Constitutive inflammation and epithelial-mesenchymal transition dictate sensitivity to nivolumab in CONFIRM: a placebo-controlled, randomised phase III trial by Dean A. Fennell, Kayleigh Hill, Min Zhang, Charlotte Poile, Sean Ewings, Essa Y. Baitei, Joanna Dzialo, Nada Nusrat, Jan Rogel, Daniel Faulkner, Christian Ottensmeier, Raffaele Califano, Gerard G. Hanna, Sarah Danson, Nicola Steele, Mavis Nye, Lucy Johnson, Kim Mallard, Joanne Lord, Calley Middleton, Peter Szlosarek, Sam Chan, Liz Darlison, Peter Wells-Jordan, Cathy Richards, James Harber, Aleksandra Bzura, Jake Spicer, Catrin Pritchard, Tamihiro Kamata, Jens C. Hahne, Maymun Jama, Edward J. Hollox, Jason F. Lester, Jin-Li Luo, Zisen Zhou, Hongji Yang, Huiyu Zhou, Astero Klampatsa, Gareth O. Griffiths

“…Non-synonymous and neoantigen mutation burden were no different between groups, however R-mesotheliomas were infiltrated with activated CD8+ T- and CD19+ B-lymphocytes, organised into tertiary lymphoid structures. B-cell infiltration correlated with pro-inflammatory chemokines including IL24 and CCL19. …”
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Barriers to effective communication on adult vaccination: results of in-depth interviews with the population and healthcare professionals of the Arkhangelsk Oblast by M. V. Lopatina, E. A. Kriger, N. R. Nizovtseva, A. V. Kudryavtsev, V. A. Yakovleva, V. А. Zinovieva, E. V. Usova, A. V. Kontsevaya, O. M. Drapkina

“…Based on the World Health Organization approach to adapting immunization programs, a qualitative study was conducted in May-June 2024 in the Arkhangelsk region, including 18 semi-structured personal in-depth interviews on adult vaccination with two following target groups: adult population (n=12) and health workers (n=6). …”
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The impact of maximal oxygen uptake (VO₂max) on athletic performance and health - a review by Julia Charkot, Wojciech Bieńkowski, bartlomiej kusy, Michał Bieńkowski, Mikołaj Charkot, Piotr Kucharczyk, Irmina Jaszczuk, Patrycja Retman

“…Results: VO₂max is influenced by genetic, physiological, and environmental factors, and can be improved through structured endurance and high-intensity interval training. …”
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Knowledge, Attitude and Willingness Towards Organ Donation among People Attending Out Patient Departments of a Tertiary Care Hospital, West Bengal: A Cross-sectional Study by Bobby Syiemlieh, Obangkokla O, Mousumi Khatun, Poonam Joshi, Latha T, Jamuna R Rani, Ajay Mallick

“…The participants were interviewed using structured questionnaires on knowledge, attitude and willingness towards organ donation. …”
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Biochemical and psychological markers of fatigue and recovery in mixed martial arts athletes during strength and conditioning training by Joanna Ostapiuk-Karolczuk, Hanna Dziewiecka, Patryk Bojsa, Mirosława Cieślicka, Monika Zawadka-Kunikowska, Kaźmierczak Wojciech, Anna Kasperska

“…This study aimed to assess temporal changes in biochemical and psychological fatigue and recovery markers during a structured 3-week strength and conditioning training program in professional MMA athletes. …”
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Psychosocial consequences of xylazine and implications for harm reduction services by Marina Plesons, William H. Eger, Erika L. Crable, Maia H. Hauschild, Corbin C. McElrath, Cyrus Owens, David W. Forrest, Angela R. Bazzi, Naida De Los Santos, Hansel E. Tookes, Tyler S. Bartholomew

