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Immune predictors of response to immune checkpoint inhibitors in mismatch repair-deficient endometrial cancer
Published 2024-07-01“…However not all responses and predictors of primary resistance are lacking.Methods We compared the immune tumor microenvironment of MMRd EC ICI-responders (Rs) and ICI non-responders (NRs), using spatial multiplexed immune profiling and unsupervised hierarchical clustering analysis.Results Overall, NRs exhibited drastically lower CD8+, absent terminally differentiated T cells, lack of mature tertiary lymphoid structures and dendritic cells, as well as loss of human leukocyte antigen class I. …”
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A Narrative Review on Advancing Pediatric Oral Health: Comprehensive Strategies for the Prevention and Management of Dental Challenges in Children
Published 2025-02-01“…Oral health is fundamental to overall well-being, especially in childhood, when dental structures and lifelong habits are established. This review provides a comprehensive analysis of children’s dental development, common oral health challenges, and evidence-based preventive strategies. …”
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Blood Biomarker‐Based Predictive Indicator for Liver Metastasis in Alpha‐Fetoprotein‐Producing Gastric Cancer and Multi‐Omics Tumor Microenvironment Insights
Published 2025-07-01“…Single‐cell RNA sequencing and multiplex immunofluorescence identified the potential roles of tumor‐associated neutrophils and tertiary lymphoid structures in shaping the immune microenvironment. These findings are validated in a real‐world cohort receiving anti‐programmed cell death 1 (anti‐PD‐1) therapy, which showed concordant effectiveness. …”
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Hood technique with the extraperitoneal approach for single port robot-assisted radical prostatectomy
Published 2025-09-01“…Introduction: The Hood technique focuses on preserving key periurethral structures to enhance urinary continence recovery. Here, we describe the extraperitoneal approach for the Hood technique for single-port robot-assisted radical prostatectomy (SP-RARP). …”
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Innovation through recycling in Iron Age plaster technology at Tell el-Burak, Lebanon
Published 2025-07-01“…The analysis extended to two other plastered installations found in separate rooms within the complex, allowing for a comprehensive comparison. An integrated program of archaeometric analysis, including optical microscopy in polarising light, X-ray powder diffraction, scanning electron microscopy, thermogravimetry, and organic residue analysis, was applied to samples from these three structures to investigate plaster composition and technological variability. …”
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The “tyranny of distance”: community-based veteran suicide prevention in Guam
Published 2025-07-01“…Findings highlight unique risk and protective factors faced by those living in Guam, as well as the utility of structured community-based suicide prevention strategies to make change among those living in island communities that are geographically distant from the mainland.…”
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Affordances and Core Features of Successful Digital Courses Design in Higher Education
Published 2025-08-01“…The findings highlight three primary affordances as most significant for successful digital course design: Structured Learning Environment (SLE), Active Learning and Engagement (AL&E), and Learner-Centered Design (LCD). …”
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Experimental Study and FEM Analysis on the Strengthening of Masonry Brick Walls Using Expanded Steel Plates and Shotcrete with and Without Glass Fiber Reinforcement
Published 2025-08-01“…Overall, the proposed strengthening techniques provided significant improvements in the seismic resistance and energy absorption capacity of masonry walls, offering practical and reliable solutions to enhance the safety and durability of existing masonry structures.…”
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Review of community-based interventions for people with serious mental illness, focusing on learning instrumental activities of daily living and enhancing wellbeing
Published 2025-12-01“…Thematic analysis identified five key mechanisms for success: individualised goal-setting, structured programs with practical learning, engagement of support systems, integration into daily life, and use of innovative technologies. …”
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The evolution of online extensive reading and web-based platforms in EFL/ESL: A narrative review of impacts, challenges, and future directions
Published 2025-05-01“…Adopting a narrative review methodology, this study utilises a structured literature matrix to synthesise findings, critically analyse, and evaluate key data from diverse research studies, offering a comprehensive understanding of OER’s pedagogical implications. …”
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A Deep Learning-Based Probabilistic Approach for Non-Destructive Testing of Aircraft Components Using Laser Ultrasonic Data
Published 2025-01-01“…Composite structures are commonly used in complex applications such as automotive and aerospace due to their high strength-to-weight ratio. …”
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A phenomenological study of sports development in schools and society of Ardabil city from the perspective of teachers and professionals
Published 2024-06-01“…Data were collected using in-depth and semi-structured interviews; the research questions were answered through interviews with people. …”
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Digital branding adoption by specialty eatery start-ups in the post-pandemic environment in India
Published 2023-12-01“…The data was analysed using the AMOS (Analysis of Moment Structures) program. The study concludes that digital branding plays a crucial role as an independent branding strategy and enhances the performance of specialty eatery start-ups in the post-pandemic era. …”
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Nurturing Sustainable Small-Scale Fisheries to Strengthen Food Sovereignty in Qikiqtarjuaq, Nunavut
Published 2025-08-01“…This qualitative case study prioritizes Inuit voices in Qikiqtarjuaq, Nunavut, to explore the complex role of small-scale fisheries in advancing food security, sovereignty, and community well-being. Semi-structured interviews (n=15) were conducted with Elders, experienced commercial fish harvesters, and local decision-makers. …”
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Decision-makers’ perspectives on the implementation of COVID-19 self-testing in Mozambique
Published 2025-06-01“…METHODS: We conducted semi-structured interviews with decision-makers involved in COVID-19 diagnosis, management, and policy development. …”
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Collaboration between educational institutions and families from the perspective of pedagogical and professional staff in schools and students of preschool and elementary pedagogy
Published 2025-07-01“…Material and methods To collect empirical data, we used a non-standardized semi-structured questionnaire. We processed the obtained empirical data through frequency analysis and univariate statistics. …”
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Roles of health promotion researchers in the planning stages of a global urban health promotion initiative: understandings identified from an interview-based case study
Published 2025-05-01“…Amid this epistemology, researchers’ understanding of their roles in specific projects and programs led by different stakeholders is essential. …”
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A Methodological Approach to Measuring the Impact of TAK-003 for the Prevention of Dengue in Dourados, Brazil: Optimizing Strategies for Public Health
Published 2025-01-01“…The selection of analytical methods, such as time series analysis, was dependent on the national and local structures of the databases and data availability.…”
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