Challenges and Obstacles in the Development of Winter Sports Tourism in the Ski Slopes of Tehran by Siavash Imeni, Leyla Asadpour Shirazi

“…The questionnaire measures barriers to tourism across seven dimensions: economic; socio-cultural; managerial-structural; resources, infrastructure, facilities, and services; marketing and advertising; legal-political; and environmental-space development. …”
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Genome-wide association analysis study and genomic prediction for resistance to soybean mosaic virus in soybean population by Tiantian Zhao, Fengmin Wang, Jin Qi, Qiang Chen, Lijuan Zhu, Luping Liu, Long Yan, Yuling Chen, Chunyan Yang, Jun Qin

“…This diversity is a valuable asset for breeding programs targeting disease management. Deep sequencing and genome-wide association studies (GWAS) of the accession population structures identified five distinct clusters and 14 significant loci associated with resistance across chromosomes 2, 4, 7, 9, 13, 14, 17, 19, and 20. …”
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Towards a universal implementation of labor companionship: a synthesis of the policy and facility environment of eight low-and-middle income countries by Soha El-Halabi, Andrea Barnabas Pembe, Alexandre Dumont, Ana Pilar Betrán, Charles Kaboré, Effie Chipeta, Guillermo Carroli, Helle Mölsted Alvesson, Hussein Kidanto, Jean-Paul Dossou, Kristi Sidney Annerstedt, Lenka Beňová, Mechthild M. Gross, Peter Waiswa, Pisake Lumbiganon, Quoc Nhu Hung Mac, Meghan A. Bohren, Claudia Hanson, Claudia Hanson

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Sm2O3-induced superconductivity enhancements in bulk Y-123 ceramics synthesized via a novel modified thermal decomposition method by Ryad Alhadei Mohamed Arebat, Mohd Mustafa Awang Kechik, Yap Siew Hong, Chen Soo Kien, Lim Kean Pah, Hussien Baqiah, Fatma Barood, Syahrul Humaidi, Hoo Keong Peh, Abdul Halim Shaari, Muhammad Kashfi Shabdin, Muralidhar Miryala

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Cloning and identification of human colipase-like 3 and its homologous cDNAs by LU Yan, XUE Yong-chang, YU Peng, WANG Ping-zhang

“…CL PSL3 was widely expressed and highly conserved in mammalian animals, such as Pan troglodytes, Equus caballus, Cavia porcellus, Loxodonta africana, Mus musculus and Rattus norvegicus, and showed very similar gene structures. Moreover, the CLPSL3 contained 18 highly conserved cysteines in all species, suggesting that it might relate to the disulfide bond formation.Colipase is a co-factor needed by pancreatic lipase for efficient dietary lipid hydrolysis. …”
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Contemporary contexts of higher medical education development: Patient-centred care in medical students’ understanding by T. D. Podkladova, L. G. Smyshliaeva, A. O. Okorokov, I. I. Soshenko

“…The research methods include theoretical, phenomenological, and structural types of analysis; survey method, expert assessments, and focus groups.Results. …”
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Morphofunctional Characteristics of the Hippocampus of White Rats in the Acute Period After Severe Traumatic Brain Injury During the Use of L-lysine Aescinat by I. P. Koshman, A. Yu. Shoronova, S. S. Stepanov, A. G. Kalinichev, V. A. Akulinin, A. S. Stepanov, D. B. Avdeyev, V. L. Molchanova

“…The revealed changes are considered not only as patho-, but also as sanogenetic structural mechanisms of protection and reorganization of the hippocampus in the acute post-traumatic period.1. …”
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High-Dose Ceftriaxone in Elderly Patients with Enterococcal Infective Endocarditis: Population Pharmacokinetics of Free Ceftriaxone and Dose Optimization by Beatriz Fernández Rubio, Fernando Docobo Pérez, Laura Herrera Hidalgo, Luis Eduardo López-Cortés, Rafael Luque Márquez, José Manuel Lomas Cabezas, Luis Fernando López-Cortés, Marta Mejías Trueba, Ana Belén Guisado Gil, Alicia Gutiérrez Valencia, Arístides de Alarcón González, María Victoria Gil Navarro

