Exploring the space of self-reproducing ribozymes using generative models by Camille N. Lambert, Vaitea Opuu, Francesco Calvanese, Polina Pavlinova, Francesco Zamponi, Eric J. Hayden, Martin Weigt, Matteo Smerlak, Philippe Nghe

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Immune predictors of response to immune checkpoint inhibitors in mismatch repair-deficient endometrial cancer by Etienne Rouleau, Ana Oaknin, Christophe Klein, Alexandra Leary, Sebastien Gouy, Patricia Pautier, Catherine Genestie, Amandine Maulard, Judith Michels, Marco de Bruyn, Emeline Colomba-Blameble, Annechien Plat, Juan Francisco Grau Bejar, Elisa Yaniz Galende, Qinghe Zeng, Audrey Le Formal, Elodie Edmond, Maëva Moreau

“…However not all responses and predictors of primary resistance are lacking.Methods We compared the immune tumor microenvironment of MMRd EC ICI-responders (Rs) and ICI non-responders (NRs), using spatial multiplexed immune profiling and unsupervised hierarchical clustering analysis.Results Overall, NRs exhibited drastically lower CD8+, absent terminally differentiated T cells, lack of mature tertiary lymphoid structures and dendritic cells, as well as loss of human leukocyte antigen class I. …”
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A Deep Learning-Based Probabilistic Approach for Non-Destructive Testing of Aircraft Components Using Laser Ultrasonic Data by Adriano Liso, Cosimo Patruno, Angelo Cardellicchio, Pierfrancesco Ardino, Nicola Gallo, Giuseppe del Prete, Valerio Dentico, Veronica Vespini, Sara Coppola, Pietro Ferraro, Vito Reno

“…Composite structures are commonly used in complex applications such as automotive and aerospace due to their high strength-to-weight ratio. …”
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Modificaciones a un transportador apilador de sacos de azúcar // Modifications to a decker transporter of sugar sacks. by F. Aguilar Parés, M. Sánchez Noa

“…<br />In the developed work it is achieved that with the same capacity and transportation longitude, as well as with the same<br />technical solution to vary the angle of inclination in the wanted range, diminish the total weight of the equipment in 20%,<br />with the employment of a professional program, the structural solution is changed and the thickness of the profiles is<br />decreased, eliminate the problems of stability. …”
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Fostering Critical Thinking through Socio-Scientific Issue-Based Problem-Based Learning in Stoichiometry Instruction by Aida Hajijah, Mariam Nasution, Nur Azizah Putri Hasibuan, Lelya Hilda, Najah Yousef Baroud

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In silico and in vivo Study of the Anti-Inflammatory Activity of Azomethine Derivatives of 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide and 2-substituted 5,6,7,8-tetra... by Chiriapkin, A.S., Kodonidi, I.P., Abisalova, I.L., Diakova, I.N.

“…In silico prediction of anti-inflammatory activity was performed using the AutoDock 4.0 program. The virtual structures of the test compounds were constructed in HyperChem 8.0.4. …”
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Efficacy of neoadjuvant chemotherapy with docetaxel and cisplatin in patients with squamous cell carcinoma of the oral cavity at high risk of progression by S. I. Kutukova, Yu. V. Ivaskova, N. P. Beliak, G. A. Raskin, A. A. Varankina, A. I. Yaremenko, A. Ya. Razumova, A. O. Cheremnykh, M. F. Manna, R. V. Orlova

“…At the 1st stage of our study, we retrospectively analyzed the data of 98 patients and determine that the NACT for patients with oral cavity squamous cell carcinoma, with 3 or more factors of an unfavorable prognosis (peripheral blood parameters indicating the presence of systemic inflammation, reduced level of infiltration of tumor structures by CD8‑tumor infiltrating lymphocytes and low expression of programmed death-ligand 1 (PD-L1) on tumor and immune cells) significantly reduces the risk of death and disease progression: hazard ratio 0.33; 95 % confidence interval 0.13–0.86; p = 0.0231. …”
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Patient safety and the second victim phenomenon in nursing and medical curricula: A qualitative study by Einav Srulovici, Mary-Elizabeth Tumelty, Ivana Meszaros Skoumalova, Patricia Vella Bonanno, Erika Kubilienė, José Joaquín Mira, Valentina Marinkovic, Anat Rafaeli, Reinhard Strametz, Susanna Tella, Anu Venesoja, Žymantė Jankauskienė, Sandra C. Buttigieg

“…Inclusion criteria required at least 5 years of experience in curriculum development at both undergraduate and postgraduate levels; there were no dropouts. Methods: Semi-structured interviews were conducted in participants' native languages, translated to English, and analyzed using thematic analysis. …”
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In Vivo Cell Migration and Growth Within Electrospun Porous Nanofibrous Scaffolds with Different Pore Sizes in a Mouse Pouch Model by David C. Markel, Therese Bou-Akl, Bin Wu, Pawla Pawlitz, Xiaowei Yu, Liang Chen, Tong Shi, Weiping Ren

