoph Ladel, Leena Sharma, David J. Hunter, C. Kent Kwoh

Get full text

¹¹⁹Sn Element-Specific Phonon Density of States of BaSnO₃ by Alexey Rulev, Hongxin Wang, Selma Erat, Murat Aycibin, Daniel Rentsch, Vladimir Pomjakushin, Stephen P. Cramer, Qianli Chen, Nobumoto Nagasawa, Yoshitaka Yoda, Artur Braun

Get full text

THE SUMMER TEMPERATURES FORECAST BY THE METHOD OF SINGULAR-SPECTRAL ANALYSIS IN THE SOUTH OF RUSSIA IN 2019-2023 by A. A. Tashilova, B. A. Ashabokov, L. A. Kesheva, N. V. Teunova

“…Using of the first twenty main components (MC20) made it possible to study and restore the internal structure of the entire time series as accurately as possible for a subsequent forecast for 5 years. …”
Get full text

Identifying predictors and assessing causal effect on hypertension risk among adults using Double Machine Learning models: Insights from Bangladesh Demographic and Health Survey. by Probir Kumar Ghosh, Md Aminul Islam, Md Ahshanul Haque, Md Tariqujjaman, Novel Chandra Das, Mohammad Ali, Md Rasel Uddin, Md Golam Dostogir Harun

“…We used logistic regression, Random forest model, Double Machine Learning (DML), and Shapley Additive exPlanations (SHAP) based on a pre-defined causal structure.<h4>Results</h4>The dataset included 11,815 individuals, and the prevalence of hypertension was 38.40%. …”
Get full text

Parental Phasing Study Identified Lineage-Specific Variants Associated with Gene Expression and Epigenetic Modifications in European–Chinese Hybrid Pigs by Chenyu Li, Mei Ge, Keren Long, Ziyin Han, Jing Li, Mingzhou Li, Zhiyan Zhang

“…In this study, we established three crossbred pig families derived from distant genetic lineages and systematically identified variants from different lineages, including single nucleotide polymorphisms (SNPs) and structural variations (SVs). At the phase level, we quantitatively analyzed gene expression, four histone modifications (H3K4me3, H3K27ac, H3K4me1, and H3K27me3), and the binding strength of transcription factor (CTCF) in backfat (BF) and longissimus dorsi (LD) muscle. …”
Get full text

Antimicrobial resistance in a protracted war setting: a review of the literature from Palestine by Ramya Kumar, Osama Tanous, David Mills, Bram Wispelwey, Yara Asi, Weeam Hammoudeh, Omar Dewachi

“…Notably, most studies attributed AMR to local practices, often overlooking broader structural and socio-political drivers. This review underscores the need to contextualize AMR within the environment, particularly under conditions of sustained warfare.IMPORTANCEThis study goes beyond merely reviewing and summarizing data on AMR in the occupied Palestinian territories (oPt), a region enduring chronic war-like conditions. …”
Get full text

Distribution of variants of the <i>TNFA</i> gene regulatory sites among Russian women of Caucasian origin with leiomyoma by V. I. Konenkov, A. V. Shevchenko, V. F. Prokofiev, E. G. Koroleva

“…The aim of our research was to analyze the distribution of TNF-238, TNF- 308 and TNF-863 structural variants at the regulatory region of the TNFA gene in a representative group of Caucasian patients with UF compared with a matched group of healthy women followed by assessment of personalized prognostic significance of suggested differences. 180 patients diagnosed with uterine fibroids and 98 practically healthy women were examined. …”
Get full text

Strengthening health system's capacity for pre-exposure prophylaxis for adolescent girls and young women and adolescent boys and young men in South Africa (SHeS'Cap-PrEP): Protocol... by Edward Nicol, Trisha Ramraj, Mbuzeleni Hlongwa, Wisdom Basera, Ngcwalisa Jama, Carl Lombard, Tracy McClinton-Appollis, Darshini Govindasamy, Desiree Pass, Noluntu Funani, Sarah Aheron, Ariana Paredes-Vincent, Jennifer Drummond, Mireille Cheyip, Sibongile Dladla, Jason Bedford, Cathy Mathews

“…In South Africa, various approaches of delivering PrEP have been adopted at different service delivery points (facility-based only, school-based only, community-based only and hybrid school-facility and community-facility models) to overcome challenges associated with individual, structural, and health systems related barriers that may hinder access to and uptake of PrEP among these populations. …”
Get full text

Diversity and distribution of helminth communities of the rodent Akodon montensis Thomas, 1913 (Rodentia: Cricetidae: Sigmodontinae) in preserved and altered environments in the At... by Camila dos Santos Lucio, Thiago dos Santos Cardoso, Rosana Gentile, Viviane Brito Dias, Milton Cezar Ribeiro, Bernardo Rodrigues Teixeira, Paulo Sérgio D'Andrea

Get full text

Changes in subarctic Pacific phytoplankton communities over the last two decades by Marta Konik, Marta Konik, Marta Konik, Brian P. V. Hunt, M. Angelica Peña, Toru Hirawake, Christian Marchese, Christian Marchese, Christian Marchese, Perumthuruthil Suseelan Vishnu, Perumthuruthil Suseelan Vishnu, Astrid Bracher, Astrid Bracher, Hongyan Xi, Maycira Costa

Get full text

Methods to improve teaching effciency for students from the People’s Republic of China at technical universities by K. P. Baslyk, V. P. Pechnikov, N. A. Tukhtarova

“…The research materials include printed works for which the appropriate methods of analysis of scientific texts are used: ● excerpts from the development programs of space industry and joint educational programs of Russia and China – aspect and diachronic method of analysis of priority areas of development of the higher school of China and promising areas of cooperation; ● the curricula of professional education in various areas and specialties of Bauman Moscow State Technical University – aspect analysis of the general provisions of engineering training programs; ● manuals on the “Basics of Rocket and Space Technology” (BRST) of Russia (USSR) and China – critical, comparative and conceptual analysis of the content features, methods and style of presentation of the material; ● BRST – aspect and phenomenological analysis of the structure and content of a special technical discipline; ● scientific works on pedagogy and psychology – aspect and system analysis of features of the education system, educational behavior and bilingual opportunities of students from China.The paper applied the problem analysis method to tackle the task in the context of publications’ shortage on teaching special technical disciplines to foreigners. …”
Get full text

Perceptions regarding rabies prevention and control in two different community settings in Vietnam using a Q-sorting approach by Doan Hoang Phu, Trang Phuong Thao, Mai Duong Tieu, Dung Nguyen Thi Thuy, Trang Nguyen Thi Phuong, Pawin Padungtod, Dinh Bao Truong

“…Although awareness of rabies is high, structural limitations – particularly inadequate access to veterinary services – hinder effective control. …”
Get full text

Calpastatin and myostatin genes polymorphism and their association with slaughter traits in the Gashun Soviet Merino breed grown in southern Russia by Nadezhda V. Shirokova, Vladimir K. Fiodorov, Izabella G. Kazarova, Ivan F. Gorlov, Marina I. Slozhenkina, Elena Y. Anisimova, Ekaterina V. Karpenko

“…Data on the CAST and MSTN gene polymorphism and the genetic structure of the studied sheep population were obtained for the first time, their association with slaughter traits was revealed, and desirable genotypes CAST_MN and MSTN_AG were determined. …”
Get full text