“…Ceftriaxone free concentration was measured at three time-points: before the administration (C_min) and two and four hours after ceftriaxone administration (C₂ and C₄). Both structural and covariate population pharmacokinetic models were built. …”
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Magnetically sensitive nanocomposites for targeted antitumor therapy with application of gemcitabine by N. M. Korniichuk, S. P. Turanska, A. L. Petranovska, M. V. Abramov, P. P. Gorbyk, N. Yu. Luk'yanova, N. V. Kusyak, V. F. Chekhun

“…The consequences of oxidative stress are induction of apoptosis, enhancement of lipid peroxidation processes, as well as structural and functional rearrangement of biological membranes. …”
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Cambios en las propiedades del suelo, posteriores a un incendio en el Parque Nacional Natural de Los Nevados, Colombia Soil changes after a fire event in a páramo ecosystem: Los Ne... by Juan Carlos Camargo-García, Miguel Ángel Dossman, José Alexander Rodríguez, Ligia María Arias, Jesús Hernando Galvis-Quintero

“…Consequently, physical properties of soils such as bulk density and structural stability were also deteriorated. Three years after the implementation of restoration activities, there are not evidences of the improvement of soils conditions; in fact, some properties tend to be more deteriorated. …”
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Constitutive inflammation and epithelial-mesenchymal transition dictate sensitivity to nivolumab in CONFIRM: a placebo-controlled, randomised phase III trial by Dean A. Fennell, Kayleigh Hill, Min Zhang, Charlotte Poile, Sean Ewings, Essa Y. Baitei, Joanna Dzialo, Nada Nusrat, Jan Rogel, Daniel Faulkner, Christian Ottensmeier, Raffaele Califano, Gerard G. Hanna, Sarah Danson, Nicola Steele, Mavis Nye, Lucy Johnson, Kim Mallard, Joanne Lord, Calley Middleton, Peter Szlosarek, Sam Chan, Liz Darlison, Peter Wells-Jordan, Cathy Richards, James Harber, Aleksandra Bzura, Jake Spicer, Catrin Pritchard, Tamihiro Kamata, Jens C. Hahne, Maymun Jama, Edward J. Hollox, Jason F. Lester, Jin-Li Luo, Zisen Zhou, Hongji Yang, Huiyu Zhou, Astero Klampatsa, Gareth O. Griffiths

“…Non-synonymous and neoantigen mutation burden were no different between groups, however R-mesotheliomas were infiltrated with activated CD8+ T- and CD19+ B-lymphocytes, organised into tertiary lymphoid structures. B-cell infiltration correlated with pro-inflammatory chemokines including IL24 and CCL19. …”
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A computational DNA methylation method to remove contaminated DNA from spent embryo culture medium for noninvasive preimplantation genetic testingResearch in context by Yidong Chen, Jin Huang, Fuchou Tang, Lu Wen, Jie Qiao

“…At the heart of ART success is preimplantation genetic testing (PGT), which enables the detection of chromosomal anomalies, single-gene disorders, and structural rearrangements, enhancing embryo selection and mitigating genetic risk. …”
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The proposed model of the body of knowledge of digital transformation for the Central Bank of the Islamic Republic of Iran by Samira Tahmasebi Ashtiani, Mohammad Hasanzadeh, Atefeh Sharif, Mostafa Amini

“…Purpose: A body of knowledge is a formal description of a field that includes a complete set of theories, methods, concepts in a structured way, and technologies. If we consider knowledge alone as the factor of individual superiority, the flow of knowledge is the factor of group superiority. …”
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Sustainable forest management: success and challenges in Ethiopia by Rusha Begna Wakweya

“…However, more effective governance structures are needed to balance the goals of forest conservation and community development2. …”
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Direito e marxismo: a política de qualificação para trabalhadores desempregados na experiência do MTD em João Pessoa / Law and marxism: the qualification policy for unemployed work... by Ítalo Giovanni Fernandes Correia, Liziane Pinto Correia, José Victor Figueiredo de Lucena