“…Methods: We conducted semi-structured qualitative interviews with 17 PWUD and 8 staff at a syringe services program in Miami, FL from June–July 2023. …”
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Awareness of breast cancer and perceived barriers to breast screening methods: a community based cross-sectional study among women in Yemen by Gamil Othman, Faisal Ali, Maria Mudathir, Heba Almoliky, Maria Al-qahtani, Nora Alezzi, Nosibah Ameen, Doa’a Anwar Ibrahim, Mohammed Mohammed Battah, Mohamed Izham Mohamed Ibrahim

“…However, challenges arise in combating breast cancer in Yemen due to the lack of patient registries, national strategies, and structured cancer treatment plans. Objective This research sought to evaluate the awareness levels of breast cancer and the perceived obstacles to breast cancer screening among adult Yemeni women. …”
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Knowledge, attitude, and practice levels of Fulani milk processors toward milk contamination and hygiene in Northern Oyo State, Nigeria by Ibraheem Ghali-Mohammed, Aminullah Ajiyobiojo Azeez, Mutiat Adenike Adetona, Akeem Adebola Bakare, Tajudeen Opeyemi Isola, Damilola Christiana Olawoye, Nma Bida Alhaji, Ismail Ayoade Odetokun

“…Demographic characteristics, personal hygiene practices, and milk handling procedures were evaluated using structured questionnaires. While 51.0% of respondents demonstrated adequate knowledge of milk contamination and 63.5% showed positive attitudes toward prevention, only 35.8% implemented acceptable hygiene practices. …”
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Citizen Science Identification of Isolated Blue Stellar Systems in the Virgo Cluster by Swapnaneel Dey, Michael G. Jones, David J. Sand, Nicolas Mazziotti, Steven Janowiecki, Gregory R. Zeimann, Paul Bennet

“…Most candidates are concentrated in relatively dense regions, roughly following filamentary structures within the cluster, but avoiding its center. …”
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Mixed-method evaluation of a culturally-adapted basic palliative care curriculum for practicing physicians in mainland China by Hongju Liu, Xiaohong Ning, Tiekuan Du, Yue Liu, Fei Li, Rachel Pozzar, Lin Tang, Isaac Siemens, Ying Zheng, Xiaoyan Dai, Breffni Hannon, Eric Krakauer, Zhimeng Jia

“…We also thematically analyzed post-course semi-structured participant interviews. Results The majority of participants were aged 41–50 (51.7%), trained in internal medicine (55.2%), worked at tertiary medical centers (93.1%), and did not have clinical PC experience (65.5%). …”
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FOXA1 enhances antitumor immunity via repressing interferon-induced PD-L1 expression in nasopharyngeal carcinoma by Ying Liu, Bo Xiang, Wei Xiong, Pan Chen, Zhaoyang Zeng, Junshang Ge, Guiyuan Li, Mei Yi

“…Forkhead box A1 (FOXA1) is one of the earliest discovered pioneer factors, which can open up compact chromatin structures to facilitate the binding of other proteins to chromatin.Methods By using RNA sequencing, it was discovered that FOXA1 suppresses the activation of the interferon signaling pathway and the expression of the related interferon-responsive genes in NPC cells. …”
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Barriers to Perinatal Care among Immigrant and Migrant Women in Southeast Minnesota by Jensen Reckhow, Kirsten A. Riggan, Emily Breutzman, Minerva Orellana, Stephanie Low, Yvonne S. Butler Tobah, Enid Y. Rivera-Chiauzzi, Megan A. Allyse, Vanessa E. Torbenson

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Community acceptance of Ivermectin mass drug administration for malaria in Southern Thailand by Pyae Linn Aung, Piyarat Sripoorote, Nattawan Rachaphaew, Jetsumon Sattabongkot, Daniel M. Parker, Wang Nguitragool, Suparat Phuanukoonnon

“…In 2022, a cross-sectional study was conducted in three districts of Surat Thani Province, southern Thailand, where an ivermectin MDA program was planned. Quantitative data were collected through structured surveys administered to randomly selected household heads using a standardized questionnaire. …”
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Knee functional outcomes and quadriceps hypotrophy after ACL reconstruction: a prospective observational study by Nagma Sheenam, Ravi Gaur, Nitesh Manohar Gonnade, Abhinav Dixit, Abins T. K., Chinchu K.