“…Cellular infiltration into traditional electrospun nanofibers (NFs) is limited due to their dense structures. We were able to obtain polycaprolactone (PCL) NFs with variable and defined pore sizes and thicknesses by using a customized programmed NF collector that controls the moving speed during electrospinning. …”
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Stress among police officials in Kerala, India: an analysis of organizational and operational factors by Mini GK, Chitra Venkateswaran, Anjana VM, Sangeeth Krishna S, Greeshma J, Greeshma PS, Revathy K, Vilma Irazola, John Romate

“…The present study examines the specific stressors associated with the operational demands and organizational structures experienced by police officers in the state of Kerala, India. …”
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Cardiac fibroblast-mediated ECM remodeling regulates maturation in an in vitro 3D engineered cardiac tissue by Yongjun Jang, Myeongjin Kang, Yong Guk Kang, Dongtak Lee, Hyo Gi Jung, Dae Sung Yoon, Jongseong Kim, Yongdoo Park

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Innovative aspects of enhancement of management processes in the higher educational institution on the basis of application of modern information and communication technologies by I. E. Zhukovskya

“…The received results can be used in activities of governing bodies, business by structures, professional and higher educational institutions as a basis for development of recommendations about development and enhancement of management processes based on application of information and communication technologies.…”
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Systematic literature review related to the theoretical knowledge base for non-invasive monitoring of the biomechanical and visco-elastic properties of the myotendinous complex in... by Ana-Andreea Cristea, Aurelian Anghelescu, Gelu Onose

“…These may include neurological injuries, such as tetraplegia, as well as non-neurological injuries affecting the vertebral structures and adjacent tissues [1,2]. Spinal cord injuries have immense disabling potential, and therapeutic options are limited [3]. …”
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SCIENTIFIC-PROJECT CONSULTING AS AN INNOVATIVE FORMAT OF POSTGRADUATE EDUCATION by G. A. Ignatieva, O. V. Tulupova

“…In general, educational consulting including development of techniques of management and planning of educational activity is applied to methodical maintenance of functioning and development of educational structures. Perspective scientific and project types of consulting in post-industrial society still have remained out-of-sight of a scientific pedagogical research. …”
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Public insight into knee osteoarthritis: a cross-sectional study from the West Bank, Palestine by Haya Jebreen Mohammed Warasna, Bashar Yaser Hasan Awad, Mohamad A. Banat, Mohammad Yaser Hasan Awad, Ahmed Farid Gadelmawla, Jameel Suliman, Tarek A. Owais, Ahmad J. Warasna

“…Abstract Background Osteoarthritis (OA) is a significant global health concern and is characterized by the degeneration of joint structures, leading to pain, stiffness, and functional limitations It is estimated that 654.1 million individuals are affected by osteoarthritis worldwide, with females, especially those older than 60 years of age, being the population most impacted. …”
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Focused low-intensity hippocampal transcranial ultrasound stimulation (TUS) for sleep disturbances in patients with chronic tinnitus: A study protocol for a pilot randomized contro... by Xi Ni, Yuk Shan Yuen, Zeyan Li, Kaipeng Wang, Natalie Shu Yang, Yi Yuan, Lin Meng, Liwei Guo, Hanna Lu

“…Compared to TMS, focused low-intensity transcranial ultrasound stimulation (TUS) is a newly developed modality of non-invasive brain stimulation that offers promising therapeutic effects by transmitting acoustic energy into deep brain structures with a high spatial resolution (i.e., sub-millimeter), which sparks interest in managing the comorbidities in ageing populations.…”
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Contribución al conocimiento de la estructura foliar de las especies de magnoliáceas colombianas Contribución al conocimiento de la estructura foliar de las especies de magnoliácea... by Schnetter Marie Luise, Lozano Contreras Gustavo

“…<span style="font-size: 9pt; font-family: 'Times New Roman', serif;" lang="EN-US">Leaf structures including epidermal features of 12 colombian species of<br />the genus Talauma and 9 species of the genus Dugandiodendron were studied.…”
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The Role of Local Government Councils in Emancipating Special Interest Groups: A Case Study of PWDs in Bukimbiri Sub-County Kisoro District. by Kamusiime, Daniel

“…The study findings showed the role of local government towards the emancipation of PWDs includes representation in councils, funding by development partners, training and sensitization of the PWDs, putting appropriate administrative structures, policy formulation review and promotion, mobilization of resources, and decentralization to encourage community participation. …”
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The Role of Local Government Councils in Emancipating Special Interest Groups: A Case Study of PWDs in Bukimbiri Sub County Kisoro District . by Kamusiime, Daniel

“…The study findings showed the role of local government towards the emancipation of PWDs includes representation in councils, funding by development partners, training and sensitization of the PWDs, putting appropriate administrative structures, policy formulation review and promotion, mobilization of resources, and decentralization to encourage community participation. …”
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Finding the Root of the Pathos in the Planning System of Iran: 5-why Technique by Elham Vafaei, Gholamreza Geraeinejad

“…To answer this important question, the pathology of the planning system is examined from two dimensions: Its stages (preparation and compiling (prerequisite, structure, process and product), approval, pre-implementation, implementation and Supervision and evaluation) and its source (inside and outside the organization). …”
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