“…Education still follows a rhythm of employability condition, now increased by the neoliberal context, in which the portfolios tend to be larger by efforts of the individuals who try to enter the job market through qualification or professionalisation programs. It is intended, thus, to review: some concepts of exploration by work and structural unemployment; the neoliberal discourse of employability that harms unemployed workers; the relationship between the theoretical basis and the extensionist experience that followed the Unemployed Workers Movement, in João Pessoa, during the conquest and participation in a public policy of qualification to combat unemployment and reflect its consequences<strong>.…”
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Talent Management Pattern Finding with a Succession Approach Using the Met-asynthesis Method by Ali tavakoli, maryam majidi, Alireza Afsharnejad, gholamreza amjadi

“…The results showed that the structural dimensions of talent management include six dimensions of organizational structure, recruitment system, training system, compensation system, performance management and evaluation system, and organizational strategy. …”
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Clinical syndromes linked to biallelic germline variants in MCM8 and MCM9 by Noah C. Helderman, Ting Yang, Claire Palles, Diantha Terlouw, Hailiang Mei, Ruben H.P. Vorderman, Davy Cats, Marcos Díaz-Gay, Marjolijn C.J. Jongmans, Ashwin Ramdien, Irma van de Beek, Thomas F. Eleveld, Andrew Green, Frederik J. Hes, Marry M. van den Heuvel-Eibrink, Annelore Van Der Kelen, Sabine Kliesch, Roland P. Kuiper, Inge M.M. Lakeman, Lisa E.E.L.O. Lashley, Leendert H.J. Looijenga, Manon S. Oud, Johanna Steingröver, Yardena Tenenbaum-Rakover, Carli M. Tops, Frank Tüttelmann, Richarda M. de Voer, Dineke Westra, Margot J. Wyrwoll, Mariano Golubicki, Marina Antelo, Laia Bonjoch, Mariona Terradas, Laura Valle, Ludmil B. Alexandrov, Hans Morreau, Tom van Wezel, Sergi Castellví-Bel, Yael Goldberg, Maartje Nielsen

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Metabolomic liquid biopsy dynamics predict early-stage HCC and actionable candidates of human hepatocarcinogenesis by Kornelius Schulze, Tim Daniel Rose, Lorenz Adlung, Manuela Peschka, Francesca Pagani, Joao Gorgulho, Thorben W. Fründt, Ismail Labgaa, Philipp K. Haber, Carolin Zimpel, Darko Castven, Arndt Weinmann, Teresa Garzia-Lezana, Moritz Waldmann, Thomas Renné, Hannah Voß, Manuela Moritz, Dorian Orlikowski, Hartmut Schlüter, Jan Baumbach, Myron Schwartz, Ansgar W. Lohse, Samuel Huber, Bruno Sangro, Rocio I.R. Macias, Laura Izquierdo-Sanchez, Jesus M. Banales, Henning Wege, Jens U. Marquardt, Augusto Villanueva, Josch Konstantin Pauling, Johann von Felden

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Antecedents and consequences affecting job plateau among school employees in Tehran by Nafiseh Ghasemi Zargar, parivash jafari, Nadergholi Ghourchian, AmirHossein Mohammaddavoudi

“…Data collection is through semi-structured interviews. Data analysis was done using thematic analysis method and MAXQDA 18 software. …”
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ZNFX1 suppresses apoptosis-associated mRNA stability in cardiomyocyte to protect against myocardial infarction by Yang Shi, Zeqi Sun, Yongchao Chen, Yanli Xie, Chen Chen, Han Lou, Jan Mohammad Omar, Lei Wang, Ling Liu, Heng Liu, Limin Zhao, Henghui Xu, Xiaohan Li, Run Xu, Zhouxiu Chen, Khuzin Dinislam, Yong Zhang, Xin Liu

“…Here, we report that ZNFX1 plays a protective role in MI by degrading mRNA of apoptosis-related genes, which possess highly structured 3′UTRs. Collectively, this study provides a novel insight into the regulatory mechanisms of programmed cell death, potentially uncovering new targets for therapeutic intervention in diseases where apoptosis is a critical factor.…”
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