“…Ultrasonography and surface electromyography revealed ongoing quadriceps muscle hypotrophy and reduced neuromuscular function, highlighting the need for targeted rehabilitation. Conclusion Structured rehabilitation post-ACL reconstruction significantly improves functional outcomes and reduces pain. …”
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Prediction of Myopia Among Undergraduate Students Using Ensemble Machine Learning Techniques by Isteaq Kabir Sifat, Tajin Ahmed Jisa, Jyoti Shree Roy, Nourin Sultana, Farhana Hasan, Md Parvez Mosharaf, Md. Kaderi Kibria

“…Methods A cross‐sectional study was conducted in Dinajpur city, collecting 514 samples through a self‐structured questionnaire covering demographic information, myopia prevalence and risk factors, knowledge and attitudes, and daily activities. …”
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ANZAED eating disorder credentialed clinician perceptions and experiences of professional development by Janet Conti, Madalyn McCormack, Gabriella Heruc, Katarina Prnjak, Rebecca Barns, Siân A. McLean, Phillipa Hay

“…Methods Participants were 28 ANZAED Credentialed Eating Disorder Clinicians who participated in a semi-structured interview after completion of an online self-report survey. …”
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A mechanism-based group psychotherapy approach to aggressive behavior (MAAP) in borderline personality disorder: a multicenter randomized controlled clinical trial by Christine Sigrist, Andreas Bechdolf, Katja Bertsch, Robin Bullenkamp, Martin Busse, Ute gr. Darrelmann, Astrid Dempfle, Martin Driessen, Thomas Frodl, Jan-Michael Kersting, Jessica Kesik, Burkhart Matzke, Corinne Neukel, Eva Niessen, Svenja Nückel, Viola Oertel, Frank Padberg, Alexandra Philipsen, Dorothee Pink, Andreas Reif, Matthias Reinhard, Carolin Steuwe, Larissa Wolkenstein, Sabine C. Herpertz, the MAAP Consortium

“…Discussion If proven superior, MAAP can be incorporated into standard psychiatric care, filling a critical gap in the current therapeutic landscape by offering a structured, cost-effective, and evidence-based treatment that directly targets the biobehavioral mechanisms underlying reactive aggression in BPD. …”
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“Beyond the flood: Exploring the psychosocial consequences and resilience challenges in the aftermath of “El Niño” in Tumbes, Peru” by Elaine C. Flores, Daniela C. Fuhr, Victoria Simms, Andres G. Lescano, Nicki Thorogood

“…Methods: Between May-June 2017, we conducted 27 semi-structured interviews and three focus groups in Spanish with 24 adult residents, including local authorities and residents from heavily and minimally El Niño affected areas. …”
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A multi-perspective qualitative study on robotic-assisted surgery training demand by Xinling Tian, Kongying Nong, Xueqi Tang, Jiani Zhai, Yihang Guo, Yueran Li, Yichuan Zhang, Yuzhe Kong, Xiaohong Tang

“…Considering the pressing necessity to formulate standardized robotic surgery training programs, our objective is to conduct multi-institutional demand assessments. …”
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Cryptic species and hybridisation in corals: challenges and opportunities for conservation and restoration by Riginos, Cynthia, Popovic, Iva, Meziere, Zoe, Garcia, Vhon, Byrne, Ilha, Howitt, Samantha M., Ishida, Hisatake, Bairos-Novak, Kevin, Humanes, Adriana, Scharfenstein, Hugo, Richards, Thomas, Briggs, Ethan, Clark, Vanessa, Lei, Chuan, Khan, Mariam, Prata, Katharine E.

“…Here, we investigate the prevalence of cryptic coral groups and assess evidence for their permeability to gene flow (hybridisation) via a structured literature review of genomic studies. Using reproducible criteria to detect distinct genetic groups that are sympatric, we find that 68% of nominal species represented in population genomic studies show evidence for comprising partially reproductively isolated groups and that these distinct groups are often linked by gene flow. …”
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